Patent application number | Description | Published |
20080213175 | Click chemistry-derived cyclic peptidomimetics as integrin markers - The present application is directed to radiolabeled cyclic peptidomimetics, pharmaceutical compositions comprising radiolabeled cyclic peptidomimetics, and methods of using the radiolabeled cyclic peptidomimetics. Such peptidomimetics can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT). | 09-04-2008 |
20090016958 | Nucleoside based proliferation imaging markers - Disclosed herein are novel radiolabeled nucleosides and methods for detecting cellular proliferation in a mammal, the method comprising administrating an effective amount of a radiolabeled nucleoside; the method comprising: a) administering to the mammal a diagnostically effective amount of the nucleoside to the mammal; b) allowing the nucleoside to distribute into the effective tissue; and c) imaging the tissue, wherein an increase in binding of the compound to tissue compared to a normal control level of binding indicates that the mammal is suffering from a disease involving cellular proliferation. | 01-15-2009 |
20090074664 | CYCLIC AZAPEPTIDES AS INTEGRIN MARKERS - The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT). | 03-19-2009 |
20090123372 | DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY - The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents. | 05-14-2009 |
20100074843 | Novel Substrate Based PET Imaging Agents - The present application is directed to radiolabeled imaging agents comprising a radiolabel, and a substrate, pharmaceutical compositions comprising radiolabeled imaging agents, and methods of using the radiolabeled imaging agents. The present application is further directed to methods of preparing the radiolabeled imaging agent. Such imaging agents can used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT). | 03-25-2010 |
20100074910 | Achievement of a high therapeutic index through molecular imaging guided targeted drug treatment - The present disclosure provides methods for treating cancer in a patient in need of such treatment, the method includes prequalifying a patient's therapeutic treatment by performing a molecular imaging procedure to the patient using a labeled biomarker specific for a cancer target at the tumor site; and administering a therapeutic effective amount of a compound comprising a targeting agent linked to a chemotherapeutic or a targeting agent linked to an antibody. Embodiments of the present invention also include compounds and compositions for using such methods. | 03-25-2010 |
20110091382 | NOVEL IMAGING AGENTS FOR DETECTING NEUROLOGICAL DYSFUNCTION - Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease. | 04-21-2011 |
Patent application number | Description | Published |
20100074844 | Cyclopeptides Containing RGD Mimetics As Imaging Markers For Integrins - Radiolabeled cyclic polypeptides, pharmaceutical compositions comprising radiolabeled cyclic polypeptides, and methods of using the radiolabeled cyclic polypeptides. Such polypeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT). | 03-25-2010 |
20100098634 | Imaging Agents Useful for Identifying AD Pathology - Provided herein are compounds and compositions which comprise the formulae as disclosed herein, wherein the compound is an amyloid binding compound. An amyloid binding compound according to the invention may be administered to a patient in amounts suitable for in vivo imaging of amyloid deposits, and distinguish between neurological tissue with amyloid deposits and normal neurological tissue. Amyloid probes of the invention may be used to detect and quantitate amyloid deposits in diseases including, for example, Down's syndrome, familial Alzheimer's Disease. In another embodiment, the compounds may be used in the treatment or prophylaxis of neurodegenerative disorders. Also provided herein are methods of allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing a neurodegenerative disease. | 04-22-2010 |
20100317842 | Development of Molecular Imaging Probes for Carbonic Anhydrase-IX Using Click Chemistry - The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents. | 12-16-2010 |
20110046378 | Novel Imaging Agents for Detecting Neurological Dysfunction - Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease | 02-24-2011 |
Patent application number | Description | Published |
20090089616 | OFFLINE HARDWARE DIAGNOSTIC ENVIRONMENT - A computer configured to operate in diagnostic mode during which the operating system is suspended. During the diagnostic mode, tests can be performed on the computer system, including hardware, and the tests do not disrupt the operating system and are not disrupted by the operating system. When diagnostic mode is triggered, execution of the operating system is suspended. When the diagnostic tests are completed, the operating system may resume operation and test data may be made available within the operating system environment. Upon resuming, the state of the computer prior to entering diagnostic mode may be restored, preventing any changes made during diagnostic mode from interfering with operation of the operating system or application components. | 04-02-2009 |
20100229022 | COMMON TROUBLESHOOTING FRAMEWORK - Techniques for improving a troubleshooting experience by providing a common troubleshooting framework. Such a framework may enable use of common elements between troubleshooters and lead to similarities between troubleshooting packages, which may improve the user experience. Further, a framework may reduce the amount of knowledge and time necessary to create troubleshooting packages, and thus encourage increased development of these troubleshooting packages. In some implementations of the framework, a troubleshooting package may be implemented in a declarative manner that outlines/describes the problems it solves and the potential solutions to those problems. The declarative troubleshooting packages may then be provided to the troubleshooting framework and may provide direction to the framework, in that the framework may execute functions as directed by the troubleshooter. | 09-09-2010 |
Patent application number | Description | Published |
20110256057 | Cyclic Azapeptides as Integrin Markers and Methods of Using - The present application is directed to radiolabeled cyclic polyazapeptides, pharmaceutical compositions comprising radiolabeled cyclic polyazapeptides, and methods of using the radiolabeled cyclic polyazapeptides. Such polyazapeptides can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT). | 10-20-2011 |
20120302755 | Imaging Agents for Detecting Neurological Dysfunction - Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease. | 11-29-2012 |
20130237686 | Methods and Compositions for the Rapid Synthesis of Radiometal-Labeled Probes - The present application is directed to rapid and efficient synthesis of radiometal-labeled probes, pharmaceutical compositions comprising radiometal-labeled probes, and methods of using the radiometal-labeled probes. Such radiometal-labeled probes can be used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT), and therapy studies. | 09-12-2013 |
20130323172 | MOLECULAR PROBES FOR MULTIMODALITY IMAGING OF ANIONIC MEMBRANE SURFACES - Embodiments provide dual modality probes for imaging phosphatidylserine (PS) exposure and other anionic membrane surfaces. In various embodiments, the probes were constructed by utilizing a) the high selectivity of synthetic zinc (II) dipicolylamine coordination complexes (Zn-DPA) for targeting externalized PS which over-expresses in apoptotic and necrotic cells, b) a near-infrared (NIR) dye for optical imaging, and c) a widely used clinically approved radionuclide for PET (or SPECT) imaging. A variety of linking elements were incorporated into the probes between the Zn-DPA and radionuclide motif to modulate the pharmacokinetics. The in vitro and in vivo data of radiolabeled dipicolylamine probes demonstrated their utilities for imaging PS exposure with multiple imaging modalities. | 12-05-2013 |
20150030540 | Imaging agents for detecting neurological dysfunction - Disclosed here in are compounds and methods of diagnosing Alzheimer's Disease or a predisposition thereto in a mammal, the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabeled carbazoles and derivatives thereof and triazoles derivatives, allowing the compound to distribute into the brain tissue, and imaging the brain tissue, wherein an increase in binding of the compound to the brain tissue compared to a normal control level of binding indicates that the mammal is suffering from or is at risk of developing Alzheimer's Disease. | 01-29-2015 |
20150182643 | Novel Substrate Based PET Imaging Agents - The present application is directed to radiolabeled imaging agents comprising a radiolabel, and a substrate, pharmaceutical compositions comprising radiolabeled imaging agents, and methods of using the radiolabeled imaging agents. The present application is further directed to methods of preparing the radiolabeled imaging agent. Such imaging agents can used in imaging studies, such as Positron Emitting Tomography (PET) or Single Photon Emission Computed Tomography (SPECT). | 07-02-2015 |
Patent application number | Description | Published |
20120201243 | Method and Apparatus for Transmitting Packet Switch Domain Service Data - The present invention discloses a method and an apparatus for transmitting packet switch domain service data. The method comprises: establishing a correlation between multiple services and a predetermined transmission channel, wherein the predetermined transmission channel comprises multiple links and multiple channels between a Point-to-Point Protocol (PPP) client and a PPP server; and according to the correlation, transmitting the service data of the multiple services between a service application side and a protocol side via the predetermined transmission channel. The present invention achieves PDP multi-link and can process the transmission of PS domain data in parallel. | 08-09-2012 |
20120273932 | POWER SUPPLY MODULE AND PACKAGING AND INTEGRATING METHOD THEREOF - A power supply module and a packaging and integrating method thereof are provided. The power supply module includes a lead frame, a passive element, an integrated circuit (IC), and a power switch Metallic Oxide Semiconductor Field Effect Transistor (MOSFET). The passive element is soldered onto the lead frame by using the surface mount technology. The IC is a flip chip and is mounted and soldered onto the lead frame. | 11-01-2012 |
20140146811 | Method and Device for Implementing Automatic Compensation for Asymmetric Delay of 1588 Link - A method and device for implementing a compensation for an asymmetry delay of a 1588 link are provided. The method comprises: measuring and calculating a value of an asymmetry delay of the 1588 uplink/downlink; performing an asymmetry delay compensation when the value of the asymmetry delay exceeds a set synchronization offset range; and continuing a normal 1588 time synchronization if the value of the asymmetry delay does not exceed the set synchronization offset range; and implementing the automatic compensation for the asymmetry delay of the 1588 link. The above-mentioned scheme can correct the asymmetry delay automatically, and ensure the quality of 1588 time synchronization. | 05-29-2014 |
20140203432 | Method for Packaging Quad Flat Non-Leaded Package Body, and Package Body - A method for packaging a quad flat non-leaded (QFN) package body. The method includes: etching an upper surface of a metal plate to process a groove to form a bond wire bench, a component bench, and a bump; processing the bump to a preset height, and assembling a component on the component bench; packaging the processed metal plate to form a package body, and exposing the surface of the processed bump on an upper surface of the package body to form a top lead; and etching a lower surface of the package body to process a bottom lead. In the present invention, large passive components can be stacked on the QFN package body with a top lead; the structure is simplified while the reliability of the welding joints is improved; a plurality of components can be stacked through the top lead to overcome the limitations of component stacking. | 07-24-2014 |
Patent application number | Description | Published |
20120310735 | CONTENT REQUESTS FOR AN ENVIRONMENT - Advertisements are selected from a plurality of advertisements and associated with an advertisement environment in a document. Document advertisement request code that is configured to issue an advertisement request for one of the selected advertisements for presentation in the advertisement environment is stored in the document. | 12-06-2012 |
20140258005 | PUBLISHER PREFERENCE SYSTEM FOR CONTENT SELECTION - Advertisements are selected from a plurality of advertisements and associated with an advertisement environment in a document. Document advertisement request code that is configured to issue an advertisement request for one of the selected advertisements for presentation in the advertisement environment is stored in the document. | 09-11-2014 |
20140279773 | Scoring Concept Terms Using a Deep Network - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for scoring concept terms using a deep network. One of the methods includes receiving an input comprising a plurality of features of a resource, wherein each feature is a value of a respective attribute of the resource; processing each of the features using a respective embedding function to generate one or more numeric values; processing the numeric values to generate an alternative representation of the features of the resource, wherein processing the floating point values comprises applying one or more non-linear transformations to the floating point values; and processing the alternative representation of the input to generate a respective relevance score for each concept term in a pre-determined set of concept terms, wherein each of the respective relevance scores measures a predicted relevance of the corresponding concept term to the resource. | 09-18-2014 |
20140279774 | Classifying Resources Using a Deep Network - Methods, systems, and apparatus, including computer programs encoded on computer storage media, for scoring concept terms using a deep network. One of the methods includes receiving an input comprising a plurality of features of a resource, wherein each feature is a value of a respective attribute of the resource; processing each of the features using a respective embedding function to generate one or more numeric values; processing the numeric values using one or more neural network layers to generate an alternative representation of the features, wherein processing the floating point values comprises applying one or more non-linear transformations to the floating point values; and processing the alternative representation of the input using a classifier to generate a respective category score for each category in a pre-determined set of categories, wherein each of the respective category scores measure a predicted likelihood that the resource belongs to the corresponding category. | 09-18-2014 |
Patent application number | Description | Published |
20140118003 | Fault diagnosis and preliminary location system and method for transformer core looseness - This invention publishes a fault diagnosis and location system for transformer core looseness, consists of vibration sensors, data collection and computer. It is of power transformer fault intelligent diagnosis technology technical field. Fault diagnosis and location method uses three vibration sensors positioned on the top of transformer tank, to obtain vibration signal, uses signal processing to analyze the signal, and obtains fault characteristics of the transformer core looseness. The characteristics respectively are 50 Hz, 150 Hz and 300 Hz frequency components, in which 300 Hz is main feature. When they reach a certain value at one position, it suggests that transformer core looseness near this position. By the comparison of differences among signals of three positions, fault location can be done. This invention manifests fault characteristics accurately and detects core looseness efficiently. | 05-01-2014 |
20150311710 | A time based global optimization dispatching method - The invention discloses a global optimization and dispatching method based on time scales. The time scale based global optimization and dispatching method disclosed herein, relies on a target value system and a dispatch model. The global optimization and dispatching method depends on the results from a variety of subtopics. The methods provide adjustment and optimization in accordance with the time scales that are given in the sub goal of each sub topic: long-term, mid-long-term, short-term, ultra short term and real time optimization. Smart distribution grid can improve operational efficiency, integrated application of new elements in the distribution network of distribution energy network, micro grid, energy storage device and non-linear loads. This invention is fully adapted to the smart grid trends, with a good prospective. | 10-29-2015 |
Patent application number | Description | Published |
20150085061 | IMMERSIVE AND INTERACTIVE VIDEOCONFERENCE ROOM ENVIRONMENT - An arrangement for a collaborative videoconferencing environment is disclosed. A display having a substantially “L-shaped” configuration allows for display of collaborative materials and video of remote participants simultaneously, which provides for a more natural interaction for a meeting participant interacting with the collaborative materials. Additionally, a camera is arranged to focus on the meeting participants shoulder while the meeting participant is interacting with the collaborative materials. Such location of the camera provides a more natural view of the collaborator to remote users. | 03-26-2015 |
20150085065 | MULTI-SITE SCREEN INTERACTIONS - A technology for interacting with a collaborative videoconferencing environment is disclosed. A display having a substantially “L-shaped” configuration allows for display of collaborative materials and video of remote participants simultaneously, which provides for a more natural interaction for a meeting participant interacting with the collaborative materials. Meeting participants in the collaborative videoconferencing environment, both locally and remote, can simultaneously interact with the same content as if they were in the same location. | 03-26-2015 |
20150089394 | MEETING INTERACTIONS VIA A PERSONAL COMPUTING DEVICE - A technology for interacting with a collaborative videoconferencing environment is disclosed. A display having a substantially “L-shaped” configuration allows for display of collaborative materials and video of remote participants simultaneously, which provides for a more natural interaction for a meeting participant interacting with the collaborative materials. Meeting participants can electronically retrieve or send materials to the collaborative meeting via interactions with their personal computing devices. | 03-26-2015 |
20150178634 | METHOD AND APPARATUS FOR HANDLING BUGS - Embodiments of the present disclosure relate to a method and apparatus for handling bugs of a target product by building a bug prediction model for the target product at least in part based on a field to which the target product is applied, the bug prediction model indicating a threshold associated with at least one performance parameter of the target product; and automatically predicting a potential bug associated with the target product based on the bug prediction model for the target product. Other embodiments are also disclosed. | 06-25-2015 |
20160041892 | SYSTEM FOR DISCOVERING BUGS USING INTERVAL ALGEBRA QUERY LANGUAGE - A system for discovering bugs comprises an input interface and a processor. The input interface is configured to receive a bug definition. The bug definition includes a set operator with a time constraint and one or more set operands. The input interface is configured to receive an event log. The processor is configured to determine a list of bug occurrences using the bug definition and the event log. | 02-11-2016 |
Patent application number | Description | Published |
20150086515 | IMAGING-AIDED GENE THERAPY USING MESENCHYMAL STEM CELLS AS TARGET-DELIVERY VEHICLE - Compositions and methods of use thereof encompass engineered mesenchymal stem cells as a vehicle to deliver secreted tissue necrosis factor-RGD4C fusion polypeptides for tumor treatment, thereby reducing side effects of TNF. A reporter gene can be included in vector constructs to monitor the localization and viability of engineered MSCs after administration into a recipient animal. The genetically modified mesenchymal stem cell can comprise an expression cassette comprising a nucleic acid sequence operably linked to a gene expression promoter and encoding the heterologous fusion polypeptide comprising a tissue necrotic factor region and an integrin-binding region. Another aspect of the disclosure encompasses embodiments of a method of modulating the proliferation of a targeted population of tumor cells by delivering a population of the genetically modified mesenchymal stem cells to tumor cells, allowing the mesenchymal stem cells to express the heterologous polypeptide, thereby reducing the proliferative capacity of the tumor cells. | 03-26-2015 |
20160136889 | METHODS OF PRODUCING THREE-DIMENSIONAL OBJECTS FROM MATERIALS HAVING MULTIPLE MECHANISMS OF HARDENING - A method of forming a three-dimensional object is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid including a mixture of (i) a light polymerizable liquid first component, and (ii) a second solidifiable component that is different from the first component; (c) irradiating the build region with light through the optically transparent member to form a solid polymer scaffold from the first component and also advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, and containing the second solidifiable component carried in the scaffold in unsolidified and/or uncured form; and (d) concurrently with or subsequent to the irradiating step, solidifying and/or curing the second solidifiable component in the three-dimensional intermediate to form the three-dimensional object. | 05-19-2016 |
20160137838 | METHODS OF PRODUCING POLYURETHANE THREE-DIMENSIONAL OBJECTS FROM MATERIALS HAVING MULTIPLE MECHANISMS OF HARDENING - A method of forming a three-dimensional object of polyurethane, polyurea, or copolymer thereof is carried out by: (a) providing a carrier and an optically transparent member having a build surface, the carrier and the build surface defining a build region therebetween; (b) filling the build region with a polymerizable liquid, the polymerizable liquid including at least one of: (i) a blocked or reactive blocked prepolymer, (ii) a blocked or reactive blocked diisocyanate, or (iii) a blocked or reactive blocked diisocyanate chain extender; (c) irradiating the build region with light through the optically transparent member to form a solid blocked polymer scaffold and advancing the carrier away from the build surface to form a three-dimensional intermediate having the same shape as, or a shape to be imparted to, the three-dimensional object, with the intermediate containing the chain extender; and then (d) heating or microwave irradiating the three-dimensional intermediate sufficiently to form from the three-dimensional intermediate the three-dimensional object of polyurethane, polyurea, or copolymer thereof. | 05-19-2016 |
20160137839 | POLYURETHANE RESINS HAVING MULTIPLE MECHANISMS OF HARDENING FOR USE IN PRODUCING THREE-DIMENSIONAL OBJECTS - A polymerizable liquid, or resin, useful for the production by additive manufacturing of a three-dimensional object of polyurethane, polyurea, or a copolymer thereof, is described. The resin includes at least one of (i) a blocked or reactive blocked prepolymer, (ii) a blocked or reactive blocked diisocyanate, or (iii) a blocked or reactive blocked diisocyanate chain extender. | 05-19-2016 |