Kearney
Daniel Kearney, Zurich CH
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20150116937 | ELECTRONIC DEVICE WITH WATERPROOF ENCLOSURE - An electronic device including a sealed enclosure, the electronic components arranged inside the sealed enclosure and including high-loss high-temperature components, a main heat sink including ribs, wherein the high-loss high-temperature components are attached to the main heat sink and the ribs of the main heat sink are arranged outside the enclosure, a cavity formed inside the enclosure and divided into a plurality of channel-like sections, the channel-like sections configured for providing air flow guidance inside the enclosure and being interconnected at their ends, wherein at least one channel-like section contains the electronic components and at least one other channel-like section contains an air-to-air heat exchanger extending from inside the sealed enclosure to outside of the sealed enclosure, wherein the electronic components inside the at least one channel like section are adapted to be cooled by air flow inside the sealed enclosure. | 04-30-2015 |
20160049354 | POWER SEMICONDUCTOR MODULE AND METHOD FOR COOLING POWER SEMICONDUCTOR MODULE - The present disclosure relates to a power semiconductor module comprising a printed circuit board (PCB), and to method of cooling such a power semiconductor module. The module comprises a power semiconductor device and an island of thermally conducting foam embedded into the printed circuit board. The power semiconductor device and the island of thermally conducting foam are positioned on top of each other, and the island is arranged to form a path for a flowing coolant cooling the power semiconductor device. | 02-18-2016 |
David Kearney, Dublin IE
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20100315303 | Folded slotted monopole antenna - A slotted monopole wideband antenna, comprising an insulating rectangular chip mounted on a carrier substrate, said carrier substrate including a feeding structure, and said chip comprising a first side adjacent to said feeding structure, a feed point of the antenna is located near said first side. An electrically conducting lamina is folded over four faces of said insulating chip, said lamina being connected to the feed point at one end, and to ground at another end. At least two slots are formed in an upper section of said folded lamina, said slots having the effect of lowering the principal resonance of said antenna, thereby providing a miniaturized antenna suitable for integration in a mobile wireless communications handset. | 12-16-2010 |
Derek Kearney, Little Hampton GB
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20120125546 | SMOKE OR FIRE BARRIER - A twin roller smoke or fire barrier having: two parallel rollers and a curtain comprised of narrow curtain portions rolled on the rollers and arranged along the length of the rollers of alternate rollers with end margins overlapping opposite each other; the barrier including: a mechanism for varying separation of the rollers by at least the change in the overall diameter of one roller and its curtain portions between wound-up and unwound states, the mechanism including: movable supported roller or rollers; whereby in the unwound state of the curtain, the overlapping margins abut or at least are separated by a negligible amount at the rollers. | 05-24-2012 |
Joseph Francis Kearney, Ballina AU
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20150360916 | A DEVICE AND METHOD FOR LIFTING AND LOWERING A LOAD - The invention relates generally to a method and a device for lifting and lowering respectively a load, said load having a lifting loop attached to said load. The device comprising: a first member having means for attachment to a lifting device and means for attachment to the lifting loop of said load; a second member having means on said second member for automatically guiding said lifting loop to define a path for coupling and uncoupling of said lifting loop to and from said first member; a securing mechanism on said first member which automatically secures said lifting loop to said first member when said lifting loop engages said first member; and a release mechanism for releasing the securing mechanism to release the lifting loop from the first member. | 12-17-2015 |
Joseph Francis Kearney, East Ballina AU
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20150360916 | A DEVICE AND METHOD FOR LIFTING AND LOWERING A LOAD - The invention relates generally to a method and a device for lifting and lowering respectively a load, said load having a lifting loop attached to said load. The device comprising: a first member having means for attachment to a lifting device and means for attachment to the lifting loop of said load; a second member having means on said second member for automatically guiding said lifting loop to define a path for coupling and uncoupling of said lifting loop to and from said first member; a securing mechanism on said first member which automatically secures said lifting loop to said first member when said lifting loop engages said first member; and a release mechanism for releasing the securing mechanism to release the lifting loop from the first member. | 12-17-2015 |
Kenneth Anthony Kearney, Downpatrick GB
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20100145202 | METHOD AND APPARATUS FOR DETERMINING INFORMATION CONCERNING THE IDENTITY OF AN INDIVIDUAL - A method of determining information concerning the identity of an individual comprising measuring at least one biometric of the individual comprising at least one bio-potential waveform generated by the individual's heart, extracting a plurality of characteristics from the bio-potential waveform comprising any of an approximate location of a point of a P peak, an approximate location of a Q-point of a QRS peak system, an approximate location of an R-point of a QRS peak system, an approximate location of an S-point of a QRS peak system, an approximate location of a point of a T peak, using the characteristics to calculate at least one waveform parameter, comparing at least one calculated waveform parameter with at least one previously-acquired waveform parameter to generate a score, and using the score to determine information concerning the identity of the individual. | 06-10-2010 |
Luke F. Kearney, Navan IE
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20150358208 | COMPONENT DEPENDENCY MAPPING SERVICE - Systems and methods are provided for mapping dependencies between system components and for analyzing and acting on possible root causes for anomalies experienced by the system components. Aspects of the present disclosure may present for display information associated with the dependency maps and ranked lists of possible root causes of anomalies. Ranking comprises determination of which operating parameters of related system components, when anomalous, will have the greatest effect on the operation of monitored system components. When possible root causes are ranked, notifications may be issued to alert administrators or other systems of the anomaly and the likely root causes. | 12-10-2015 |
Michael J. Kearney, Carindale Qld AU
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20130013509 | METHOD AND SYSTEM FOR PROCESSING MICROPAYMENT TRANSACTIONS - Methods and systems for performing micropayment transactions over communication networks is provided. These methods and systems enable ubiquitous micropayments by providing a seamless payment solution in which micropayment is one of a plurality of payments facilitated. In an embodiment, the transaction value may be compared to a predefined threshold, and processed as a micropayment if said value is less than said threshold, and otherwise processed using a second processing system. In another embodiment, the transaction may be processed as a micropayment if the payee has previously been verified by the micropayment processing system. In a third embodiment, the transaction takes place using the payee's website. | 01-10-2013 |
Michael Peter Kearney, Milton AU
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20130231855 | COLLISION AVOIDANCE SYSTEM AND METHOD FOR HUMAN COMMANDED SYSTEMS - A method of implementing an optimal avoidance filter for interposing between a human operator issued movement commands and a corresponding machine control system of a movable machine, for the avoidance of collisions with objects. The method: includes inputting a detailed representation of objects in the vicinity of the movable machine; and formulating a hierarchical set of bounding boxes around the objects. The hierarchical set including refinement details depending on the current positional state of the movable machine, with objects closer to the machine having higher levels of refinement details. The method further includes utilizing the resultant hierarchical set as a set of constraints for a mixed integer optimisation problem to determine any alterations to the issued movement commands so as to avoid collisions with any objects. | 09-05-2013 |
20150057815 | SUPERVISORY CONTROL OF AUTOMATED IRRIGATION CHANNELS - A method of delivery of fluid through a computer controlled fluid network, the network including: regulators to control the flow of fluid to deliver a predetermined amount thereof to at least one customer; a first control system for opening and closing the regulators, which collects data based on timed measurements of fluid levels upstream and downstream of respective regulators and the opening positions of respective regulators, using data analysis to provide models for prediction of fluid levels between regulators; a second control system that is a supervisory layer interacting with the first control system to provide adjustments to the controlling of the regulators based on constraint and future flow load; and a third control system interacting with the first and second control systems, which processes fluid delivery requests from the at least one customer to provide a flow load delivery schedule based on the hydraulic capacity of the network. | 02-26-2015 |
Niall Kearney, Killeagh IE
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20110121872 | SEMICONDUCTOR DEVICE, WIRELESS COMMUNICATION DEVICE AND METHOD FOR GENERATING A SYNTHESIZED FREQUENCY SIGNAL - A semiconductor device comprises synthesized frequency generation logic arranged to receive a reference signal, and to generate a synthesized frequency signal from the reference signal. The synthesized frequency generation logic comprises programmable divider logic arranged to receive the reference signal and to generate a divided signal comprising a frequency with a period substantially equal to N times that of the reference signal, where N comprises a programmable integer value. The synthesizer frequency generation logic is arranged to generate the synthesized frequency signal comprising a frequency with a period substantially equal to 1/M that of the divided signal, where M comprises a further programmable integer value. | 05-26-2011 |
20110151804 | SEMICONDUCTOR DEVICE, WIRELESS COMMUNICATION DEVICE AND METHOD FOR GENERATING A SYNTHESIZED FREQUENCY SIGNAL - A semiconductor device comprises synthesized frequency generation logic arranged to receive a reference signal, and to provide an output frequency signal. The synthesized frequency generation logic comprises divider logic arranged to receive the reference signal and to generate a divided signal comprising a frequency with a period equal to N times that of the reference signal. The synthesized frequency generation logic is further arranged to generate the synthesized frequency signal comprising a frequency with a period equal to 1/M that of the divided signal. The synthesized frequency generation logic comprises or is operably coupled to decision logic module and comprises or is operably coupled to a switching logic module such that the decision logic module is arranged to determine whether a near-integer spur arises in using the synthesized frequency signal, and configures the switching logic module to select the synthesized frequency signal in response thereto. | 06-23-2011 |
20110260761 | TEMPERATURE COMPENSATION IN A PHASE-LOCKED LOOP - An integrated circuit comprises a digital phase-locked loop for a wireless communications unit. The digital phase-locked loop comprises a voltage controlled oscillator and a digital tuning subsystem. An input of the digital tuning subsystem receives the output signal from the voltage controlled oscillator, and an output of the digital tuning subsystem is supplied to the voltage controlled oscillator. A digital voltage generator is adapted to store at least two predetermined forcing voltages. The digital voltage generator is adapted to select one of the at least two predetermined forcing voltages, in dependence on a current temperature value, and to supply it as a forcing voltage to an input of the voltage controlled oscillator, prior to the phase locked loop achieving lock. A wireless communication unit and a method of tuning a phase-locked loop are also provided. | 10-27-2011 |
Niall Kearney, Dublin IE
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20100097110 | WIRELESS COMMUNICATION UNIT, INTEGRATED CIRCUIT COMPRISING A VOLTAGE CONTROLLED OSCILLATOR AND METHOD OF OPERATION THEREFOR - A wireless communication unit comprises a frequency generation circuit employing a phase locked loop (PLL) circuit comprising a voltage controlled oscillator having a modulation port for directly modulating a signal output from the voltage controlled oscillator. The voltage controlled oscillator is operably coupled to at least one switch and a capacitor bank comprising one or more varactors. A controller is arranged to switch in one or more varactors associated with the modulation port of the phase locked loop circuit to provide an inverse cubic relationship to the direct modulated signal. | 04-22-2010 |
Niall K. Kearney, Dublin IE
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20090001518 | Varactor - A varactor comprising a first layer separated from a second layer by an insulating layer, wherein the first layer is a first type of semiconductor material and the second layer is a second type of semiconductor material and the insulation layer is arranged to allow an accumulation region to be formed in the first layer and second layer when a positive bias is applied to the first layer and the second layer and a depletion region to be formed in the first layer and second layer when a negative bias is applied to the first layer and the second layer. | 01-01-2009 |
Niall Kevin Kearney, Cork IE
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20160134301 | DELTA-SIGMA MODULATOR HAVING TRANSCONDUCTOR NETWORK FOR DYNAMICALLY TUNING LOOP FILTER COEFFICIENTS - A dynamically tunable transconductor includes a voltage-to-current converter stage for generating a current signal based on a voltage signal; and a current scaling stage for scaling the current signal by a scaling factor to achieve a particular transconductance. Current scaling stage includes a coarse tune mechanism having an associated coarse tune step and a fine tune mechanism having an associated fine tune step, where the scaling factor is a ratio of the coarse tune step to the fine tune step. A delta-sigma modulator can implement the transconductor to generate loop filter coefficients by dynamically tuning the transconductance to achieve a particular resistance. | 05-12-2016 |
Niall Kevin Kearney, Killeagh IE
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20150073739 | APPARATUS AND METHOD FOR EVALUATING THE PERFORMANCE OF A SYSTEM IN A CONTROL LOOP - A monitoring circuit for monitoring the performance of a phase locked loop having a divider therein, the divider comprising at least a first counter, the monitoring circuit comprising at least one memory element for capturing a value of the first counter after a predetermined time from a system event in the operation of the phase locked loop, a variability calculator for comparing a value of the counter with a preceding value of the counter to calculate a variation, and a circuit responsive to the estimate of variation for outputting a status signal. | 03-12-2015 |
20150365118 | LOW INTERMEDIATE FREQUENCY RECEIVER - An LIF receiver includes a receiver path comprising: a mixer for mixing a received RF signal with a local oscillator signal to provide an IF signal at a lower frequency than the received RF signal, a bandpass filter for filtering the IF signal, a PGA for amplifying the filtered IF signal, an ADC for converting the amplified filtered IF signal to a digital signal, a converter for converting the digital signal to a baseband digital signal, and an AGC for setting a gain of the PGA in response to a magnitude of the received RF signal. A programmable DC signal source injects a programmed DC offset signal into the amplified filtered IF signal converted by the ADC, and a signal sensor, operatively connected to the receiver path after the PGA, determines a polarity of PGA signal output for a programmed DC offset signal. A controller determines a programmed DC offset signal minimizing a magnitude of the baseband signal in the absence of a received RF signal for at least one gain setting of the PGA. | 12-17-2015 |
Paul Kearney, Cork IE
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20100283643 | SIMULTANEOUS SAMPLING ANALOG TO DIGITAL CONVERTER - The invention is a novel scheme of performing an analog to digital conversion of simultaneous sampled analog inputs using multiple sample and hold circuits and a single successive approximation analog to digital converter (“SAR ADC”). Each of the analog inputs are stored on capacitors in the sample and hold circuits, and the sample and holds are sequentially connected to the capacitor DAC. After the digital conversion of the of the input signals stored on a sample and hold, the connected sample and hold is disconnected and the charge on the DAC is reset before the next sample and hold circuit is connected. The process is repeated until all analog inputs have been converted. | 11-11-2010 |
Paul Kearney, Montreal CA
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20120142558 | DIAGNOSTIC LUNG CANCER PANEL AND METHODS FOR ITS USE - Disclosed herein are novel diagnostic lung cancer panels and the use of these panels to diagnose, predict, and characterize lung cancer and to monitor or predict treatment efficacy. | 06-07-2012 |
20120238476 | ALZHEIMER'S DISEASE DIAGNOSTIC PANELS AND METHODS FOR THEIR USE - Novel compositions, methods, assays and kits directed to a diagnostic panel for Alzheimer's disease are provided. In one embodiment, the diagnostic panel includes one or more proteins associated with Alzheimer's disease. | 09-20-2012 |
Paul E. Kearney, Montreal CA
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20100183630 | Tat-005 and Methods of Assessing and Treating Cancer - Surprisingly, the present inventors have discovered that expression of TAT-005 protein in human patients is associated with cancer, and that the over-expressed protein is present in plasma membrane fractions. Thus, the present inventors have discovered that TAT-005 is associated with abnormal development and growth, and may be useful as a target for the identification of anti-cancer com\ pounds, including antibodies for use in immunotherapy. Accordingly, the present invention provides methods for the identification of compounds that inhibit TAT-005 expression or activity, comprising: contacting a candidate compound with a TAT-005 and detecting the presence or absence of binding between said compound and said TAT-005, or detecting a change in TAT-005 expression or activity. Methods are also included for the identification of compounds that modulate TAT-005 expression or activity, comprising: administering a compound to a cell or cell population, and detecting a change in TAT-005 expression or activity. The methods of the invention are useful for the identification of anti-cancer compounds. | 07-22-2010 |
Paul Edward Kearney, Montreal CA
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20130156692 | VEGF-SPECIFIC CAPTURE AGENTS, COMPOSITIONS, AND METHODS OF USING AND MAKING - The present application provides biligand and triligand protein-catalyzed capture (PCC) agents that specifically bind VEGF, as well as the use of these capture agents as detection, diagnosis, and treatment agents. | 06-20-2013 |
20130157891 | ORGAN SPECIFIC DIAGNOSTIC PANELS AND METHODS FOR IDENTIFICATION OF ORGAN SPECIFIC PANEL PROTEINS - The present application provides novel compositions, methods, and assays for use in identification of appropriate diagnostic markers in blood. These compositions, methods, and assays are capable of distinguishing normal levels of detectable markers from changes in marker levels that are indicative of changes in health status. | 06-20-2013 |
20130203096 | Selected Reaction Monitoring Assays - Provided herein are methods for developing selected reaction monitoring mass spectrometry (LC-SRM-MS) assays. | 08-08-2013 |
20150219666 | INTEGRATED QUANTIFICATION METHOD FOR PROTEIN MEASUREMENTS IN CLINICAL PROTEOMICS - Methods are provided for determining the expression level of target proteins in a subject. A plurality of respective peptide transitions are generated from a plurality of proteins obtained from a biological sample from the subject, wherein the plurality of proteins comprises both target and normalizing proteins. A mass spectroscopy (MS) signal intensity is measured from the plurality of respective peptide transitions and a plurality of corresponding stable isotope-labeled internal standard (SIS) peptide transitions. For each of the plurality of proteins, a response ratio is calculated between the MS signal intensity of the respective peptide transition and the corresponding SIS peptide transition. The response ratio for each target protein is normalized by a sample-dependent normalization factor calculated from the response ratio for each normalizing protein, wherein the normalized response ratios provide a determination of the expression level of the target proteins. | 08-06-2015 |
Paul J. Kearney, Felixstowe GB
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20090122970 | Authentication Apparatus - An authentication device for fitting at the entrance to a property includes an externally facing interface including a speaker and a microphone; an internally facing interface comprising a speaker, a microphone and a keypad; and a processing unit including electrical interfaces to both the internally and externally facing interfaces and to a telephone unit. The internally facing keypad includes a button which permits a user to cause the processing unit to initiate a call using the telephone unit to a remote voice verification centre via the telephone unit and the PSTN to which it is interfaced when in use (via standard telephone socket). The processing unit is additionally operable to communicate audio signals between the remote voice verification centre and at least the externally facing interface (i.e. the speaker and microphone thereof), whereby a visitor may be remotely verified by the remote voice verification centre before the householder grants the visitor admission to the property. | 05-14-2009 |
Peter Kearney, Fridingen DE
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20130292894 | METHOD AND DEVICE FOR THE GENERATION AND/OR CONVEYANCE OF A SHINGLED STREAM OF FLAT, FLEXIBLE OBJECTS - A device for the generation of a shingled stream of flat, flexible objects along a conveyor path, wherein successive objects develop an overlap with a length, includes a first and a second suction and conveyor device having a first and second unit, respectively, and each having at least one conveyor belt. The first and second units are each configured to generate a vacuum through a whirlwind to attract at least one of the objects and are each disposed in a casing having a suction aperture. The second suction and conveyor device is disposed downstream from the first suction and conveyor device in a direction of the conveyor path with a mutual offset corresponding to the length of the overlap and is disposed at an angle relative to the direction of the conveyor path. The first and second suction are separated by a spacing in a transversal direction. | 11-07-2013 |
Peter Xavier Kearney, Friding DE
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20110272877 | VORTEX SUCTION SEPARATOR DEVICE - A system for separating an article from the outer part of a stack and conveying it along a transfer path includes a stack assembly configured to receive a stack of articles. A mounting assembly including at least one vortex suction unit is disposed so as to face the stack of articles at least one of a leading edge and a trailing edge thereof. The vortex suction unit includes a conveyor configured to transport an article from the stack. | 11-10-2011 |
Peter Xavier Kearney, Doernick DE
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20150061309 | DEVICE FOR LIFTING AND POSITIONING AN OBJECT - A device for lifting and positioning an object includes first means for generating a low pressure by a whirlwind for suctioning the object. The first means are arranged inside a housing having a suction opening. The housing has at least one friction element which at least partly covers the suction opening. | 03-05-2015 |
Peter Xavier Kearney, Fridingen DE
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20110056804 | SYSTEM FOR CONVEYING AN ARTICLE USING VORTEX SUCTION UNITS - A system for conveying an article along a transfer path includes at least a first and a second vortex suction unit disposed in sequence in a direction of the transfer path. A conveyor is configured to support the article relative to at least one of the suction units and a main controller is configured to separately control the vortex suction units so as to convey the article along the transfer path using the conveyor. | 03-10-2011 |
20120086163 | STACK FEEDING AERATION DEVICE AND METHOD - An aeration device adapted to aerate one or more sheets of a stack of sheets includes a side blower configured to selectively provide an air stream at an outlet thereof along an airstream direction so as to impinge against at least a portion of the stack. A height detecting device is configured to detect a height of an uppermost sheet of the stack. A side blower adjustment device is configured to adjust a height of the side blower and/or an angle of the airstream direction so as to track, by the air stream, the uppermost sheet of the stack based on an input from the height detecting device. | 04-12-2012 |
20140318929 | SYSTEM FOR CONVEYING AN ARTICLE USING VORTEX SUCTION UNITS - A system for conveying an article along a transfer path includes at least a first and a second vortex suction unit disposed in sequence in a direction of the transfer path. A conveyor is configured to support the article relative to at least one of the suction units and a main controller is configured to separately control the vortex suction units so as to convey the article along the transfer path using the conveyor. | 10-30-2014 |
Phil Kearney, Picton AU
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20120083596 | Pharmaceutical Composition - The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 17 nucleobases which are complementary to human microRNAs. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC. | 04-05-2012 |
Phil Kearney, Au-Picton AU
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20100004320 | Pharmaceutical Composition - The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 17 nucleobases which are complementary to human microRNAs. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC. | 01-07-2010 |
Phil Kearney, Picton Nsw AU
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20120238618 | Pharmaceutical Composition Comprising Anti-miRNA Antisense Oligonucleotides - The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from the group consisting of miR19b, miR21, miR122a, miR155 and miR375. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC. | 09-20-2012 |
20140329883 | Pharmaceutical Composition Comprising Anti-miRNA Antisense Oligonucleotides - The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from the group consisting of miR19b, miR21, miR122a, miR155 and miR375. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC. | 11-06-2014 |
20160060627 | Pharmaceutical Composition for Inhibition of Disease-inducing microRNAs - The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 17 nucleobases which are complementary to human microRNAs. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC. | 03-03-2016 |
Phil Kearney, New South Wales AU
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20100286234 | Pharmaceutical Composition Comprising Anti-Mirna Antisense Oligonucleotides - The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human microRNAs selected from the group consisting of miR19b, miR21, miR122a, miR155 and miR375. The short oligonucleotides are particularly effective at alleviating miRNA repression in vivo. It is found that the incorporation of high affinity nucleotide analogues into the oligonucleotides results in highly effective anti-microRNA molecules which appear to function via the formation of almost irreversible duplexes with the miRNA target, rather than RNA cleavage based mechanisms, such as mechanisms associated with RNaseH or RISC. | 11-11-2010 |
Robert Kearney, Montreal CA
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20090149334 | METHODS AND APPARATUS FOR DETECTING LIQUID INSIDE INDIVIDUAL CHANNELS IN A MULTI-CHANNEL PLATE - There is provided a method of measuring properties of a liquid contained in individual wells inside a multi-well array, the method comprising steps of providing capacitor electrodes in the multi-well array, the electrodes adapted to detect a capacitance value of each one of the individual wells without interference of neighboring wells, measuring a capacitance inside each one of the individual wells, and using the capacitance measurements to calculate at least one property of the liquid contained in each one of the individual wells. There is further provided an apparatus for measuring properties of a liquid contained in individual wells inside a multi-well array, and a method of controlling quality of liquid handling task that is repeated across a set of individual wells inside a multi-well array. | 06-11-2009 |
Sean Patrick Kearney, Dorset GB
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20150134818 | DATA SHARING METHOD AND DATA SHARING GATEWAY CONFIGURATION - It is disclosed herein a computer implemented method for sharing one or more application items in a data sharing gateway. The method includes storing one or more application items in the gateway in which each application item is independent of a user or user account and registering one or more users with the data sharing gateway such that each user can dynamically use each application item stored in the gateway. | 05-14-2015 |
Sinead Kearney, Castleisland IE
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20160121329 | MICROFLUIDIC DEVICE - Microfluidic devices and in particular microfluidic devices incorporating a cascading valve arrangement for selectively controlling the flow of a fluid within the microfluidic device are described. Specific examples of a microfluidic device comprising a sacrificial valve ( | 05-05-2016 |
Trevor Neil Kearney, Victoria AU
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20110164945 | BLIND RIVET AND A METHOD OF JOINING THEREWITH - The invention relates to blind rivets and to methods of joining therewith. The method of the invention is suitable for joining two or more workpieces with a blind rivet. The method includes the first step of positioning a blind rivet at a point of overlap of two or more workpieces, the blind rivet including a rivet body and a mandrel. The next step involves rotating the mandrel about a longitudinal axis thereof and contacting the mandrel with the overlapping workpieces, wherein the mandrel is rotated at a speed to cause plasticization of the overlapping workpieces. The method then involves causing the mandrel to penetrate through the plasticized overlapping workpieces and form an aperture therethrough. A further step of the method involves capturing a portion of the overlapping workpieces that is displaced upon the penetration of the mandrel and securing the rivet body within the aperture to join the overlapping workpieces. The invention also includes a workpiece penetrating and joining blind rivet. The blind rivet includes a rivet body including a shank having a first end, a second end and an axial passage extending through the shank between the first and second ends. Also included is a mandrel including a shaft positioned within the axial passage and a head at one end of the shaft for contacting a workpiece wherein the mandrel is configured so that when contacting the workpiece, being rotated about a longitudinal axis thereof at a speed to cause plasticization of the workpiece and being caused to penetrate through the plasticized workpiece the mandrel cores a portion of the plasticised workpiece, displaces the portion from the workpiece and forms an aperture in the workpiece. | 07-07-2011 |