Patent application number | Description | Published |
20090045332 | SUBSTRATE FOR MASS SPECTROMETRY, MASS SPECTROMETRY, AND MASS SPECTROMETER - Provided is a substrate for mass spectrometry, which enables a detection of a high molecular weight compound to be conducted at a high sensitivity, and can avoid the fragmentation so that there is substantially no obstacle to the analysis of a low molecular weight region. The substrate is a substrate for mass spectrometry for use in laser desorption/ionization mass spectrometry, containing a metal and having a porous structure on a surface thereof, wherein at least one functional group selected from the group consisting of a carboxyl group, a sulfonic group and an ammonium chloride group is covalently bonded to the surface of the substrate. | 02-19-2009 |
20090233373 | MULTISITE PHOSPHORYLATED PEPTIDE (PROTEIN) RECOGNIZING COMPOUND AND DETECTION METHOD, IMAGING METHOD, ALZHEIMER'S DISEASE DIAGNOSING METHOD AND REAGENT KIT USING THE SAME - There are provided a novel compound which captures a multisite phosphorylated peptide or protein specifically to a phosphorylation site and a method for detecting a multisite phosphorylated peptide or protein using the same. In particular, there are provided a compound which specifically detects an excessively phosphorylated tau protein observed in the brain affected by Alzheimer's disease and a method for diagnosing Alzheimer's disease in vitro or in vivo using the compound. By bringing a metal complex compound having two dipicolylamine (Dpa) moieties and a spacer including a chromogenic or luminescent functional group or atom group into contact with a multisite phosphorylated peptide or protein, the compound recognizes the distance between phosphate groups and specifically binds to the peptide or the protein, and a multisite phosphorylated peptide or protein or a kinase activity is optically detected by measuring the change, or a multisite phosphorylated peptide or protein or kinase activity is imaged by an optical imaging method applying the change in the luminescence. | 09-17-2009 |
20090266982 | MASS SPECTROMETRY SUBSTRATE AND MASS SPECTROMETRY METHOD - A mass spectrometry method that makes it possible to perform high-sensitivity detection of a desorbed/ionized object substance to be measured in mass spectrometry in which the object substance to be measured is desorbed and ionized. The method includes placing at least an ionizing agent having two or more functional groups represented by Formula (1) below in a molecule: | 10-29-2009 |
20100225314 | NUCLEAR MAGNETIC RESONANCE MEASURING METHOD - The present invention provides a method for measuring nuclear magnetic resonance that employs a compound in which a plurality of nuclei is labeled with isotopes as a probe agent, highly selectively and highly sensitively obtains a nuclear magnetic resonance signal of the above described probe agent, and can attach a spatial positional information to the above described nuclear magnetic resonance signal, and an apparatus therefore. | 09-09-2010 |
20100247444 | COMPOUND, DIAGNOSTIC AGENT, NUCLEAR MAGNETIC RESONANCE ANALYSIS METHOD, NUCLEAR MAGNETIC RESONANCE IMAGING METHOD, MASS SPECTROMETRY METHOD AND MASS SPECTROMETRY IMAGING METHOD - To produce a labeled compound for a selected biological substance not using a radioisotope atom which has a risk of exposure to radioactivity and limitation on handling time but using a stable isotope atom; and that the labeled compound can be measured with good sensitivity separably from naturally occurring compounds of the selected biological substance which are substituted with the stable isotope atom. Choline as a biological substance is labeled by substituting the nitrogen atom of the quaternary ammonium group and all the carbon atoms of the methyl group attached to the nitrogen atom with respective isotopes | 09-30-2010 |
20100248279 | SUBSTRATE PROBE, ENZYME-ACTIVITY DETECTION METHOD BY A MULTI-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE METHOD AND ENZYME-ACTIVITY IMAGING METHOD - Substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method. | 09-30-2010 |
20100326956 | METHOD FOR MANUFACTURING SUBSTRATE FOR MASS SPECTROMETRY - A substrate for mass spectrometry for effectively performing ionization has been demanded. The substrate for mass spectrometry includes a base, a porous film formed on the base, and an inorganic material film formed on the porous film. The inorganic material film has a plurality of concaves formed vertically to the base, and the diameter of the concaves is not less than 1 nm and less than 1 μm. | 12-30-2010 |
20110028713 | AZA COMPOUNDS AND PRODUCTION METHOD THEREOF, AND METAL COMPLEXES AS MRI CONTRAST AGENTS - A core of a cyclic structure represented by (—N—(CH | 02-03-2011 |
20130288345 | SUBSTRATE PROBE, ENZYME-ACTIVITY DETECTION METHOD BY A MULTI-DIMENSIONAL NUCLEAR MAGNETIC RESONANCE METHOD AND ENZYME-ACTIVITY IMAGING METHOD - An object of the present invention is to provide a substrate probe capable of detecting enzyme activity with high accuracy and a method for detecting the enzyme activity by a multi nuclear magnetic resonance method using the substrate probe. Multi-dimensional nuclear magnetic resonance is performed by using a substrate probe, which is used for measuring enzyme activity by a multi-dimensional nuclear magnetic resonance method and characterized by containing a enzyme recognition site that is selectively recognized by an active-state enzyme, as at least one constitutional unit, and a group to which at least three nuclear magnetic resonance active nuclei each having a nuclear spin and a different resonance frequency are connected, being present specifically to the enzyme recognition, thereby detecting presence of the substrate probe and the enzyme activity. Alternatively, imaging of the enzyme activity is performed by a multi-dimensional nuclear resonance imaging method. | 10-31-2013 |
20140017605 | FILM, APPARATUS HAVING FILM, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS - There is provided a film having resistance to an increase in the friction coefficient resulting from wearing. The film has a first portion having hardness of 0.01 to 3 GPa and a second portion. The hardness ratio of the second portion to the first portion is of 1.2 to 30. The first portion and the second portion form a first surface portion and a second surface region of the film, respectively. Each of the first portion and the second portion extends to a depth of 75% or more of the thickness of the film. In a 1 mm×1 mm square region disposed on an arbitrary position of the surface of the film, the second surface region accounts for 10% to 80% by area of the square region, and the first surface region and the second surface region account for 50% or more by area of the square region. | 01-16-2014 |
20140051018 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS - The present invention relates to an electrophotographic photosensitive member including a support and a photosensitive layer formed on the support. The electrophotographic photosensitive member has a surface layer containing a polyarylate resin and acicular inorganic fillers. The acicular inorganic fillers are basic and have a number-average aspect ratio of 5 to 50 and a Mohs hardness of 2 to 6. | 02-20-2014 |
20140113225 | ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, INTERMEDIATE TRANSFER MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS - There are provided an electrophotographic photosensitive member and an intermediate transfer member each having good lubricity and good cleaning property on its surface, a process cartridge and an electrophotographic apparatus each including the electrophotographic photosensitive member, and an electrophotographic apparatus including the intermediate transfer member. Therefore, a surface layer of the electrophotographic photosensitive member or intermediate transfer member of the present invention contains a matrix component and a rotatably-retained spherical particle that is not bound with the matrix component and is rotatably retained in a pore in the matrix component. | 04-24-2014 |
20140275521 | Aza metal complexes - A core of a cyclic structure represented by (—N—(CH | 09-18-2014 |
20140315124 | METHOD OF PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, METHOD OF PRODUCING ORGANIC DEVICE, AND EMULSION FOR CHARGE TRANSPORTING LAYER - Provided are a method of producing an electrophotographic photosensitive member, particularly, a method of producing an electrophotographic photosensitive member and an organic device by which, in a method of forming a charge transporting layer, the stability of an application liquid for the layer after long-term storage is improved while the usage of an organic solvent in the application liquid is curtailed, and the layer having high uniformity is formed. The method is a method of producing an electrophotographic photosensitive member which includes a support and a charge transporting layer formed thereon, the method including: preparing a solution including: a first liquid whose solubility in water under 25° C. and 1 atmosphere is 1.0 mass % or less; a second liquid whose solubility in water under 25° C. and 1 atmosphere is 5.0 mass % or more; a charge transporting substance; and a binder resin; preparing an emulsion by dispersing the solution in water; forming a coat for the layer on the support by using the emulsion; and forming the layer by heating of the coat. | 10-23-2014 |
20140322434 | METHODS FOR PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER AND ORGANIC DEVICE EACH HAVING CHARGE TRANSPORTING LAYER - A method for producing an electrophotographic photosensitive member has a charge transporting layer, including preparing a first solution containing a specified first liquid, a charge transporting substance and a binder resin, preparing a second solution containing a specified second liquid and water, preparing an emulsion from the first and second solutions, forming the emulsion coating, and heating the coat to form the charge transporting layer, and a method for producing an organic device has a charge transporting layer, including preparing a first solution containing a specified first liquid and a charge transporting substance, preparing a second solution containing a specified second liquid and water, preparing an emulsion from the first and second solutions, forming the emulsion coating, and heating the coat to form the charge transporting layer are used. | 10-30-2014 |
20140342285 | PROCESS FOR PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER - In a process for producing an electrophotographic photosensitive member, in particular, a process of forming a charge transporting layer, a production process is provided by which the stability of a charge transporting layer coating fluid even after its storage for a long time is improved so as to form a coat for a charge transporting layer having a high uniformity. In a process for producing an electrophotographic photosensitive member having a charge transporting layer on a support, a production process is used in which a coat of (i) a liquid dispersion comprised of particles containing a charge transporting material, particles containing a binder resin, and an aqueous dispersion medium, or (ii) a liquid dispersion comprised of particles containing both a charge transporting material and a binder resin, and an aqueous dispersion medium, is formed on the support and then the coat is heated at a temperature not less than the melting point of the charge transporting material to form the charge transporting layer. | 11-20-2014 |
20140377564 | INTERMEDIATE TRANSFER MEMBER FOR ELECTROPHOTOGRAPHY AND ELECTROPHOTOGRAPHIC APPARATUS - An intermediate transfer member for electrophotography comprising a substrate and a surface layer provided on the substrate. The surface layer comprises a binder resin and a perfluoropolyether. An extraction amount of the perfluoropolyether per 10 mm | 12-25-2014 |
20140377695 | MEMBER FOR ELECTROPHOTOGRAPHY, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS - A member for electrophotography having a multilayer structure or a single-layer structure, including an outermost layer which satisfies the following A, B and C:
| 12-25-2014 |