Knight, PA
David John Knight, Mount Jewett, PA US
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20120147894 | METHODS AND APPARATUS TO PROVISION CLOUD COMPUTING NETWORK ELEMENTS - Methods and apparatus to provision cloud computing network elements are disclosed. A disclosed example method includes receiving a selection of a cloud networking template from a client, wherein the cloud networking template includes a data center connector type and a wide area network connector type, configuring a virtual machine on a host server based on the cloud networking template, configuring a data center connector based on the data center connector type, configuring a wide area network connector based on the wide area network connector type, and coupling the wide area network connector to the data center connector and coupling the data center connector to the virtual machine within the host server to enable the client to access the virtual machine. | 06-14-2012 |
20140223434 | Methods and Apparatus to Provision Cloud Computing Network Elements - Methods and apparatus to provision cloud computing network elements are disclosed. A disclosed example method includes receiving a selection of a cloud networking template from a client, wherein the cloud networking template includes a data center connector type and a wide area network connector type, configuring a virtual machine on a host server based on the cloud networking template, configuring a data center connector based on the data center connector type, configuring a wide area network connector based on the wide area network connector type, and coupling the wide area network connector to the data center connector and coupling the data center connector to the virtual machine within the host server to enable the client to access the virtual machine. | 08-07-2014 |
David M. Knight, Benwyn, PA US
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20120063998 | Method for Treating Psoriatic Arthritis by Administering an Anti-IL-12 Antibody - Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as psoriatic arthritis. | 03-15-2012 |
David M. Knight, Radnor, PA US
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20100021477 | DESIGN AND GENERATION OF HUMAN DE NOVO pIX PHAGE DISPLAY LIBRARIES - Described and claimed herein are combinatorial synthetic Fab libraries displayed on a phage pIX protein. The libraries were built on scaffolds representing the most frequently used genes in human antibodies, which were diversified to mirror the variability of natural antibodies. After selection using a diverse panel of proteins, numerous specific and high-affinity Fabs were isolated. By a process called in-line maturation the affinity of some antibodies was improved up to one hundred-fold yielding low pM binders suitable for in vivo use. This work thus demonstrates the feasibility of displaying complex Fab libraries as pIX-fusion proteins for antibody discovery and lays the foundations for studies on the structure-function relationship of antibodies. | 01-28-2010 |
20130064760 | Method for Treating Crohn's Disease By Administering An Anti-IL-12 Antibody - Isolated anti-IL-12 antibodies, nucleic acids encoding antibodies or antibody portions, vectors, host cells, and methods of making are useful for production of antibody or portions for treating and/or diagnosing IL-12 related conditions, diseases, and disorders, such as Crohn's disease. | 03-14-2013 |
Linda Knight, Bryn Mawr, PA US
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20100284921 | TARGETED NANOPARTICLES FOR INTRACELLULAR CANCER THERAPY - This invention provides constructs comprising a targeting member immobilized on a detectable particulate, in which binding of the targeting member to a target structure on a surface of a cancer cell triggers internalization of the construct. Such constructs can be used to identify or monitor cancer cells in cell cultures or in a tissue. Such construct can also be used to kill or prevent growth of cancer cells in vivo. Also included in the invention are methods for killing or preventing growth of cancer cells in vivo. | 11-11-2010 |
Marc Knight, Parkesburg, PA US
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20110231055 | MAINTENANCE SYSTEM AND METHOD FOR VEHICLE FLEETS - A system and method for managing a fleet of vehicles including a control unit on one or more vehicles in the fleet of vehicles, a data collection unit on one or more vehicles in the fleet of vehicles in communication with the control unit, a server having an operational database for receiving data from one of the control unit and the data collection unit, and a telemetry module having access to the operational database for initiating an action based on an analysis of data on the server. | 09-22-2011 |
Michael J. Knight, Pittsburgh, PA US
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20080270110 | AUTOMATIC SPEECH RECOGNITION WITH TEXTUAL CONTENT INPUT - A method of recognizing speech includes extracting textual content from a visual content time segment associated with a rich media presentation. A textual content input comprising a word from the extracted textual content is created. The textual content input is provided to an automatic speech recognition algorithm such that there is an increased probability that the automatic speech recognition algorithm recognizes the word within an audio content time segment associated with the rich media presentation. | 10-30-2008 |
20080270138 | AUDIO CONTENT SEARCH ENGINE - A method of generating an audio content index for use by a search engine includes determining a phoneme sequence based on recognized speech from an audio content time segment. The method also includes identifying k-phonemes which occur within the phoneme sequence. The identified k-phonemes are stored within a data structure such that the identified k-phonemes are capable of being compared with k-phonemes from a search query. | 10-30-2008 |
20080270344 | RICH MEDIA CONTENT SEARCH ENGINE - A method of generating a set of search results. An audio content search results set including an individual audio content search result corresponding to a rich media time segment is generated. A visual content search results set including an individual visual content search result corresponding to the rich media time segment is also generated. A relevance of the rich media time segment is determined based at least in part on an individual search result count. The individual search result count is a sum of a number of individual audio content search results corresponding to the rich media time segment and a number of individual visual content search results corresponding to the rich media time segment. The rich media time segment is included in an ordered set of search results, wherein an order of the rich media time segment is based at least in part on the determined relevance. | 10-30-2008 |
Richard Knight, Philadelphia, PA US
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20090305031 | NANODIAMOND MANUFACTURE AND PROCESS FOR MAKING THEREOF - Disclosed are novel coatings and other components of articles of manufacture featuring the inclusion of nanodiamonds therein. Also disclosed are methods of achieving such inclusion and methods of utilizing the resultant, improved articles. | 12-10-2009 |
Steven D. Knight, Philadelphia, PA US
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20080255182 | Certain chemical entities, compositions, and methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 10-16-2008 |
20090286841 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 11-19-2009 |
20090306127 | Certain Chemical Entities, Compositions and Methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 12-10-2009 |
20090312365 | Certain Chemical Entities, Compositions, and Methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 12-17-2009 |
20120283287 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 11-08-2012 |
20130096315 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 04-18-2013 |
Steven D. Knight, West Chester, PA US
Patent application number | Description | Published |
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20100069453 | Certain Chemical Entities, Compositions, and Methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed. | 03-18-2010 |
Steven D. Knight, Collegeville, PA US
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20130053383 | INDAZOLES - Herein are disclosed indazoles of formula (I) | 02-28-2013 |
20130053397 | INDOLES - Herein are disclosed indoles of formula (I) where the various groups are defined herein, and which are useful in treating cancer. | 02-28-2013 |
20130059849 | AZAINDAZOLES - Herein are disclosed azaindazoles of formula (I) | 03-07-2013 |
20130345200 | INDOLES - Herein are disclosed indoles of formula (I) | 12-26-2013 |
20140350013 | INDAZOLES - Herein are disclosed indazoles of formula (I) | 11-27-2014 |
Steven David Knight, West Chester, PA US
Patent application number | Description | Published |
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20090005580 | Compounds, compositions and methods - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 01-01-2009 |
20100105767 | COMPOUNDS, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 04-29-2010 |
20110230550 | COMPOUNDS, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 09-22-2011 |
20120209012 | COMPOUNDS, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 08-16-2012 |
20130053436 | COMPOUNDS, COMPOSITIONS AND METHODS - Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed. | 02-28-2013 |