Patent application number | Description | Published |
20110213558 | METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR - The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors. The method of the invention can rapidly predict activation energy for phase I metabolites at a practical level without having to perform a docking experiment between any additional CYP450 and the substrate, or a quantum mechanical calculation, thereby making it easier to develop new drugs using a computer. Also, the present invention may propose a strategy for increasing the bioavailability of drugs through the avoidance of metabolites based on the possibility of drug metabolism. Furthermore, the method of the present invention proposes new empirical approaches which can also be easily applied to activation energies for various chemical reactions, and makes it possible to explain physical and chemical factors that determine activation energy. In addition, through the prediction of activation energy according to the present invention, it is possible to predict i) metabolic products, ii) the relative rate of metabolism, iii) metabolic regioselectivity, iv) metabolic inhibition, v) drug-drug interactions, and vi) the toxicity of a metabolite. | 09-01-2011 |
20120084012 | METHOD FOR PREDICTING ACTIVATION ENERGY USING ATOMIC FINGERPRINT DESCRIPTOR OR ATOMIC DESCRIPTOR - The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors. | 04-05-2012 |
20130042904 | SOLAR CELL MODULE - A solar cell module includes a window unit integrally formed with a transparent substrate unit, a plurality of solar cells, and an electrode unit electrically connected to the solar cells. The solar cells and the electrode unit are provided in the transparent substrate unit. | 02-21-2013 |
20130321358 | COORDINATE INDICATING DEVICE AND COORDINATE MEASURING DEVICE FOR MEASURING INPUT COORDINATES OF COORDINATE INDICATING DEVICE - A coordinate indicating device which inputs coordinates to a coordinate measuring device is provided. The coordinate indicating device includes a power receiver for wirelessly receiving drive power from the coordinate measuring device, a rectifier for rectifying the wirelessly received drive power into Direct Current (DC) drive power, a battery for storing the rectified drive power, an actuator for outputting at least one of preset vibration, frictional force, and electrostatic force, based on relative positions of the coordinate measuring device and the coordinate indicating device by using the rectified drive power provided from the battery, a coordinate indicator for indicating coordinates at predetermined coordinates on the coordinate measuring device, and a shielding portion for shielding the coordinate indicator. | 12-05-2013 |
20130328447 | ACTUATOR USING ELECTRO-ACTIVE POLYMER AND ELECTRONIC DEVICE THEREWITH - An actuator using an electro-active polymer is provided. The actuator includes a vibration plate fixed to an electronic device; at least one electro-active polymer attached to the vibration plate, and activated when electric voltage is applied thereto; and at least one mass joined to at least one a combination member disposed on the vibration plate. | 12-12-2013 |
20140091536 | TOUCH PANEL SEALING APPARATUS - A sealing apparatus of a touch panel provided in a portable terminal including a body and the touch panel, wherein the sealing apparatus is attached and coupled to a coupling area between the body and the touch panel to seal the coupling area while the touch panel is suspended over the body by a resilient member. | 04-03-2014 |
20140285329 | TERMINAL DEVICE FOR PROVIDING HAPTIC EFFECT USING HAPTIC ENGINE AND CONTROLLING METHOD THEREFOR - A terminal device controlling method that provides a haptic effect using a haptic engine is provided, which includes sensing a haptic event, executing a non-physical parameter-based haptic function in a haptic engine so as to determine a vibration pattern corresponding to the haptic event, transferring the vibration pattern from the haptic engine to a device driver, and driving, through the device driver, a vibrator based on the vibration pattern so as to embody a haptic effect. | 09-25-2014 |
20160094081 | WIRELESS POWER TRANSMITTER AND WIRELESS POWER RECEIVER - A wireless power transmitter is provided. The wireless power transmitter includes a power supply unit that supplies Alternating Current (AC) power having a predetermined voltage value, a rectification unit that is connected to the power supply unit, and rectifies the AC power, a voltage adjustment unit that is connected to the rectification unit, and adjusts a magnitude of an output voltage value of the rectified power, and outputs the adjusted power to a power transmission unit, the power transmission unit that generates the adjusted power output from the voltage adjustment unit as a signal in a form in which wireless power transmission is possible, and transmits the generated signal to a wireless power receiver, and a control unit that controls the magnitude of the output voltage value of the rectified power to be adjusted by the voltage adjustment unit in accordance with a predetermined criterion. | 03-31-2016 |