Patent application number | Description | Published |
20080319476 | Hemostatic mineral compositions and uses thereof - The invention generally relates to compositions and methods for promoting hemostasis and sealing a wound by producing an adhesive cast. In particular, the invention provides compositions comprising clay minerals with specified particle sizes, which, when applied to a bleeding area, allow for a desired result in at least one of the following activities: stopping blood flow from a wound, forming a cohesive mass, sealing a wound, promoting coagulant activity, sorbing a body fluid, and adhering to tissue. For example, the desired result can be sealing the wound using an adhesive cast made of clay minerals mixed with blood or other wound fluids. | 12-25-2008 |
20090155342 | Mineral technologies (MT) for acute hemostasis and for the treatment of acute wounds and chronic ulcers - Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided. | 06-18-2009 |
20090202617 | Gas based wound and tissue therapeutics - This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue. | 08-13-2009 |
20100144597 | Novel combinatorial approaches to enhancing oxygen transport to tissues - The subject application provides for a method for enhancing oxygen delivery to a tissue in a subject comprising administering to the subject a composition comprising two or more compounds selected from the group consisting of a hemoglobin based oxygen carrier, a nonhemoglobin based oxygen carrier, a rheologic modulator, a diffusion changing compound, a volume expander, and a vasomodulator. The subject application also provides for a method for enhancing oxygen delivery to a tissue in a subject comprising administering to the subject a composition comprising a perfluorocarbon and one or more compounds selected from the group consisting of a hemoglobin based oxygen carrier, a nonhemoglobin based oxygen carrier, a rheologic modulator, a diffusion changing compound, a volume expander, and a vasomodulator. | 06-10-2010 |
20100292624 | Mineral Technologies (MT) for Acute Hemostasis and for the Treatment of Acute Wounds and Chronic Ulcers - Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided. | 11-18-2010 |
20120006331 | PREVENTION OF VENTILATOR ASSOCIATED PNEUMONIA (VAP) - Ventilator associated pneumonia (VAP) may be prevented in a patient, or its occurrence reduced in a population of patients, by using an anti-VAP device or an anti-VAP material such as an anti-VAP mouthpiece that absorbs secretions. By reducing the problem of bacterial-containing secretions that otherwise build up in the airway of, and elsewhere in, the intubated patient, VAP can be prevented from occurring in intubated patients, such as patients intubated with an endotracheal tube (ETT) or a nasogastric tube. Anti-VAP mouthpieces also are useable in non-intubated patients to maintain oral hygiene. | 01-12-2012 |
20120136224 | Combining Predictive Capabilities of Transcranial Doppler (TCD) with Electrocardiogram (ECG) to Predict Hemorrhagic Shock - A real-time decision-support system predicts hemorrhagic shock of a patient by analysis of electrocardiogram (ECG) signals and transcranial Doppler (TCD) signals from the patient. These signals are subject to signal decomposition using Discrete Wavelet Transform (DWT) to sets of wavelet coefficients and selecting significant signal features. Machine learning is applied to the significant features to evaluate and classify hypovolemia severity based on the input ECG and TCD signals from the patient. The classification of blood loss severity is displayed in real-time. An extension of the decision-support system integrates Arterial Blood Pressure (ABP) signals and thoracic electrical bio-impedance (DZT) signals with the ECG and TCD signals from the patient to evaluate severity of hypovolemia. | 05-31-2012 |
20120143037 | Accurate Pelvic Fracture Detection for X-Ray and CT Images - Accurate pelvic fracture detection is accomplished with automated X-ray and Computed Tomography (CT) images for diagnosis and recommended therapy. The system combines computational methods to process images from two different modalities, using Active Shape Model (ASM), spline interpolation, active contours, and wavelet transform. By processing both X-ray and CT images, features which may be visible under one modality and not under the other are extracted and validates and confirms information visible in both. The X-ray component uses hierarchical approach based on directed Hough Transform to detect pelvic structures, removing the need for manual initialization. The X-ray component uses cubic spline interpolation to regulate ASM deformation during X-ray image segmentation. Key regions of the pelvis are first segmented and identified, allowing detection methods to be specialized to each structure using anatomical knowledge. The CT processing component is able to distinguish bone from other non-bone objects with similar visual characteristics, such a blood and contrast fluid, permitting detection and quantification of soft tissue hemorrhage. The CT processing component draws attention to slices where irregularities are detected, reducing the time to fully examine a pelvic CT scan. The quantitative measurement of bone displacement and hemorrhage area are used as input for a trauma decision-support system, along with physiological signals, injury details and demographic information. | 06-07-2012 |
20120184840 | Automated Measurement of Brain Injury Indices Using Brain CT Images, Injury Data, and Machine Learning - A decision-support system and computer implemented method automatically measures tee midline shift in a patient's brain using Computed Tomography (CT) images. The decision-support system and computer implemented method applies machine learning methods to features extracted from multiple sources, including midline shift, blood amount, texture pattern and other injury data, to provide a physician an estimate of intracranial pressure (ICP) levels. A hierarchical segmentation method, based on Gaussian Mixture Mode! (GMM), is used. In this approach, first an Magnetic Resonance Image (MRI) ventricle template, as prior knowledge, is used to estimate the region for each ventricle. Then, by matching the ventricle shape it) CT images to fee MRI ventricle template set, the corresponding MRI slice is selected. From the shape matching result, the feature points for midline estimation in CT slices, such as the center edge points of the lateral ventricles, are detected. The amount of shift, along with other information such as brain tissue texture features, volume of blood accumulated in the brain, patient demographics, injury information, and features extracted from physiological signals, are used to train a machine learning method to predict a variety of important clinical factors, such as intracranial pressure (ICP), likelihood of success a particular treatment, and the need and/or dosage of particular drugs. | 07-19-2012 |
20120184898 | GAS BASED WOUND AND TISSUE THERAPEUTICS - This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue. | 07-19-2012 |
20120219612 | Mineral Technologies (MT) for Acute Hemostasis and for the Treatment of Acute Wounds and Chronic Ulcers - Compositions comprising clay minerals and methods for their use in promoting hemostasis are provided. The compositions comprise clay minerals such as bentonite, and facilitate blood clotting when applied to a hemorrhaging wound. Electrospun or electrosprayed materials (e.g. bandages, micron beads, etc.) which include clay minerals, and methods for the treatment of acute hemorrhage, are also provided. | 08-30-2012 |
20120269420 | Image Processing and Machine Learning for Diagnostic Analysis of Microcirculation - Automated quantitative analysis of microcirculation, such as density of blood vessels and red blood cell velocity, is implemented using image processing and machine learning techniques. Detection and quantification of the microvasculature is determined from images obtained through intravital microscopy. The results of quantitatively monitoring and assessing the changes that occur in microcirculation during resuscitation period assist physicians in making diagnostically and therapeutically important decisions such as determination of the degree of illness as well as the effectiveness of the resuscitation process. Advanced digital image processing methods are applied to provide quantitative assessment of video signals for detection and characterization of the microvasculature (capillaries, venules, and arterioles). The microvasculature is segmented, the presence and velocity of Red Blood Cells (RBCs) is estimated, and the distribution of blood flow in capillaries is identified for a variety of normal and abnormal cases. | 10-25-2012 |
20130266668 | USE OF HEMOGLOBIN EFFECTORS TO INCREASE THE BIOAVAILABILITY OF THERAPEUTIC GASES - Methods which increase the bioavailability of beneficial gases in the circulatory system are provided. The methods involve administering agents that changes the binding affinity of a medicinal gas such as NO, CO, H | 10-10-2013 |
20130289471 | GAS BASED WOUND AND TISSUE THERAPEUTICS - This invention provides articles of manufacture and bandages comprising compartments and layers comprising oxygen and other therapeutic gas storage forms and perfluorocarbons. This invention also provides for methods of delivering oxygen and other therapeutic gases to a tissue in a subject comprising a administering to the tissue a composition comprising a perfluorocarbon and a oxygen or therapeutic gas storage form, so as to thereby deliver oxygen or the therapeutic gas to the tissue. | 10-31-2013 |