Patent application number | Description | Published |
20100262069 | Photodynamic Bone Stabilization Systems and Methods for Reinforcing Bone - Photodynamic bone stabilization systems are disclosed herein. In an embodiment, a photodynamic bone stabilization system includes a catheter having an elongated shaft with a proximal end adapter, a distal end releasably engaging an expandable portion, and a longitudinal axis therebetween; a light-conducting fiber configured to transmit light energy to the expandable portion; a light-sensitive liquid monomer comprising an initiator, wherein the initiator is activated when the light-conducting fiber transmits the light energy to initiate polymerization of the light-sensitive liquid monomer; and a cooling medium configured to control polymerization temperature, wherein the catheter comprises an inner void sufficiently designed to pass the light-sensitive liquid monomer into the expandable portion, and wherein the catheter comprises an inner lumen sufficiently designed to pass the light-conducting fiber into the expandable portion and configured to circulate the cooling medium. | 10-14-2010 |
20100265733 | Attachment System for Light-Conducting Fibers - In an embodiment, an attachment system for communicating light energy from a light source to a light-conducting fiber includes a light pipe body sufficiently designed to engage a distal end of a light pipe, the light pipe body comprising at least one opening configured to dissipate heat buildup from light energy; a front assembly sufficiently designed to engage the light pipe body, the front assembly comprising an orifice and at least one opening configured to dissipate heat buildup from light energy; a light-conducting fiber body sufficiently designed to engage the front assembly and to hold a proximal portion of a light-conducting fiber, the light-conducting fiber body positioned in the orifice of the front assembly; and an optical taper assembly sufficiently designed to hold an optical taper, the optical taper assembly positioned between and spaced apart from the front assembly, and positioned between and spaced apart from the light pipe. | 10-21-2010 |
20120262939 | Attachment System for Light-Conducting Fibers - In an embodiment, an attachment system for communicating light energy from a light source to a light-conducting fiber includes a light pipe body sufficiently designed to engage a distal end of a light pipe, the light pipe body comprising at least one opening configured to dissipate heat buildup from light energy; a front assembly sufficiently designed to engage the light pipe body, the front assembly comprising an orifice and at least one opening configured to dissipate heat buildup from light energy; a light-conducting fiber body sufficiently designed to engage the front assembly and to hold a proximal portion of a light-conducting fiber, the light-conducting fiber body positioned in the orifice of the front assembly; and an optical taper assembly sufficiently designed to hold an optical taper, the optical taper assembly positioned between and spaced apart from the front assembly, and positioned between and spaced apart from the light pipe. | 10-18-2012 |
20130003406 | Attachment System for Light-Conducting Fibers - In an embodiment, an attachment system for communicating light energy from a light source to a light-conducting fiber includes a light pipe body sufficiently designed to engage a distal end of a light pipe, the light pipe body comprising at least one opening configured to dissipate heat buildup from light energy; a front assembly sufficiently designed to engage the light pipe body, the front assembly comprising an orifice and at least one opening configured to dissipate heat buildup from light energy; a light-conducting fiber body sufficiently designed to engage the front assembly and to hold a proximal portion of a light-conducting fiber, the light-conducting fiber body positioned in the orifice of the front assembly; and an optical taper assembly sufficiently designed to hold an optical taper, the optical taper assembly positioned between and spaced apart from the front assembly, and positioned between and spaced apart from the light pipe. | 01-03-2013 |
20130023877 | PHOTODYNAMIC BONE STABILIZATION SYSTEMS AND METHODS FOR REINFORCING BONE - Photodynamic bone stabilization systems are disclosed herein. In an embodiment, a photodynamic bone stabilization system includes a catheter having an elongated shaft with a proximal end adapter, a distal end releasably engaging an expandable portion, and a longitudinal axis therebetween; a light-conducting fiber configured to transmit light energy to the expandable portion; a light-sensitive liquid monomer comprising an initiator, wherein the initiator is activated when the light-conducting fiber transmits the light energy to initiate polymerization of the light-sensitive liquid monomer; and a cooling medium configured to control polymerization temperature, wherein the catheter comprises an inner void sufficiently designed to pass the light-sensitive liquid monomer into the expandable portion, and wherein the catheter comprises an inner lumen sufficiently designed to pass the light-conducting fiber into the expandable portion and configured to circulate the cooling medium. | 01-24-2013 |
Patent application number | Description | Published |
20090081157 | Immunostimulatory Combinations for Vaccine Adjuvants - This invention discloses immunostimulatory combinations of Tumor Necrosis Factor Receptor Superfamily (TN-FRSF) agonists, Toll-Like Receptor (TLR) agonists, “domain present in NAIP, CIITA, HET-E, TP-I (NACHT)-Leucine Rich Repeat (LRR)” or “NLR” agonists, RIG-I-Like Helicase or “RLH” agonists, purinergic receptor agonists and cytokine/chemokine receptor agonists, together with delivery methods. The combinations, when used alone at the site of pathology, provide immunostimulation that induces host humoral and cellular immunologic responses to eliminate pathogens or neoplasms. Alternatively, when the combinations are used with a defined antigens, these combinations can induce focused humoral and cellular immunologic responses useful as prophylactic and/or ameliorative therapeutic modalities for infections and the treatment of neoplastic disorders. | 03-26-2009 |
20130039942 | Compositions and Methods for Self-Adjuvanting Vaccines against Microbes and Tumors - The present invention is drawn to compositions and methods to enhance an immune response in order to prevent or treat infections or hyperproliferative diseases such as cancer. More particularly, the composition is an immuno stimulator intracellular signaling peptide fused directly or indirectly to a peptide that leads to multimerization into complexes of three or more units, where the intracelluar signaling peptide must be present in a complex of three or more units in order to stimulate an immune response. Inserting this fusion construct into viruses like HIV-1 or introducing it into dendritic cells or tumor cells is predicted to lead to a positive therapeutic effect in humans, non-human mammals, birds, and fish. | 02-14-2013 |
Patent application number | Description | Published |
20110282242 | Instrument for Applying Therapeutic Cells, with Proximal Portion for Processing Therapeutic Cells - A tissue harvesting and processing apparatus comprises a body and a distally extending needle. The needle includes an aperture configured to receive tissue. A tissue cutting member is movable relative to the needle to sever a specimen from tissue protruding through the aperture. A tissue processor is operable to mince tissue severed by the tissue cutting member. The minced tissue may be mixed with a medical fluid component contained in a reservoir. The medical fluid mixture may be expelled through an applier tip coupled with the body. The tissue processor may comprise a mincing die such that tissue specimens are minced upon being extruded through the mincing die. The tissue processor may comprise a blade that cooperates with a sliding press. The tissue processor may comprise auger blade sections that cooperate with inwardly extending pins. A mixing piston may mix the minced tissue with the medical fluid component. | 11-17-2011 |
20110282324 | Multi-Chamber Therapeutic Cell Applicator Instrument - A surgical device comprises a housing, a plurality of media reservoirs, an end effector, and a pumping device. Each media reservoir is configured to receive at least one component of a tissue repair composition. The end effector is configured for insertion into a lumen to deliver a tissue repair composition into that lumen. The end effector has at least one fluid conduit and at least one orifice in communication with the fluid conduit. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the plurality of media reservoirs through the fluid conduit of the end effector such that the tissue repair composition is expelled from the at least one orifice. The media reservoirs may contain medical fluid components such as viable cells and scaffold material to repair a fistula or address some other condition in a patient. | 11-17-2011 |
20110282381 | Therapeutic Cell Applicator Instrument with Modular Tips - A surgical device comprises a housing, a bioprocessing module, an end effector, and a pumping device. The bioprocessing module comprises media reservoirs, fluid conduits in communication with the reservoirs, and a port through which media is expelled. The end effector is configured for insertion into a lumen and delivering a tissue repair composition into that lumen. The end effector has at least one fluid conduit extending therethrough and at least one orifice in communication with the fluid conduit. The fluid conduit in the first end effector is in fluid communication with the port on the bioprocessing module. The pumping device is operable to urge a tissue repair composition comprising at least a portion of the contents of the media reservoirs through the fluid conduit of the first end effector such that the tissue repair composition is expelled from the at least one orifice. | 11-17-2011 |