Patent application number | Description | Published |
20120045512 | METHODS AND SUBSTRATES FOR DIFFERENTIATION OF NEURAL STEM CELLS - The present invention is directed to methods and substrates for promoting the differentiation of neural stem cells to neurons. | 02-23-2012 |
20120115962 | CYCLODEXTRIN-MODIFIED POLYAMINES FOR DELIVERY OF THERAPEUTIC MOLECULES - The present invention is directed to drug delivery vehicles comprising one or more cyclodextrin moieties conjugated to a dendritic polyamine for the delivery of small molecule and protein therapeutic molecules and nucleic acid therapeutic molecules, and methods of making and using the delivery vehicles. | 05-10-2012 |
20120149781 | STEM CELL DIFFERENTIATION USING NOVEL LIGHT-RESPONSIVE HYDROGELS - This application discloses a light-responsive hydrogel-based platform that can modulate multiple microenvironmental signals to direct the differentiation of human induced pluripotent stem cell-derived neural progenitor cells (hiPSC-NPCs) into neuronal cells. The invention provides novel methods for directing differentiation of neural stem cells into neurons useful for treatment of degenerative diseases or disorders, including but not limited to Alzheimer's, Parkinson's, or spinal cord injury (SCI). | 06-14-2012 |
20120220053 | GRAPHENE-ENCAPSULATED NANOPARTICLE-BASED BIOSENSOR FOR THE SELECTIVE DETECTION OF BIOMARKERS - A field effect transistor (FET) with a source electrode and a drain electrode distanced apart from each other on a semi-conductor substrate, and a gate electrode consisting of a uniform layer of reduced graphene oxide encapsulated semiconductor nanoparticles (rGO-NPs), wherein the gate electrode is disposed between and contacts both the source and drain electrodes. Methods of making and assay methods using the FETs are also disclosed, including methods in which the rGO-NPs are functionalized with binding partners for biomarkers. | 08-30-2012 |
20130221346 | Zinc Oxide-Based Thin Film Transistor Biosensors with High Sensitivity and Selectivity - This application discloses ZnO film transistor-based immunosensors ZnO-bioTFT), 2T biosensor arrays formed from two integrated ZnO-bioTFTs. ITIR-based nonvolatile memory (NVM) arrays formed from ZnO-bioTFT (T) integrated with ZnO-based resistive switches (R), as well as integrated bioTFT (IBTFT) sensor systems formed from 2T biosensor arrays and ITIR NVM arrays. Through biofunctionalization, these biosensors can perform immunosensing with high seminvity and selectivity, and therefore have a wide range of applications, for example, in detecting target biomolecules or small molecules, and potential application in cancer diagnosis and treatment. | 08-29-2013 |
20130236552 | NANOTOPOGRAPHY-MEDIATED REVERSE UPTAKE PLATFORM FOR NUCLEIC ACID DELIVERY AND APPLICATIONS THEREOF - This application discloses a nanotopography-mediated reverse uptake (NanoRU) platform useful for intracellular delivery of nucleic acids into mammalian cells, in particular stem cells, as well as methods of preparation and applications thereof. In particular, this system can be used to deliver small interfering ribonucleic acids (siRNAs) into neural stem cells and enhance neuronal differentiation of the stem cells. | 09-12-2013 |
20130343996 | GRAPHITE-COATED MAGNETIC NANOPARTICLES - The present invention relates to graphite-coated magnetic nanoparticles, methods for the synthesis of graphite-coated magnetic nanoparticles, and methods of using graphite-coated magnetic nanoparticles for targeted delivery of siRNA-based therapy, as multimodal imaging probes and for hyperthermia cancer treatment. | 12-26-2013 |
20150081018 | METHODS AND SUBSTRATES FOR DIFFERENTIATION OF NEURAL STEM CELLS - The present invention is directed to methods and substrates for promoting the differentiation of neural stem cells to neurons. | 03-19-2015 |