Patent application number | Description | Published |
20130310419 | PYRROLE DERIVATIVES USED AS MODULATORS OF ALPHA7 NACHR - The present invention is related to pyrrole derivatives of formula I as the modulators of nicotinic acetylcholine receptors particularly the α7 subtype. The invention includes pyrrole derivatives, analogues, their prodrugs, their isotopes, their metabolites, pharmaceutically acceptable salts, polymorphs, solvates, optical isomers, clathrates, co-crystals, combinations with suitable medicament and pharmaceutical compositions thereof. The present invention also includes process of preparation of the said compounds and intended use in therapy of them. Owing to the modulatory activity of the pyrrole derivatives on the nicotinic acetylcholine receptors, the invention finds application in the prophylaxis and therapy of disorders encompassing the involvement of cholinergic transmission in the central and peripheral nervous system. The invention relates to the ability of pyrrole derivatives to modulate the cholinergic transmission and efficacy of the endogenous neurotransmitter ACh thorough the nicotinic acetylcholine receptors particularly the α7 subtype. | 11-21-2013 |
20130331387 | HETEROARYL DERIVATIVES AS ALPHA7 NACHR MODULATORS - Disclosed is a compound of formula (I), wherein Z, m and R | 12-12-2013 |
20140018327 | Pyrrole Derivatives as Nicotinic Acetylcholine Receptor Modulators for Use in the Treatment of Neurodegenerative Disorders Such as Alzheimer's and Parkinson's Disease - Disclosed is a compound of formula (I) wherein ‘a’ and R | 01-16-2014 |
20140155433 | BIARYL DERIVATIVES AS NACHR MODULATORS - Disclosed is a compound of formula (I): wherein ‘D’, ‘E’, ‘m’, ‘n’ and R | 06-05-2014 |
20150231143 | Heteroaryl Derivatives as Alpha7 NACHR Modulators - Disclosed is a compound of formula I: | 08-20-2015 |
20150291617 | Thiazole Derivatives as Alpha 7 nAChR Modulators - Disclosed is a compound of formula (I) wherein Y, Ring D, m and R | 10-15-2015 |
20150299178 | Thiazole Derivatives as Alpha 7 NACHR Modulators - Disclosed is a compound of formula (I), wherein R | 10-22-2015 |
20150344422 | Pyrrole Derivatives as Alpha 7 NACHR Modulators - Disclosed are compounds of the Formula (I), wherein R | 12-03-2015 |
20150361041 | Pyrrole Derivatives as Alpha 7 NACHR Modulators - Disclosed is a compound of formula (I), wherein R | 12-17-2015 |
20160107990 | 4-(5-(4-CHLOROPHENYL)-2-(2-CYCLOPROPYLACETYL)-1,4-DIMETHYL-1H-PYRROL-3-YL)- BENZENESULFONAMIDE AS ALPHA 7 NACHR MODULATOR - Disclosed are an alpha 7 nAChR receptor modulator compound, 4-(5-(4-chlorophenyl)-2-(2-cyclopropylacetyl)-1,4-dimethyl-1H-pyrrol-3-yljbenzenesulfonamide, its tautomeric form, its pharmaceutically acceptable salts, pharmaceutical compositions comprising the compound or a salt thereof, and a method of treating various diseases, disorders or conditions, for example, Alzheimer's disease, mild cognitive impairment, senile dementia, vascular dementia, dementia of Parkinson's disease, and attention deficit disorder. | 04-21-2016 |
20160137600 | Pyrrole Derivatives as Alpha 7 nAChR Modulators - Disclosed are compounds of the formula (I), wherein R | 05-19-2016 |
Patent application number | Description | Published |
20130225600 | OXAZOLINE AND ISOXAZOLINE DERIVATIVES AS CRAC MODULATORS - The present invention relates to compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I). | 08-29-2013 |
20150111900 | SUBSTITUTED PYRIDINE COMPOUNDS AS CRAC MODULATORS - The present invention relates to compounds described herein Formula (I) and pharmaceutical acceptable salts thereof, which modulate the activity of calcium release-activated calcium (CRAC) channel. The invention also describes the compounds of Formula (I) and pharmaceutical compositions containing such compounds thereof for treating, managing, and/or lessening the severity of diseases, disorders, syndromes or conditions associated with the modulation of calcium release-activated calcium (CRAC) channel. | 04-23-2015 |
20160022673 | OXAZOLE AND ISOXAZOLE CRAC MODULATORS - The present invention relates to compounds of Formula (I) along with processes for their preparation that are useful for treating, preventing and/or managing the diseases, disorders, syndromes or conditions associated with the modulation of CRAC. The invention further relates to methods of treating, preventing managing and/or lessening the diseases, disorders, syndromes or conditions associated with the modulation of CRAC of Formula (I). | 01-28-2016 |