Kolinsky
Jan Kolinsky, Prague 4 CZ
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20140277600 | Stabilized Deteministic Optimization Based Control System and Method - The embodiments described herein include one embodiment that provides a control method, including determining a first stabilizing feasible control trajectory of a plurality of variables of a controlled process, determining a second stabilizing feasible control trajectory for the plurality of variables for a second time step subsequent to the first time step, determining a first cost of applying the first feasible control trajectory at the second time step, determining a second cost of applying the second feasible control trajectory at the second time step, comparing the first and second costs, selecting the first feasible control trajectory or the second feasible control trajectory based upon the comparison in a predetermined time frame, and controlling the controlled process by application of the selected control trajectory. | 09-18-2014 |
20140280301 | Sequential Deteministic Optimization Based Control System and Method - The embodiments described herein include one embodiment that a control method including executing an infeasible search algorithm during a first portion of a predetermined sample period to search for a feasible control trajectory of a plurality of variables of a controlled process, executing a feasible search algorithm during a second portion of the predetermined sample period to determine the feasible control trajectory if the infeasible search algorithm does not determine a feasible control trajectory, and controlling the controlled process by application of the feasible control trajectory. | 09-18-2014 |
Jan Kolinsky, Prauge 4 CZ
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20140277601 | Deterministic Optimization Based Control System and Method for Linear and Non-Linear Systems - The embodiments described herein include one embodiment that provides a control method including determining a linear approximation of a pre-determined non-linear model of a process to be controlled, determining a convex approximation of the nonlinear constraint set, determining an initial stabilizing feasible control trajectory for a plurality of sample periods of a control trajectory, executing an optimization-based control algorithm to improve the initial stabilizing feasible control trajectory for a plurality of sample periods of a control trajectory, and controlling the controlled process by application. | 09-18-2014 |
Kenneth Kolinsky, Bloomingdale, NJ US
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20120045433 | COMBINATION THERAPY - The present invention relates to a combination therapy of propane-1-sulfonic acid {3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide, or a pharmaceutically acceptable salt thereof, and an topoisomerase inhibitor for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the topoisomerase inhibitor is irinotecan, or a pharmaceutically acceptable salt thereof, and the disorder is colorectal cancer involving a tumor comprising b-Raf having the V600E mutation. | 02-23-2012 |
20120045434 | COMBINATION THERAPY - The present invention relates to a combination therapy of propane-1-sulfonic acid {3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluoro-phenyl}-amide, or a pharmaceutically acceptable salt thereof, and an EGFR inhibitor for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. | 02-23-2012 |
20120148533 | COMBINATION THERAPY - The present invention relates to a combination therapy of propane-1-sulfonic acid{3-[5-(4-chloro-phenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl-2,4-difluoro-phenyl]-amide}, or a pharmaceutically acceptable salt thereof, and an interferon for treating a patient suffering from a proliferative disorder, in particular a solid tumor, for example, colorectal cancer, melanoma, and thyroid cancer. In particular, the present invention relates to such a therapy wherein the interferon is peginterferon alfa-2a and the disorder is melanoma containing the V600E b-Raf mutation. | 06-14-2012 |
20130245039 | COMBINATION THERAPY FOR PROLIFERATIVE DISORDERS - Treatment of proliferative diseases with a combination of a b-Raf inhibitor and MDM2 inhibitor. | 09-19-2013 |