Kharazi
Alex Kharazi, Somerset, NJ US
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20080247263 | Method to Increase Production Rate of a Continuous Mixer or Extruder - Compounding or extrusion rates can be increased by splitting the polymer solid feed. Melting of additional solid polymer is significantly assisted by excess enthalpy from incoming melt from a primary mixing stage. Depending on resin rheology and melting characteristics, rate increases were achieved of from up to about 55 to about 100% rate increase over the use of a single feed at the same rotor speed. The net result is a decrease in the overall SEI (specific energy input to the polymer) and thus melt temperatures. | 10-09-2008 |
Alex Kharazi, San Diego, CA US
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20130177537 | STEM CELLS AND METHODS FOR INCORPORATING ENVIRONMENTAL FACTORS AS A MEANS FOR ENHANCING STEM CELL PROLIFERATION AND PLASTICITY - Disclosed are methods for expanding stem cells that use a unique combination of environmental factors and cell culture conditions to produce stem cells having enhanced proliferation and differentiation characteristics. Also disclosed are methods for enhancing the engraftment and/or migratory potential of stem cells for therapeutic uses. Stem cells having unique proliferation, differentiation, migratory and engraftment characteristics are also disclosed. | 07-11-2013 |
20140242047 | TRANSGENIC THERAPEUTIC STEM CELLS AND METHODS FOR THEIR USE AND MANUFACTURE - The invention relates to transgenic stem cells for therapeutic use. Stem cells according to the invention comprise at least one therapeutic trans gene that is expressed when transplanted to a subject. Methods of use and manufacturing the transgenic stem cells of the invention are also contemplated, including the use of transiently transgenic G-CSF bone marrow stem cells for treating the penumbra of ischemic tissues such as central nervous system tissues. | 08-28-2014 |
Alexandar Kharazi, San Diego, CA US
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20140286910 | STEM CELLS AND METHODS INCORPORATING ENVIRONMENTAL FACTORS AS A MEANS FOR ENHANCING STEM CELL PROLIFERATION AND PLASTICITY - Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension. The environmental factors and culture conditions of the invention produce stem cells having an enhanced therapeutic ability and enhanced proliferation in culture. Stem cells of the invention retain their plasticity through a higher number of cell passages relative to know methods of stem cell culture. The invention also contemplates the use of such stem cells in the treatment of neurodegenerative disorders including Alzheimer's disease and stroke. | 09-25-2014 |
Alexander Kharazi, San Diego, CA US
Patent application number | Description | Published |
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20090253591 | METHODS FOR IDENTIFYING NEURIPOTENT CELLS - The invention is a method for using an avian embryo to identify the neuripotency of a cell population. The invention may be used for applications such as screening for candidate neuripotent cell lines for masterbanking, validation of working cell banks, and identifying agents and conditions capable of inducing neural differentiation in a cell population. | 10-08-2009 |
20100209398 | Compositions of stem cells and stem cell factors and methods for their use and manufacture - Therapeutic stem cells and methods for their use and manufacture. Stem cells are produced under conditions in which the stem cells are exposed to at least one environmental factor, including decreased oxygen tension. The environmental factors and culture conditions of the invention produce stem cells having an enhanced therapeutic ability and enhanced proliferation in culture. Stem cells of the invention retain their plasticity through a higher number of cell passages relative to know methods of stem cell culture. | 08-19-2010 |
20120077272 | CELLULAR SCAFFOLD - A cellular scaffold that is suitable for tissue regeneration, cell culture and in vitro assays. The invention relates to a layered cell scaffold that is seeded with mesenchymal and ectodermal cells. The layered cellular scaffold comprises an inoculum of mesenchymal cells and ectodermal cells positioned between two opposing scaffolds in a sandwich configuration. The layered cell scaffold provides a functional skin equivalent that is suitable for transplantation and in vitro cell-based assays. | 03-29-2012 |
Ludmilla Kharazi, San Diego, CA US
Patent application number | Description | Published |
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20120077272 | CELLULAR SCAFFOLD - A cellular scaffold that is suitable for tissue regeneration, cell culture and in vitro assays. The invention relates to a layered cell scaffold that is seeded with mesenchymal and ectodermal cells. The layered cellular scaffold comprises an inoculum of mesenchymal cells and ectodermal cells positioned between two opposing scaffolds in a sandwich configuration. The layered cell scaffold provides a functional skin equivalent that is suitable for transplantation and in vitro cell-based assays. | 03-29-2012 |