Patent application number | Description | Published |
20130061783 | GROMMET ASSEMBLY FOR WORK SURFACES - A work surface includes a grommet and door assembly that provides for routing of utility lines through an opening in the work surface. The door pivots in first and second opposite directions about first and second axes, respectively, to first and second open positions. Magnetic connectors retain the door during pivoting about the first and second axes, and also retain the door in a closed position. | 03-14-2013 |
20130314852 | WORK AND VIDEOCONFERENCE ASSEMBLY - A monitor support assembly comprising a support frame including a first elongated frame member forming a first surface and a second elongated frame member forming a second surface, the second frame member supported adjacent and parallel to the first frame member with the first surface facing the second surface and forming an elongated gap, a panel assembly including a first panel member having oppositely facing substantially parallel front and rear surfaces and a second panel member having oppositely facing substantially parallel front and rear surfaces, the second panel member supported adjacent the first panel member with the front surface of the first panel member facing the rear surface of the second panel member, the panel assembly supported within the gap by the first and second frame members and an electronic display mounted to the front surface of the second panel member. | 11-28-2013 |
20140311050 | Work and Videoconference Assembly - A monitor support assembly comprising a base designed to rest on an ambient floor surface, the base having a rear end, an upright frame structure mounted to and extending vertically upward from the base spaced forward of the rear end, the frame structure including first and second vertical members and at least a top frame member that extends horizontally between the first and second vertical members, a shroud assembly mounted to the upright frame structure including at least a first central wall member and first and second additional wall members, the first and second additional wall members extending from the first and second lateral edges in the same direction, the first central wall member and the additional wall members forming a receiving space, and a mounting plate mountable to the rear surface of a displays screen and releasably supported by the upright frame structure within the receiving space wherein a depth dimension of the receiving space is sufficient to accommodate a display screen mounted therein via the mounting plate. | 10-23-2014 |
Patent application number | Description | Published |
20130161599 | ELECTRO-CHEMICAL SENSORS, SENSOR ARRAYS AND CIRCUITS - An electro-chemical sensor includes a first electrode, a second electrode spaced apart from the first electrode, and a semiconductor channel in electrical contact with the first and second electrodes. The semiconductor channel includes a trapping material. The trapping material reduces an ability of the semiconductor channel to conduct a current of charge carriers by trapping at least some of the charge carriers to localized regions within the semiconductor channel. The semiconductor channel includes at least a portion configured to be exposed to an analyte to be detected, and the trapping material, when exposed to the analyte, interacts with the analyte so as to at least partially restore the ability of the semiconductor channel to conduct the current of charge carriers. | 06-27-2013 |
20140191218 | X-RAY-SENSITIVE DEVICES AND SYSTEMS USING ORGANIC PN JUNCTION PHOTODIODES - An x-ray detector includes a first electrode, a second electrode spaced apart from the first electrode, an organic p-type semiconducting layer disposed between the first and second electrodes, and an organic n-type semiconducting layer disposed between the first and second electrodes and in contact with the organic p-type semiconducting layer to form a pn-junction layer therebetween. At least one of the organic p-type semiconducting layer or the organic n-type semiconducting layer includes an x-ray absorbing material blended therein. | 07-10-2014 |
20140220704 | ARTICLES COMPRISING TEMPLATED CROSSLINKED POLYMER FILMS FOR ELECTRONIC DETECTION OF NITROAROMATIC EXPLOSIVES - The present invention provides devices and articles of manufacture comprising a low-voltage operable, highly sensitive, and selectively responsive polymer for the detection of nitroaromatic compounds, including explosives. Resistive devices were fabricated by simple spin-coating on flexible and transparent substrates as well as silicon substrates, and were stable under ambient temperature and oxygen levels before exposure to the nitroaromatics. After exposure to 2,4,6-trinitrotoluene (TNT), the devices showed increased conductance, even with pg quantities of TNT, accompanied by a confirming color change from colorless to deep red. The relative conductance increase per unit exposure is the highest yet reported for TNT. Aromatic anion salts, on the other hand, did not induce any electronic responses. Methods of making the articles and devices, and their use are also provided. | 08-07-2014 |
Patent application number | Description | Published |
20100214069 | METHOD AND SYSTEM FOR STATE ENCODING - A system comprising at least one piece of equipment; a plurality of sensors adapted to measure one or more operating parameters of the equipment; and a signature generator adapted to encode a plurality of data streams from the sensors into an operating signature for the equipment. | 08-26-2010 |
20100219950 | REMOTE MONITORING SYSTEMS AND METHODS - A method comprising selecting a piece of equipment to be monitored; selecting a plurality of operating parameters to monitor; calculating a deviation for each of the operating parameters; and calculating a composite index for the piece of equipment based on the deviations. | 09-02-2010 |
20120016607 | REMOTE MONITORING SYSTEMS AND METHODS - A system for monitoring an industrial process, comprising one or more sensors connected to one or more operating components of the industrial process; a remote monitoring station, comprising a computer and a database; and a connection between the one or more sensors and the remote monitoring station, wherein the remote monitoring station is at least about 100-2500 miles away from the industrial process, for example 500-1000 miles. | 01-19-2012 |
20140240095 | METHOD AND SYSTEM FOR STATE ENCODING - A system comprising at least one piece of equipment; a plurality of sensors adapted to measure one or more operating parameters of the equipment; and a signature generator adapted to encode a plurality of data streams from the sensors into an operating signature for the equipment. | 08-28-2014 |
Patent application number | Description | Published |
20120267775 | System and Method to Manufacture an Implantable Electrode - The method of the preferred embodiments includes the steps of providing a base having a frame portion and a center portion; building a preliminary structure coupled to the base; removing a portion of the preliminary structure to define a series of devices and a plurality of bridges; removing the center portion of the base such that the frame portion defines an open region, wherein the plurality of bridges suspend the series of devices in the open region defined by the frame; and encapsulating the series of devices. The method is preferably designed for the manufacture of semiconductor devices, and more specifically for the manufacture of encapsulated implantable electrodes. The method, however, may be alternatively used in any suitable environment and for any suitable reason. | 10-25-2012 |
20120323288 | HYBRID CLUSTERED NEURAL INTERFACE SYSTEM - An apparatus comprises a flexible substrate. The flexible substrate includes a first substrate surface, a surface electrode array that includes a plurality of electrodes disposed on the first substrate surface, one or more flexible neural probes substantially orthogonal to the first substrate surface and insertable into biological tissue, and a penetrating electrode array that includes a plurality of electrodes formed on the one or more flexible neural probes, wherein electrodes of the surface electrode array and the penetrating electrode array are configured to one or both of receive a neural signal from a neural signal source and provide electrical stimulation energy to a neural stimulation target. | 12-20-2012 |
20130030352 | NEUROMODULATION TRANSFECTION SYSTEM WITH ACTIVE FLUID DELIVERY - A neural interface array including an optical waveguide, a thin film electrode array associated with the optical waveguide, the thin film electrode array having a plurality of electrodes, and a fluid delivery channel attached to at least one of the optical waveguide and the thin film electrode array. Also disclosed are methods for optical stimulation and a neural interface system with active fluid delivery. | 01-31-2013 |
20130030353 | NEUROMODULATION TRANSFECTION SYSTEM WITH PASSIVE FLUID DELIVERY - An implantable optical electrode having a thin film electrode array including a plurality of electrodes, a light source associated with the thin film electrode array, and a passive bioactive agent delivery module associated with the thin film electrode array. Also disclosed are methods of manufacturing the array and a neural interface system with passive fluid delivery. | 01-31-2013 |
20130090525 | NEURAL INTERFACE SYSTEM WITH AN EDGE ARRAY - The neural interface system of one embodiment includes a cylindrical shaft, a lateral extension longitudinally coupled to at least a portion of the shaft and having a thickness less than a diameter of the shaft, and an electrode array arranged on the lateral extension and radially offset from the shaft, including electrode sites that electrically interface with their surroundings. The method of one embodiment for making the neural interface system includes forming a planar polymer substrate with at least one metallization layer, patterning on at least one metallization layer an electrode array on a first end of the substrate, patterning conductive traces on at least one metallization layer, rolling a portion of the substrate toward the first end of the substrate, and securing the rolled substrate into a shaft having the first end of the substrate laterally extending from the shaft and the electrode array radially offset from the shaft. | 04-11-2013 |
20130137955 | Implantable Electrode Lead System with a Three Dimensional Arrangement and Method of Making the Same - One embodiment of the invention includes an implantable electrode lead system that includes a series of shims stacked upon each other, a series of first components, and a series of second components connected to the series of first components through a series of connectors. One of the first components extends from one of the shims, and another of the first components extends from another one of the shims. The shims position the first components in a three dimensional arrangement. | 05-30-2013 |
20130144365 | NEURAL DEVICE WITH MODULAR ELECTRODE ARRAY - An apparatus comprises a flexible substrate including a modular electrode array disposed on the flexible substrate. The modular electrode array includes a plurality of electrode modules, where an electrode module includes a plurality of electrodes. The flexible substrate also includes a spatial separation between the electrode modules of the modular electrode array, and conductive interconnect coupled to the electrodes of the plurality of electrodes. | 06-06-2013 |
20140027888 | SYSTEM AND METHOD TO MANUFACTURE AN IMPLANTABLE ELECTRODE - The method of the preferred embodiments includes the steps of providing a base having a frame portion and a center portion; building a preliminary structure coupled to the base; removing a portion of the preliminary structure to define a series of devices and a plurality of bridges; removing the center portion of the base such that the frame portion defines an open region, wherein the plurality of bridges suspend the series of devices in the open region defined by the frame; and encapsulating the series of devices. The method is preferably designed for the manufacture of semiconductor devices, and more specifically for the manufacture of encapsulated implantable electrodes. The method, however, may be alternatively used in any suitable environment and for any suitable reason. | 01-30-2014 |
20150047179 | WAVEGUIDE NEURAL INTERFACE DEVICE - A waveguide neural interface device including: a neural device implantable in tissue and including an array of electrode sites that electrically communicate with their surroundings, in which the array of electrode sites includes at least one recording electrode site; and a waveguide, coupled to the neural device, that carries light along a longitudinal axis and includes a light directing element that redirects the carried light from the waveguide to illuminate selectively targeted tissue, in which at least a portion of the redirected light is directed laterally away from the longitudinal axis and the recording electrode site is configured to sample illuminated tissue. A method for assembling a waveguide neural interface device is also described. | 02-19-2015 |
Patent application number | Description | Published |
20090102068 | SYSTEM AND METHOD TO MANUFACTURE AN IMPLANTABLE ELECTRODE - The method of the preferred embodiments includes the steps of providing a base having a frame portion and a center portion; building a preliminary structure coupled to the base; removing a portion of the preliminary structure to define a series of devices and a plurality of bridges; removing the center portion of the base such that the frame portion defines an open region, wherein the plurality of bridges suspend the series of devices in the open region defined by the frame; and encapsulating the series of devices. The method is preferably designed for the manufacture of semiconductor devices, and more specifically for the manufacture of encapsulated implantable electrodes. The method, however, may be alternatively used in any suitable environment and for any suitable reason. | 04-23-2009 |
20090240314 | IMPLANTABLE ELECTRODE LEAD SYSTEM WITH A THREE DIMENSIONAL ARRANGEMENT AND METHOD OF MAKING THE SAME - One embodiment of the invention includes an implantable electrode lead system that includes a series of shims stacked upon each other, a series of first components, and a series of second components connected to the series of first components through a series of connectors. One of the first components extends from one of the shims, and another of the first components extends from another one of the shims. The shims position the first components in a three dimensional arrangement. | 09-24-2009 |
20110112591 | Waveguide neural interface device - A waveguide neural interface device including: a neural device implantable in tissue and including an array of electrode sites that electrically communicate with their surroundings, in which the array of electrode sites includes at least one recording electrode site; and a waveguide, coupled to the neural device, that carries light along a longitudinal axis and includes a light directing element that redirects the carried light from the waveguide to illuminate selectively targeted tissue, in which at least a portion of the redirected light is directed laterally away from the longitudinal axis and the recording electrode site is configured to sample illuminated tissue. A method for assembling a waveguide neural interface device is also described. | 05-12-2011 |
Patent application number | Description | Published |
20090076732 | SYSTEMS AND METHODS FOR THE ANALYSIS OF MECHANICAL PROPERTIES OF MATERIALS - The various embodiments of the present invention relate generally to the analysis of the mechanical properties of materials. More particularly, the various embodiments of the present invention relates to systems and methods of deriving the static and dynamic mechanical properties of deformative materials, for example, but not limited to, biological surfaces. The systems and methods of the present invention can be used to derive and evaluate the mechanical properties of many biological surfaces and subsurfaces, including but not limited to the skin. | 03-19-2009 |
20100140461 | SYSTEMS AND METHODS FOR REAL TIME MULTISPECTRAL IMAGING - Multispectral filter arrays and methods of making and using the arrays are described herein. Multispectral imaging systems and methods of making and using the systems are also described. A multispectral filter array includes a mosaic of light sensitive elements that includes a first element sensitive to a first narrow spectral region, a second element sensitive to a second narrow spectral region, and a third element sensitive to a third narrow spectral region. A multispectral imaging system includes an illumination system having at least three lighting elements, each of which are configured to transmit light at a different wavelength, and the multispectral filter array. | 06-10-2010 |
20140088380 | Systems and Methods for Real Time Multispectral Imaging - Multispectral filter arrays and methods of making and using the arrays are described herein. Multispectral imaging systems and methods of making and using the systems are also described. A multispectral filter array includes a mosaic of light sensitive elements that includes a first element sensitive to a first narrow spectral region, a second element sensitive to a second narrow spectral region, and a third element sensitive to a third narrow spectral region. A multispectral imaging system includes an illumination system having at least three lighting elements, each of which are configured to transmit light at a different wavelength, and the multispectral filter array. | 03-27-2014 |
Patent application number | Description | Published |
20130193463 | Methods Of Integrating LED Chips With Heat Sinks, And Led-Based Lighting Assemblies Made Thereby - An LED-based lighting assembly includes a heat sink having at least one pedestal with an upwardly facing, upper planar surface that is raised in a vertical direction relative to an upwardly facing, lower planar surface of the heat sink. A PCB forms an aperture corresponding to the pedestal, includes electrical conductors on an upper surface thereof, and is attached to the lower planar surface. The upper planar surface extends into the aperture, and one or more LED chips attach directly to the upper planar surface and connect to the conductors such that light emits upwardly. A method of integrating LEDs with a heat sink includes mounting a PCB to a planar surface of the heat sink, mounting one or more LED chips to a raised surface of the heat sink that is not covered by the PCB, and electrically connecting the LED chips to conductors on the PCB. | 08-01-2013 |
20140125213 | Methods Of Integrating LED Chips With Heat Sinks, And LED-Based Lighting Assemblies Made Thereby - An LED-based lighting assembly includes a heat sink having at least one pedestal with an upwardly facing, upper planar surface that is raised in a vertical direction relative to an upwardly facing, lower planar surface of the heat sink. A PCB forms an aperture corresponding to the pedestal, includes electrical conductors on an upper surface thereof, and is attached to the lower planar surface. The upper planar surface extends into the aperture, and one or more LED chips attach directly to the upper planar surface and connect to the conductors such that light emits upwardly. A method of integrating LEDs with a heat sink includes mounting a PCB to a planar surface of the heat sink, mounting one or more LED chips to a raised surface of the heat sink that is not covered by the PCB, and electrically connecting the LED chips to conductors on the PCB. | 05-08-2014 |
Patent application number | Description | Published |
20080305026 | METHOD FOR PRODUCING A BOROHYDRIDE - A method for producing a borohydride is described and which includes the steps of providing a source of borate; providing a material which chemically reduces the source of the borate to produce a borohydride; and reacting the source of borate and the material by supplying heat at a temperature which substantially effects the production of the borohydride. | 12-11-2008 |
20100270142 | COMBUSTION FLAME PLASMA HYBRID REACTOR SYSTEMS, CHEMICAL REACTANT SOURCES AND RELATED METHODS - Combustion flame-plasma hybrid reactor systems, chemical reactant sources, and related methods are disclosed. In one embodiment, a combustion flame-plasma hybrid reactor system comprising a reaction chamber, a combustion torch positioned to direct a flame into the reaction chamber, and one or more reactant feed assemblies configured to electrically energize at least one electrically conductive solid reactant structure to form a plasma and feed each electrically conductive solid reactant structure into the plasma to form at least one product is disclosed. In an additional embodiment, a chemical reactant source for a combustion flame-plasma hybrid reactor comprising an elongated electrically conductive reactant structure consisting essentially of at least one chemical reactant is disclosed. In further embodiments, methods of forming a chemical reactant source and methods of chemically converting at least one reactant into at least one product are disclosed. | 10-28-2010 |
20110236272 | CHEMICAL REACTOR FOR CONVERTING A FIRST MATERIAL INTO A SECOND MATERIAL - A chemical reactor and method for converting a first material into a second material is disclosed and wherein the chemical reactor is provided with a feed stream of a first material which is to be converted into a second material; and wherein the first material is combusted in the chemical reactor to produce a combustion flame, and a resulting gas; and an electrical arc is provided which is passed through or superimposed upon the combustion flame and the resulting gas to facilitate the production of the second material. | 09-29-2011 |
20130300289 | ELECTRODE ASSEMBLIES, PLASMA GENERATING APPARATUSES, AND METHODS FOR GENERATING PLASMA - Electrode assemblies for plasma reactors include a structure or device for constraining an arc endpoint to a selected area or region on an electrode. In some embodiments, the structure or device may comprise one or more insulating members covering a portion of an electrode. In additional embodiments, the structure or device may provide a magnetic field configured to control a location of an arc endpoint on the electrode. Plasma generating modules, apparatus, and systems include such electrode assemblies. Methods for generating a plasma include covering at least a portion of a surface of an electrode with an electrically insulating member to constrain a location of an arc endpoint on the electrode. Additional methods for generating a plasma include generating a magnetic field to constrain a location of an arc endpoint on an electrode. | 11-14-2013 |
Patent application number | Description | Published |
20100217356 | Method to reduce heating at implantable medical devices including neuroprosthetic devices - A method to control tissue/device heating at implantable medical devices including neuroprosthetic devices. In a first embodiment, thermal conductivity of components of the implantable medical devices including the neuroprosthetic devices is increased. In a second embodiment, the implantable medical devices including the neuroprosthetic devices are cooled by using heat-sinks. In a third embodiment, portions of the implantable medical devices including the neuroprosthetic devices are replaced with specific thermal properties. In a fourth embodiment, the implantable medical devices including the neuroprosthetic devices are coated with a drug/material that will induce surrounding tissue to become more resistant to temperature increases. In a fifth embodiment, the temperature increase near the implantable devices including the neuroprosthetic devices is determined using a modified bio-heat transfer model. In a sixth embodiment, the shape of the outer or the inner surface of the device is modified. | 08-26-2010 |
20130226267 | Method to reduce heating at implantable medical devices including neuroprosthetic devices - A method to control tissue/device heating at implantable medical devices including neuroprosthetic devices. In a first embodiment, thermal conductivity of components of the implantable medical devices including the neuroprosthetic devices is increased. In a second embodiment, the implantable medical devices including the neuroprosthetic devices are cooled by using heat-sinks. In a third embodiment, portions of the implantable medical devices including the neuroprosthetic devices are replaced with specific thermal properties. In a fourth embodiment, the implantable medical devices including the neuroprosthetic devices are coated with a drug/material that will induce surrounding tissue to become more resistant to temperature increases. In a fifth embodiment, the temperature increase near the implantable devices including the neuroprosthetic devices is determined using a modified bio-heat transfer model. In a sixth embodiment, the shape of the outer or the inner surface of the device is modified. | 08-29-2013 |
Patent application number | Description | Published |
20080309617 | Graphical communication user interface - New devices, systems and methods are hereby provided that enable a user to open a communication channel by selecting an image on a monitor. A device that includes a monitor and a graphical position user input mechanism is configured to display one or more images on the monitor, to receive a graphical position user input selecting one of the images, and to open a communication channel directed to a contact information element associated with the selected image. For example, this may include placing a phone call to a selected recipient, or opening an email, instant messaging, or text message composition panel addressed to a selected recipient, by touching, clicking on, or otherwise selecting an image of the recipient, or an image that is associated with the recipient. | 12-18-2008 |
20140215404 | GRAPHICAL COMMUNICATION USER INTERFACE - New devices, systems and methods are hereby provided that enable a user to open a communication channel by selecting an image on a monitor. A device that includes a monitor and a graphical position user input mechanism is configured to display one or more images on the monitor, to receive a graphical position user input selecting one of the images, and to open a communication channel directed to a contact information element associated with the selected image. For example, this may include placing a phone call to a selected recipient, or opening an email, instant messaging, or text message composition panel addressed to a selected recipient, by touching, clicking on, or otherwise selecting an image of the recipient, or an image that is associated with the recipient. | 07-31-2014 |
Patent application number | Description | Published |
20110032449 | PERFORATED BACKLIGHT - A backlight includes a lower light guide having a specularly reflecting bottom surface and an opposing specularly reflecting perforated mirror film having a plurality of light transmission apertures. The specularly reflecting perforated mirror film has a polymeric multilayer structure, where non-perforated areas of the specularly reflecting perforated mirror film have a light reflectance value of 98% or greater and the specularly reflecting bottom surface has a light reflectance value of 98% or greater. A light collimating injector directs input light into the lower light guide. The light propagating generally parallel to the specularly reflecting perforated mirror film along a horizontal plane. The light collimating injector provides input rays into a vertical plane, the vertical plane being orthogonal to the horizontal plane, and forming an angle having an absolute value of 30 degrees or less with an intersection of the vertical and horizontal planes. An upper light cavity is disposed on the lower light guide. The upper light cavity has a light emission surface and a light input surface. The light input surface is at least partially defined by the specularly reflecting perforated mirror film. The upper light cavity has a thickness defined by the light emission surface and the light input surface. The thickness is equal to or greater than a distance between adjacent light transmission apertures. | 02-10-2011 |
20120064296 | ANTIGLARE FILMS COMPRISING MICROSTRUCTURED SURFACE - The present invention concerns antiglare films having a microstructured surface. | 03-15-2012 |
20120113622 | LIGHT REDIRECTING FILM AND DISPLAY SYSTEM INCORPORATING SAME - A light redirecting film ( | 05-10-2012 |
20120147593 | LIGHT REDIRECTING FILM AND DISPLAY SYSTEM INCORPORATING SAME - Light redirecting film is disclosed. The light redirecting film includes a first major surface that includes a plurality of first microstructures that extend along a first direction. The light redirecting film also includes a second major surface that is opposite to the first major surface and includes a plurality of second microstructures. The second major surface has an optical haze that is in a range from about 4% to about 20% and an optical clarity that is in a range from about 20% to about 60%. The light redirecting film has an average effective transmission that is not less than about 1.55. | 06-14-2012 |
20130038939 | ANTIREFLECTIVE FILMS COMPRISING MICROSTRUCTURED SURFACE - The present invention concerns antireflective films comprising a high refractive index layer ( | 02-14-2013 |
20130070341 | LIGHT REDIRECTING FILM AND DISPLAY SYSTEM INCORPORATING SAME - Optical films for redirecting light are described, and optical systems, such as display systems, incorporating such optical films are described. | 03-21-2013 |
Patent application number | Description | Published |
20080241757 | Reproducible, high yield method for fabricating ultra-short T-gates on HFETs - A method for fabricating ultra-short T-gates on heterojunction field effect transistors (HFETs) comprising the steps of (a) providing a coating of three layers of resists, with polymethylmethacrylate (PMMA) with high molecular weight on the bottom, polydimethylglutarimide (PMGI) in the middle, and PMMA with low molecular weight on the top; (b) in a first exposure, exposing and developing the layers with a dose of a developer that is high enough to allow the developer to break the top PMMA but low to avoid contributing significantly to the overall dose received in the bottom PMMA layer; and (c) in a second exposure, using an exposure and developing process to define 0.03-0.05 um openings in the bottom PMMA layer. | 10-02-2008 |
20100301395 | Asymmetrically recessed high-power and high-gain ultra-short gate HEMT device - A high-power and high-gain ultra-short gate HEMT device has exceptional gain and an exceptionally high breakdown voltage provided by an increased width asymmetric recess for the gate electrode, by a composite channel layer including a thin indium arsenide layer embedded in the indium gallium arsenide channel layer and by double doping through the use of an additional silicon doping spike. The improved transistor has an exceptional 14 dB gain at 110 GHz and exhibits an exceptionally high 3.5-4 V breakdown voltage, thus to provide high gain, high-power and ultra-high frequency in an ultra-short gate device. | 12-02-2010 |
20130230951 | ASYMMETRICALLY RECESSED HIGH-POWER AND HIGH-GAIN ULTRA-SHORT GATE HEMT DEVICE - A high-power and high-gain ultra-short gate HEMT device has exceptional gain and an exceptionally high breakdown voltage provided by an increased width asymmetric recess for the gate electrode, by a composite channel layer including a thin indium arsenide layer embedded in the indium gallium arsenide channel layer and by double doping through the use of an additional silicon doping spike. The improved transistor has an exceptional 14 dB gain at 110 GHz and exhibits an exceptionally high 3.5-4 V breakdown voltage, thus to provide high gain, high-power and ultra-high frequency in an ultra-short gate device. | 09-05-2013 |
Patent application number | Description | Published |
20080286306 | HIV vaccines based on Env of multiple clades of HIV - In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens. | 11-20-2008 |
20090208531 | ANTIVIRAL AGENTS AND VACCINES AGAINST INFLUENZA - These vaccines target H5N1, H1, H3 and other subtypes of influenza and are designed to elicit neutralizing antibodies, as well as cellular immunity. The DNA vaccines express hemagglutinin (HA) or nucleoprotein (NP) proteins from influenza which are codon optimized and/or contain modifications to protease cleavage sites of HA which affect the normal function of the protein. Adenoviral constructs expressing the same inserts have been engineered for prime boost strategies. Protein-based vaccines based on protein production from insect or mammalian cells using foldon trimerization stabilization domains with or without cleavage sites to assist in purification of such proteins have been developed. Another embodiment of this invention is the work with HA pseudotyped lentiviral vectors which would be used to screen for neutralizing antibodies in patients and to screen for diagnostic and therapeutic antivirals such as monoclonal antibodies. | 08-20-2009 |
20090286860 | Method of using adenoviral vectors to induce an immune response - The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an V clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively. | 11-19-2009 |
20100074916 | AVIAN INFLUENZA VACCINE - H5 hemagglutinin (HA) polypeptides are provided that are adapted to humans through mutations that change receptor specificity in the H1 serotype, and related polynucleotides, methods, compositions, and vaccines. | 03-25-2010 |
20110171260 | INFLUENZA DNA VACCINATION AND METHODS OF USE THEREOF - The present invention relates to an influenza immunogen that includes one or more DNA constructs encoding at least two divergent influenza HAs, wherein each of such one or more DNA constructs encodes one or more of the at least two divergent influenza HAs. Such an immunogen, when administered to a subject, induces an immune response to a plurality of strains of influenza virus, wherein at least one strain of the plurality of strains does not encode any of the divergent influenza HAs encoded by the immunogen. The divergent influenza HAs can be swine influenza HAs or equine influenza HAs, such as influenza H1 HAs or influenza H3 HAs. The invention also relates to a method to use such an immunogen to induce such an immune response as well as to DNA constructs comprising such divergent influenza HAs. Such an immunogen can provide a heterologous as well as a homologous immune response. Such an immunogen can be used to induce an immune response against evolving influenza virus. | 07-14-2011 |
20110274721 | HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIV - In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a singlr clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens. | 11-10-2011 |
20120219583 | NUCLEIC ACID SEQUENCES ENCODING EXPANDABLE HIV MOSAIC PROTEINS - The invention is directed to a nucleic acid molecule encoding a HIV-1 polypeptide which comprises the nucleic acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, or SEQ ID NO: 4. The invention also provides a method of inducing an immune response against HIV-1 in a mammal. | 08-30-2012 |
20120302627 | METHOD OF USING ADENOVIRAL VECTORS TO INDUCE AN IMMUNE RESPONSE - The invention provides a method of inducing an immune response against a human immunodeficiency virus (HIV) in a mammal. The method comprises administering to the mammal an adenoviral vector composition comprising one or more adenoviral vectors encoding two or more different HIV antigens, the production of which induces an immune response against HIV in the mammal. The invention also provides an adenoviral vector composition comprising four adenoviral vectors encoding an HIV clade A Env protein, an HIV clade B Env protein, an HIV clade C Env protein, and a fusion protein comprising an HIV clade B Gag protein and Pol protein, respectively. | 11-29-2012 |
Patent application number | Description | Published |
20080214437 | Methods and compositions for reducing activity of the atrial natriuretic peptide receptor and for treatment of diseases - Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide receptor, such as NPRA and NPRC, or combinations of these therapies. Routes used for delivering polynucleotides encoding a natriuretic peptide, or, for example, siRNA that down regulates natriuretic peptide receptor include subcutaneous injection, oral gavage, transdermal and intranasal delivery routes. Compositions can include chitosan, chitosan derivatives, and chitosan derivative and a lipid. Transdermal delivery can use a transdermal cream. Intranasal delivery can use a dropper or an aspirator for delivery of a mist. Oral gavage delivers equivalent to oral delivery. Delivery permits cell and tissue specific targeting of gene therapies resulting in expression of a natriuretic peptide or down regulation of natriuretic peptide receptor. A variety of cancers, asthma and viral diseases can be treated therapeutically using the methods and compositions of the present invention. | 09-04-2008 |
20100260725 | Materials and Methods for Treating Allergic and Inflammatory Conditions - The subject invention provides for the utilization of bone-marrow derived stem cells in the treatment of allergic and inflammatory diseases. In one embodiment, the invention provides for treatment of asthma. Bone-marrow derived stem cells can be used for decreasing inflammation and alter the course of immune response in the lung. | 10-14-2010 |
20140343120 | METHODS AND COMPOSITIONS FOR REDUCING ACTIVITY OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR AND FOR TREATMENT OF DISEASES - Methods, compositions and devices are provided by the present invention for reducing activity of a natriuretic peptide receptor and other signals. Therapeutic treatments are provided by use of polynucleotides encoding a natriuretic peptide or by regulating the expression of natriuretic peptide receptor, such as NPRA and NPRC, or combinations of these therapies. Routes used for delivering polynucleotides encoding a natriuretic peptide, or, for example, siRNA that down regulates natriuretic peptide receptor include subcutaneous injection, oral gavage, transdermal and intranasal delivery routes. Compositions can include chitosan, chitosan derivatives, and chitosan derivative and a lipid. Transdermal delivery can use a transdermal cream. Intranasal delivery can use a dropper or an aspirator for delivery of a mist. Oral gavage delivers equivalent to oral delivery. Delivery permits cell and tissue specific targeting of gene therapies resulting in expression of a natriuretic peptide or down regulation of natriuretic peptide receptor. A variety of cancers, asthma and viral diseases can be treated therapeutically using the methods and compositions of the present invention. | 11-20-2014 |
Patent application number | Description | Published |
20100004179 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY - Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein. | 01-07-2010 |
20100167994 | TARGETING OF EWS-FLI1 AS ANTI-TUMOR THERAPY - Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein. | 07-01-2010 |
20100317739 | HISTONE DEACETYLASE INHIBITORS - Novel histone deacetylase inhibitors, including novel fluorescent histone deacetylase inhibitors, are described. Methods for making and using the same, e.g., to treat cancer, are provided. | 12-16-2010 |
20120196896 | Treatment for Oxidative Stress and/or Hypertension - One aspect of the invention relates to compounds, compositions and methods for treating oxidative stress and/or hypertension. In certain embodiments, the invention relates to a mixture of tempol and an angiotensin receptor blocker (ARB) and the use of said mixture to treat oxidative stress and/or hypertension. In certain embodiments, the invention relates to a tempol/ARB adduct and the use of said adduct to treat oxidative stress and/or hypertension. | 08-02-2012 |
20130158063 | Compounds, Compositions and Methods Related to PPAR Antagonists - Disclosed are compounds, compositions and methods related PPAR antagonists. Certain compounds are effective at inhibiting PPARs. The compositions can be used to inhibit PPARs, treat cancer and treat metabolic disorders. | 06-20-2013 |
20150051260 | METHODS AND COMPOSITIONS FOR TREATING EWINGS SARCOMA FAMILY OF TUMORS - Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors. | 02-19-2015 |