Kodadek
Robert Kodadek, Long Beach, NY US
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20150233787 | AIR GAP CRAWLER INSTALLATION DEVICE - A device for installing a modular crawler into an air gap of rotating electrical machinery and removing the crawler from the air gap has a reconfigurable handle attached to a curved head made from metallic material. The crawler is magnetically attached to the curved head when it is desired to insert the crawler into the air gap or remove the crawler from the air gap. The head can be rolled in the field into the curvature needed to match the stator's inner surface so that the installation device can easily be inserted in the air gap. The handle has several joints that can be adjusted in the field as needed for the best reachability. A camera is mounted on the curved head so that an operator can see the interface region between the curved head, crawler and air gap. | 08-20-2015 |
Robert E. Kodadek, Long Beach, NY US
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20150316195 | SYSTEM AND METHOD FOR PIPELINE MAINTENANCE - A system and method for pipeline maintenance may include a payload and a transport module having the payload attached thereto. The transport module may include a plurality of movable arms each having at least one respective wheel. At least some of the wheels may be drive wheels which are operable in a first orientation to drive the transport module linearly along a length of a pipeline, and are further operable in a second orientation to drive the transport module circumferentially around an inner surface of the pipeline. At least some of the arms are operable to move the payload in a generally radial direction toward and away from an interior surface of the pipeline. | 11-05-2015 |
Thomas Kodadek, Jupiter, FL US
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20100303805 | IDENTIFICATION OF SMALL MOLECULES RECOGNIZED BY ANTIBODIES IN SUBJECTS WITH NEURODEGENERATIVE DISEASES - The present invention provides for the identification of individuals having neurodegenerative diseases (ND). Peptoids recognized by Parkinson's Disease- and Alzheimer's Disease-specific antibodies are identified, allowing one to diagnose or predict ND in subjects. | 12-02-2010 |
20100303835 | PEPTOID LIGANDS FOR ISOLATION AND TREATMENT OF AUTOIMMUNE T-CELLS - The present invention provides for the identification of autoreactive T cell populations from individuals having autoimmune diseases, such as multiple sclerosis and EAE. Peptoids recognized by autoreactive T cells can be used to identify various types of autoimmune disease, and can also be used to target therapies against such populations. | 12-02-2010 |
20110092384 | COMPOSITIONS AND METHODS FOR PRODUCING CODED PEPTOID LIBRARIES - Embodiments of the invention are directed to a one-bead-two-compound method for the creation of encoded cyclic peptoid libraries. This scheme is useful for the creation of cyclic peptoid microarrays since only the cyclic peptoid, not the linear encoding molecule, contains an attachment residue and thus can be spotted onto an activated substrate. | 04-21-2011 |
20120219574 | ANTIGEN SURROGATES IN AUTOIMMUNE DISEASE - The present invention provides for the identification of an antigen surrogate to the native antigens for the autoimmune disease pemphigus vulgaris. Ligands are discovered using large random peptoid or cyclic peptoid libraries that are screened against known antibodies to autoimmune diseases. The ligands may be useful as drugs in the treatment of such diseases and can also be used in combination with the concomitant removal of T-cells associated with autoimmune disorders. | 08-30-2012 |
20120220482 | COMPOSITIONS AND METHODS FOR SCREENING PEPTOID LIBRARIES - Certain embodiments are directed to methods for screening synthetic libraries and characterizing the resultant hits that combines many of the attractive features of bead library screening and microarray-based analysis in a seamless fashion. | 08-30-2012 |
20130178835 | IDENTIFYING SYNTHETIC LIGANDS THAT BIND T-CELLS FROM PATIENTS HAVING AN AUTOIMMUNE DISEASE - The present invention provides for the identification of autoreactive T cell populations from individuals having autoimmune diseases, such as multiple sclerosis and EAE. Peptoids recognized by autoreactive T cells can be used to identify various types of autoimmune disease, and can also be used to target therapies against such populations. | 07-11-2013 |
20140147455 | ANTIGEN SURROGATES IN AUTOIMMUNE DISEASE - The present invention provides for the identification of an antigen surrogate to the native antigens for the autoimmune disease pemphigus vulgaris. Ligands are discovered using large random peptoid or cyclic peptoid libraries that are screened against known antibodies to autoimmune diseases. The ligands may be useful as drugs in the treatment of such diseases and can also be used in combination with the comcomitant removal of T-cells associated with autoimmune disorders. | 05-29-2014 |
20140271488 | Chiral compounds of varying conformational rigidity and methods of synthesis - Synthesis of compounds having varying degrees of conformational rigidity is obtained via a low cost, high yield and efficient synthetic reactions. The library of compounds is structurally diverse having at least one or more chiral centers and providing large numbers of compounds having building block diversity and substantial scaffold diversity. The compounds further provide a novel method for obtaining candidate therapeutic agents for prevention, treatment or diagnosis of diseases. | 09-18-2014 |
20140315831 | Synthesis of Libraries of Peptide Tertiary Amides - The present disclosure is directed to a novel class of peptide-like oligomers called peptide tertiary amides (PTAs) and a combinatorial library of PTAs along with synthetic routes for the preparation of large combinatorial libraries of these compounds. The peptide tertiary amides provide an exceptional source of high affinity and selective protein ligands that are useful as tools for biological research and as drug leads, among others. | 10-23-2014 |
20150377879 | PEPTOIDS THAT BIND SPECIFIC ANTIGENS - Combinatorial libraries were generated providing a vast number of diverse peptoid ligands. From these libraries, ligands were identified which specifically bind molecules associated with autoimmune diseases, such as antibodies specific to aquaporin-4 (AQP4), binding of which to AQP4 causes the autoimmune disease, Neuoromyelitis Optica. Methods of generating peptoid libraries and for diagnosing Neuromyelitis Optica are also provided. | 12-31-2015 |
Thomas Kodadek, Dallas, TX US
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20090246124 | HIGH AFFINITY VEGF-RECEPTOR ANTAGONISTS - A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function. | 10-01-2009 |
Thomas Kodadek US
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20110077201 | HIGH AFFINITY VEGF-RECEPTOR ANTAGONISTS - A cell-based screen is reported can be used to identify specific receptor-binding compounds in a combinatorial library of peptoids (N-alkylglycine oligomers) displayed on beads. This strategy was applied to the isolation of Vascular Endothelial Growth Factor Receptor 2 (VEGFR2)-binding peptoids, which were optimized to create lead compounds with high affinity for VEGFR2. One of these peptoids was shown to be an antagonist of VEGF-VEGFR2 interaction and receptor function. | 03-31-2011 |
Thomas J. Kodadek, Dallas, TX US
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20100035765 | Protein and Antibody Profiling Using Small Molecule Microarrays - Aspects of the present invention describe methodology by which arrays of synthetic molecules can be created and employed for various types of proteomics profiling experiments. The most important of these from a clinical standpoint are the visualization of antibody and T cell binding patterns, which could be employed as a tool for monitoring the state of the immune system of a patient. This may be a generally useful tool for the diagnosis of many types of disease states. Similar techniques are employed to detect the post-translational modification of specific proteins, a tool for the visualization of induction of signal transduction pathways in cells and tissues treated with drugs. Finally, aspects of the invention teache a method for the creation of simpler arrays with less than 100 features that are, nonetheless, effective for protein profiling experiments. | 02-11-2010 |
Thomas J. Kodadek, Jupiter, FL US
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20160131662 | PROTEIN AND ANTIBODY PROFILING USING SMALL MOLECULE MICROARRAYS - Aspects of the present invention describe methodology by which arrays of synthetic molecules can be created and employed for various types of proteomics profiling experiments. The most important of these from a clinical standpoint are the visualization of antibody and T cell binding patterns, which could be employed as a tool for monitoring the state of the immune system of a patient. This may be a generally useful tool for the diagnosis of many types of disease states. Similar techniques are employed to detect the post-translational modification of specific proteins, a tool for the visualization of induction of signal transduction pathways in cells and tissues treated with drugs. Finally, aspects of the invention teach a method for the creation of simpler arrays with less than 100 features that are, nonetheless, effective for protein profiling experiments. | 05-12-2016 |