Patent application number | Description | Published |
20100185397 | METHOD FOR IDENTIFYING NUCLEOTIDE SEQUENCE, METHOD FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, APPARATUS FOR IDENTIFYING NUCLEOTIDE SEQUENCE, APPARATUS FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE, PROGRAM FOR IDENTIFYING NUCLEOTIDE SEQUENCE, AND PROGRAM FOR ACQUIRING SECONDARY STRUCTURE OF NUCLEIC ACID MOLECULE - It is intended to provide a method for identifying a nucleotide sequence necessary for expressing an affinity for a target substance in nucleotide sequences of nucleic acid molecules such as aptamers having the affinity for the target substance based on a homology of the respective nucleotide sequences and an evaluation value related to the affinity of the nucleotide sequences, and a method for predicting a secondary structure of a nucleic acid molecule containing the identified nucleotide sequence. The method for identifying a nucleotide sequence necessary for expressing an affinity for a target substance in nucleotide sequences of nucleic acid molecules having such an affinity is characterized by comprising the steps of: extracting a single-strand region from the nucleotide sequences of nucleic acid molecules by excluding nucleotides capable of forming a stem structure; and searching a motif sequence based on an evaluation value of the affinity from the single-strand region. | 07-22-2010 |
20100216650 | METHOD OF PREDICTING NUCLEIC ACID HIGHER-ORDER STRUCTURE, APPARATUS FOR PREDICTING NUCLEIC ACID HIGHER-ORDER STRUCTURE, AND PROGRAM FOR PREDICTING NUCLEIC ACID HIGHER-ORDER STRUCTURE - The object of the present invention is to provide a method of predicting a higher-order structure of a nucleic acid sequence typified by a G quartet structure, and an apparatus and a program that execute the method. The method according to the present invention relates to a method of predicting a nucleic acid higher-order structure that predicts a higher-order structure of a nucleic acid sequence, the method, including the steps of: extracting bases capable of forming a higher-order structure as a higher-order structure candidate from said nucleic acid sequence; extracting bases capable of forming a stem structure as a stem structure candidate from said nucleic acid sequence; and searching an optimal combinatorial structure based on the higher-order structure candidate and the stem structure candidate. | 08-26-2010 |
20110125681 | FEATURE EXTRACTION METHOD, FEATURE EXTRACTION APPARATUS, AND FEATURE EXTRACTION PROGRAM - Provided are a feature extraction method of creating a feature vector for objectively evaluating the sequence of aptamer on the basis of the biological features and a feature extraction apparatus and a feature extraction program for performing the method. The feature extraction method according to the present invention includes a step of predicting a secondary structure of a base sequence applied and a step of creating a feature vector based on a predicted secondary structure of the sequence. | 05-26-2011 |
20120003749 | NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO 2,4,6-TRINITROPHENYL SKELETON, METHOD FOR DETECTING COMPOUND HAVING 2,4,6-TRINITROPHENYL SKELETON USING THE NUCLEIC ACID MOLECULE, AND USE OF THE NUCLEIC ACID MOLECULE - The present invention relates to a nucleic acid molecule capable of binding to a 2,4,6-trinitrophenyl skeleton, a method for detecting a compound having the 2,4,6-trinitrophenyl skeleton using the nucleic acid molecule, use of the nucleic acid molecule for detecting a compound having the 2,4,6-trinitrophenyl skeleton, and a method for detecting a compound having the 2,4,6-trinitrophenyl skeleton. | 01-05-2012 |
20120129720 | APTAMER THAT RECOGNIZES PEPTIDE - An aptamer capable of binding to a histidine peptide is provided. A nucleic acid used as the aptamer capable of binding to a histidine peptide is any of the following nucleic acids (a) to (d): (a) a nucleic acid having a base sequence represented by SEQ ID NO: 17: GGUN | 05-24-2012 |
20120202195 | NUCLEIC ACID ELEMENT FOR USE IN ANALYSIS, AND ANALYTICAL METHOD, ANALYTICAL REAGENT, AND ANALYTICAL INSTRUMENT USING SAME - The technique by which simple analysis of an intended subject to be analyzed can be carried out is provided. In this technique, a nucleic acid element | 08-09-2012 |
20120208867 | HMGB1 BINDING NUCLEIC ACID MOLECULE AND APPLICATIONS THEREOF - A nucleic acid molecule that can bind to HMGB1 protein and applications thereof are provided. A nucleic acid molecule having a dissociation constant for HMGB1 protein of 5×10 | 08-16-2012 |
20130102480 | PREDICTION DEVICE, PREDICTION METHOD, PROGRAM, AND RECORDING MEDIUM - The present invention provides a prediction device, a prediction method, a program, and a recording medium, with which whether or not desired aptamer sequences are enriched can be predicted easily. The prediction device of the present invention | 04-25-2013 |
20130123350 | NUCLEIC ACID MOLECULE CAPABLE OF BINDING TO c-MET AND USE THEREOF - The present invention provides a nucleic acid molecule capable of binding to c-Met as a substance that can be used for clarification of the pathogenic mechanism of diseases caused by c-Met, diagnosis and treatment of the diseases, and the like, and also the use thereof. The c-Met binding nucleic acid molecule of the present invention is any one of the following nucleic acid molecules (A1), (A2), (B1), and (B2). | 05-16-2013 |
20130273530 | ANALYTICAL DEVICE AND ANALYTICAL METHOD - The present invention provides a technique capable of simply analyzing a target to be analyzed. An analytical device of the present invention includes a basal plate; a nucleic acid element; and a detection section of detecting a signal. The nucleic acid element and the detection section are arranged on the basal plate. The nucleic acid element includes a first nucleic acid molecule and a second nucleic acid molecule. The first nucleic acid molecule is a nucleic acid molecule capable of binding to a target. The second nucleic acid molecule is a nucleic acid molecule capable of binding to streptavidin. When the target does not bind to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is inactivated. When the target binds to the first nucleic acid molecule, a binding capacity of the second nucleic acid molecule to the streptavidin is activated. The detection section detects binding between the second nucleic acid molecule and the streptavidin. The target is bound to the first nucleic acid molecule, so that the streptavidin is bound to the second nucleic acid molecule. Thus, the target can be analyzed through detecting the binding between the second nucleic acid molecule and the streptavidin using the detection device. | 10-17-2013 |