Patent application number | Description | Published |
20130150259 | BIOMARKERS FOR THE EARLY DETECTION OF BREAST CANCER - The present invention provides reagents and methods for breast cancer detection. | 06-13-2013 |
20140141991 | HIGH THROUGHPUT DETECTION OF FUSION PROTEINS - A method and related microfluidic chip and kit for high throughput detection of proteins of interest contained in a sample is disclosed. The method comprises of specifically labeling fusion proteins in a complex sample with fusion tag specific fluorophores that specifically bind the fusion tags coupled to the proteins of interest, and subjecting the sample to automated capillary electrophoresis, wherein the presence of the proteins of interest in the sample is detected by fluorescence signals associated with the fusion tag specific fluorophores. | 05-22-2014 |
20140162902 | Cell-Based Materials and Methods for Defining Pharmacogenetic Differences in Drug Metabolism - Cell lines harboring a range of polymorphisms using recombinant cytochrome P450 or other chemical-metabolizing enzymes in a parent cell line that is minimally expressing or devoid of its own cytochrome P450 protein or other chemical-metabolizing enzymes of interest can be placed into an array format to enable high throughput screening of one or more chemicals for CYP450 or other enzyme-dependent metabolism (FIG. | 06-12-2014 |
20140357527 | METHOD AND APPARATUS FOR MEASURING PHOSPHORYLATION KINETICS ON LARGE ARRAYS - The disclosure provides for methods and apparatuses relating to technology for monitoring chemical and/or biological reactions. Some methods provided herein relate to utilization of NAPPA technology to create large protein arrays suitable for use in combination with various ISFET arrays to enable massive parallel assays of kinase activity and inhibition. Some devices provided herein relate to CMOS chips which utilize the NAPPA array technology to build protein inventories of interest upon an ISFET architecture. Further devices provided herein are capable, inter alia, of processing the arrays created by the combination of NAPPA technology and ISFET architecture. | 12-04-2014 |
20140371091 | Programmable Arrays - Biomolecule arrays on a substrate are described which contain a plurality of biomolecules, such as coding nucleic acids and/or isolated polypeptides, at a plurality of discrete, isolated, locations. The arrays can be used, for example, in high throughput genomics and proteomics for specific uses including, but not limited molecular diagnostics for early detection, diagnosis, treatment, prognosis, monitoring clinical response, and protein crystallography. | 12-18-2014 |
20150152484 | MICROBIOME MARKERS AND THERAPIES FOR AUTISM SPECTRUM DISORDERS - The present disclosure provides for characterization of normal flora and identifying biomarkers in the gut of healthy, neruotypical subjects. Aspect of the disclosure provide for the characterization of the gut microbiome in ADS subjects, characterized by reduced richness and significant loss of the ‘ | 06-04-2015 |
20150362497 | Autoantibody Signature for the Early Detection of Ovarian Cancer - Methods for identifying antigens as potential biomarkers for the early detection of ovarian cancer, as well as kits for utilizing said antigens as biomarkers and in personalized medicine/therapeutics assessment. Protein microarrays displaying full-length candidate antigens were developed and sequentially screening to select candidate autoantibody biomarkers to limit the false discovery rate inherent to large-scale proteomic screening. | 12-17-2015 |
20160041159 | BIOSENSOR MICROARRAY COMPOSITIONS AND METHODS - Described herein are biosensor microarrays comprising detector polypeptide monolayers substantially free of contaminants. Also provided are methods for generation of such biosensor microarrays by capture of polypeptides by arrays comprising capture moieties and associated sensors. | 02-11-2016 |