Kopka
Christian Kopka, Bonn DE
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20100220176 | VISUAL AID WITH THREE-DIMENSIONAL IMAGE ACQUISITION - The task of providing a device which makes it possible for the natural visual faculty of a partially vision-impaired person to be restored or supported as realistically as possible by means of a visual aid or visual prosthesis is achieved with the visual aid according to the invention in that, beyond the pure acquisition of a two-dimensional image, additional information is included in the image processing. For this purpose, a visual aid system is proposed which, during the reproduction of the processed image, visualizes additional information regarding the spatial position and/or specific attributes of objects in the acquired image which is associated with objects in the acquired image. The present invention thus affords the advantage that a three-dimensional image of the current environment of the user can be acquired owing to the fact that the image visualized to the user by the visual aid system according to the invention comprises additional information, for example, about the relative distance of the objects contained in the image and a depth-selective representation of the acquired image can thus be achieved. | 09-02-2010 |
20140009591 | VISION AID WITH THREE-DIMENSIONAL IMAGE ACQUISITION - The task of providing a device which makes it possible for the natural visual faculty of a partially vision-impaired person to be restored or supported as realistically as possible by means of a visual aid or visual prosthesis is achieved with the visual aid according to the invention in that, beyond the pure acquisition of a two-dimensional image, additional information is included in the image processing. For this purpose, a visual aid system is proposed which, during the reproduction of the processed image, visualizes additional information regarding the spatial position and/or specific attributes of objects in the acquired image which is associated with objects in the acquired image. The present invention thus affords the advantage that a three-dimensional image of the current environment of the user can be acquired owing to the fact that the image visualized to the user by the visual aid system according to the invention comprises additional information, for example, about the relative distance of the objects contained in the image and a depth-selective representation of the acquired image can thus be achieved. | 01-09-2014 |
Christian Martin Kopka, Bonn DE
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20110004271 | VISUAL PROSTHESIS SYSTEM FOR DISPLAYING VIDEO IMAGE AND TEXT DATA - A visual prosthesis system comprises a retina implant at least partly located in the interior of a patient's eye. The retina implant comprises an array of micro-contacts adapted for contacting ganglia of the patient's retinal tissue. The visual prosthesis system further comprises a data processing unit with an additional interface for receiving an external signal from an external signal source, the data processing unit being adapted for converting the external signal into corresponding stimulation data for the retina implant, and a wireless transmission unit adapted for transmitting the stimulation data to the retina implant via wireless transmission. The retina implant is adapted for receiving the stimulation data and for stimulating the micro-contacts according to the stimulation data. | 01-06-2011 |
Ihor Kopka, Hampton, NJ US
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20100168076 | DIPHENYL SUBSTITUTED ALKANES - The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors. Compounds of Formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents. | 07-01-2010 |
Ihor Kopka, Warren, NJ US
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20120108595 | PLATELET-ACTIVATING FACTOR RECEPTOR ANTAGONISTS - Cyclohexyl sulfonamide compounds which are platelet-activating factor (PAF) receptor antagonists. Said compounds may be useful, for example, for the treatment of atherosclerosis or other PAF-mediated disorders, including inflammatory, cardiovascular, and immune disorders. | 05-03-2012 |
Ihor E. Kopka, Hampton, NJ US
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20090253705 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS - The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor. | 10-08-2009 |
20100190761 | DIPHENYL SUBSTITUTED ALKANES - The instant invention provides compounds of Formula I which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of Formula I are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents. | 07-29-2010 |
20110028461 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS - The present invention provides compounds of Formula I, pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor. | 02-03-2011 |
20110028481 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS - The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor. | 02-03-2011 |
20110190346 | Diphenyl Substituted Alkanes as Flap Inhibitors - The instant invention provides compounds of formula I which are 5-lipoxygenase activating protein inhibitors. | 08-04-2011 |
20120258963 | HYDROXYMETHYL PYRROLIDINES AS BETA 3 ADRENERGIC RECEPTOR AGONISTS - The present invention provides compounds of Formula (I), pharmaceutical compositions thereof, and method of using the same in the treatment or prevention of diseases mediated by the activation of β3-adrenoceptor. | 10-11-2012 |
Joachim Kopka, Berlin DE
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20080288174 | Method for Identifying the Function of a Gene - Described is a method for determining the function of a gene. This method involves determining the amount of transcript for each of a set of candidate genes in samples taken from different phenotypic and/or genotypic states of an organism and determining the amount of each of a plurality of metabolites in different samples taken from the same states as those mentioned above. Subsequently, the data obtained is analyzed by suitable mathematical methods in order to identify a transcript and metabolites which correlate in the different states, thereby identifying a transcript corresponding to a gene which influences the amount of metabolites in the organism. Furthermore described is a method for identifying a gene which is capable of modifying the amount of a metabolite in an organism and to a method for identifying a metabolite which is capable of modifying the amount of a transcript in an organism. Likewise, uses of the genes and metabolites identified in the aforementioned methods are described. | 11-20-2008 |
20090032462 | METHOD FOR THE EXTRACTION OF COMPONENTS MADE FROM ORGANIC MATERIAL - The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture. | 02-05-2009 |
20110272353 | PROCESS FOR EXTRACTING CONSTITUENTS FROM ORGANIC MATERIAL - The present invention relates to a process for extracting constituents from organic material, comprising the step of extracting with a monophasic mixture of 50% by volume to 90% by volume of methanol and 50 to 10% by volume of water and optionally 0% by volume to 40% by volume of a further solvent or solvent mixture. | 11-10-2011 |
Klaus Kopka, Münster DE
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20090041664 | 5-Pyrrolidinylsulfonyl Isatin Derivatives - The present invention relates to novel 5-pyrrolidinylsulfonyl isatin derivatives, non-peptidyl Caspase binding Radioligands (CbRs) and CbR-transporter conjugates derived from said isatin derivatives, diagnostic compositions comprising said compounds of the invention and their use for non-invasive diagnostic imaging. | 02-12-2009 |
20090169483 | FLUORESCENT PHOTOPROBE FOR THE IMAGING OF ENDOTHELIN RECEPTORS - The present invention relates to a endothelin receptor antagonist conjugate of the formula (I) wherein R | 07-02-2009 |
20130004430 | FLUORESCENT PHOTOPROBE FOR THE IMAGING OF ENDOTHELIN RECEPTORS - The present invention relates to an endothelin receptor antagonist conjugate of the formula (I) wherein R | 01-03-2013 |
20130149239 | 5-PYRROLIDINYLSULFONYL-ISATIN DERIVATIVES - The present invention relates to novel | 06-13-2013 |
Klaus Kopka, Münster DE
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20090169483 | FLUORESCENT PHOTOPROBE FOR THE IMAGING OF ENDOTHELIN RECEPTORS - The present invention relates to a endothelin receptor antagonist conjugate of the formula (I) wherein R | 07-02-2009 |
Klaus Kopka, Muenster DE
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20120282180 | Compounds with Matrix-Metalloproteinase Inhibitory Activity and Imaging Agents Thereof - The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration. The invention furthermore discloses intermediates in the synthesis of the inhibitors of matrix-metalloproteinases (MMPs) of the invention and of the diagnostic imaging agents of the invention and kits for the preparation of the pharmaceutical composition of the invention. | 11-08-2012 |
20130217887 | Compounds With Matrix-Metalloproteinase Inhibitory Activity and Imaging Agents Thereof - Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved. | 08-22-2013 |
Klaus Kopka, Dossenheim DE
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20150110715 | Double-Labeled Probe for Molecular Imaging and Use Thereof - The present invention relates to a compound or a pharmaceutically acceptable salt thereof having a chemical structure comprising: (A) at least one motif specifically binding to cell membranes of neoplastic cells; (B) at least one chelator moiety of radiometals; and (C) at least one dye moiety; wherein said compound has a molecular weight of not more than 5 kDa. Further, the invention refers to a method for producing such compound and to the in vivo and in vitro uses thereof. | 04-23-2015 |
Lars Kopka, Paderborn DE
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20140207994 | CIRCUIT ARRANGEMENT FOR UNIVERSAL CONNECTION OF A BUS PARTICIPANT TO AT LEAST ONE BUS - A circuit arrangement for connecting a bus participant to at least one bus, having an interface for connecting the bus participant to the circuit arrangement, a first bus input, and a first bus output between which the bus participant is switchable via the interface. The circuit arrangement includes a second bus input and output for connecting the bus to the circuit arrangement in a ring topology in such a way that the first bus output is connected at least indirectly to the second bus input and the second bus output is connected at least indirectly to the first bus input via the bus. The bus in the circuit arrangement can be separated to obtain a line topology and can be configured as bus-terminating at one of the bus inputs or bus outputs. A system for the functional testing of bus participants on a bus in a simulation environment is provided. | 07-24-2014 |
Markus Kopka, Ditzingen DE
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20090271012 | Method or System for Displaying an Internet Page on a Visualization Device of an Industrial Automation Device - There is described a method for displaying an Internet page an/or an intranet page on a visualization device of an industrial automation device, wherein the method relates to data of the Internet page and/or intranet page which are stored in a first data format on a server. In this case, the industrial automation device can be unburdened of tasks for displaying the page. The data of the Internet page and/or intranet page can be transmitted to a data processing device via the Internet and/or an intranet and can be received by the data processing device, after which the data processing device converts the data of the Internet page and or intranet page, which are in the first data format, into a second data format, after which these converted data are transmitted to the industrial automation device and/or to the visualization device of the industrial automation device. Following this, the page can be fully or partially displayed on the visualization device of the industrial automation device. | 10-29-2009 |