Kim, MA
Bokyung Kim, Amherst, MA US
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20080230514 | METHOD OF PRODUCING NANOPATTERNED TEMPLATES - Nanopatterned substrates can be prepared by a method that includes forming a block copolymer film on a substrate, annealing the block copolymer film, surface reconstructing the annealed block copolymer film, coating an etch-resistant layer on the surface reconstructed block copolymer film, etching the resist-coated block copolymer film to create an etched article comprising a nanopatterned substrate, and separating the etch-resistant layer and the block copolymer film from the nanopatterned substrate. The method is applicable to a wide variety of substrate materials, avoids any requirement for complicated procedures to produce long-range order in the block copolymer film, and avoids any requirement for metal functionalization of the block copolymer. | 09-25-2008 |
20100086801 | METHOD OF PRODUCING NANOPATTERNED ARTICLES, AND ARTICLES PRODUCED THEREBY - Nanopatterned surfaces are prepared by a method that includes forming a block copolymer film on a substrate, annealing and surface reconstructing the block copolymer film to create an array of cylindrical voids, depositing a metal on the surface-reconstructed block copolymer film, and heating the metal-coated block copolymer film to redistribute at least some of the metal into the cylindrical voids. When very thin metal layers and low heating temperatures are used, metal nanodots can be formed. When thicker metal layers and higher heating temperatures are used, the resulting metal structure includes nanoring-shaped voids. The nanopatterned surfaces can be transferred to the underlying substrates via etching, or used to prepare nanodot- or nanoring-decorated substrate surfaces. | 04-08-2010 |
20130302632 | METHOD OF PRODUCING NANOPATTERNED ARTICLES, AND ARTICLES PRODUCED THEREBY - Nanopatterned surfaces are prepared by a method that includes forming a block copolymer film on a substrate, annealing and surface reconstructing the block copolymer film to create an array of cylindrical voids, depositing a metal on the surface-reconstructed block copolymer film, and heating the metal-coated block copolymer film to redistribute at least some of the metal into the cylindrical voids. When very thin metal layers and low heating temperatures are used, metal nanodots can be formed. When thicker metal layers and higher heating temperatures are used, the resulting metal structure includes nanoring-shaped voids. The nanopatterned surfaces can be transferred to the underlying substrates via etching, or used to prepare nanodot- or nanoring-decorated substrate surfaces. | 11-14-2013 |
Byungsub Kim, Cambridge, MA US
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20100202506 | CIRCUITS AND METHODS FOR DFE WITH REDUCED AREA AND POWER CONSUMPTION - A 1/n-rate decision feedback equalizer (DFE) and method include a plurality of branches. Each branch includes a summer circuit configured to add a feedback signal to a received input, and a latch configured to receive an output of the summer circuit in accordance with a clock signal. A feedback circuit includes a multiplexer configured to receive as input, an output of each branch, the multiplexer having a clocked select input and configured to multiplex the output of each branch to assemble a full rate bit sequence, and a filter configured to provide cancellation of intersymbol interference (ISI) from the received input to be provided to the summer circuit of each branch. | 08-12-2010 |
20120314757 | CIRCUITS AND METHODS FOR DFE WITH REDUCED AREA AND POWER CONSUMPTION - A 1/n-rate decision feedback equalizer (DFE) and method include a plurality of branches. Each branch includes a summer circuit configured to add a feedback signal to a received input, and a latch configured to receive an output of the summer circuit in accordance with a clock signal. A feedback circuit includes a multiplexer configured to receive as input, an output of each branch, the multiplexer having a clocked select input and configured to multiplex the output of each branch to assemble a full rate bit sequence, and a filter configured to provide cancellation of intersymbol interference (ISI) from the received input to be provided to the summer circuit of each branch. | 12-13-2012 |
20130287089 | CIRCUITS AND METHODS FOR DFE WITH REDUCED AREA AND POWER CONSUMPTION - A 1/n-rate decision feedback equalizer (DFE) and method include a plurality of branches. Each branch includes a summer circuit configured to add a feedback signal to a received input, and a latch configured to receive an output of the summer circuit in accordance with a clock signal. A feedback circuit includes a multiplexer configured to receive as input, an output of each branch, the multiplexer having a clocked select input and configured to multiplex the output of each branch to assemble a full rate bit sequence, and a filter configured to provide cancellation of intersymbol interference (ISI) from the received input to be provided to the summer circuit of each branch. | 10-31-2013 |
Charles Kim, Cambridge, MA US
Patent application number | Description | Published |
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20090264653 | USEFUL INDOLE COMPOUNDS - Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO. | 10-22-2009 |
20100197708 | INDOLE COMPOUNDS - Indole derivatives that are useful for treating pain, inflammation and other conditions are described. Certain of the compounds are benzyl derivatives and others are benzoyl derivatives. The compounds are substituted at least at the 3 position of the indole. | 08-05-2010 |
20110150834 | CRTH2 MODULATORS - Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I: | 06-23-2011 |
20110312945 | CRTH2 MODULATORS - Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by formula I | 12-22-2011 |
20120184516 | sGC Stimulators - Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 07-19-2012 |
20130178475 | sGC STIMULATORS - Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 07-11-2013 |
20130196960 | Cannabinoid Receptor Agonists - The present disclosure relates to compounds useful as agonists of cannabinoid receptors. The disclosure also provides pharmaceutically acceptable compositions comprising the compounds of the disclosure and methods of using the compositions in the treatment of various disorders either alone or in combination therapy. The compounds have Formula (I), or are pharmaceutically acceptable salts thereof: | 08-01-2013 |
20130259830 | CRTH2 MODULATORS - Modulators of CRTH2, particularly antagonists of CRTH2, that are useful for treating various disorders, including asthma and respiratory disorders are disclosed. The compounds fall within a genus described by Formula I: | 10-03-2013 |
20140088071 | sGC STIMULATORS - Compounds of Formula (IA) and Formula (IB) are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 03-27-2014 |
20140323448 | sGC STIMULATORS - Compounds of Formula I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 10-30-2014 |
20150018353 | 2-BENZYL, 3-(PYRIMIDIN-2-YL) SUBSTITUTED PYRAZOLES USEFUL AS SGC STIMULATORS - Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed. | 01-15-2015 |
Chun-Hyung Kim, Lexington, MA US
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20090253617 | DIAGNOSIS AND TREATMENT OF ATTENTIONAL DISORDERS - This invention features methods and compositions useful for the treatment and diagnosis of attentional disorders including attention deficit hyperactivity disorder (ADHD). Also disclosed are methods for identifying compounds useful for such therapy. | 10-08-2009 |
20120128655 | INDUCED PLURIPOTENT STEM CELLS - The present invention concerns the delivery of certain reprogramming factor proteins into cells, such as differenti-atedsomatic cells, in order to induce the epi-genetic reprogramming of the cell so it becomes a pluripotent stem cell. The reprogramming factor protein(s) may be Sox2, Klf4, Oct3/4, c-Myc, Lin28, Nanog, or any protein with reprogramming (-enhancing) activity. These proteins may be linked recombinantly or chemically to a cell penetrating peptide that helps facilitate the introduction of these proteins into the target cell and may be preferably expressed in mammalian cells to maintain them in active forms. Accordingly, the present method of inducing pluripotent stem cell (iPS) formation avoids the use of viral or DNA-based expression vectors or the expression of reprogramming factor genes within target cells, which are known to be harmful to the host target cell and cause cancer. | 05-24-2012 |
20140142173 | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF A NEURODEGENERATIVE DISEASE, COMPRISING A DAPHNE GENKWA EXTRACT OR A COMPOUND ISOLATED THEREFROM - The present invention relates to: a pharmaceutical composition or a Nurr1 activating composition for the prevention or treatment of a neurodegenerative disease or a disease induced by impaired Nurr1 function, wherein the composition comprises an active ingredient in the form of genkwanin N or yuanhuacine, a | 05-22-2014 |
20140370132 | COMPOSITION CONTAIING JETBEAD EXTRACTS - The present invention relates to a pharmaceutical composition for preventing or treating Parkinson's disease, which comprises, as an active ingredient, a | 12-18-2014 |
20150023930 | AMINOQUINOLINE DERIVATIVES AND USES THEREOF - Described herein are aminoquinoline and aminoacridine based hybrids, pharmaceutical compositions and medicaments that include such aminoquinoline and aminoacridine based hybrids, and methods of using such compounds for diagnosing and/or treating infections, neurodegerative diseases or disorders, inflammation, inflammation associated diseases and disorders, and/or diseases or disorders that are treatable with dopamine agonists such as the restless leg syndrome. | 01-22-2015 |
Daekeun Kim, Cambridge, MA US
Patent application number | Description | Published |
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20090278058 | 3D TWO-PHOTON LITHOGRAPHIC MICROFABRICATION SYSTEM - An imaging system is provided that includes a optical pulse generator for providing an optical pulse having a spectral bandwidth and includes monochiromatic waves having different wavelengths. A dispersive element receives a second optical pulse associated with the optical pulse and disperses the second optical pulse at different angles on the surface of the dispersive element depending on wavelength. One or more focal elements receives the dispersed second optical pulse produced on the dispersive element. The one or more focal element recombine the dispersed second optical pulse at a focal plane on a specimen where the width of the optical pulse is restored at the focal plane. | 11-12-2009 |
Dae-Young Kim, Lexington, MA US
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20090318162 | BOOSTING A SIGNAL-TO-INTERFERENCE RATIO OF A MOBILE STATION - In a cell of a cellular wireless communication system, the SIR of at least one user in a sector of the cell is altered by temporarily reducing transmissions on a forward link in at least one other sector of the cell or a sector in another cell in accordance with a pattern. | 12-24-2009 |
20110065464 | BOOSTING A SIGNAL-TO-INTERFERENCE RATIO OF A MOBILE STATION - In a cell of a cellular wireless communication system, the SIR of at least one user in a sector of the cell is altered by temporarily reducing transmissions on a forward link in at least one other sector of the cell or a sector in another cell in accordance with a pattern. | 03-17-2011 |
Dennis M. Kim, Somerville, MA US
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20090202966 | Method For Assessing Auditory Attention And Vigilance - Provided are methods for assessing the attentional state of a subject by scoring the subject's response to auditory stimuli. The methods can be used to diagnose psychological and behavioral disorders, such as attention deficit disorder or hyperkinetic disorder. | 08-13-2009 |
Dohoon Kim, Somerville, MA US
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20100075926 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL - The invention provides methods and compounds for the treatment of neurological disorders, including Alzheimer's disease, Parkinson's disease, Huntington's disease, ALS (Amyotrophic Lateral Sclerosis), traumatic brain injury, ischemic brain injury or a stroke. In one aspect the compounds are HDAC1 activators. Exemplary HDAC1 activators include metal chelators, iron chelators, deferoxamin, flavonoids, compounds comprising a catechol moity, ginkgetin K, Chembridge 5104434, sciadopilysin, tetrahydrogamboic acid, TAM-11, LY 235959, CGS 19755, SK&F 97541, etidronic acid, levonordefrin, methyldopa, ampicillin trihydrate, D-aspartic acid, gamma-D-glutamylaminomethylsulfonic acid, phenazopyridine to hydrochloride, oxalamine citrate salt, podophyllotoxin, SK&F 97541, (+-)-4-amino-3-(5-chloro-2-thienyl)-butanoic acid, (RS)-(tetrazol-5-yl) glycine, R(+)-SKF-81297, gambogic acid, and derivatives thereof. | 03-25-2010 |
Dongshin Kim, Lexington, MA US
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20100234674 | MICROFLUIDIC SYSTEMS AND METHODS - Microfluidic systems and methods. A microfluidic device for in vitro fertilization comprises a substrate and a plurality of microchannels disposed in the substrate, including an inlet of at least two of the plurality of microchannels arranged on the substrate to align with a fluid-handling device. Another microfluidic system for assaying a plurality of cells comprises a substrate and a plurality of microfluidic channels comprising a source channel, a sink channel, and a cell chamber. An insert for a microfluidic system comprises a substrate configured to be inserted into a dish and a plurality of microscale wells disposed in the substrate. A microfluidic channel comprises a substrate and at least one microchannel having an open inlet, an open outlet, a channel, and an opening in the substrate disposed over a portion of the channel. A device for providing an amount of fluid for a fluidic system comprises a main reservoir, an aspiration well, tubing coupling the reservoirs, and a seal closing the main reservoir. Air tubing having a hydrophobic end extends into the at least one aspiration well. | 09-16-2010 |
Enoch Kim, Boston, MA US
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20090001049 | METHODS OF ETCHING ARTICLES VIA MICROCONTACT PRINTING - Improved methods of forming a patterned self-assembled monolayer on a surface and derivative articles are provided. According to one method, an elastomeric stamp is deformed during and/or prior to using the stamp to print a self-assembled molecular monolayer on a surface. According to another method, during monolayer printing the surface is contacted with a liquid that is immiscible with the molecular monolayer-forming species to effect controlled reactive spreading of the monolayer on the surface. Methods of printing self-assembled molecular monolayers on nonplanar surfaces and derivative articles are provided, as are methods of etching surfaces patterned with self-assembled monolayers, including methods of etching silicon. Optical elements including flexible diffraction gratings, mirrors, and lenses are provided, as are methods for forming optical devices and other articles using lithographic molding. A method for controlling the shape of a liquid on the surface of an article is provided, involving applying the liquid to a self-assembled monolayer on the surface, and controlling the electrical potential of the surface. | 01-01-2009 |
20090166903 | MOLDED WAVEGUIDES - Chemically or biochemically active agents or other species are patterned on a substrate surface by providing a micromold having a contoured surface and forming, on a substrate surface, a chemically or biochemically active agent or fluid precursor of a structure. A chemically or biochemically active agent or fluid precursor also can be transferred from indentations in an applicator to a substrate surface. The substrate surface can be planar or non-planar. Fluid precursors of polymeric structures, inorganic ceramics and salts, and the like can be used to form patterned polymeric articles, inorganic salts and ceramics, reactive ion etch masks, etc. at the surface. The articles can be formed in a pattern including a portion having a lateral dimension of less than about 1 millimeter or smaller. The indentation pattern of the applicator can be used to transfer separate, distinct chemically or biochemically active agents or fluid precursors to separate, isolated regions of a substrate surface. Waveguide arrays, combinatorial chemical or biochemical libraris, etc. can be made. Differences in refractive index of waveguide and cladding can be created by subjecting the waveguide and cladding, made of indentical prepolymeric material, to different polymerization or cross-linking conditions. Interferometers are defined by coupling arrays of waveguides, where coupling can be controlled by altering the difference in refractive index between cladding and waveguide at any desired location of the array. Alteration and refractive index can be created photochemically, chemically, or the like. Sensors also are disclosed, including biochemical sensors. | 07-02-2009 |
Ernest S. Kim, Cambridge, MA US
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20090078865 | APPARATUS AND SYSTEMS FOR PROCESSING SAMPLES FOR ANALYSIS VIA ION MOBILITY SPECTROMETRY - The invention provides an interface assembly for delivering an ionized analyte from an ionization apparatus into an ion mobility spectrometer. This allows analysis of biological and non-biological samples, even non-volatile solids, via differential mobility spectrometry, without fragmentation of molecules. The invention also provides portable sample analysis systems that operate at ambient pressure. Systems of the invention may be used for high molecular weight species detection, for example, drinking water contaminants, pathogenic biological agents, bio-organic substances, non-biological material, peptides, proteins, oligonucleotides, polymers, bacteria, and hydrocarbons. | 03-26-2009 |
20100323916 | High-Throughput Biological Screening - In one embodiment, a high-throughput flow system includes an array of wells and a separate mechanical tip positioned within each well. Each mechanical tip is separately actuated to impart a shear stress pattern. | 12-23-2010 |
20130053823 | Drug Delivery Apparatus - An implantable drug delivery apparatus for delivering a drug into a bodily fluid in a bodily cavity of a patient over a period of time includes a drug supply reservoir to supply drug into a delivery channel and an actuator for delivering the drug to a predetermined location in the bodily cavity of the patient, such as, for example, a cochlea of a human ear. The drug is loaded into the delivery channel while producing substantially negligible flow at an outlet of the delivery channel. | 02-28-2013 |
20130144266 | METHODS FOR REDUCING THE BLOOD PRIMING VOLUME AND MEMBRANE SURFACE AREA IN MICROFLUIDIC LUNG ASSIST DEVICES - A device and method for oxygenating blood is disclosed herein. The device includes a plurality of passive mixing elements that causes a fluid to mix as it flows through the device. The passive mixing elements continually expose new red blood cells to the portion of the flow channel where oxygenation can occur. Accordingly, in some implementations, the device and method uses less blood to prime the device and allows for the oxygenation of blood with a substantial shorter flow channel when compared to conventional oxygenation methods and devices. | 06-06-2013 |
20140190884 | COMPACT HYDRAULIC MANIFOLD STRUCTURE FOR SHEAR SENSITIVE FLUIDS - An compact hydraulic manifold for transporting shear sensitive fluids is provided. A channel network can include a trunk and branch architecture coupled to a bifurcation architecture. Features such as tapered channel walls, curvatures and angles of channels, and zones of low fluid pressure can be used to reduce the size while maintaining wall shear rates within a narrow range. A hydraulic manifold can be coupled to a series of microfluidic layers to construct a compact microfluidic device. | 07-10-2014 |
Estrella Kim, Medford, MA US
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20100117554 | High Frequency Integrated HID Lamp With Run-Up Current - A high frequency ballast for a metal halide lamp comprises a controller, a switch, and an oscillator. The ballast is rated at a higher power than the steady state operating power of the lamp. The controller ignites the lamp at a frequency which is less than the steady state operating frequency of the lamp and ignites the lamp at a current which is greater than the steady state operating current of the lamp. | 05-13-2010 |
Grace Kim, Cambridge, MA US
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20110137244 | Tissue Expander Configured for Drug Delivery - A device includes a tissue expanding portion and an enclosure positioned on a surface of the tissue expanding portion. The enclosure includes an enclosure wall and a drug formulation pocket defined by the enclosure wall. A solid drug formulation that includes a drug is housed within the drug formulation pocket | 06-09-2011 |
Grace Y. Kim, Cambridge, MA US
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20100136517 | MATRIX STABILIZATION OF AGGREGATION-BASED ASSAYS - Methods and apparatus for stabilization of aggregation-based assays are described. In various embodiments, anti-analytes are dispersed within a matrix. A solution containing analytes brought into contact with the matrix, so that analytes may permeate throughout at least a portion of the matrix. In some embodiments, the anti-analytes and analytes are mobile within the matrix. As aggregates form and increase in size, the aggregates become substantially immobile within the matrix. As a result, signals representative of an amount of aggregation within the matrix can remain substantially constant. In various aspects, matrix-stabilized aggregation-based assays provide for reliable quantitative analysis of analyte concentration with test solutions. | 06-03-2010 |
20100152704 | Method for Intravesical Drug Delivery - Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity. | 06-17-2010 |
20110212163 | MAGNETIC HEATING FOR DRUG DELIVERY AND OTHER APPLICATIONS - The present invention generally relates to systems and methods for releasing a compound from an article using an external trigger, for example, magnetic fields. One aspect of the invention is generally directed to an article containing a magnetically-susceptible material. Exposure of the magnetically-susceptible material to a magnetic field, such as an oscillating magnetic field, may cause the magnetically-susceptible material to increase in temperature. This increase in temperature may be used, in some embodiments, to cause the release of a drug or other releasable material from the article. For instance, the drug may be contained in a heat-sensitive material in thermal communication with the magnetically-susceptible material, or the drug may be contained within an enclosure that is isolated, at least in part, by a heat-sensitive material in thermal communication with the magnetically-susceptible material. Other aspects of the invention are directed to systems and methods of making or using such articles, e.g., by implanting the article within a subject, methods of treatment involving such articles, kits including such articles, or the like. | 09-01-2011 |
20140350473 | INTRAVESICAL DRUG DELIVERY DEVICE - Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug can be released. The device is configured for minimally invasive insertion into a body cavity, such as the bladder. The hollow tube may be elastomeric to permit the device to be elastically deformed from its initial shape into an elongated shape for passage through a catheter, where following such passage the device can return to or toward its initial shape to facilitate retention of the device in the body cavity. The body may have a narrow, elongated shape effective to permit insertion of the drug delivery device through a catheter without necessarily deforming the body, yet include flexible projections which effect retention within the body cavity. | 11-27-2014 |
Hadong Kim, Methuen, MA US
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20100116998 | RADIATION DETECTOR AND DETECTION METHOD HAVING REDUCED POLARIZATION - A direct conversion radiation detector includes a detector body made from a direct conversion material, a plurality of segmented electrode members operatively coupled to a radiation-receiving side of the detector body and at least one electrode operatively coupled to a second side of the detector body. The radiation detector is configured such that received radiation is incident on the segmented electrode members. The radiation detector provides reduced polarization effects for a variety of high flux radiation detection applications. | 05-13-2010 |
20130026364 | MIXED IONIC-ELECTRONIC CONDUCTOR-BASED RADIATION DETECTORS AND METHODS OF FABRICATION - A method of fabricating a mixed ionic-electronic conductor (e.g. TlBr)-based radiation detector having halide-treated surfaces and associated methods of fabrication, which controls polarization of the mixed ionic-electronic MIEC material to improve stability and operational lifetime. | 01-31-2013 |
Hahn Kim, Somerville, MA US
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20090313449 | eXtreme Virtual Memory - A method and computer program product for orchestrating the distribution and management of parallel data on a parallel hierarchical storage system is presented. A hierarchical map of the parallel data is provided. The hierarchical map comprises a plurality of map objects, wherein each map object describes how to partition a given array of data into a plurality of subarrays of data created by a parent map object of the map object and how to store the parallel data into the parallel computer's storage hierarchy. | 12-17-2009 |
Heejin Kim, Belmont, MA US
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20090118506 | 6,11-BRIDGED BIARYL MACROLIDES - The present invention discloses compounds of formula I, II or, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 05-07-2009 |
20090264380 | 6,11-BRIDGED BIARYL MACROLIDES - The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 10-22-2009 |
20120035352 | 6-11 Bicyclic Ketolide Derivatives - The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 02-09-2012 |
20130165641 | 6,11-BRIDGED BIARYL MACROLIDES - The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 06-27-2013 |
20140135485 | 6-11 BICYCLIC KETOLIDE DERIVATIVES - The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 05-15-2014 |
20140187780 | 6,11-BRIDGED BIARYL MACROLIDES - The present invention discloses compounds of formula I, II or X, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 07-03-2014 |
Heejin Kim, Allston, MA US
Patent application number | Description | Published |
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20080242865 | PROCESSES FOR THE PREPARATION OF HYDROXYLAMINES - The present invention relates generally to novel methods for the synthesis of O-(6-pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine which is an essential reagent in the synthesis of one of the bridged erythromycin derivatives and their respective pharmaceutically acceptable salts in PCT Application WO 03/097659 A1. In particular, the present invention relates to processes and intermediates for the preparation of a compound of formula (Ia): | 10-02-2008 |
20090209547 | C-8 HALOGENATED MACROLIDES - The present invention discloses compounds of formula (I) or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 08-20-2009 |
20090270457 | 6,11-BICYCLOLIDES: BRIDGED BIARYL MACROLIDE DERIVATIVES - The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 10-29-2009 |
20090324577 | 6-11 Bicyclic Ketolide Derivatives - The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: | 12-31-2009 |
Hwa-Ok Kim, Lexington, MA US
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20100009992 | AMPK MODULATORS - The present invention relates to compounds and pharmaceutically acceptable salts, esters and prodrugs of Formula (I) or (II): | 01-14-2010 |
20120302576 | AMPK MODULATORS - The present invention relates to compounds and pharmaceutically acceptable salts, esters and prodrugs of Formula (I) or (II): | 11-29-2012 |
Hyun D. Kim, Weston, MA US
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20100331812 | Pharmaceutical Formulations for Iontophoretic Delivery of an Immunomodulator - The present invention describes pharmaceutical formulations and methods suitable for iontophoretic delivery of the formulations to a subject. The formulations comprise an immunomodulator, such as imiquimod, and optionally include various agents and excipients. The formulations can be used as a treatment for skin diseases and conditions such as actinic keratosis, basal cell carcinoma and genital warts. The short term iontophoretic delivery of the formulations results in the creation of a depot effect in the skin of the subject, allowing for a sustained delivery. The shortened delivery time minimizes local side effects at the application site. | 12-30-2010 |
20130072899 | Pharmaceutical Formulations for Iontophoretic Delivery of Gallium - Pharmaceutical formulations suitable for iontophoresis thereof that provide enhanced iontophoretic delivery of gallium to at least one body surface are described and methods for administering gallium to a body surface via iontophoresis. In one embodiment, the body surface is human skin. | 03-21-2013 |
Hyun D. Kim, Bedford, MA US
Hyungchul Kim, Cambridge, MA US
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20090048281 | Organic Compounds - Compounds of Formula (I); in salt or zwitterionic form wherein R | 02-19-2009 |
Hyung Jun Kim, Cambridge, MA US
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20080271625 | High-Throughput Apparatus for Patterning Flexible Substrates and Method of Using the Same - The present invention is directed to a high-throughput apparatus for patterning a flexible substrate and methods of using the same. | 11-06-2008 |
Hyungshul Kim, Cambridge, MA US
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20100168132 | QUINUCLIDINE DERIVATIVES AND THEIR USE AS MUSCARINIC M3 RECEPTOR ANTAGONISTS - Compounds of Formula (I) ; in salt or zwitterionic form wherein R | 07-01-2010 |
Je Hong Kim, Andover, MA US
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20090257245 | LIGHT GUIDES AND BACKLIGHT SYSTEMS INCORPORATING PRISMATIC STRUCTURES AND LIGHT REDIRECTORS - Improved apparatus and method for collecting and directing light from a source via a light guide and modulated display assembly in an efficient manner through the design and use of prismatic optical structures, diffusers and/or light redirectors. | 10-15-2009 |
Je Hong Kim, Lexington, MA US
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20110122474 | DISPLAY APPARATUS AND METHODS FOR MANUFACTURE THEREOF - Display devices incorporating light modulators are disclosed along with methods of manufacturing such devices. According to some aspects of the invention, a control matrix for controlling light modulators of a display includes a light absorbing layer that includes a material having a substantially light absorbing property. | 05-26-2011 |
20110205756 | LIGHT GUIDES AND BACKLIGHT SYSTEMS INCORPORATING PRISMATIC STRUCTURES AND LIGHT REDIRECTORS - Apparatus and method for collecting and directing light from a source via a light guide and modulated display assembly in an efficient manner through the design and use of prismatic optical structures, diffusers and/or light redirectors. The prismatic optical structures may include a plurality of rear-facing prisms and/or front-facing prisms, each with an associated prism apex angle. The prism apex angle for each of the prisms may be selected such that on-axis brightness intensity and/or total optical power extraction of the display are improved. | 08-25-2011 |
20110242844 | LIGHT GUIDES AND BACKLIGHT SYSTEMS INCORPORATING LIGHT REDIRECTORS AT VARYING DENSITIES - Light guides and backlight systems are disclosed that include one or more groups of geometric light redirectors whose density and/or orientation across the surface of a light guide varies to improve light emission uniformity and to reduce visual artifacts. | 10-06-2011 |
20120275184 | LIGHT GUIDES AND BACKLIGHT SYSTEMS INCORPORATING PRISMATIC STRUCTURES AND LIGHT REDIRECTORS - Improved apparatus and method for collecting and directing light from a source via a light guide and modulated display assembly in an efficient manner through the design and use of prismatic optical structures, diffusers and/or light redirectors. | 11-01-2012 |
20120300497 | LIGHT GUIDES AND BACKLIGHT SYSTEMS INCORPORATING LIGHT REDIRECTORS AT VARYING DENSITIES - Light guides and backlight systems are disclosed that include one or more groups of geometric light redirectors whose arrangement and/or orientation across the surface of a light guide varies to improve light emission uniformity and to reduce visual artifacts. | 11-29-2012 |
20130082607 | REFLECTIVE AND TRANSFLECTIVE OPERATION MODES FOR A DISPLAY DEVICE - A direct-view display apparatus includes a transparent substrate, an internal light source, a plurality of light modulators coupled to the transparent substrate, and a controller for controlling the states of the plurality of light modulators and the internal light source. The controller is configured to cause the display to transition from one of a transmissive, reflective and transflective mode, to a second of said modes. | 04-04-2013 |
20130250619 | LIGHT GUIDES AND BACKLIGHT SYSTEMS INCORPORATING PRISMATIC STRUCTURES AND LIGHT REDIRECTORS - Improved apparatus and method for collecting and directing light from a source via a light guide and modulated display assembly in an efficient manner through the design and use of prismatic optical structures, diffusers and/or light redirectors. | 09-26-2013 |
Jinhong Kim, Brookline, MA US
Patent application number | Description | Published |
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20090122383 | MEMS Michelson Interferometer and Method of Fabrication - An interferometer system includes an optical bench and at least two mirror structures, being patterned from one or more layers on the optical bench and erected to extend substantially perpendicularly to the bench to define two interferometer arms to provide a Micro-Electro-Mechanical Systems (MEMS) interferometer. The MEMS interferometer is further implemented in a Fourier transform spectrometer, which includes a common housing containing the interferometer and a gas cell, possibly including a preconcentrator. | 05-14-2009 |
20100284017 | Miniature Fourier Transform Spectrometer and Method of Operation - A Micro-Electro-Mechanical Systems (MEMS) interferometer is implemented in a Fourier transform spectrometer, which includes a common housing containing the interferometer and a gas cell, possibly including a preconcentrator. The interferometer system includes an optical bench and at least two mirror structures, being patterned from one or more layers on the optical bench and erected to extend substantially perpendicularly to the bench to define two interferometer arms to provide a MEMS interferometer. | 11-11-2010 |
20110063619 | MEMS Michelson Interferometer and Method of Fabrication - An interferometer system includes an optical bench and at least two mirror structures, being patterned from one or more layers on the optical bench and erected to extend substantially perpendicularly to the bench to define two interferometer arms to provide a Micro-Electro-Mechanical Systems (MEMS) interferometer. The MEMS interferometer is further implemented in a Fourier transform spectrometer, which includes a common housing containing the interferometer and a gas cell, possibly including a preconcentrator. | 03-17-2011 |
Jongseong Kim, Boston, MA US
Patent application number | Description | Published |
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20080206894 | Bioresponsive Hydrogels - The invention is a structure capable of detecting a target molecule, the invention including a functionalized polymer matrix having chemically reactive groups and at least one biomolecule attached to the chemically reactive groups to form a surface-modified bioresponsive polymer matrix. | 08-28-2008 |
Joon Bae Kim, Lexington, MA US
Patent application number | Description | Published |
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20110080937 | TRANSMIT PSD CEILING IN PACKET-BASED OFDM SYSTEMS - Adjusted maximum transmit PSD levels have an effect on the SNR. If the ADC noise is assumed to be the limiting factor, then there can be a benefit for reducing the maximum transmit PSD level. For example, by lowering the maximum transmit PSD level from −50 dBm/Hz to −70 dBm/Hz results in an increase in SNR for subcarriers above 30 MHz. The SNR for subcarriers above 30 MHz can increase from 30 db (−80−(−110)) to 50 db (−80−(−130)). Therefore, by changing the maximum transmit PSD level, applying a ceiling on PSD mask, the aggregate sum of the available SNR's over the available subcarriers is increased, therefore increasing the obtainable OFDM data rate. In other words, a maximum transmit PSD mask can be used to lower the transmit PSD value of at least one subcarrier which results in an increase in SNR for at least one subcarrier. | 04-07-2011 |
20110080963 | IDENTIFICATION OF PACKET TRAFFIC TRANSMITTED BY VARIOUS DEVICES OPERATED IN MULTIPLE OVERLAPPED FREQUENCY BANDS IN PACKET-BASED OFDM SYSTEMS - Techniques for header encoding include encoding a plurality of bits using a forward error correction code, generating an FEC codeword comprising a plurality of encoded bits, and concatenating a first copy of the FEC codeword with a second copy of the FEC codeword, wherein the concatenating comprises cyclically shifting by two bits the second concatenated copy of the FEC codeword relative to the first concatenated copy of the FEC codeword, wherein the encoded bits of the first and second copies of the FEC codewords are modulated on at least one OFDM symbol. techniques for header decoding include receiving a plurality of encoded bits comprising at least two concatenated copies of an FEC codeword, decoding a first copy of the FEC codeword to generate a first plurality of decoded bits, and decoding a second copy of the FEC codeword to generate a second plurality of decoded bits. | 04-07-2011 |
20110103436 | TRANSMIT PSD CEILING IN PACKET-BASED OFDM SYSTEMS - Adjusted maximum transmit PSD levels have an effect on the SNR. If the ADC noise is assumed to be the limiting factor, then there can be a benefit for reducing the maximum transmit PSD level. For example, by lowering the maximum transmit PSD level from −50 dBm/Hz to −70 dBm/Hz results in an increase in SNR for subcarriers above 30 M Hz. The SNR for subcarriers above 30 MHz can increase from 30 db (−80-(−110)) to 50 db (−80-(−130)). Therefore, by changing the maximum transmit PSD level, applying a ceiling on PSD mask, the aggregate sum of the available SNR's over the available subcarriers is therefore increasing the obtainable OFDM data rate. In other words, a maximum transmit PSD mask can be used to lower the transmit PSD value of at least one subcarrier which results in an increase in SNR for at least one subcarrier. | 05-05-2011 |
20110110437 | IDENTIFICATION OF PACKET TRAFFIC TRANSMITTED BY VARIOUS DEVICES OPERATED IN MULTIPLE OVERLAPPED FREQUENCY BANDS IN PACKET-BASED OFDM SYSTEMS - Techniques for header encoding include encoding a plurality of bits using a forward error correction code, generating an FEC codeword comprising a plurality of encoded bits, and concatenating a first copy of the FEC codeword with a second copy of the FEC codeword, wherein the concatenating comprises cyclically shifting by two bits the second concatenated copy of the FEC codeword relative to the first concatenated copy of the FEC codeword, wherein the encoded bits of the first and second copies of the FEC codewords are modulated on at least one OFDM symbol. techniques for header decoding include receiving a plurality of encoded bits comprising at least two concatenated copies of an FEC codeword, decoding a first copy of the FEC codeword to generate a first plurality of decoded bits, and decoding a second copy of the FEC codeword to generate a second plurality of decoded bits. | 05-12-2011 |
20110182254 | CHANNEL ADAPTATION FOR MULTICARRIER ARRANGEMENT - Implementations related to updating channel adaptation parameters are described. In one implementation, an R2T frame, such as an acknowledgment (ACK) frame, is modified to carry a partial bit allocation table (BAT). The R2T frame may be received by a transceiver apparatus and the partial BAT carried in the header or extended header(s) of R2T frame may be used to update a BAT stored in the transceiver. In another implementation, a message frame is modified to carry a partial BAT. The message frame may be received by a transceiver apparatus and the partial BAT used to update a BAT stored in the transceiver. A unique identification number generated by the receiving transceiver apparatus may be used to synchronize BATs stored in two communicating transceivers without necessity of exchanging additional control messages. | 07-28-2011 |
20110235657 | Multimode Apparatus and Method - A method and apparatus are herein provided to align media access control (MAC) cycles of networks of different medium types. Information is obtained that indicates a timing information of a first MAC cycle in a first network of a first medium type and a second MAC cycle in a second network of a second medium type. A buffer is provided for storing the timing information. Alignment information is derived based on the timing information of the first/second network that enables alignment of the MAC cycles between the first and second networks. A controller unit is provided for deriving the alignment information. | 09-29-2011 |
20110271333 | ADMISSION OF A NODE TO THE NETWORK - In at least one implementation a method includes receiving an identifier associated with a device, entering the identifier into a network controller device, inviting the device associated with the identifier to join a network, admitting the device associated with the identifier to the network, sending the device associated with the identifier a name of the network, and confirming that the device has joined the network as a device recognized by the network controller device. | 11-03-2011 |
20120057483 | Frame Structure For Multi-Input Multi-Output - Described herein are implementations related to data communication using a frame that includes at least two data packets. One of the data packets includes a preamble that is separated from a payload by a gap, void or empty space. Another of the data packets includes a preamble that is aligned with the gap, void or empty space. A receiver of the frame may perform channel measurements during the gap, void or empty space. | 03-08-2012 |
20120163399 | TIME-MULTIPLEXED MULTI-WIRE COMMUNICATIONS SYSTEM - A system includes a universal transceiver and a switch coupled to the universal transceiver, wherein the switch is configured to selectively couple a terminal of the universal transceiver to one of a plurality of different physical media. The universal transceiver is configured to generate a global schedule based on at least one input received by the universal transceiver, wherein the global schedule controls the switch. | 06-28-2012 |
20120170625 | HEADER REPETITION IN PACKET-BASED OFDM SYSTEMS - An OFDM communication system is described that allows different values of D in a single domain where nodes are operating in different portions of frequency bands. For the power-line medium, G.9960 has defined two over-lapped baseband bandplans, 50 MHz-PB and 100 MHz-PB. In this exemplary scenario, the level of frequency diversity is different depending on the bandplan, hence providing different header decodibility if D is fixed to 1. If D is fixed to 2, then it increases reliability for the narrow-band devices, but may also unnecessarily increase overhead for the wide-band devices. An exemplary aspect is therefore directed to techniques to accommodate different repetitions schemes (D=1, . . . , DMAX and H=I, . . . , H | 07-05-2012 |
20120189072 | COMBINED DATA AND PROBE (CDP) FRAME - A system or method in an OFDM communication environment includes transmitting, by a transmitter, and/or receiving, by a receiver, a frame that includes one or more preamble symbols, one or more header symbols, a plurality of data symbols, and a plurality of probe symbols. The probe symbols are predefined symbols that do not carry user data and are generated by modulating a predefined pseudo-random bit sequence (PRBS). A frame header, communicated in the one or more header symbols, includes one or more bit fields that indicate that the frame includes N probe symbols, wherein N is an integer greater than 1, and wherein the plurality of probe symbols are transmitted or received after the one or more header symbols and before the plurality of data symbols. | 07-26-2012 |
20120236879 | COEXISTENCE IN COMMUNICATION SYSTEM - Representative implementations of devices and techniques provide communication between networked nodes operating on a communication network medium. In an implementation, a node generates a broadcast frame that includes at least a preamble, a header, and a payload. The preamble and header are generated according to a first protocol type and the payload is generated according to a second protocol type. | 09-20-2012 |
20120275528 | PACKET DETECTOR - There are several exemplary ways to more efficiently communicate an out-of-domain seed to a receiver—in a first technique, the seed can be indicated in the header portion or data portion of a packet. For example, the header portion of the packet could contain one or more bit fields that indicate the value of the LFSR seed used for the preamble portion of the packet. The receiver would learn the out-of-domain seed after receiving a first out-of-domain packet and decoding the header portion of that packet. After learning the out-of-domain seed, the receiver could send a packet indicating the value of the out-of-domain seed to the local master. The local master could then transmit the value of the out- of-domain seed in the header portion or data portion of a local MAP frame. | 11-01-2012 |
20120324554 | AUTOMATIC DEVICE PAIRING - One embodiment relates to a security apparatus. The apparatus includes a security controller. The security controller is within a secure domain. The controller is configured to receive a trigger event from a first device outside the secure domain and a second trigger event. The controller is configured to automatically generate a secure password from a provisional password using a secure password provisioning protocol in response to the first trigger event and the second trigger event. The controller is also configured to pair the first device with the secure domain by establishing secure communications using the secure password. | 12-20-2012 |
20130077638 | NETWORKING COEXISTENCE METHOD SYSTEM & APPARATUS - An apparatus and method are provided for a network having a controller ( | 03-28-2013 |
20130094517 | PAYLOAD FOR MULTI-INPUT MULTI-OUTPUT - Described herein are implementations related to data communication using a frame that includes at least two data packets. In one implementation, a first of the data packets includes at least a payload with repeated payload portions to increase diversity gain. A second of the data packets includes at least a payload with repeated payload portions to increase diversity gain. The repeated payload portions of the second data packet are shuffled or rotated in relation to the repeated data payload portions of the first data packet. In one implementation, the frame is conveyed in a Power Line Communication (PLC) system. | 04-18-2013 |
20130254618 | PADDING AFTER CHANNEL ENCODING REPETITION AND INTERLEAVING - Described herein are techniques related to the generation of data blocks that collectively include padding appended before a first or after a last of the data blocks. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. | 09-26-2013 |
20130265920 | POWER BOOST IN COMMUNICATION SYSTEM - Representative implementations of devices and techniques provide communication between networked nodes operating on a communication network medium. In an implementation, a node generates a broadcast frame that includes at least a preamble and a payload. The preamble of the broadcast frame may include auxiliary information. The auxiliary information may be associated with one or more symbols of the preamble. The auxiliary information may contain power boost information. | 10-10-2013 |
20130272309 | MAC CYCLE ALIGNMENT METHOD FOR NEIGHBORING NETWORK COORDINATION - Representative implementations of devices and techniques provide communication between networked nodes while minimizing interference from neighbor network communication. Medium Access Control (MAC) cycles at the nodes may be aligned to MAC cycles of neighbor nodes and/or networks based on decoded timing information detected by the nodes. | 10-17-2013 |
20130279552 | NOISE REDUCTION BETWEEN PROXIMATE NETWORKS - Representative implementations of devices and techniques provide noise reduction between proximate networks by minimizing interference from nearby network communication. A processing module determines a performance condition of a network and communicates with one or more nodes at a nearby network based on the performance condition of the network. | 10-24-2013 |
20130287045 | HEADER ALIGNMENT IN COMMUNICATION SYSTEM - Representative implementations of devices and techniques provide communication between networked nodes operating on a communication network medium. In an implementation, a node generates a broadcast frame that includes at least a preamble and a payload. The preamble of the broadcast frame may include supplemental information. The supplemental information may be associated with one or more symbols of the preamble. The supplemental information may contain predetermined header information for use by nodes operating on the communication network medium. | 10-31-2013 |
20140071997 | ROBUST PREAMBLE FOR COMMUNICATION OVER NOISY MEDIA - Described herein are techniques related to data communications using a data packet having at least one frame with a robust preamble for use over media having a high degree of non-stationary noise (e.g., impulsive noise). The described techniques employ a preamble with a structure having multiple transitions between the preamble sections. Each transition indicates the start of the upcoming frame. With the techniques described herein, if noise damages the transitions between such sections beyond recognition, the receiver can still determine the frame start time from the one or more of the undamaged transitions. Thus, the robustness of communications via the noisy media is significantly increased. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. | 03-13-2014 |
20140140358 | Probe Frame for Single-Input Single-Output and Multi-Input Multi-Output - Described herein are implementations related to the generation of probe frames. In one implementation, a generated probe frame includes two symbols, where the two symbols are different. In one implementation, a first of the two symbols is a probe symbol and a second of the two symbols is a quiet symbol. | 05-22-2014 |
20140233615 | PACKET DETECTOR - There are several exemplary ways to more efficiently communicate an out-of-domain seed to a receiver—in a first technique, the seed can be indicated in the header portion or data portion of a packet. For example, the header portion of the packet could contain one or more bit fields that indicate the value of the LFSR seed used for the preamble portion of the packet. The receiver would learn the out-of-domain seed after receiving a first out-of-domain packet and decoding the header portion of that packet. After learning the out-of-domain seed, the receiver could send a packet indicating the value of the out-of-domain seed to the local master. The local master could then transmit the value of the out-of-domain seed in the header portion or data portion of a local MAP frame. | 08-21-2014 |
Joseph L. Kim, Wayland, MA US
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20090176774 | Compounds and methods of use - Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes. | 07-09-2009 |
20110201602 | PROTEIN KINASE MODULATORS AND METHOD OF USE - The present invention relates to chemical compounds having a general formula I | 08-18-2011 |
20110251199 | NITROGEN-CONTAINING BICYCLIC HETEROARYL COMPOUNDS AND METHODS OF USE - The present invention comprises a new class of compounds capable of modulating Raf kinase and, accordingly, useful for treatment of Raf kinase mediated diseases, including melanomas, tumors and other cancer-related conditions. The compounds have a general Formula I | 10-13-2011 |
20120065185 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE - Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. | 03-15-2012 |
20130158019 | PYRIMIDINE COMPOUNDS THAT INHIBIT ANAPLASTIC LYMPHOMA KINASE - Compounds of Formula I are useful inhibitors of anaplastic lymphoma kinase. Compounds of Formula I have the following structure: | 06-20-2013 |
20130273004 | SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE - Selected heterocyclic compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. | 10-17-2013 |
20140088100 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR - Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases. | 03-27-2014 |
20140296206 | COMPOSITIONS USEFUL FOR TREATING DISORDERS RELATED TO KIT - Compounds and compositions useful for treating disorders related to Kit are described herein. | 10-02-2014 |
20140378481 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR - Described herein are inhibitors of FGFR, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions to inhibit the activity of tyrosine kinases. | 12-25-2014 |
June J. Kim, Brookline, MA US
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20110105549 | BRANCHED 3- AND 6-SUBSTITUTED QUINOLINES AS CGRP RECEPTORS ANTAGONISTS - The present invention is directed to novel branched 3- and 6-substituted quinoline derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved. | 05-05-2011 |
Jung-Won Kim, Cambridge, MA US
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20100045974 | Compact Background-Free Balanced Cross-Correlators - A compact, background-free, balanced cross-correlator enables (a) the detection of a timing error between two ultrashort pulses with (sub-)femtosecond resolution and (b) the timing synchronization of ultrashort pulse lasers using the output signal of the detector to close a phase-locked loop and can therefore serve as an integral part of femtosecond timing distribution and synchronization systems. | 02-25-2010 |
Ki Hean Kim, Belmont, MA US
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20100259605 | SYSTEMS AND METHODS FOR VOLUMETRIC TISSUE SCANNING MICROSCOPY - In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest. | 10-14-2010 |
20130142413 | SYSTEMS AND METHODS FOR VOLUMETRIC TISSUE SCANNING MICROSCOPY - In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest. | 06-06-2013 |
20140355862 | SYSTEMS AND METHODS FOR VOLUMETRIC TISSUE SCANNING MICROSCOPY - In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest. | 12-04-2014 |
Ki Hean Kim, Watertown, MA US
Patent application number | Description | Published |
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20090072171 | Systems and methods for volumetric tissue scanning microscopy - In accordance with preferred embodiments of the present invention, a method for imaging tissue, for example, includes the steps of mounting the tissue on a computer controlled stage of a microscope, determining volumetric imaging parameters, directing at least two photons into a region of interest, scanning the region of interest across a portion of the tissue, imaging a plurality of layers of the tissue in a plurality of volumes of the tissue in the region of interest, sectioning the portion of the tissue and imaging a second plurality of layers of the tissue in a second plurality of volumes of the tissue in the region of interest, detecting a fluorescence image of the tissue due to said excitation light; and processing three-dimensional data that is collected to create a three-dimensional image of the region of interest. | 03-19-2009 |
Kitai Kim, Brighton, MA US
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20100069251 | METHODS FOR PRODUCING EMBRYONIC STEM CELLS FROM PARTHENOGENETIC EMBRYOS - Means for producing embryonic stem (pES) cells which have a heterozygous genome that is matched to an individual donor are provided. In one embodiment, a means for the generation and isolation of parthenogenetic embryonic stem (pES) cells which have regions of heterozygosity that are fully matched to the oocyte donor at the MHC loci (e.g. (h-)p(MI)ES cells is provided. This is in contrast to the traditional methods of parthenogenesis that generate parthenogenetic embryonic stem (pES) cells having a substantially homozygous haploidentical set of chromosomes that are homozygous at the MHC loci. | 03-18-2010 |
Kwang S. Kim, Andover, MA US
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20090152105 | Proton exchange membrane (PEM) electrochemical cell having an integral electrically-conductive, resiliently compressible, porous pad - Electrolysis cell comprises, in one embodiment, a proton exchange membrane (PEM), an anode positioned along one face of the PEM, and a cathode positioned along the other face of the PEM. An electrically-conductive, compressible, spring-like, porous pad for defining a fluid cavity is placed in contact with the outer face of the cathode. The porous pad comprises a mat of carbon fibers bound together with one or more, preferably thermoplastic, resins, the mat having a density of about 0.2-1.5 g/cm | 06-18-2009 |
Kyunghee Kim, Cambridge, MA US
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20100268056 | Washable wearable biosensor - A washable, wearable biosensor that can gather sensor data, communicate the sensed data by wireless protocols, and permits the analysis of sensed data in real-time as a person goes about their normal lifestyle activities. The biosensor can be worn in multiple positions, can be put on or removed quickly without having to apply or remove gels and adhesives, and provides a snug, comfortable fit to gather data with minimal motion artifacts. The textile, wearable device can support integrated photoplethysmography, skin conductance, motion, and temperature sensors in a small wearable package. The supported sensors may be coupled to utilization devices by channel-sharing wireless protocols to enable the transmission of data from multiple users and multiple sensors (e.g. both sides of body, wrists or hands and feet, or multiple people). An on-board processor, or the receiving utilization device, can map patterns of the physiological and motion data to signals or alerts such as a likely seizure, drug craving, or other states that the wearer may exhibit or experience. The sensor data may be sent by wireless transmission and received by a mobile phone or other personal digital device, a computer, a favorite toy, or another wearable device. The sensors may include multiple photoplethysmographs and/or one or more EDAs which perform a time-domain measurement of skin conductance | 10-21-2010 |
Larry Kim, Cambridge, MA US
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20090292677 | Integrated web analytics and actionable workbench tools for search engine optimization and marketing - Methods and systems disclosed herein relate to a private keyword database and method of generating the database, such as compilation, manipulation, segmentation, analysis, and leveraging, to enable search engine optimization and marketing tools. The private keyword database may include search marketing data, such as keywords, a character string, a phrase, a slogan, an idiom, a string of characters of alpha-numeric codes, and the like, which may be aggregated from any number of public and proprietary data sources. Related user interfaces, applications, and computer program products are disclosed. | 11-26-2009 |
20090299998 | Keyword discovery tools for populating a private keyword database - Methods and systems disclosed herein relate to keyword discovery tools for populating a private keyword database. Keyword discovery relates to continuously and automatically in incrementing a working keyword data set for new periods of time based on retrieval of at least one of new traffic-generating keywords and new suggested keywords. Related user interfaces, applications, and computer program products are disclosed. | 12-03-2009 |
20140040011 | WEB BASED PAY PER CLICK PERFORMANCE GRADER - A performance grader tool for performing evaluation of an advertising campaign is provided that includes a reporting module that receives campaign data associated with the advertising campaign and performs one or more selective metric-base analysis on the campaign data and produces metric-based data used in evaluating the advertising campaign. The reporting module selectively displays the metric-based data in a plurality of reporting formats to the user. | 02-06-2014 |
Leeann Kim, Somerville, MA US
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20100188796 | Method And Apparatus for Microcontact Printing of MEMS - The embodiments disclosed herein are directed to fabrication methods useful for creating MEMS via microcontact printing by using small organic molecule release layers. The disclose method enables transfer of a continuous metal film onto a discontinuous platform to form a variable capacitor array. The variable capacitor array can produce mechanical motion under the application of a voltage. The methods disclosed herein eliminate masking and other traditional MEMS fabrication methodology. The methods disclosed herein can be used to form a substantially transparent MEMS having a PDMS layer interposed between an electrode and a graphene diaphragm. | 07-29-2010 |
20120069488 | METHOD AND APPARATUS FOR MICROCONTACT PRINTING OF MEMS - The embodiments disclosed herein are directed to fabrication methods useful for creating MEMS via microcontact printing by using small organic molecule release layers. The disclose method enables transfer of a continuous metal film onto a discontinuous platform to form a variable capacitor array. The variable capacitor array can produce mechanical motion under the application of a voltage. The methods disclosed herein eliminate masking and other traditional MEMS fabrication methodology. The methods disclosed herein can be used to form a substantially transparent MEMS having a PDMS layer interposed between an electrode and a graphene diaphragm. | 03-22-2012 |
Leeann Kim, Dover, MA US
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20090208753 | Methods and articles including nanomaterial - A method of depositing a nanomaterial onto a donor surface comprises applying a composition comprising nanomaterial to a donor surface. In another aspect of the invention there is provided a method of depositing a nanomaterial onto a substrate. Methods of making a device including nanomaterial are disclosed. An article of manufacture comprising nanomaterial disposed on a backing member is disclosed. | 08-20-2009 |
20090215208 | Composition including material, methods of depositing material, articles including same and systems for depositing material - Methods for depositing nanomaterial onto a substrate are disclosed. Also disclosed are compositions useful for depositing nanomaterial, methods of making devices including nanomaterials, and a system and devices useful for depositing nanomaterials. | 08-27-2009 |
20090215209 | Methods of depositing material, methods of making a device, and systems and articles for use in depositing material - Methods for depositing material and/or nanomaterial are disclosed. Also disclosed are methods of making devices including nanomaterials, systems useful for depositing materials and/or nanomaterials, surface treated articles for depositing material and/or nanomaterial onto a substrate, and surface treated transfer surfaces. | 08-27-2009 |
20140004686 | COMPOSITION INCLUDING MATERIAL, METHODS OF DEPOSITING MATERIAL, ARTICLES INCLUDING SAME AND SYSTEMS FOR DEPOSITING MATERIALS | 01-02-2014 |
Leslie J. Kim, Boston, MA US
Patent application number | Description | Published |
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20110088097 | SYSTEM AND METHOD FOR PREVENTING DELIVERY OF UNSOLICITED AND UNDESIRED ELECTRONIC MESSAGES BY KEY GENERATION AND COMPARISON - A sending device prepares a key for each electronic message sent by the device by applying an algorithm to specified data in the message and then incorporates the key in the message. A receiving device, upon receipt of an electronic message, locates the incorporated key and the data from which a sending device practicing the invention would have prepared it. The receiving device communicates a confirmation request to the purported sending device which contains the key and the data for its preparation. The sending device receives the confirmation messages and prepares a comparison key by applying the algorithm to the data in the confirmation request. The sending device replies to the confirmation request confirming that the sending device sent the message if the comparison key matches the key in the confirmation request and otherwise responds with a denial. | 04-14-2011 |
Lily Yvonne Kim, Brookline, MA US
Patent application number | Description | Published |
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20110027181 | Device including altered microorganisms, and methods and systems of use - Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent. | 02-03-2011 |
20110028945 | Device including altered microorganisms, and methods and systems of use - Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent. | 02-03-2011 |
20110172826 | Device including altered microorganisms, and methods and systems of use - Devices, methods, and systems are described for administration to at least one biological tissue of at least one device including at least one altered microorganism. In an embodiment, the altered microorganism includes at least one nucleic acid construct encoding at least one therapeutic agent. | 07-14-2011 |
Meekyung Kim, Cambridge, MA US
Patent application number | Description | Published |
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20090072271 | EPITAXIAL GROWTH OF THIN SMOOTH GERMANIUM (Ge) ON SILICON (Si) UTILIZING AN INTERFACIAL SILICON GERMANIUM (SiGe) PULSE GROWTH METHOD - Disclosed is a method of growing thin and smooth germanium (Ge) on a strained or relaxed silicon (Si) layer comprising the steps of: (a) treating surface of the strained or relaxed Si layer to gaseous precursors of both Si (e.g., silane) and Ge (e.g., germane) for a predetermined short time duration Δt, where 1≦Δt≦30 seconds; and (b) depositing a thin Ge film on top of said treated Si layer, wherein said treatment step of (a) reduces growth time and surface roughness of the thin Ge film (e.g., sub-5 nm or sub-20 nm thick) deposited on the Si layer. The treatment step (a) can be conducted at a steady predetermined temperature T, where 450≦T≦900° C. The predetermined short time duration Δt can be chosen such that less than 10 A of SiGe is deposited. | 03-19-2009 |
Michael B. Kim, Boston, MA US
Patent application number | Description | Published |
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20080286278 | Process for in vivo treatment of specific biological targets in bodily fluids - A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent. | 11-20-2008 |
20120179143 | PROCESS FOR IN VIVO TREATMENT OF SPECIFIC BIOLOGICAL TARGETS IN BODILY FLUIDS - A process for treating biological targets in a fluid of a biological organism, including introducing a fluid comprising a biological target to an assembly comprising an inlet connected to receive the fluid and an outlet connected to pass the fluid from the assembly, wherein the assembly comprises a flow chamber for conveying a flow of the fluid, and a capture zone comprising a target-specific binding agent, wherein during flow of the fluid through the flow chamber, the biological target undergoes flux rolling along the target-specific binding agent. | 07-12-2012 |
Mikyung Kim, Watertown, MA US
Patent application number | Description | Published |
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20110033522 | REAGENTS FOR INDUCING AN IMMUNE RESPONSE - The present disclosure relates to reagents (antigenic and/or immunogenic reagents) and kits that are useful in a variety of in vitro, in vivo, and ex vivo methods including, e.g., methods for inducing an immune response, or for generating an antibody, in a subject. The reagents described herein can be used in the treatment or prevention of HIV-1 infections. In addition, the disclosure provides methods and compositions useful for designing (or identifying) an agent that binds to an membrane proximal external region (MPER) of an HIV-1 gp160 polypeptide or an agent that inhibits the fusion of an HIV-1 particle to a cell. | 02-10-2011 |
Nam-Deuk Kim, Andover, MA US
Patent application number | Description | Published |
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20090196469 | Statistical Quality Assessment of Fingerprints - The present invention relates generally to human fingerprints. More specifically the present invention relates to assessing the quality of a fingerprint image. An assessment is made by analyzing characteristics of image sub-regions. For example, the characteristics may include statistics that are associated with a sub-region. If a sub-region is found to have unacceptable characteristics, it can be modified through a morphological operation to compensate for the unacceptable characteristics. | 08-06-2009 |
Norman Kim, Westford, MA US
Patent application number | Description | Published |
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20090005457 | Solid forms comprising (-)-O-desmethylvenlafaxine and uses thereof - Solid forms comprising a compound useful in the treatment, prevention and management of various conditions and diseases are provided herein. In particular, the invention provides solid forms comprising (−)—O-desmethylvenlafaxine, including salts thereof, having utility for the treatment, prevention and management of conditions and disorders including, but not limited to, affective disorders such as depression, bipolar and manic disorders, attention deficit disorder, attention deficit disorder with hyperactivity, Parkinson's disease, epilepsy, cerebral function disorders, obesity and weight gain, incontinence, dementia and related disorders. | 01-01-2009 |
Oak Kim, Cambridge, MA US
Patent application number | Description | Published |
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20110086822 | Substituted Tetracycline Compounds - The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression. | 04-14-2011 |
Oak K. Kim, Cambridge, MA US
Patent application number | Description | Published |
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20080312193 | Substituted Tetracycline Compounds for Treatment of Inflammatory Skin Disorders - Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described. | 12-18-2008 |
20090131481 | Transcription Factor Modulating Compounds and Methods of Use Thereof - Substituted benzimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections are also provided. | 05-21-2009 |
20090170812 | Transcription factor modulating compounds and methods of use thereof - Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms. | 07-02-2009 |
20100249076 | PRODRUGS OF 9-AMINOMETHYL TETRACYCLINE COMPOUNDS - The invention pertains to prodrugs of 9-aminomethyl substituted tetracycline compounds, methods of using the compounds, and pharmaceutical compositions containing them. | 09-30-2010 |
20100305072 | Substituted Tetracycline Compounds - The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms. | 12-02-2010 |
20110059962 | TRANSCRIPTION FACTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF - Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of using substituted benzimidazole compounds, in, e.g., reducing virulence and infectivity, inhibiting biofilms and treating bacterial infections, are also provided. | 03-10-2011 |
20110306611 | Transcription factor modulating compounds and methods of use thereof - Substituted benzoimidazole compounds useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. Methods of making and using substituted benzoimidazole compounds, as well as pharmaceutical preparations thereof, in, e.g., reducing antibiotic resistance and inhibiting biofilms. | 12-15-2011 |
20130345179 | Substituted tetracycline compounds for treatment of inflammatory skin disorders - Methods and compositions for the treatment of skin disorders (e.g., acne, rosacea) are described. | 12-26-2013 |
20150045329 | SUBSTITUTED TETRACYCLINE COMPOUNDS - The present invention pertains, at least in part, to novel substituted tetracycline compounds. These tetracycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for tetracycline compounds such as blocking tetracycline efflux and modulation of gene expression. | 02-12-2015 |
Peter S. Kim, Lexington, MA US
Patent application number | Description | Published |
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20100196397 | Five-helix protein - Five-Helix protein, which comprises the three N-helices and at least two, but not three, of the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, such as amino acid residue linkers, is disclosed. Six-Helix protein, which includes the three N-helices and the three C-helices of the trimer-of-hairpin structure of HIV gp41, separated by linkers, is also disclosed. | 08-05-2010 |
Sang-Gook Kim, Wayland, MA US
Patent application number | Description | Published |
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20090117363 | NANO-ENGINEERED MATERIAL ARCHITECTURES: ULTRA-TOUGH HYBRID NANOCOMPOSITE SYSTEM - A hybrid nanocomposite architecture is presented. The architecture includes a first composite ply oriented at a first orientation. The architecture also includes a carbon nanotube (CNT) film layer including a plurality of CNT pellets disposed therein, each of the CNT bundles including a plurality of CNTs extending from the bottom surface of the CNT film layer to a top surface of the CNT film layer, the CNT film layer disposed in an abutting relationship with the first composite ply. The architecture further includes a second composite ply which may be oriented at a second orientation, the second composite ply disposed in an abutting relationship with the CNT film layer, and wherein the CNTs of the CNT film layer act as a penetrating bridge across an interface between the first composite ply and the second composite ply. | 05-07-2009 |
20100132080 | METHOD OF MAKING AND ASSEMBLING CAPSULATED NANOSTRUCTURES - An encapsulated nanostructure fabricated using layers of polymer material and further processed for use in a micro-scale target device is presented. The fabrication includes the formation on a substrate of an array of encapsulated nanostructures. The encapsulated nanostructures each include a nanostructure and a micro-scale, multi-block structure that encapsulates the nanostructure. Each encapsulated nanostructure can be made usable by a target device by removing, e.g., by etching, one of the layers to expose a portion of the nanostructure. | 05-27-2010 |
20110247937 | Method and apparatus for permeating flow desalination - A water desalination system and method in accordance with the principles of the present invention employs capacitive deionization to remove ions from source water to produce deionzed and waste water. The process employs charged electrodes to attract ions of opposite polarity from the source water. The process of discharging the electrodes employs solvent drag | 10-13-2011 |
20130162102 | TUNABLE ULTRASOUND TRANSDUCERS - A variety of micromachined structures are disclosed for use in DC-tunable ultrasound transducers. | 06-27-2013 |
20130199600 | ARTICLES, SYSTEMS, AND METHODS RELATING TO THERMAL STABILITY OF NANOSTRUCTURED AND/OR MICROSTRUCTURED MATERIALS - The present invention generally relates to articles, systems, and methods relating to the thermal stability of nanostructured and/or microstructured materials. | 08-08-2013 |
20130278111 | PIEZOELECTRIC MICROMACHINED ULTRASOUND TRANSDUCER WITH PATTERNED ELECTRODES - A piezoelectric micro-machined ultrasonic transducer (PMUT) uses multiple electrodes, e.g., in a radial pattern for a disc, to improve performance. The multiple electrodes may be differentially driven to operate the PMUT in d | 10-24-2013 |
20150068599 | METALLIC DIELECTRIC PHOTONIC CRYSTALS AND METHODS OF FABRICATION - A metallic-dielectric photonic crystal is formed with a periodic structure defining a plurality of resonant cavities to selectively absorb incident radiation. A metal layer is deposited on the inner surfaces of the resonant cavities and a dielectric material fills inside the resonant cavities. This photonic crystal can be used to selectively absorb broadband solar radiation and then reemit absorbed radiation in a wavelength band that matches the absorption band of a photovoltaic cell. The photonic crystal can be fabricated by patterning a sacrificial layer with a plurality of holes, into which is deposited a supporting material. Removing the rest of the sacrificial layer creates a supporting structure, on which a layer of metal is deposited to define resonant cavities. A dielectric material then fills the cavities to form the photonic crystal. | 03-12-2015 |
Sung Jae Kim, Melrose, MA US
Patent application number | Description | Published |
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20090242406 | METHODS FOR FABRICATING ELECTROKINETIC CONCENTRATION DEVICES - The present invention provides a device and methods of use thereof in concentrating a species of interest and/or controlling liquid flow in a device. The methods make use of a device comprising a fluidic chip comprising a planar array of channels through which a liquid comprising a species of interest can be made to pass with at least one rigid substrate connected thereto such that at least a portion of a surface of the substrate bounds the channels, and a high aspect ratio ion-selective membrane is embedded within the chip, attached to at least a portion of the channels. The device comprises a unit to induce an electric field in the channel and a unit to induce an electrokinetic or pressure driven flow in the channel. | 10-01-2009 |
20100187112 | NANOFLUIDIC PRECONCENTRATION DEVICE IN AN OPEN ENVIRONMENT - This invention provides a device and methods for increasing the concentration of a charged species in solution, wherein the solution containing the concentrated species is exposed to the environment. Such solution can be formed on a surface or on a tip of a measurement device. The open-environment concentration technique overcomes the disadvantages of in-channel concentration devices, especially by eliminating flow-induced delivery processes that lead to concentration losses. Combined with direct contact dispensing, methods of this invention can be used for various applications such as immunoassay and MALDI-MS. | 07-29-2010 |
20110198225 | AMPLIFIED ELECTROKINETIC FLUID PUMPING SWITCHING AND DESALTING - The present invention provides a device and methods of use thereof for desalting a solution. The methods, inter-alia, make use of a device comprising microchannels, which are linked to conduits, whereby induction of an electric field in the conduit results in the formation of a space charge layer within the microchannel. The space charge layer provides an energy barrier for salt ions and generates an ion depletion zone proximal to the linkage region between the microchannel and the conduit. The method thus enables the removal of salt ions from the region proximal to the conduit and their accumulation in a region distant from the conduit, within the microchannel. | 08-18-2011 |
20110220498 | Method for Building Massively-Parallel Preconcentration Device for Multiplexed, High-Throughput Applications - A multiplexed concentration interface that can connect with a plurality of microchannels, conventional 96 well plates or other microarrays is disclosed. The interface can be used in biosensing platforms and can be designed to detect single or multiple targets such as DNA/RNA, proteins and carbohydrates/oligosaccharides. The multiplexed concentration device will provide a set of volume-matched sample preparation and detection strategies directly applicable by ordinary researchers. Furthermore, a multiplexed microfluidic concentrator without buffer channels is disclosed. | 09-15-2011 |
20120247979 | Method for Enhancing Current Throughput in an Electrochemical System - An electrochemical system with reduced limiting-current behavior is disclosed. The electrochemical system is useful for fuel cells and bio-sensors. In part, the invention relates a method of reducing or eliminating limiting-current behavior in the operation electrochemical systems, in particular those with ion-selective membrane or electrochemical electrodes, by spatially reducing the convection near the membrane or the electrode. The invention further relates to electrochemical systems in which micropores, microarrays or pillar arrays are used to reduce convection in comparison to conventional systems without microarrays, micropores or pillar arrays. | 10-04-2012 |
20130256134 | METHODS FOR FABRICATING ELECTROKINETIC CONCENTRATION DEVICES - The present invention provides a device and methods of use thereof in concentrating a species of interest and/or controlling liquid flow in a device. The methods make use of a device comprising a fluidic chip comprising a planar array of channels through which a liquid comprising a species of interest can be made to pass with at least one rigid substrate connected thereto such that at least a portion of a surface of the substrate bounds the channels, and a high aspect ratio ion-selective membrane is embedded within the chip, attached to at least a portion of the channels. The device comprises a unit to induce an electric field in the channel and a unit to induce an electrokinetic or pressure driven flow in the channel. | 10-03-2013 |
20140322630 | Method for Enhancing Current Throughput in an Electrochemical System - An electrochemical system with reduced limiting-current behavior is disclosed. The electrochemical system is useful for fuel cells and bio-sensors. In part, the invention relates a method of reducing or eliminating limiting-current behavior in the operation electrochemical systems, in particular those with ion-selective membrane or electrochemical electrodes, by spatially reducing the convection near the membrane or the electrode. The invention further relates to electrochemical systems in which micropores, microarrays or pillar arrays are used to reduce convection in comparison to conventional systems without microarrays, micropores or pillar arrays. | 10-30-2014 |
20140332386 | Method of Building Massively-Parallel Ion Concentration Polarization Separation Device - Ion Concentration Polarization (ICP) purification devices and methods for building massively-parallel implementations of the same, said devices being suitable for separation of salts, heavy metals and biological contaminants from source water. | 11-13-2014 |
Sungjee Kim, Cambridge, MA US
Patent application number | Description | Published |
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20100102277 | Stabilized semiconductor nanocrystals - A semiconductor nanocrystal associated with a polydentate ligand. The polydentate ligand stabilizes the nanocrystal. | 04-29-2010 |
20120168694 | Tellurium-containing nanocrystalline materials - Tellurium-containing nanocrystallites are produced by injection of a precursor into a hot coordinating solvent, followed by controlled growth and annealing. Nanocrystallites may include CdTe, ZnTe, MgTe, HgTe, or alloys thereof. The nanocrystallites can photoluminesce with quantum efficiencies as high as 70%. | 07-05-2012 |
Sun H. Kim, Needham, MA US
Patent application number | Description | Published |
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20090275501 | Somatostatin-dopamine chimeric analogs - Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: | 11-05-2009 |
20100179304 | Somatostatin-Dopamine Chimeric analogs - Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8β-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH | 07-15-2010 |
20100204449 | METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS - The present invention relates to methods and intermediates for chemical synthesis of polypeptides and proteins, and more particularly to methods and intermediates for chemically ligating a peptide fragment containing N-terminal β-methyl-cysteine (SEQ ID NO: 1) with another peptide fragment having C-terminal thioester to generate a β-amino-thioester intermediate that spontaneously rearranges to form an amide bond. The invention also relates to methods of synthesizing β-methyl-cysteine (SEQ ID NO: 1) and its protected forms. Furthermore, the invention relates to converting a β-methyl-thiazolidine residue to a β-methyl-cysteine (SEQ ID NO: 1) residue of polypeptides and proteins. | 08-12-2010 |
20110038885 | CHEMOKINE ANALOGS - The present invention is directed to peptide analogs of chemokine, the pharmaceutically acceptable salts thereof, to methods of using such analogs to treat mammals and to pharmaceutical compositions useful therefor comprising said analogs. | 02-17-2011 |
Sun Hyuk Kim, Needham, MA US
Patent application number | Description | Published |
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20100113367 | PEPTIDE-CYTOTOXIC CONJUGATES - The invention features targeted cytotoxic compounds and methods relating to their therapeutic use for the treatment of neoplasia and other conditions. | 05-06-2010 |
20140121354 | Somatostatin-Dopamine Chimeric Analogs - The present invention relates to novel somatostatin-dopamine chimeric analogs and their therapeutic uses for the inhibition, prevention, and/or treatment of neoplasia, neuroendocrine tumors, Cushing's disease/syndrome, and other conditions. | 05-01-2014 |
Taeman Kim, North Billerica, MA US
Patent application number | Description | Published |
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20090127455 | Ion guide for mass spectrometers - The present invention relates generally to mass spectrometry and the analysis of chemical samples, and more particularly to ion guides for use therein. The invention described herein comprises an improved method and apparatus for transporting ions from a first pressure region in a mass spectrometer to a second pressure region therein. More specifically, the present invention provides a segmented ion funnel for more efficient use in mass spectrometry (particularly with ionization sources) to transport ions from the first pressure region to the second pressure region. | 05-21-2009 |
20110147584 | ION GUIDE FOR MASS SPECTROMETERS - The present invention relates generally to mass spectrometry and the analysis of chemical samples, and more particularly to ion guides for use therein. The invention described herein comprises an improved method and apparatus for transporting ions from a first pressure region in a mass spectrometer to a second pressure region therein. More specifically, the present invention provides a segmented ion funnel for more efficient use in mass spectrometry (particularly with ionization sources) to transport ions from the first pressure region to the second pressure region. | 06-23-2011 |
Wonyoung Kim, Cambridge, MA US
Patent application number | Description | Published |
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20110018511 | INTEGRATABLE EFFICIENT SWITCHING DOWN CONVERTER - A converter circuit and methods for operating the same. The converter circuit includes a supply voltage, a capacitor, an inductor, and four stacked switching elements. Each switching element is adjustable from a low resistance state to a high resistance state by a control signal. The inductor outputs current to a circuit load. The circuit may be operated in a first mode such that the output is adjustable between the supply voltage and half the supply voltage. Alternatively, in a second mode of operation, the output is adjustable from half the supply voltage to a ground voltage. | 01-27-2011 |
Yong-In Kim, Westborough, MA US
Patent application number | Description | Published |
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20090175875 | Molecules and Methods for Modulating Complement Component - Compositions that bind to C3b epitopes and methods of using the compositions are described herein. | 07-09-2009 |
20100034809 | Compositions and Methods for Antibodies Targeting Complement Protein C5 - The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof. | 02-11-2010 |
20100291106 | COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING COMPLEMENT PROTEIN C3B - The present invention relates to antibodies and antigen binding fragments thereof that bind to both human and cynomolgus complement protein C3b, as well as compositions and methods of use thereof. | 11-18-2010 |
20130022615 | Compositions and Methods for Antibodies Targeting Complement Protein C5 - The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof. | 01-24-2013 |
20130064836 | Compositions and Methods for Antibodies Targeting Complement Protein C5 - The present invention relates to antibodies targeting complement protein C5 and compositions and methods of use thereof. | 03-14-2013 |
20130295102 | COMPOSITIONS AND METHODS FOR ANTIBODIES TARGETING FACTOR P - The present invention relates to antibodies or antigen binding fragments thereof that bind to complement Factor P and used thereof as well as combinations of anti-Factor P antibodies with antibodies or antigen binding fragments thereof that bind to complement component 5 (C5). | 11-07-2013 |
Yong K. Kim, North Dartmouth, MA US
Patent application number | Description | Published |
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20080274326 | FABRIC BASED LAMINAR COMPOSITE AND METHOD FOR MANUFACTURE THEREOF - Fiber based z-directional reinforced composites having enhanced inter-laminar strength, impact toughness, transmission properties (electrical and thermal conduction) and coefficient of thermal expansion are provided. The composites include at least two substrates separated by a reinforcement zone that includes a plurality of fibers disposed in a binder resin. At least some, and in one embodiment, a majority, of the fibers are oriented so as to be substantially perpendicular to the substrates. Multi-layered composites having more than two substrate layers can also be formed. Methods for forming such composites are also provided. | 11-06-2008 |
20090035599 | HIGH EFFICIENCY BIOCONVERSION SURFACE MATERIALS - Flocked textile materials are disclosed as a support media for bacteria that actively biochemically convert noxious chemical species. Flocked fibrous netting materials as bioconversion support media are favorable to biological growth and provide excellent liquid (e.g. wastewater) flow through its structure as well as accommodating aeration processes. The disclosed support materials can be geometrically designed and positioned in many ways including stacked sheets/plies, rolled sheets in single or multi-walled tubes, and continuous belts or webs that can be self-cleaning and configured to operate in an automated process control mode. The disclosed support media facilitate development of compact and durable biofilter structures at a low cost. | 02-05-2009 |
20130330502 | PANEL FOR ABSORBING MECHANICAL IMPACT ENERGY AND METHOD OF MANUFACTURE - A panel for absorbing mechanical impact energy includes a substrate and a multiplicity of fibers attached, by one of their ends, to the substrate with their other ends extending away from the substrate. The panel may include a thin, porous covering layer that overlies the free ends of the fibers. The porosity of the cover and the fiber density of the fibers may allow for breathability of the panel. The panels may be flexible and may be used in body protection devices such as helmets, body armor as well as in other environments. Panels may be configured in a variety of energy absorbing arrangements for differing applications. | 12-12-2013 |
Yong K. Kim, Dartmouth, MA US
Patent application number | Description | Published |
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20110046715 | Auxetic Fabric Structures and Related Fabrication Methods - Auxetic fabric structures, of the sort which can be useful in conjunction with composite materials, and related methods of fabrication. | 02-24-2011 |
20110262951 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers. | 10-27-2011 |
20110262952 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends. | 10-27-2011 |
20130096463 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers which have randomly splayed terminal ends. | 04-18-2013 |
20130196363 | COLLECTION DEVICE AND MATERIAL - Swabs, and materials of the present disclosure, and methods of making same, include randomly arranged sea-island bicomponent fibers. | 08-01-2013 |
Yong Ku Kim, Dartmouth, MA US
Patent application number | Description | Published |
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20110072626 | NOVEL FABRIC FINISHING METHODS AND FABRICS - This invention provides methods for finishing knitted fabrics and fabrics finished by the novel process. In one embodiment, the method of finishing a knitted fabric includes the steps of: (a) stretching the fabric above about 5% but less than about 25% in width, and above about (−)7% but less than about 10% in length, (b) heat-setting the fabric to the stretched width and length at a temperature above about 120 degrees Centigrade and lowefthan about 250 degrees Centigrade, and (c) applying a polymeric protective binder coating resin to the fabric at a concentration of at least 5% but less than 25% based on the weight of the fabric. | 03-31-2011 |
Yongtae Kim, Cambridge, MA US
Patent application number | Description | Published |
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20080200329 | Method for Producing Catalyst - A method for producing a catalyst, comprising the step of supporting a metal atom on a support in which a thiol group is introduced on its surface. The catalyst is useful for a catalytic electrode of fuel cells, a composite electrode of capacitors or secondary batteries, a catalyst for an organic synthesis, a catalyst for an environmental cleanup, or the like. | 08-21-2008 |
Yushan Kim, Cambridge, MA US
Patent application number | Description | Published |
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20090068255 | USE OF MATRIX METALLOPROTEINASE INHIBITORS IN SKIN CARE - The application of matrix metalloproteinase (MMP) inhibitors to the skin inhibits the degradation of proteins found in the skin including collagen, elastin, and other basement membrane and extracellular matrix protein. MMP inhibitors may be used in both cosmetic compositions and pharmaceutical compositions for application to skin. MMP inhibitors are formulated with a cosmetically suitable vehicle or pharmaceutically acceptable excipient for application to the skin as creams, lotions, ointments, solutions, face masks, etc. As cosmetics, the inventive MMP inhibitor compositions are applied to the skin to prevent or reduce the appearance of wrinkles, pigmentation changes, loss of elasticity, or other effects associated with aging or sun damage. As pharmaceuticals, the inventive MMP inhibitor compositions may also be applied to the skin to treat or prevent a skin disease (e.g., proliferative disease, inflammatory disease). | 03-12-2009 |