Patent application number | Description | Published |
20080223787 | Membrane based volatile component-removal devices for liquid chromatography - In a liquid chromatographic system, removing at least part of a volatile component from the liquid sample stream after separation by flowing it through a volatile component-removal device including a porous wall having a surface coating of a permeable polymer less than 10 μm thick. A liquid chromatographic system suitable for performing the method. Also, a liquid chromatographic system in which volatile component is removed prior to separation across the same type of membrane or across a membrane made of a copolymer of perfluoro-2,2-dimethyl-1,3-dioxole. | 09-18-2008 |
20080245668 | Parking a Sample Stream and Suppressing the Sample - Pretreatment method and apparatus to remove matrix ions from a liquid sample, prior to separation of the sample analytes (e.g. by chromatography), by flowing the liquid sample into a sample compartment and stopping the flow. The sample compartment has a wall comprising an ion exchange membrane having exchangeable ions of the same charge as the matrix ions to be removed. A regenerant liquid stream flows through a regenerant flow compartment on the other side of the membrane from said parked liquid sample. Matrix ions in the parked liquid sample are transported across the membrane into the regenerant flow compartment. Suppression may be performed electrolytically and/or chemically. A concentrator column may also be used. | 10-09-2008 |
20080311672 | Membrane based concentrators - A sample concentrator for concentrating analytes in a solvent-containing liquid sample stream, including concentrator housing having a sample stream flow channel and a gas stream flow channel having an inlet and an outlet, a heater for gas in the gas stream conduit, and a hydrophilic ion exchange or non-ionic membrane barrier separating said gas stream flow channel and said sample stream flow channel. Solvent is evaporated from the liquid sample stream in said sample stream flow channel in or at the interface with said membrane, when the gas stream is at an elevated temperature. A regeneration step is used to regenerate the ion exchange membrane barrier. | 12-18-2008 |
20090127200 | Barrier with a seated ion exchange bead and method - Ion transport apparatus (e.g. an electrolytic eluent generator or a suppressor for ion chromatography) in which ions in a first chamber are transported to a liquid in second chamber through a wall comprising an ion exchange bead sealed in a bead seat. The wall is capable of transport ions but of substantially blocking bulk liquid flow. | 05-21-2009 |
20090145777 | Titration device and method - A titration apparatus comprising a titration reservoir for a non-flowing sample solution to be titrated; an ion source reservoir comprising an ion source solution of selected ions; an ion exchange membrane barrier capable of passing ions from the ion source solution to the titration reservoir, but of blocking bulk liquid flow; a first electrode in electrical communication with the ion source reservoir; and a second electrode in electrical communication with the titration reservoir. Also, an electrolytic titrant generator for use in the titration apparatus. | 06-11-2009 |
20090166293 | CHEMICAL SUPPRESSORS AND METHOD OF USE - A non-electrolytic method and apparatus for treating an aqueous sample stream including analyte ions and matrix ions of opposite charge, for pretreatment or suppression. The apparatus includes an ion exchange membrane capable of passing only ions of opposite charge to the analyte ions, a sample stream flow channel, a first aqueous stream ion receiving flow channel adjacent one side of the sample stream flow channel and separated therefrom by the first ion exchange membrane, and stationary flow-through ion exchange packing disposed in the sample stream flow channel. The ion receiving channel has an ion exchange capacity for the matrix ions less than about 25% of the ion exchange capacity for the matrix ions. | 07-02-2009 |
20090211979 | Ion chromatography system with eluent recycle - Ion chromatography apparatus including (a) a chromatographic column, (b) a source of an aqueous eluent liquid stream, (c) a detector, (d) a recycle line between the detector and the chromatographic column, and (e) a purifying device disposed along the recycle line including ion exchange removal medium. Also, such apparatus with an electrolytic purifying device disposed along the recycle line. Also, methods of using such apparatus. | 08-27-2009 |
20090211980 | ION CHROMATOGRAPHY SYSTEMS WITH FLOW-DELAY ELUENT RECYCLE - A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods. | 08-27-2009 |
20090218238 | ION DETECTOR AND SYSTEM - Apparatus and method for detecting current or potential generated in a liquid sample suitable for use in a chromatography or other liquid sample analytical system. One embodiment is an electrolytic ion transfer device with a signal detector in communication with the electrodes of the transfer device. Another is a combination ion transfer device/electrolyte generator. Another substitutes a detector for the ion transfer device in the combination. | 09-03-2009 |
20090221079 | SAMPLE PRETREATMENT AND EXTRACTION - A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface. | 09-03-2009 |
20090289009 | Ion chromatography systems with flow-delay eluent recycle - A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods. | 11-26-2009 |
20100139376 | IC SYSTEM INCLUDING SAMPLE PRETREATMENT AND USING A SINGLE PUMP - An IC system including sample preparation. The system includes a liquid sample injection loop, an ion concentrator, an ion separator, and only a single pump for pumping fluid through the system. | 06-10-2010 |
20110174737 | ION CHROMATOGRAPHY SYSTEMS WITH FLOW-DELAY ELUENT RECYCLE - A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods. | 07-21-2011 |
20110210055 | HIGH CAPACITY ION CHROMATOGRAPHY STATIONARY PHASES AND METHOD OF FORMING - The present invention provides a new design for high capacity stationary phases for chromatography, for example, ion chromatography. The stationary phases include a first polymer layer in contact with and at least partially coating the substrate of the stationary phase. The first polymer layer serves as a foundation for the attachment, and in various embodiments, the growth and attachment, of a highly hyperbranched polymer structure, typically based on one or more products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the hyperbranched polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucleophilic polyfunctional compound reacting with an electrophilic compound. | 09-01-2011 |
20120006103 | ION DETECTOR AND SYSTEM - Apparatus and method for detecting current or potential generated in a liquid sample suitable for use in a chromatography or other liquid sample analytical system. One embodiment is an electrolytic ion transfer device with a signal detector in communication with the electrodes of the transfer device. Another is a combination ion transfer device/electrolyte generator. Another substitutes a detector for the ion transfer device in the combination. | 01-12-2012 |
20120028368 | SAMPLE PRETREATMENT AND EXTRACTION - A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface. | 02-02-2012 |
20120141328 | CHEMICAL SUPPRESSORS AND METHOD OF USE - A non-electrolytic method and apparatus for treating an aqueous sample stream including analyte ions and matrix ions of opposite charge, for pretreatment or suppression. The apparatus includes an ion exchange membrane capable of passing only ions of opposite charge to the analyte ions, a sample stream flow channel, a first aqueous stream ion receiving flow channel adjacent one side of the sample stream flow channel and separated therefrom by the first ion exchange membrane, and stationary flow-through ion exchange packing disposed in the sample stream flow channel. The ion receiving channel has an ion exchange capacity for the matrix ions less than about 25% of the ion exchange capacity for the matrix ions. | 06-07-2012 |
20120231195 | ELECTROSTATICALLY BOUND HYPERBRANCHED ANION EXCHANGE SURFACE COATING PREPARED VIA CONDENSATION POLYMERIZATION USING DITERTIARY AMINE LINKERS FOR IMPROVED DIVALENT ANION SELECTIVITY - The present invention provides a new design for high capacity stationary phases for dianion selective ion chromatography. The stationary phases include one or more layers which are products of condensation polymerization. Multiple components are of use in forming the first polymer layer and the condensation polymer structure, thereby providing a stationary phase that can be engineered to have a desired property such as ion capacity, ion selectivity, and the like. Exemplary condensation polymers are formed by the reaction of at least one polyfunctional compound with at least one compound of complimentary reactivity, e.g., a nucleophilic polyfunctional compound reacting with an electrophilic compound. | 09-13-2012 |
20130048498 | THREE-ELECTRODE BUFFER GENERATOR AND METHOD - An electrodialytic buffer generator is described. The buffer generator may include a central buffer-generating channel having an inlet and outlet, a second chamber, and a third chamber. The buffer-generating channel, the second chamber, and the third chamber may each include an electrode. The buffer generator may also include a first ion exchange barrier and a second ion exchange barrier. The first ion exchange barrier can be disposed between the second chamber and the buffer-generating channel. The second ion exchange barrier can be disposed between the third chamber and the buffer-generating channel. | 02-28-2013 |
20130220814 | ELECTROLYTIC BUFFER GENERATOR - Buffer generators are described based on electrodialytic devices. The methods of using these devices can generate buffers for diverse applications, including separations, e.g., HPLC and ion chromatography. Also provided are chromatographic devices including the buffer generators, generally located upstream from a chromatography column, sample injector valve or both. | 08-29-2013 |
20130233093 | SORPTION OF WATER FROM A SAMPLE USING A POLYMERIC DRYING AGENT - A method of extracting an analyte from a sample is described where the sample includes water. The sample and polymeric drying agent are added to a container. The polymeric drying agent includes a cationic monomer, an anionic monomer, and a crosslinker. The polymeric drying agent is configured to sorb water from the sample. | 09-12-2013 |
20130256232 | ION CHROMATOGRAPHY SYSTEMS WITH FLOW-DELAY ELUENT RECYCLE - A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods. | 10-03-2013 |
20130259750 | ION CHROMATOGRAPHY SYSTEMS WITH FLOW-DELAY ELUENT RECYCLE - A chromatographic method including chromatographically separating sample ionic species in an eluent stream, detecting the separated sample ionic species, catalytically combining hydrogen and oxygen gases or catalytically decomposing hydrogen peroxide in a catalytic gas elimination chamber, and recycling the effluent stream from the chamber to the chromatography separation column. The residence time between the detector and the chamber is at least about one minute. Also, flowing the recycle sequentially through two detector effluent flow channels of an electrolytic membrane suppressor. Also, applying heat or UV energy between the detector and the chamber. Also, detecting bubbles after the chamber. Also, a Platinum group metal catalyst and ion exchange medium in the chamber. Apparatus for performing the methods. | 10-03-2013 |
20130316466 | SAMPLE PRETREATMENT AND EXTRACTION - A method for pretreating and extracting a liquid sample by sorbing an aqueous liquid sample, including an organic analyte and an acid or a base, in a solid sorbent material, and at least partially neutralizing the acid or base by reaction with neutralizing ions retained on a support surface, and contacting the liquid sample-sorbed sorbent material at elevated temperature and pressure with an organic solvent to extract the analyte into said solvent, preferably in a vessel having an extraction chamber with a zirconium metal interior surface. | 11-28-2013 |
20140063487 | METHOD AND DEVICE TO EXTRACT AN ANALYTE FROM A SAMPLE WITH GAS ASSISTANCE - A method of extracting an analyte from a sample is described. The sample is added to a sample container. A liquid solvent and a gas are added into the sample container. The addition of the gas is controlled to establish an elevated pressure within the sample container. The liquid solvent is heated to an elevated temperature that is below the boiling temperature of the liquid solvent at the elevated pressure. A type of gas is used that does not transition to a supercritical fluid at the elevated temperature and pressure used in the extraction process. The analyte can dissolve from the solid sample into the liquid solvent. Next, at least a portion of the liquid solvent containing the dissolved analyte can be removed from the sample container for subsequent analysis. | 03-06-2014 |
20140134050 | SUPPRESSOR DEVICE - An apparatus for detecting analytes in a liquid sample may include an elongated primary channel through which an ionic species flows, the primary channel extending through a primary channel member, a first regenerant channel through which a regenerant flows, the first regenerant channel extending adjacent to the primary channel and being formed in a first block, a first charged barrier having exchangeable ions capable of passing ions of only one charge, positive or negative, and of blocking bulk liquid flow, the first charged barrier disposed between the primary channel member and the first block for separating the primary channel from the first regenerant channel, and a first sealing member disposed between the first charged barrier and the first block defining the first regenerant channel. | 05-15-2014 |
20140332387 | CURRENT EFFICIENT ELECTROLYTIC DEVICE AND METHOD - A sandwich suppressor in an ion chromatography system in which loosely packed ion exchange resin of low density is disposed in the central sample stream flow channel. Also, a method of using the suppressor is described. | 11-13-2014 |
20150076005 | ELECTROLYTIC FOUR-CHANNEL DEVICE AND METHOD - An electrolytic device includes four channels separated by three charged barriers. The device can be used to suppress an eluent stream containing separated sample analyte ions and/or to pretreat a sample stream containing unseparated analyte ions. | 03-19-2015 |