Knutsen
Alan Knutsen, Webster Groves, MO US
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20130202633 | DETERMINATION OF IMMUNOGENIC PEPTIDES IN LYSOSOMAL ENZYMES AND INDUCTION OF ORAL TOLERANCE - Disclosed are methods and compositions for determining immunodominant peptides of target enzymes used in enzyme replacement therapy for lysosomal storage disorders. More specifically disclosed are immunodominant peptides for N-acetylgalactosamine-6-sulfatase (GALNS). Also disclosed are methods of inducing oral tolerance towards a target enzyme through oral administration of immunodominant peptides prior to commencing enzyme replacement therapy. More specifically disclosed is a method of inducing oral tolerance for GALNS, by orally administering specific immunodominant peptides for GALNS; in subjects suffering from mucopolysaccharidosis type IVA prior to commencing enzyme replacement therapy using GALNS. | 08-08-2013 |
Andrew K. Knutsen, Washington, DC US
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20150047109 | Energy Dissipation System For A Helmet - A helmet consists of an inner and outer shell that are connected posterior of the head via a two degree freedom of movement rotating hinge. The connector allows for angular rotation about the inferior/superior and left/right axes. One potential mechanism for the connector is four springs, located left, right, inferior and superior of the connector, connected to both the inner and outer layers. The goal of the springs is two-fold—to provide resistance in the event that the outer layer rotates with respect to the inner layer about either axis in response to an impact or applied force, and to rapidly return the outer layer to its equilibrium position post-impact or after the removal of the applied force. | 02-19-2015 |
Eirik Knutsen, Tromso NO
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20160063022 | RAPID INDEXING OF DOCUMENT TAGS - Document tags are rapidly indexed using a text based index and a graph index. A tag signal is received. A tag and a type of the tag that are located in the tag signal are stored in a data store. The tag is indexed as a tag document in the text based index. One or more relationships between the tag and a content document are managed in the graph index. | 03-03-2016 |
Eirik Knutsen, Oslo NO
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20150154252 | ENHANCED SERVICE ENVIRONMENTS WITH USER-SPECIFIC WORKING SETS - Systems, methods, and software are disclosed herein for implementing enhanced search environments. In one implementation, an enhanced service environment includes a working set service that receives event signals initiated by working set agents in various application services. The working set agents communicate the event signals to nominate events occurring in the application services for inclusion in a working set of information specific to a user. The nominations may be based at least in part on a working set model specific to the user. In response to receiving the event signals, the working set service determines which of the events qualify for inclusion in the working set of information based at least in part on the working set model. For each event that qualifies for inclusion, the working set is modified to include at least the event. | 06-04-2015 |
Hans Knutsen, Akrehamn NO
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20080271932 | Method and System for Weighing - The present invention relates to a system and a method for weighing a section of a structure ( | 11-06-2008 |
Harald Knutsen, Bryne NO
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20080223760 | Sieve Apparatus and Method For Use of Same - The present invention describes an apparatus and a method of screening a material containing a solid and fluid, where the material is placed on an upper side of a screen element ( | 09-18-2008 |
Holly A. Knutsen, Palos Park, IL US
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20100055231 | FLAVOR RELEASING CORES AND THEIR USE IN CHEWING GUM - Flavor releasing structures for chewing gum have about 30% to about 60% thermoplastic cellulose material, about 5% to about 50% non-cellulosic thermoplastic polymer, and about 10% to about 40% porous flavor reservoir material. Optionally the flavor releasing structure may comprise about 5% to about 25% plasticizer. The cores may be coated with a flavor barrier coating. | 03-04-2010 |
20110104239 | PROBIOTIC CHEWING GUM METHOD OF MANUFACTURE - An extruded, centerfilled or coated confectionary material is provided which contains a probiotic which is capable of having a shelf life greater than about six months. A chewing gum production method is also provided which produces stick, centerfilled and coated chewing gum with probiotics without substantial loss of probiotics due to excess water, heat or pressure. Probiotics may be included in the chewing gum mass of the stick or coated chewing gum, in the liquid or powder center of a centerfilled gum, in the coating of the coated chewing gum, or as an additional layer upon the stick. The probiotics delivered to the oral cavity provide an oral health benefit to the consumer through suppression of pathogenic bacteria. | 05-05-2011 |
Jan-Erik Knutsen, Oslo NO
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20130009737 | Transformer - A polyphase transformer ( | 01-10-2013 |
20130021126 | TRANSFORMER - A transformer comprising columns, wherein each of the columns comprises a magnetic material, a length axis, an upper end, and a lower end, an upper yoke in contact with the upper end and a lower yoke in contact with the lower end, wherein at least yokes comprises two parallel sub-yokes and a yoke connector connecting the two parallel sub-yokes, at least one primary winding on at least one of the columns configured to produce alternating magnetic flux in a closed magnetic circuit defined by the columns and the yokes, at least one secondary winding on at least one of the columns, and at least one control winding on the yoke connector, wherein the at least one control winding is configured to produce direct magnetic flux in a closed magnetic circuit defined by the yokes and the respective yoke connector, wherein the respective yoke connector is in a magnetically symmetrical position. | 01-24-2013 |
Judi Lois Knutsen, Cambridge GB
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20140199417 | Antihistamines Combined with Dietary Supplements for Improved Health - The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected B vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans. | 07-17-2014 |
20150125548 | COMBINATION NUTRITIONAL AND NUTRACEUTICAL PRODUCTS - The present invention is directed to nutritional and nutraceutical compositions which comprise novel mixtures of two or more indole-based dietary supplements such as L-tryptophan and melatonin, together with selected minerals and vitamins that stimulate tryptophan metabolism in the direction of serotonin and melatonin, and to their use in a preferred embodiment of the invention in a readily ingested beverage form, optionally combined with a range of other natural ingredients designed to improve the health and state of mind of human subjects. Alternative dosage forms, such as tablets for oral dosing, and dosage forms for buccal and sublingual administration, including thin films, are also incorporated in the present invention. Health improvements include the treatment of disorders of circadian rhythm, such as shift work disorder and jet lag, the induction of relaxation and a restful frame of mind, as well as providing restorative sleep function. The compositions have utility in the treatment of jet lag disorder, circadian rhythm sleep disorders including shift work disorder, and other sleep-related problems. | 05-07-2015 |
Kevin A. Knutsen, Ramsey, MN US
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20120239069 | Transseptal Puncturing Device - A medical device for creating access through tissue is disclosed. In an embodiment, the device facilitates puncturing of tissue at a target access site while limiting the risk of perforating other tissue adjacent the target site. For example, the device may be used to puncture the atrial septum for access into the left atrium from the right atrium. According to aspects of this disclosure, the device integrates a puncturing needle into a dual lumen elongate tube. The extension of the needle beyond the distal endface of the elongate tube may be limited by an actuator coupled in the handle of the device. | 09-20-2012 |
Kjeli Knutsen, Tonstad NO
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20090188717 | METHOD AND A DEVICE FOR DIRECTIONAL CONTROL OF A ROCK DRILLING MACHINE - A method for the directional control of a rock-drilling ma-chine, the drilling unit ( | 07-30-2009 |
Lars Jacob Stray Knutsen, West Chester, PA US
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20140080787 | Method for the Treatment of Neuropathies Associated with Charcot-Marie-Tooth 1A (CMT1A) Disease - The present invention relates to compositions and methods for the treatment, prevention, and diagnosis of neuropathies due to PMP22 mis-expression in a subject having Charcot-Marie-Tooth disease, especially Charcot-Marie-Tooth 1A disease. The present invention incorporates the use of small molecule proteasome inhibitors such as, but not limited to, Bortezomib to inhibit or reduce the overexpression of the PMP2 gene. | 03-20-2014 |
20140199417 | Antihistamines Combined with Dietary Supplements for Improved Health - The present invention provides combinations comprising a sedating antihistamine and selected indole-based natural products such as L-tryptophan, 5-hydroxytryptophan and melatonin, along with pharmaceutically acceptable calcium and magnesium salts and selected B vitamins. These combinations are useful in providing a medicament for improving sleep in mammals, especially humans. | 07-17-2014 |
20150125548 | COMBINATION NUTRITIONAL AND NUTRACEUTICAL PRODUCTS - The present invention is directed to nutritional and nutraceutical compositions which comprise novel mixtures of two or more indole-based dietary supplements such as L-tryptophan and melatonin, together with selected minerals and vitamins that stimulate tryptophan metabolism in the direction of serotonin and melatonin, and to their use in a preferred embodiment of the invention in a readily ingested beverage form, optionally combined with a range of other natural ingredients designed to improve the health and state of mind of human subjects. Alternative dosage forms, such as tablets for oral dosing, and dosage forms for buccal and sublingual administration, including thin films, are also incorporated in the present invention. Health improvements include the treatment of disorders of circadian rhythm, such as shift work disorder and jet lag, the induction of relaxation and a restful frame of mind, as well as providing restorative sleep function. The compositions have utility in the treatment of jet lag disorder, circadian rhythm sleep disorders including shift work disorder, and other sleep-related problems. | 05-07-2015 |
Lars J.s. Knutsen, West Chester, PA US
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20100273779 | Pyridazinone Derivatives - The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition. | 10-28-2010 |
20100280007 | Pyridazinone Derivatives - The present invention is directed to novel pyridizinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition. | 11-04-2010 |
20100311752 | Substituted pyridazine derivatives - The present invention is directed to compounds having histamine H | 12-09-2010 |
20110288075 | Pyridazinone Derivatives - The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition/cognitive disorders. | 11-24-2011 |
20120004231 | Substituted Pyridazine Derivatives - The present invention is directed to compounds having histamine H | 01-05-2012 |
20140142088 | PYRIDAZINONE DERIVATIVES - The present invention is directed to novel pyridazinone derivatives that mediate enzymatic activity. In particular, the compounds may be effective in the treatment of diseases or disease states related to the activity of the histamine H3 receptor, including, for example, neurodegenerative disorders, sleep/wake disorders, attention deficit hyperactivity disorder and cognition. | 05-22-2014 |
Neil W. Knutsen, Milwaukee, WI US
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20100274393 | METHOD AND APPARATUS FOR DISABLING PORTS IN A MOTOR CONTROL SYSTEM - A motor control host includes a plurality of ports, a memory, and a processing device. The memory is operable to store an enable mask defining an enablement state for each of the ports. The processing device is operable to send a first message over those selected ports having an affirmative enablement state to maintain a communication link over the selected ports and inhibit the first message for those ports having a negative enablement state. A method for configuring a motor control system including a motor control host having a plurality of ports includes storing an enable mask defining an enablement state for each of the ports. A first message is sent over those selected ports having an affirmative enablement state to maintain a communication link over the selected ports. The first message is inhibited for those ports having a negative enablement state. | 10-28-2010 |
Rune Knutsen, Hundvag NO
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20150028043 | Closure for a Container, Beverage Container and a Method of Operating a Closure - A closure is for a container, for example a beverage container. In some examples the closure comprises an outer portion connectable to an opening of the container, an axially actuatable inner portion having a sealing member for restricting fluid flow through the closure with the inner portion in a first position and allowing fluid flow through the closure with the inner portion in a second position axially displaced relative to the outer portion, and an annular membrane connecting the outer and inner portions and configured to provide a returning force to resiliently bias the inner portion towards the first position. A beverage container comprises a closure. A method is for operating a closure. | 01-29-2015 |
Rune Knutsen, Nedenes NO
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20150131557 | Methods and Systems for Dynamic Speed Change on High SpeedInterconnects - Methods of changing a data rate of communication over an interface between a data transmitter and a data receiver are disclosed, wherein the data transmitter is associated with a first processor and transmitting data over the interface and the data receiver is associated with a second processor. The data transmitter transmits and the data receiver receives data over the interface at a first data rate. At the first processor, it is determined to change the first data rate to a second data rate. The data transmitter transmits and the data receiver receives a request to change the first data rate to the second data rate. In response thereto, a response message is transmitted by the data receiver and received by the data transmitter. When the response message comprises an acknowledgement to change the first data rate to the second data rate, the data transmitter transmits and the data receiver receives data over the interface at the second data rate. Corresponding protocol, electronic circuit and electronic device are also enclosed. | 05-14-2015 |
Stian Valentin Knutsen, Nesbru NO
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20130001111 | DRINKING BOTTLE WITH MULTIPLE COMPARTMENTS AND REPLACEABLE AMPOULES - A drinking bottle ( | 01-03-2013 |
Thorleiv Knutsen, Asker NO
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20100017138 | SYSTEM HAVING A NETWORK CONNECTED TO MULTIPLE DIFFERENT TYPES OF SURVEY SENSORS - A system includes a network, multiple different types of survey sensors connected to the network, and a controller connected to the network. The multiple different types of survey sensors are configured to communicate different types of measurement data over the network to the controller. | 01-21-2010 |