Kirkland, CA
David Kirkland, Campbell, CA US
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20120059298 | ORTHOTIC DEVICE - An orthotic device including a forearm support section configured to be releasably attached to a user's arm, a hand support section configured to be releasably attached to the user's hand, and an adjustable joint coupled to the forearm support section and the hand support section. At least one electromyography sensor is coupled to the forearm support section and positioned to sense activity of muscles in the user's arm, at least one electrode is coupled to the forearm support section and configured to provide electrical stimulation to muscles in the user's arm, and a controller is operatively coupled to the at least one electrode, the controller being configured to deliver electrical stimulation to the at least one electrode. | 03-08-2012 |
Janet Kirkland, Fremont, CA US
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20100117222 | Void Reduction in Indium Thermal Interface Material - Thermal interface materials and method of using the same in packaging are provided. In one aspect, a thermal interface material is provided that includes an indium preform that has a first surface and a second surface opposite to the first surface, an interior portion and a peripheral boundary. The indium preform has a channel extending from the peripheral boundary towards the interior portion. The channel enables flux to liberate during thermal cycling. | 05-13-2010 |
Janet Kirkland, Sonora, CA US
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20130309814 | LID ATTACH PROCESS - Various methods of attaching a lid to an integrated circuit substrate are provided. In one aspect, a method of attaching a lid to a substrate that has an integrated circuit positioned thereon is provided. An adhesive is applied to the substrate and an indium film is applied to the integrated circuit. The lid is positioned on the adhesive. The adhesive is partially hardened and the indium film is reflowed. The adhesive is cured. | 11-21-2013 |
John Kirkland, Irvine, CA US
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20140295938 | GAME DEVICE, GAME CONTROL METHOD, AND STORAGE MEDIUM STORING A PROGRAM - A game device includes a lottery unit to decide stop positions of spinning slot reels of a first reel group displayed on a display and select a type of battle action among plural types of battle action, with reference to the stop positions. The device includes a decision unit configured to decide the selected type of battle action as a battle action by a player character. Each type of battle action has an attribution associated with a set of symbols of the slot reels at the stop positions. The plural types of battle action include a first type of battle action having a first attribution to attack an enemy character and a second type of battle action having a second attribution different from the first attribution. The device includes a determination unit configured to decrease hit points of the enemy character and the player character. | 10-02-2014 |
Mike Kirkland, Van Nuys, CA US
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20100001824 | Autotransformer using printed wireboard - An autotransformer for use in low frequency, high power applications that uses a stack of printed wire boards constructed of a top, inner, and bottom layer including electrical trace windings circumventing the transformer core and formed in the inner layer for direct thermal contact with a heat sink interface providing a uniform and consistent heat path down to the heat sink plate. The autotransformer further includes a board to board connection employing solder cups to electrically connect between predetermined printed wire board traces. The printed wire board autotransformer also may use a non-planar interface for thermal interface with a non-planar heat sink plate surface. | 01-07-2010 |
Richard Kirkland, San Diego, CA US
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20110071042 | BIOMARKERS FOR DETERMINING SENSITIVITY OF BREAST CANCER CELLS TO HER2-TARGETED THERAPY - The present invention provides compositions and methods for detecting the expression and/or activation states of components of signal transduction pathways in cells such as tumor cells. Information on the expression and/or activation states of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments. | 03-24-2011 |
20130012407 | METHODS FOR PREDICTING RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER TO THERAPY - The present invention provides compositions and methods for detecting the expression and/or activation levels of components of signal transduction pathways in tumor cells such as triple-negative metastatic breast tumor cells. Information on the expression and/or activation levels of components of signal transduction pathways derived from use of the present invention can be used for cancer diagnosis, prognosis, and in the design of cancer treatments. | 01-10-2013 |
20140273006 | METHOD OF THERAPY SELECTION FOR PATIENTS WITH CANCER - The present invention provides methods for detecting, measuring and quantitating the expression and activation states of signal transduction analytes in cells such as tumor cells. The invention also provides methods for selecting therapy, optimizing therapy, monitoring therapeutic efficacy, and/or detecting therapeutic resistance. Accordingly, the methods are useful for improving cancer therapy selection and disease monitoring. | 09-18-2014 |
Thomas Kirkland, Atascadero, CA US
Patent application number | Description | Published |
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20090099147 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS - The present invention relates to non-steroidal progesterone receptor modulators of the general formula I | 04-16-2009 |
20100210630 | Diamine Derivatives as Inhibitors of Leukotriene A4 Hydrolase - This invention is directed to compounds of formula (I): | 08-19-2010 |
20120064554 | METHODS FOR ASSAYING ENZYME ACTIVITIES - The present invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be performed in one step. The compounds described herein features peptide-based compounds having at least one blocked lysine or arginine residue which are coupled to reporter moieties. The methods described herein involve reacting a compound described herein with an enzyme, such as a histone deacetylase enzyme or a histone acetyltransferase enzyme, and an endopeptidase that recognizes basic amino acids to release the reporter moiety which may be subsequently detected. | 03-15-2012 |
20130123243 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE - This invention is directed to compounds of formula (I): | 05-16-2013 |
20140099655 | METHODS FOR ASSAYING ENZYME ACTIVITIES - The present invention provides compounds and methods for assaying activities of enzymes such as histone deacetylases and histone acetyltransferases. In some embodiments, the methods may be performed in one step. The compounds described herein features peptide-based compounds having at least one blocked lysine or arginine residue which are coupled to reporter moieties. The methods described herein involve reacting a compound described herein with an enzyme, such as a histone deacetylase enzyme or a histone acetyltransferase enzyme, and an endopeptidase that recognizes basic amino acids to release the reporter moiety which may be subsequently detected. | 04-10-2014 |
20140194307 | RECOGNITION OF CELLULAR TARGET BINDING BY A BIOACTIVE AGENT USING INTRACELLULAR BIOLUMINESCENCE RESONANCE ENERGY TRANSFER - The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, or portions, components, or subunits of bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith. | 07-10-2014 |
20140194325 | RECOGNITION OF CELLULAR TARGET BINDING BY A BIOACTIVE AGENT USING INTRACELLULAR BIOLUMINESCENCE RESONANCE ENERGY TRANSFER - The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith. | 07-10-2014 |
20140199712 | COMPOSITIONS AND METHODS FOR CAPTURE OF CELLULAR TARGETS OF BIOACTIVE AGENTS - The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith. | 07-17-2014 |
20140287427 | COMPOSITIONS AND METHODS FOR CAPTURE OF CELLULAR TARGETS OF BIOACTIVE AGENTS - The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture dimers), surfaces (e.g., displaying, capture ligands, capture proteins, or capture dimers), and methods of capturing and identifying the cellular targets of a bioactive agent therewith. | 09-25-2014 |
20140322738 | SUBSTRATES FOR COVALENT TETHERING OF PROTEINS TO FUNCTIONAL GROUPS OR SOLID SURFACES - The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates. | 10-30-2014 |
20140322794 | SUBSTRATES FOR COVALENT TETHERING OF PROTEINS TO FUNCTIONAL GROUPS OR SOLID SURFACES - The present invention provides haloalkane substrates, and linkers for connecting such substrates to functional elements (e.g., tags, labels, surfaces, etc.). Substrates and linkers described herein find use, for example, in labeling, detection, and immobilization of proteins, cells, and molecules. In particular, the linkers provided herein find use within substrates for dehalogenase variants that form covalent bonds with their haloalkane substrates. | 10-30-2014 |
20140348747 | ACTIVATION OF BIOLUMINESCENCE BY STRUCTURAL COMPLEMENTATION - Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide. | 11-27-2014 |
20140363375 | ACTIVATION OF BIOLUMINESCENCE BY STRUCTURAL COMPLEMENTATION - Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide. | 12-11-2014 |
20150080382 | DIAMINE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE A4 HYDROLASE - This invention is directed to compounds of formula (I): | 03-19-2015 |
Thomas A. Kirkland, Atascadero, CA US
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20130317207 | CARBOXY X RHODAMINE ANALOGS - The present invention provides novel fluorescent dyes and kits containing the same, which are useful for labeling a wide variety of biomolecules, cells and microorganisms. The present invention also provides various methods of using the fluorescent dyes for research and development, forensic identification, environmental studies, diagnosis, prognosis and/or treatment of disease conditions. | 11-28-2013 |
Thomas Andrew Kirkland, Canyon, CA US
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20090075989 | NON-STEROIDAL PROGESTERONE RECEPTOR MODULATORS - The present invention relates to non-steroidal progesterone receptor modulators of the general formula 1, | 03-19-2009 |
Thomas Andrew Kirkland, American Canyon, CA US
Patent application number | Description | Published |
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20090270381 | Non-steroidal progesterone receptor modulators - The present invention relates to non-steroidal progesterone receptor modulators of the general formula I, | 10-29-2009 |
William Eric Kirkland, Petaluma, CA US
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20100005942 | Ergonomic Guitar - An ergonomic guitar including a contoured guitar body, a neck attached to the body, and a headstock on the distal end of the neck. A plurality of strings extending from the headstock to the body, a portion of the strings lying on a playing plane over the body. The contoured guitar body includes a front face located on a front or playing side of the body with a front edge extending around the periphery of the front face, and a rear face located on the back of the body and having a rear edge extending around the periphery of the rear face. At least a portion of the rear edge having a concave curvature relative to the playing plane such that the curved portion of the rear edge curves away from the playing plane. | 01-14-2010 |