Patent application number | Description | Published |
20130315517 | ABRASION RESISTANCE IN WELL FLUID WETTED ASSEMBLIES - Enhanced abrasion resistance in well fluid wetted assemblies is described. The bearing set of the invention provides an enhanced abrasion resistance that is better capable of withstanding friction from solids in electric submersible pump (ESP) well production applications. The flutes, grooves, sectors and intersections of the invention provide improved fluid and solid flow through assembly components, which improves cooling while the assembly is in operation and reduces body wear, thereby increasing the lifespan of the ESP system. | 11-28-2013 |
20140050570 | APPARATUS, SYSTEM AND METHOD FOR PUMPING GASEOUS FLUID - An apparatus, system and method for pumping gaseous fluid are described. The gas separator of the invention homogenizes at least a portion of produced well fluid and vents unhomogenized gas thereby improving the efficiency and decreasing the downtime of the assembly. A system for pumping gaseous fluid from an underground well comprises a gas separator, the gas separator comprising an impeller configured to homogenize at least a portion of a gas and a liquid in a pumped fluid to obtain homogenized fluid, the impeller comprising a top side open to the diffuser and a truncated vane located at a mid-pitch location between at least two untruncated vanes starting from a bottom side of the impeller, and a gas separation chamber downstream of the impeller, the gas separation chamber configured to vent an unhomogenized gas, and a centrifugal pump arranged to receive the homogenized fluid from the gas separation chamber. | 02-20-2014 |
20140140811 | ABRASION RESISTANCE IN WELL FLUID WETTED ASSEMBLIES - Enhanced abrasion resistance in well fluid wetted assemblies is described. The bearing set of the invention provides an enhanced abrasion resistance that is better capable of withstanding friction from solids in electric submersible pump (ESP) well production applications. The flutes, grooves, sectors and intersections of the invention provide improved fluid and solid flow through assembly components, which improves cooling while the assembly is in operation and reduces body wear, thereby increasing the lifespan of the ESP system. | 05-22-2014 |
Patent application number | Description | Published |
20110217267 | GENE THERAPY VECTORS AND CYTOSINE DEAMINASES - This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. | 09-08-2011 |
20110268720 | FORMULATIONS OF 5-FLUOROCYTOSINE AND USES THEREOF - The disclosure provides an extended release formulation of 5-fluorocytosine. In another aspect, a method of treating a fungal disease is provided. The method comprises administering to a subject in need thereof a fungus-treating effective amount of a composition comprising 5-fluorocytosine. In yet another aspect, a method of treating a cancer is provided. The method comprises administering to a subject in need thereof a sufficient amount of an expression vector to induce expression of cytosine deaminase which is capable of converting 5-fluorocytosine to 5-fluorourcail in cells of the cancer and a cancer-treating effective amount of a composition comprising 5-fluorocytosine. | 11-03-2011 |
20110287020 | RECOMBINANT VECTORS - This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. | 11-24-2011 |
20120087894 | PRODUCER CELLS FOR REPLICATION COMPETENT RETROVIRAL VECTORS - The disclosure provide cell lines and methods for the production of vectors and viral particles useful in gene therapy. | 04-12-2012 |
20130130986 | CANCER TREATMENT WITH RECOMBINANT VECTOR - This disclosure provides modified cytosine deaminases(CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. It further provides use of such modified CDs with a thymosin-alpha-1 polypeptide in the treatment of disease and disorders. | 05-23-2013 |
20130266931 | RETROVIRUS DETECTION - Provided are methods and compositions useful for detecting viral infection or contamination in a biological sample. | 10-10-2013 |
20130323301 | ENHANCED CANCER TREATMENT AND MONITORING USING RECOMBINANT VECTORS - This disclosure relates to replication competent viral vectors for treating cell proliferative disorders. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics. | 12-05-2013 |
20140178340 | CANCER COMBINATION THERAPY AND RECOMBINANT VECTORS - This disclosure relates to a combination therapy of chemotherapeutics and/or radiosensitizing agents with a replication competent viral vectors for treating cell proliferative disorders and chemotherapeutic treatments. The disclosure further relates to the use of such replication competent viral vectors for delivery and expression of a heterologous nucleic acid in normal and diseased tissues and methods and compositions that facilitate such delivery and expression to tissues in vivo and in vitro. The disclosure further relates to replication competent retroviral vectors for these uses and in conjunction with methods and compositions that facilitate in vivo therapeutics. | 06-26-2014 |
20140178854 | ANTISERA ASSAYS FOR MLV RELATED VIRUSES IN HUMANS AND OTHER MAMMALS - The disclosure provide cell lines and methods for the production of vectors and viral particles useful in diagnostics and therapeutics. | 06-26-2014 |
20140242033 | GENE THERAPY VECTORS AND CYTOSINE DEAMINASES - This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. | 08-28-2014 |
20150273029 | RETROVIRAL VECTOR WITH MINI-PROMOTER CASSETTE - This disclosure provides a retroviral replicating vector for gene delivery comprising a therapeutic cassette containing at least one mini-promoter linked to a gene to be expressed. | 10-01-2015 |
20160053232 | RECOMBINANT VECTORS - This disclosure provides modified cytosine deaminases (CDs). The disclosure further relates to cells and vector expressing or comprising such modified CDs and methods of using such modified CDs in the treatment of disease and disorders. | 02-25-2016 |
Patent application number | Description | Published |
20090105811 | Intravascular Devices for Cell-Based Therapies - Disclosed herein are vascular cell encapsulation devices that can deliver cell type(s) for the treatment of a disease or disorder. | 04-23-2009 |
20100196439 | Angiogenesis Mechanism and Method, and Implantable Device - Various methods and devices are provided for providing therapy to a living body. In one embodiment, an implanted permeable container has living cells provided therein, and various nutrients and/or agents are provided into the container to promote cell life. | 08-05-2010 |
20120277748 | BONE PLATE - A plate for connecting a first portion of bone and a second portion of bone is disclosed. The plate comprises a central longitudinal axis, a first end portion extending along the central longitudinal axis and configured to affix to the first portion of bone, a second end portion extending along the central longitudinal axis and configured to affix to the second portion of bone, and an intermediary portion extending along the central longitudinal axis and between the first end portion and the second end portion. The intermediary portion comprises three continuous segments of material, two segments of which extend along a direction substantially parallel to the central longitudinal axis, and one segment of which extends along a direction substantially perpendicular to the central longitudinal axis. | 11-01-2012 |
20130261715 | MEDICAL LEADS - Medical leads, such as medical electrical leads and medical neurological leads, that include a polymeric material that includes a silicone-urethane-containing polymer having improved hydrolytic stability. | 10-03-2013 |
Patent application number | Description | Published |
20100185704 | CLIENT-BASED CACHING OF REMOTE FILES - A lease system is described herein that allows clients to request a lease to a remote file, wherein the lease permits access to the file across multiple applications using multiple handles without extra round trips to a server. When multiple applications on the same client (or multiple components of the same application) request access to the same file, the client specifies the same lease identifier to the server for each open request or may handle the request from the cache based on the existing lease. Because the server identifies the client's cache at the client level rather than the individual file request level, the client receives fewer break notifications and is able to cache remote files in more circumstances. Thus, by providing the ability to cache data in more circumstances common with modern applications, the lease system reduces bandwidth, improves server scalability, and provides faster access to data. | 07-22-2010 |
20110314070 | OPTIMIZATION OF STORAGE AND TRANSMISSION OF DATA - The present invention extends to methods, systems, and computer program products for end-to-end optimization of data storage and transmission of data. Details of how data is stored within a data store are exposed to clients and applications. Clients and applications are enabled to makes requests to data stores to obtain data as it is actually stored upon within the data store to eliminate redundant processing of the requested data. Compression and de-duplication of data within a data store are leveraged to increase the efficiency and reduce latency of data transmitted over a LAN or WAN. | 12-22-2011 |
20120143999 | CLIENT-BASED CACHING OF REMOTE FILES - A lease system is described herein that allows clients to request a lease to a remote file, wherein the lease permits access to the file across multiple applications using multiple handles without extra round trips to a server. When multiple applications on the same client (or multiple components of the same application) request access to the same file, the client specifies the same lease identifier to the server for each open request or may handle the request from the cache based on the existing lease. Because the server identifies the client's cache at the client level rather than the individual file request level, the client receives fewer break notifications and is able to cache remote files in more circumstances. Thus, by providing the ability to cache data in more circumstances common with modern applications, the lease system reduces bandwidth, improves server scalability, and provides faster access to data. | 06-07-2012 |
20120254396 | PROVIDING A WITNESS SERVICE - Described are embodiments directed at providing a witness service that sends notifications with a resource state to clients. Embodiments provide a protocol that includes various messages for registering and receiving notifications regarding the state of a resource. The protocol may include a message for requesting node information from a first node in a cluster. The node information identifies nodes in the cluster that provide a witness service, which monitors a resource. The protocol includes a message that is used to register with the witness service for notifications regarding a state, or state change, of a network or cluster resource. The protocol also includes messages for sending notifications with state information of the resource. | 10-04-2012 |
20130066941 | CLUSTERED CLIENT FAILOVER - An application instance identifier is employed with various systems and methods in order to provide a requestor with continuous access to a resource when operating in a client clustered environment. A requestor residing on a first client in may attempt to access a resource. The first client sends a request to access the resource. The request may be associated with an application instance identifier that identifiers the requestor. At some point, the first client fails and the requestor is associated with a second client via a failover mechanism. The second client sends a second request to access the resource on behalf of the requestor. The second request is associated with the requestor's application instance identifier. The application instance identifier is used to identify the second request as belonging to the same requestor as the first request, thereby granting the second request to access the resource while avoiding a conflict situation. | 03-14-2013 |
20130067095 | SMB2 SCALEOUT - Systems and methods are disclosed for clients and servers operating in a scaled cluster environment. Efficiencies are introduced to the process of connecting a client to a clustered environment by providing the client with the ability to attempt a connection with multiple servers in parallel. Servers operating the in the clustered environment are also capable of providing persistent storage of file handles and other state information. Ownership of the state information and persistent handles may be transferred between servers, thereby providing clients with the opportunity to move from one server to another while maintaining access to resources in the clustered environment. | 03-14-2013 |
20130254272 | CLIENT-BASED CACHING OF REMOTE FILES - A lease system is described herein that allows clients to request a lease to a remote file, wherein the lease permits access to the file across multiple applications using multiple handles without extra round trips to a server. When multiple applications on the same client (or multiple components of the same application) request access to the same file, the client specifies the same lease identifier to the server for each open request or may handle the request from the cache based on the existing lease. Because the server identifies the client's cache at the client level rather than the individual file request level, the client receives fewer break notifications and is able to cache remote files in more circumstances. Thus, by providing the ability to cache data in more circumstances common with modern applications, the lease system reduces bandwidth, improves server scalability, and provides faster access to data. | 09-26-2013 |
20130254492 | ACCESS REQUESTS WITH CACHE INTENTIONS - A lease system is described herein that allows clients to request a lease to a remote file, wherein the lease permits access to the file across multiple applications using multiple handles without extra round trips to a server. When multiple applications on the same client (or multiple components of the same application) request access to the same file, the client specifies the same lease identifier to the server for each open request or may handle the request from the cache based on the existing lease. Because the server identifies the client's cache at the client level rather than the individual file request level, the client receives fewer break notifications and is able to cache remote files in more circumstances. Thus, by providing the ability to cache data in more circumstances common with modern applications, the lease system reduces bandwidth, improves server scalability, and provides faster access to data. | 09-26-2013 |
20130304821 | PROVIDING A WITNESS SERVICE - Described are embodiments directed at providing a witness service that sends notifications with a resource state to clients. Embodiments provide a protocol that includes various messages for registering and receiving notifications regarding the state of a resource. The protocol may include a message for requesting node information from a first node in a cluster. The node information identifies nodes in the cluster that provide a witness service, which monitors a resource. The protocol includes a message that is used to register with the witness service for notifications regarding a state, or state change, of a network or cluster resource. The protocol also includes messages for sending notifications with state information of the resource. | 11-14-2013 |
20140244688 | ACCESS REQUESTS WITH CACHE INTENTIONS - A lease system is described herein that allows clients to request a lease to a remote file, wherein the lease permits access to the file across multiple applications using multiple handles without extra round trips to a server. When multiple applications on the same client (or multiple components of the same application) request access to the same file, the client specifies the same lease identifier to the server for each open request or may handle the request from the cache based on the existing lease. Because the server identifies the client's cache at the client level rather than the individual file request level, the client receives fewer break notifications and is able to cache remote files in more circumstances. Thus, by providing the ability to cache data in more circumstances common with modern applications, the lease system reduces bandwidth, improves server scalability, and provides faster access to data. | 08-28-2014 |
20150106516 | PROVIDING A WITNESS SERVICE - Described are embodiments directed at providing a witness service that sends notifications with a resource state to clients. Embodiments provide a protocol that includes various messages for registering and receiving notifications regarding the state of a resource. The protocol may include a message for requesting node information from a first node in a cluster. The node information identifies nodes in the cluster that provide a witness service, which monitors a resource. The protocol includes a message that is used to register with the witness service for notifications regarding a state, or state change, of a network or cluster resource. The protocol also includes messages for sending notifications with state information of the resource. | 04-16-2015 |
20150256640 | ACCESS REQUESTS WITH CACHE INTENTIONS - A lease system is described herein that allows clients to request a lease to a remote file, wherein the lease permits access to the file across multiple applications using multiple handles without extra round trips to a server. When multiple applications on the same client (or multiple components of the same application) request access to the same file, the client specifies the same lease identifier to the server for each open request or may handle the request from the cache based on the existing lease. Because the server identifies the client's cache at the client level rather than the individual file request level, the client receives fewer break notifications and is able to cache remote files in more circumstances. Thus, by providing the ability to cache data in more circumstances common with modern applications, the lease system reduces bandwidth, improves server scalability, and provides faster access to data. | 09-10-2015 |
20150365482 | SMB2 SCALEOUT - Systems and methods are disclosed for clients and servers operating in a scaled cluster environment. Efficiencies are introduced to the process of connecting a client to a clustered environment by providing the client with the ability to attempt a connection with multiple servers in parallel. Servers operating the in the clustered environment are also capable of providing persistent storage of file handles and other state information. Ownership of the state information and persistent handles may be transferred between servers, thereby providing clients with the opportunity to move from one server to another while maintaining access to resources in the clustered environment. | 12-17-2015 |
Patent application number | Description | Published |
20090126313 | System and method for erecting a tower - A method, a system, and a device for erecting a tower. The method comprises assembling proximate to the ground a base section, top section, and one or more intermediate sections of the tower into an assembled tower lying in a substantially horizontal first plane, the assembled tower comprising a top end including the top section and a bottom end including the base section. The method also includes orienting the attitude of the assembled tower using a lift initiator to lie in a second plane defining an acute angle to the first plane, so that the top end of the tower is higher in elevation than the bottom end. The method also includes lifting the assembled tower from the second plane to a vertical plane with a primary lift assembly and coupling the assembled tower to the foundation. The primary lift assembly may comprise a pulley having a continuous loop of cable connected to a counter-balanced tackle-block system. | 05-21-2009 |
20090158680 | Tower foundation - Non-cementitious tower foundations and structures, kits and methods for making the non-cementitious tower foundations. Aspects of the present invention operate to decouple the required mass for the foundation from the structural components needed to resist compression and tension forces. Aspects of the present invention include a foundation structure made of structural components for resisting the expected forces transferred from the tower. This foundation structure may be filled with non-cementitious fill of any type to provide the required mass to stabilize the foundation and the tower. A non-cementitious tower foundation structure includes a central shaft; a storage tank; and structural members coupling the central shaft to the storage tank. The storage tank comprises one or more voids for containing non-cementitious fill as ballast to stabilize the central shaft. The total volume capacity of the voids may be at least a threshold volume. | 06-25-2009 |
20120210662 | Tower Foundation - Non-cementitious tower foundations and structures, kits and methods for making the non-cementitious tower foundations. Aspects of the present invention operate to decouple the required mass for the foundation from the structural components needed to resist compression and tension forces. Aspects of the present invention include a foundation structure made of structural components for resisting the expected forces transferred from the tower. This foundation structure may be filled with non-cementitious fill of any type to provide the required mass to stabilize the foundation and the tower. A non-cementitious tower foundation structure includes a central shaft; a storage tank; and structural members coupling the central shaft to the storage tank. The storage tank comprises one or more voids for containing non-cementitious fill as ballast to stabilize the central shaft. The total volume capacity of the voids may be at least a threshold volume. | 08-23-2012 |
20120285118 | System and Method for Erecting a Tower - A method, a system, and a device for erecting a tower. The method comprises assembling proximate to the ground a base section, top section, and one or more intermediate sections of the tower into an assembled tower lying in a substantially horizontal first plane, the assembled tower comprising a top end including the top section and a bottom end including the base section. The method also includes orienting the attitude of the assembled tower using a lift initiator to lie in a second plane defining an acute angle to the first plane, so that the top end of the tower is higher in elevation than the bottom end. The method also includes lifting the assembled tower from the second plane to a vertical plane with a primary lift assembly and coupling the assembled tower to the foundation. | 11-15-2012 |
20130139453 | TOWER FOUNDATION - Tower foundations and structures, kits and methods for making the tower foundations. Aspects of the present invention operate to decouple the required mass for the foundation from the structural components needed to resist compression and tension forces. Aspects of the present invention include a foundation structure made of structural components including pre-cast concrete, cast-in place concrete, reinforced concrete, pre-stressed concrete, pre-tensioned concrete and post-tensioned concrete, for resisting the expected forces transferred from the tower. | 06-06-2013 |
20130291454 | TOWER FOUNDATION - The foundation structure includes a plurality of structural members. A first end of each structural member is coupled to a central shaft. In appropriate soil conditions, the foundation structure is buried in the soil and the soil itself constrains the mass at the base of the foundation and keeps it from moving. The foundation structure is made of structural components comprises a material, including concrete pre-cast concrete, cast-in place concrete, reinforced concrete, pre-stressed concrete, pre-tensioned concrete and post-tensioned concrete, for resisting the expected forces transferred from the tower. | 11-07-2013 |