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Jaffe, US

Adam Jaffe, Leonia, NJ US

Patent application numberDescriptionPublished
20080201210SYSTEM AND METHOD FOR MANAGING INTELLECTUAL PROPERTY - The present invention relates to methods and systems for intellectual property management. In an embodiment, a system includes an intellectual property asset inventory system to manage an inventory of intellectual property assets. A product inventory system manages an inventory of products, where the inventory of products corresponds to a plurality of products and one or more of the products of the plurality of products are associated with one or more of the intellectual property assets of the plurality of intellectual property assets. A marketing management system manages a plurality of marketing projects, where one or more of the marketing projects of the plurality of marketing projects are associated with at least one of (i) one or more products of the plurality of products, and (ii) one or more intellectual property assets of the plurality of intellectual property assets.08-21-2008

Adam Jaffe, Mayfield Heights, OH US

Patent application numberDescriptionPublished
20140059416SEGMENTING FORMS FOR MULTIPLE USER COMPLETION - The claimed subject matter provides a system and/or a method that facilitates completing multiple electronic document applications. An interface component can receive two or more electronic documents, wherein each electronic document includes at least two or more questions with respective fill-in fields to be completed by a user input. A master field component can create a master field list that includes a first subset of questions and a second subset of questions and the first subset of questions is targeted toward a first user to answer and the second subset of questions are targeted toward second user to answer. A user segregation manager component can ensure an independent and secure log in to the master field list for each user to provide information. A form aggregation component can leverage the master field list to populate or update the electronic document.02-27-2014

Alex Jaffe, Seattle, WA US

Patent application numberDescriptionPublished
20090319288SUGGESTING CONTACTS FOR SOCIAL NETWORKS - A social network is managed by applying connectivity and similarity measures to social network information to identify possible new relationships between social network users, and then automatically suggest those identified relationships to the social network users. The social network information can include user profile information and indicate existing social relationships between the users in the social network. Users can provide feedback regarding the suggestions, including indications whether the relationship was accepted, consummated, or declined. The social network information can be updated using the feedback. Similarity measures can be based on one or more of shared contacts, or common interests or activities, or content associated with social network users, or ratings within the social network of users and/or their content. Possible relationships having similarity measures that suggest the users likely to already know each other, can be omitted and not suggested.12-24-2009

Allan S. Jaffe, Rochester, MN US

Patent application numberDescriptionPublished
20130143232METHODS FOR THE DETECTION AND MONITORING OF ACUTE MYOCARDIAL INFARCTION - Disclosed herein are methods of detecting and/or prognosing myocardial infarction by detecting a proteolytic fragment of caspase-3 such as the p17 fragment or the p12 fragment. The myocardial infarction can be STEMI or NSTEMI.06-06-2013

Aron Brandon Jaffe, Boston, MA US

Patent application numberDescriptionPublished
20160046710NOTCH2 BINDING MOLECULES FOR TREATING RESPIRATORY DISEASES - The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. In the lung, perturbations of this balance are hallmarks of human respiratory diseases, including goblet cell metaplasia and enhanced mucus secretion in asthma and chronic obstructive pulmonary disease. We found that inflammatory cytokine treatment resulted in a skewing of basal cell differentiation towards a goblet cell fate, culminating in enhanced mucus production. We identified Notch2 as a key node required for cytokine-induced goblet cell metaplasia in vitro and in vivo Inhibition of Notch2 prevents goblet cell metaplasia induced by a broad range of stimuli, which is a hallmark of many respiratory diseases.02-18-2016

Barry Jaffe, Freeport, NY US

Patent application numberDescriptionPublished
20120012635STAPLER FOR PREVENTING SIMULTANEOUS DISPENSING OF MULTIPLE STAPLES - Staplers and methods of stapling are described. The stapler includes a topsail configured to support a plurality of staples, the staples being slidably moveable on the topsail; a blade configured to drive an end staple of the plurality of staples out of the stapler and into an object to staple; a pusher configured to urge the plurality of staples on the topsail in a direction toward the blade; a finger configured to move between at least two positions by movement of the blade, a first position where the finger does not substantially counter action of the pusher, and a second position where the finger is engaged with the plurality of staples to substantially counter action of the pusher on the staples to keep the plurality of staples excluding the end staple away from the blade.01-19-2012

Bruce Jaffe, Yarrow Point, WA US

Patent application numberDescriptionPublished
20110289066SEARCH-HIGHLIGHTER SYSTEM AND METHOD - A text string may be captured when a user initiates a selection event in a web browser. In response to the selection event, the text string is derived from the selected element(s) in a rendered web page. The text string is automatically placed in a web-search text-entry field of the web browser without further instructions from the user. The user can modify the text string before querying a web-search engine.11-24-2011

Claudia B. Jaffe, Portland, OR US

Patent application numberDescriptionPublished
20100187440LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.07-29-2010
20110044858BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM - The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.02-24-2011
20120168643LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.07-05-2012
20120181936SYSTEM AND METHOD FOR METERED DOSAGE ILLUMINATION IN A BIOANALYSIS OR OTHER SYSTEM - A system and method for metered dosage illumination in a bioanalysis or other system. In accordance with an embodiment, an illumination system or subsystem is described that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can also be precisely controlled to generate only a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. Although the examples herein illustrate the providing of metered dosage illumination in the context of a bioanalysis system, the techniques can be similarly used to provide metered dosage illumination in the context of other types of system.07-19-2012
20120181937SYSTEM AND METHOD FOR METERED DOSAGE ILLUMINATION IN A BIOANALYSIS OR OTHER SYSTEM - A system and method for metered dosage illumination in a bioanalysis or other system includes an illumination system or subsystem that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can be precisely controlled to generate a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. The system and method is particularly useful in any quality-control, analysis, or assessment-based environment. Typical research and development applications can include quality control, instrument calibration, and light output standardization; while clinical and diagnostics applications can include clinical monitoring, bioassay calibration and control for diagnostics, treatment and or therapeutic evaluation.07-19-2012
20120235061LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.09-20-2012
20120236585LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.09-20-2012
20120238472BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM - The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.09-20-2012
20120252704BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM - The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.10-04-2012
20130099135LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.04-25-2013
20130188331SOLID STATE CONTINUOUS WHITE LIGHT SOURCE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output.07-25-2013
20130188383SOLID STATE CONTINUOUS WHITE LIGHT SOURCE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.07-25-2013
20130188384SOLID STATE CONTINUOUS WHITE LIGHT SOURCE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.07-25-2013
20130188388SOLID STATE CONTINUOUS WHITE LIGHT SOURCE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.07-25-2013
20130234047SYSTEM AND METHOD FOR CONTROLLED INTENSITY ILLUMINATION IN A BIOANALYSIS OR OTHER SYSTEM - A system and method for controlled illumination in a bioanalysis or other system where excitation of fluorescent molecules is desirable. In an embodiment, an illumination system is described which can provide excitation light at a controlled intensity to provide quantitative results. In an embodiment, a solid state light engine is described which includes a plurality of color channels each providing light output suitable for exciting a fluorescent molecule, a light to frequency converter which receives a portion of the light output, a counter which maintains a count of a signal from the light to frequency converter, and a light intensity circuit, responsive to the counter, which adjusts the color channels to control the intensity of the light output.09-12-2013
20130242595SOLID STATE LIGHT SOURCE WITH HYBRID OPTICAL AND ELECTRICAL INTENSITY CONTROL - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon light sources for applications in microscopy, fluorescence microscopy, and endoscopy. The illumination system includes hybrid optical and electrical control of output intensity in which the light output of one or more of the light sources is attenuated optically such that it is not necessary to reduce the electrical drive power/current of the LEDs at a level where the spectral power distribution is variable. One or more fixed, selectable, or variable neutral density filters is interposed in the output beam of one or more sources to achieve optical attenuation of the light output. The hybrid optical and electrical control of output intensity allows greater dynamic range of intensity to be achieved than could be achieved with electrical control of the LEDs alone while maintaining the desired spectral power distribution.09-19-2013
20130335992SOLID STATE LIGHT SOURCE FOR PHOTOCURING - A compact passively-cooled solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for photocuring applications. The solid state illumination system utilizes LED modules to generate high intensity light output suitable for photocuring. The light output is continuous in the visible spectrum from 380 nm to 530 nm and is suitable for photocuring using a wide range of photoinitiators. A touchscreen interface allows programming of spectral output, intensity and duration. Output can be initiated using the touchscreen interface and/or a foot pedal.12-19-2013
20140192405ADJUSTABLE COLLIMATOR FOR COUPLING A LIGHT GUIDE TO A MICROSCOPE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. In an embodiment, the solid state illumination system is coupled to a microscope using a liquid light guide. The liquid light guide is coupled to a microscope using an adjustable collimator which optimizes the light output for input to the optical train of the microscope.07-10-2014
20160123886INTEGRATED FLUORESCENCE SCANNING SYSTEM - An integrated fluorescence scanning system is provided. The integrated fluorescence scanner combines an embedded computer, light engine, microscope, and motion stage into a compact rack-mountable network appliance that allows for automation of fluorescence microscopy. In an embodiment, the integrated fluorescence scanner includes a solid-state light engine which can provide intense, pure, and stable light across the spectrum required for imaging of all fluorophores of interest. The embedded computer allows for autonomous operation, and network appliance features including synchronous multi-scanner operation and monitoring, multisite operation via a single control terminal, and calibration for inter and intra instrument consistency.05-05-2016

Patent applications by Claudia B. Jaffe, Portland, OR US

Danene Jaffe, Weston, FL US

Patent application numberDescriptionPublished
20100005811Beverage Preservation, Chilling, and Dispensing System - A chamber for receipt and retention of a bottled beverage has a dispensing cartridge that interacts with a bottle to remove air therein to preserve the beverage under vacuum and to dispense the beverage under pressure. The vacuum and air pressure within the bottle is applied through a concentric pair of tubes introduced into the bottle as a part of the dispensing cartridge. A reversible pump is in fluid communication with the tubes. The chamber is maintained at a user-selected temperature using a thermoelectric cooling unit.01-14-2010
20150225222Beverage Preservation, Chilling and Dispensing System - A chamber for receipt and retention of a bottled beverage has a dispensing cartridge that interacts with a bottle to remove air therein to preserve the beverage under vacuum and to dispense the beverage under pressure. The vacuum and air pressure within the bottle is applied through a concentric pair of tubes introduced into the bottle as a part of the dispensing cartridge. A reversible pump is in fluid communication with the tubes. The chamber is maintained at a user-selected temperature using a thermoelectric cooling unit.08-13-2015

Daniel M. Jaffe, Tucson, AZ US

Patent application numberDescriptionPublished
20150081575PROFESSIONAL NETWORKING SYSTEM AND METHODS - A professional networking system is provided. The system includes a plurality of member websites, each being associated with a member of the professional networking system, and each having a unique domain name. The system further includes a professional networking application that is hosted at least partially on a server and electronically accessible over at least one network system to at least one member computer device. The professional networking application is configured to provide members controlling access to their respective associated websites of the plurality of member websites. A member recommendation module is further included that is configured to receive from a member a recommendation for another member and to facilitate display of the recommendation on a website associated with the recommended member.03-19-2015

David Jaffe, Cambridge, MA US

Patent application numberDescriptionPublished
20090148842Preparation of templates for methylation analysis - The invention relates to a method of preparing and using a library of template polynucleotides suitable for use as templates in solid-phase nucleic acid amplification and sequencing reactions to determine the methylation status of the cytosine bases in the library. In particular, the invention relates to a method of preparing and analysing a library of template polynucleotides suitable for methylation analysis.06-11-2009

David Jaffe, Orange Village, OH US

Patent application numberDescriptionPublished
20140208507BED FRAMES WITH FRAME COVER ASSEMBLIES - The present disclosure and related inventions describe various embodiments of cover assemblies for bed frames which are both structural and aesthetic which provide a wide variety of bed frame assemblies of unique construction. The bed frame assembly removably attaches to the outer surface of the longitudinal members of a bed frame to conceal exposed bed frame members and provide a more pleasant, customized view of an entire sleep structure.07-31-2014

David E. Jaffe, Riverhead, NY US

Patent application numberDescriptionPublished
20160135765ACTIVE WATER PHANTOM FOR THREE-DIMENSIONAL ION BEAM THERAPY QUALITY ASSURANCE - An Active Water Phantom is designed to provide fast, accurate, high resolution, complete Quality Assurance of patient-specific treatment plans utilizing intensity-modulated Ion Beam Therapy, prior to their delivery to the patient. The detection medium is a tissue-equivalent water-based liquid scintillator material. A three-dimensional pattern of scintillation light, emitted upon ion beam irradiation, is reconstructed from three orthogonal two-dimensional light yield profiles, which are read out for each individual beam energy layer. The 3-D information has dose measurement accuracy 1-2% and spatial resolution 1-2 millimeters. The measurement sequence provides up to four orders of magnitude more data characterizing the treatment plan than currently commercially available alternatives, all in a time period no greater than that needed for actual delivery of the dose fraction to a patient. The system provides sophisticated control and readout of the cameras or photo-detectors, data archiving and analysis, simulation capabilities, and 3-D dose image reconstruction and visualization.05-19-2016

Eileen K. Jaffe, Jenkintown, PA US

Patent application numberDescriptionPublished
20080286847ALTERNATE MORPHEEINS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES - A composition having an agent adapted to affect a multimeric protein by binding to a binding site of the multimeric protein and thereby affecting an equilibrium of units, wherein the multimeric protein has an assembly having a plurality of said units, wherein each of the units has a first complementary surface and a second complementary surface and wherein the first complementary surface of one unit is associated with the second complementary surface of another unit, provided that the assembly is at least one of different quaternary isoforms on a condition that in the multimeric protein (1) a structure of each of the units determines a structure of the different quaternary isoforms, (2) the units are in the equilibrium and (3) the structure of the different quaternary isoforms influences a function of the multimeric protein.11-20-2008
20090048324ALTERNATE MORPHEEIN FORMS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES - A composition having an agent adapted to affect a multimeric protein by binding to a binding site of the multimeric protein and thereby affecting an equilibrium of units, wherein the multimeric protein has an assembly having a plurality of said units, wherein each of the units has a first complementary surface and a second complementary surface and wherein the first complementary surface of one unit is associated with the second complementary surface of another unit, provided that the assembly is at least one of different quaternary isoforms on a condition that in the multimeric protein (1) a structure of each of the units determines a structure of the different quaternary isoforms, (2) the units are in the equilibrium and (3) the structure of the different quaternary isoforms influences a function of the multimeric protein.02-19-2009
20110207816ALTERNATE MORPHEEINS OF ALLOSTERIC PROTEINS AS A TARGET FOR THE DEVELOPMENT OF BIOACTIVE MOLECULES - A composition having an agent adapted to affect a multimeric protein by binding to a binding site of the multimeric protein and thereby affecting an equilibrium of units, wherein the multimeric protein has an assembly having a plurality of said units, wherein each of the units has a first complementary surface and a second complementary surface and wherein the first complementary surface of one unit is associated with the second complementary surface of another unit, provided that the assembly is at least one of different quaternary isoforms on a condition that in the multimeric protein (1) a structure of each of the units determines a structure of the different quaternary isoforms, (2) the units are in the equilibrium and (3) the structure of the different quaternary isoforms influences a function of the multimeric protein.08-25-2011
20130004504METHOD OF MODULATING PHENYLALANINE HYDROXYLASE STRUCTURE AND FUNCTION - A method of affecting a multimeric protein comprising an equilibrium of assembly states, each assembly having a plurality of units, wherein each of the units comprises a first complementary surface and a second complementary surface and wherein the first complementary surface of one unit is associated with the second complementary surface of another unit, provided that the assembly is at least one of different quaternary isoforms under four conditions, wherein the method comprising: applying to the multimeric protein a composition comprising a compound adapted to affect formation of an active form of the multimeric protein; associating the composition with an active form of the multimeric protein; and promoting the multimeric protein to assemble into the active form, thereby affecting the multimeric protein to form the active form, wherein the multimeric protein is phenylalanine hydroxylase.01-03-2013

Patent applications by Eileen K. Jaffe, Jenkintown, PA US

Elaine Jaffe, Great Falls, VA US

Patent application numberDescriptionPublished
20120225793METHODS FOR IDENTIFYING, DIAGNOSING, AND PREDICTING SURVIVAL OF LYMPHOMAS - Gene expression data provides a basis for more accurate identification and diagnosis of lymphoproliferative disorders. In addition, gene expression data can be used to develop more accurate predictors of survival. The present invention discloses methods for identifying, diagnosing, and predicting survival in a lymphoma or lymphoproliferative disorder on the basis of gene expression patterns. The invention discloses a novel microarray, the Lymph Dx microarray, for obtaining gene expression data from a lymphoma sample. The invention also discloses a variety of methods for utilizing lymphoma gene expression data to determine the identity of a particular lymphoma and to predict survival in a subject diagnosed with a particular lymphoma. This information will be useful in developing the therapeutic approach to be used with a particular subject.09-06-2012

Elaine S. Jaffe, Great Falls, VA US

Patent application numberDescriptionPublished
20110195064SURVIVAL PREDICTOR FOR DIFFUSE LARGE B CELL LYMPHOMA - The invention provides methods and materials related to a gene expression-based survival predictor for diffuse large B cell lymphoma (DLBCL) patients.08-11-2011
20150132297SURVIVAL PREDICTOR FOR DIFFUSE LARGE B CELL LYMPHOMA - The invention provides methods and materials related to a gene expression-based survival predictor for DLBCL patients.05-14-2015

Eric Jaffe, Greenwich, CT US

Patent application numberDescriptionPublished
20130231990METHODS AND SYSTEMS FOR PROVIDING PERSONAL SHOPPING SERVICES - A method and system for providing personal shopping assistance via a computing device includes hosting a database of information regarding a customer, hosting a database of information regarding a personal shopper, and associating the customer with the personal shopper. The personal shopper is provided the ability to recommend at least one of a product or a service relevant to the customer and receiving an indication of the purchase of the recommended product or service by the customer. An incentive system may provide a reward to the personal shopper based upon the purchased product or service, including a commission or other reward. The system may be implemented on a desktop and/or mobile device as desired to provide flexibility in implementation.09-05-2013

Herbert Jaffe US

Patent application numberDescriptionPublished
20110088971Collapsible step and extension ladder - A ladder formed of easily storable sections is quickly assembled to form a step ladder, extension ladder, hoist, scaffolding or fence. The base and top of the extension ladder include separate stabilizers which prevent the ladder from tipping or from damaging the fascia. The upper stabilizer may be converted to perform a second function as a hoist, substantially reducing the cost and space needed for storage of the invention.04-21-2011

Jacob Jaffe, Cambridge, MA US

Patent application numberDescriptionPublished
20150354006MARKERS FOR ACUTE LYMPHOBLASTIC LEUKEMIA - The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors.12-10-2015
20160091485MARKERS FOR EZH2 INHIBITORS - The invention provides methods of detecting an EZH2 mutation and associated epigenetic markers in a cancer cell, methods cancer diagnosis and methods of screening for EZH2 inhibitors.03-31-2016

Jacob Jaffe, Boston,, MA US

Patent application numberDescriptionPublished
20150354006MARKERS FOR ACUTE LYMPHOBLASTIC LEUKEMIA - The invention provides methods of detecting a NSD2 mutation in a cancer cell, methods cancer diagnosis and methods of screening for NSD2 inhibitors.12-10-2015

Jeffery Jaffe, Bellingham, WA US

Patent application numberDescriptionPublished
20140326028Concealed Handcuff Key - Described herein are several versions of concealed handcuff keys including a key concealed within a pouch as a zipper pull, a key concealed as a common pen cap/clip, a key concealed as a coin, a key concealed as a bootlace/shoelace end, and a key concealed within a receiver in the back side of a belt buckle.11-06-2014

Jeffrey M. Jaffe, Brookline, MA US

Patent application numberDescriptionPublished
20110041126MANAGING WORKLOADS IN A VIRTUAL COMPUTING ENVIRONMENT - Methods and apparatus involve continuous management of workloads, including regular monitoring, profiling, tuning and fault analysis by way of instrumentation in the workloads themselves. Broadly, features contemplate collecting current state information from remote or local workloads and correlating it to predefined operational characteristics to see if such defines an acceptable operating state. If so, operation continues. If not, remediation action occurs. In a virtual environment with workloads performing under the scheduling control of a hypervisor, state information may also come from a hypervisor as well as any guest user and kernel spaces of an attendant operating system. Executable instructions in the form of probes gather this information from items of the stack available for control and deliver it to the management system. Other features contemplate supporting/auditing third party cloud computing services, validating service level agreements, and consulting independent software vendors. Security, computing systems and computer program products are other embodiments.02-17-2011

Joel Jaffe, Bellingham, WA US

Patent application numberDescriptionPublished
20140326028Concealed Handcuff Key - Described herein are several versions of concealed handcuff keys including a key concealed within a pouch as a zipper pull, a key concealed as a common pen cap/clip, a key concealed as a coin, a key concealed as a bootlace/shoelace end, and a key concealed within a receiver in the back side of a belt buckle.11-06-2014

Joel Jaffe, Glenview, IL US

Patent application numberDescriptionPublished
20110319153System and Method for Blind Selection of Plural Selectable Elements Prior to a Reveal in a Wagering Game - A method for conducting a wagering game on a wagering game device includes using one or more processors to define, in a game feature, a plurality of selectable elements, at least some of the plurality of selectable elements being associated with selectable element awards. The method also includes receiving player selections of the selectable elements, subject to a predefined geometric rule-based selection constraint, until the player has either selected a selectable element associated with a game-ending outcome or completed selections from among the plurality of selectable elements. The method further includes revealing the selectable element awards only after all player selections of the selectable elements have been received and awarding to the player any selectable element awards relating to any selected selectable elements.12-29-2011
20130090158System and Method for Assessing and Providing Location-Based Benefits - A gaming system includes a community server, processor, communications controller, and physical memory device bearing instructions for execution by the processor. The system processes gaming session information relating to a player's wagering-game machine gaming session and determines whether the gaming session information satisfies a condition precedent to an award of player profile content. The processor stores the player profile content in association with the player identified in the gaming session information and the information sent to the wagering-game server by the communications controller includes information relating to a location-based incentive available to the player.04-11-2013
20140057701GAMING INCENTIVES BASED ON MEASURED EFFECT OF USER WEB ACTIVITY - A gaming system includes at least one gaming server having at least one processor and at least one memory device storing instructions. The instructions, when executed by the at least one processor, cause the at least one gaming server to assign one or more unique identifiers to a registrant, monitor for web activity associated with the one or more unique identifiers and initiated by the registrant, measure an effect of the web activity, and convert the measured effect into a gaming incentive.02-27-2014
20140162762GAMING SYSTEM WITH PRIVACY FEATURES - A wagering game system includes a peripheral device with a peripheral device display and at least one processor configured to execute at least one application to display information on the peripheral device display. The system also includes a wagering game terminal with a terminal display configured to display a wagering game and a player-accessible interface configured to allow a player to communicatively couple the peripheral device to the wagering game terminal. The at least one application includes a wagering game application relating to the wagering game displayed on the terminal display of the wagering game terminal, and the at least one processor of the peripheral device executes the wagering application to display, on the peripheral device display, wagering game information relating to the wagering game.06-12-2014
20140206442GAMING SYSTEM AND METHODS ADAPTED TO UTILIZE RECORDED PLAYER GESTURES - A method of utilizing a player's movements in association with a wagering game event, includes sensing a player's movements using a movement sensing device, storing a representation of the player's movements in non-transient computer-readable storage media in association with player-identifying information, associating the representation of the player's movements with the wagering game event in the storage media, and replaying the representation of the player's movements on one or more display devices operatively associated with a wagering game machine responsive to an occurrence of the wagering game event.07-24-2014
20160071359GAMING SYSTEM WITH PRIVACY FEATURES - A wagering game system includes a peripheral device with a peripheral device display and at least one processor configured to execute at least one application to display information on the peripheral device display. The system also includes a wagering game terminal with a terminal display configured to display a wagering game and a player-accessible interface configured to allow a player to communicatively couple the peripheral device to the wagering game terminal. The at least one application includes a wagering game application relating to the wagering game displayed on the terminal display of the wagering game terminal, and the at least one processor of the peripheral device executes the wagering application to display, on the peripheral device display, wagering game information relating to the wagering game.03-10-2016

Patent applications by Joel Jaffe, Glenview, IL US

Joel R. Jaffe, Chicago, IL US

Patent application numberDescriptionPublished
20110118000WAGERING GAME WITH ACCUMULATION-BONUS FEATURE THAT IS PLAYED UPON PLAYER'S SELECTION - A gaming system for conducting a wagering game includes an accumulation-bonus feature which allows a player to cache awards to a bonus object. A player selects when to use the bonus object in a secondary playfield to enhance the cached awards.05-19-2011

Jonathan Jaffe, Gallatin, TN US

Patent application numberDescriptionPublished
20080265047RAILWAY TIE OF NON-HOMOGENEOUS CROSS SECTION USEFUL IN ENVIRONMENTS DELETERIOUS TO TIMBER - Disclosed herein is a railroad tie comprising a core comprising wood or a wood product, and a first sleeve encapsulating the core, wherein the first sleeve comprises at least one of the group consisting of plastic, plastic-composite, or non-plastic polymers. A second sleeve may additionally encapsulate the first. In a preferred embodiment, the first sleeve is comprised primarily of poly ethylene terephthalate, and the second sleeve is comprised primarily of high density poly ethylene.10-30-2008

Jonathan Jaffe, Annandale, NJ US

Patent application numberDescriptionPublished
20130303985NEEDLE ASSISTED JET INJECTION ADMINISTRATION OF TESTOSTERONE COMPOSITIONS - The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.11-14-2013

Jonathan E. Jaffe, Gallatin, TN US

Patent application numberDescriptionPublished
20090254530INDIGENOUS AUTHENTICATION AND SEARCHING SYSTEM AND METHOD - An apparatus and system for authenticating and searching data is provided. The apparatus includes a tightly coupled housing, an authenticator in the tightly coupled housing, a first archival storage in the tightly coupled housing, an indexer in the tightly coupled housing, and an index storage in the tightly coupled housing. The authenticator receives a file from an external email system, the authenticator creates first and second self-authenticating copies of the file, the first archival storage stores the first self-authenticating file, the indexer dissembles the second self-authenticating copy into components of the second self-authenticating copy, and the index storage stores the components of the second self-authenticating in a searchable format.10-08-2009
20130004705EMBEDDED RECEIVER FOR FASTENERS - A receiver plate for embedding within a fastener target area of a fabricated body is disclosed, with the receiver plate providing tri-axial motion resistance for a fastener that may be inserted into the fabricated body and through the receiver plate at an imprecisely determined location within the fastener target area. Also disclosed is a fabricated body adapted for insertion of fasteners within a target area comprising a molded body portion, and a receiver plate embedded within the molded body portion in a target area. Further disclosed is a fastener and receiver plate for use with a body in which the receiver plate is embedded, wherein the fastener has a head, a shaft and a tapered tip.01-03-2013
20150278814SYSTEM FOR MERCHANT AND NON-MERCHANT BASED TRACTIONS UTILIZING SECURE NON-RADIATING COMMUNICATIONS WHILE ALLOWING FOR SECURE ADDITIONAL FUNCTIONALITY - Methods, apparatuses, non-transitory computer program products, systems, and mobile terminal devices are disclosed for performing wireless financial transactions which separate an account identification and transaction authorization from a single charge card into two separate elements, which include at least an encrypted account identifier and a transaction-adaptive, context sensitive, dynamically content-rich, transaction authorization.10-01-2015

Patent applications by Jonathan E. Jaffe, Gallatin, TN US

Kathy L. Jaffe, Cookeville, TN US

Patent application numberDescriptionPublished
20100163483FOOD PROCESSING RESOURCE RECOVERY - A method of hydrolyzing peptide bonds in waste material from dissolved air flotation (DAF float) wastewater treatment systems is disclosed. The method according to the disclosure comprises controlling the pH of said DAF float; adding a lytic agent to said pH controlled DAF float; and incubating the lytic agent/DAF float mixture. The hydrolyzed peptide bonds allow for the cleaving of oil molecules from protein material thereby increasing oil extraction from wastewater streams.07-01-2010

Leonard Jaffe, Morristown, NJ US

Patent application numberDescriptionPublished
20080208097Protective device against frictional irritation due to wearing thong-type sandals and other footwear - A device is provided which gives protection from frictional injury to the web space between toes due to the wearing of thong-type sandals or other similar footwear. The device is comprised of a flat, flexible, medically inert, and preferably transparent plastic material which is can be configured in a variety of shapes and which has a plantar base portion which fits under the toes and on the bottom of the foot, stabilizing the device from moving, a web spacer portion which fits between the toes and provides protection from frictional injury, and a dorsal flap portion which anchors the device to the top side of the foot.08-28-2008

Mark D. Jaffe, Essex Junction, VT US

Patent application numberDescriptionPublished
20110193146Charge Carrier Barrier for Image Sensor - A pixel sensor structure, method of manufacture and method of operating. Disclosed is a buffer pixel cell comprising a barrier region for preventing stray charge carriers from arriving at a dark current correction pixel cell. The buffer pixel cell is located in the vicinity of the dark current correction pixel cell and the buffer pixel cell resembles an active pixel cell. Thus, an environment surrounding the dark current correction pixel cell is similar to the environment surrounding an active pixel cell.08-11-2011

Mark David Jaffe, Shelburne, VT US

Patent application numberDescriptionPublished
20080213948DUAL WIRED INTEGRATED CIRCUIT CHIPS - A semiconductor device having wiring levels on opposite sides and a method of fabricating a semiconductor structure having contacts to devices and wiring levels on opposite sides. The method including fabricating a device on a silicon-on-insulator substrate with first contacts to the devices and wiring levels on a first side to the first contacts, removing a lower silicon layer to expose the buried oxide layer, forming second contacts to the devices through the buried oxide layer and forming wiring levels over the buried oxide layer to the second contacts.09-04-2008
20080308948WAFER-TO-WAFER ALIGNMENTS - Structures for aligning wafers and methods for operating the same. The structure includes (a) a first semiconductor wafer including a first capacitive coupling structure, and (b) a second semiconductor wafer including a second capacitive coupling structure. The first and second semiconductor wafers are in direct physical contact with each other via a common surface. If the first and second semiconductor wafers are moved with respect to each other by a first displacement distance of 1 nm in a first direction while the first and second semiconductor wafers are in direct physical contact with each other via the common surface, then a change of at least 1012-18-2008
20090065925DUAL-SIDED CHIP ATTACHED MODULES - An electronic device and method of packaging an electronic device. The device including: a first substrate, a second substrate and an integrated circuit chip having a first side and an opposite second side, a first set of chip pads on the first side and a second set of chip pads on the second side of the integrated circuit chip, chip pads of the first set of chip pads physically and electrically connected to corresponding substrate pads on the first substrate and chip pads of the second set of chip pads physically and electrically connected to substrate pads of the substrate.03-12-2009
20090121260DOUBLE-SIDED INTEGRATED CIRCUIT CHIPS - A double-sided integrated circuit chips, methods of fabricating the double-sided integrated circuit chips and design structures for double-sided integrated circuit chips. The method includes removing the backside silicon from two silicon-on-insulator wafers having devices fabricated therein and bonding them back to back utilizing the buried oxide layers. Contacts are then formed in the upper wafer to devices in the lower wafer and wiring levels are formed on the upper wafer. The lower wafer may include wiring levels. The lower wafer may include landing pads for the contacts. Contacts to the silicon layer of the lower wafer may be silicided.05-14-2009
20090121287DUAL WIRED INTEGRATED CIRCUIT CHIPS - A semiconductor device having wiring levels on opposite sides, a method of fabricating a semiconductor structure having contacts to devices and wiring levels on opposite sides, and a design structure of a semiconductor device having wiring levels on opposite sides. The method including fabricating a device on a silicon-on-insulator substrate with first contacts to the devices and wiring levels on a first side to the first contacts, removing a lower silicon layer to expose the buried oxide layer, forming second contacts to the devices through the buried oxide layer and forming wiring levels over the buried oxide layer to the second contacts.05-14-2009
20100044759DOUBLE-SIDED INTEGRATED CIRCUIT CHIPS - A semiconductor structure and method of fabricating the structure. The method includes removing the backside silicon from two silicon-on-insulator wafers having devices fabricated therein and bonding them back to back utilizing the buried oxide layers. Contacts are then formed in the upper wafer to devices in the lower wafer and wiring levels are formed on the upper wafer. The lower wafer may include wiring levels. The lower wafer may include landing pads for the contacts. Contacts to the silicon layer of the lower wafer may be silicided.02-25-2010
20110062542STRUCTURES, DESIGN STRUCTURES AND METHODS OF FABRICATING GLOBAL SHUTTER PIXEL SENSOR CELLS - Pixel sensor cells, method of fabricating pixel sensor cells and design structure for pixel sensor cells. The pixel sensor cells including: a photodiode body in a first region of a semiconductor layer; a floating diffusion node in a second region of the semiconductor layer, a third region of the semiconductor layer between and abutting the first and second regions; and dielectric isolation in the semiconductor layer, the dielectric isolation surrounding the first, second and third regions, the dielectric isolation abutting the first, second and third regions and the photodiode body, the dielectric isolation not abutting the floating diffusion node, portions of the second region intervening between the dielectric isolation and the floating diffusion node.03-17-2011
20110241082DOUBLE-SIDED INTEGRATED CIRCUIT CHIPS - A semiconductor structure and method of fabricating the structure. The method includes removing the backside silicon from two silicon-on-insulator wafers having devices fabricated therein and bonding them back to back utilizing the buried oxide layers. Contacts are then formed in the upper wafer to devices in the lower wafer and wiring levels are formed on the upper wafer. The lower wafer may include wiring levels. The lower wafer may include landing pads for the contacts. Contacts to the silicon layer of the lower wafer may be silicided.10-06-2011
20110302542DOUBLE-SIDED INTEGRATED CIRCUIT CHIPS - A double-sided integrated circuit chips, methods of fabricating the double-sided integrated circuit chips and design structures for double-sided integrated circuit chips. The method includes removing the backside silicon from two silicon-on-insulator wafers having devices fabricated therein and bonding them back to back utilizing the buried oxide layers. Contacts are then formed in the upper wafer to devices in the lower wafer and wiring levels are formed on the upper wafer. The lower wafer may include wiring levels. The lower wafer may include landing pads for the contacts. Contacts to the silicon layer of the lower wafer may be silicided.12-08-2011

Patent applications by Mark David Jaffe, Shelburne, VT US

Michael Jaffe, Maplewood, NJ US

Patent application numberDescriptionPublished
20090325296ELECTROSPUN ELECTROACTIVE POLYMERS FOR REGENERATIVE MEDICINE APPLICATIONS - Due to the size and complexity of tissues such as the spinal cord and articular cartilage, specialized constructs incorporating cells as well as smart materials may be a promising strategy for achieving functional recovery. Aspects of the present invention describe the use of an electroactive, or piezoelectric, material that will act as a scaffold for stem cell induced tissue repair. Embodiments of the inventive material can also act alone as an electroactive scaffold for repairing tissues. The piezoelectric material of the present invention acts as a highly sensitive mechanoelectrical transducer that will generate charges in response to minute vibrational forces.12-31-2009
20100233807Substrate Recognition By Differentiable Human Mesenchymal Stem Cells - The invention described herein provides a structure for growing isolated differentiable human mesenchymal cells, which includes a three-dimensional matrix of fibers. The matrix serves as an implantable scaffolding for delivery of differentiable human mesenchymal cells in tissue engineering. The invention further provides compositions that contain the three-dimensional matrix of fibers seeded with isolated differentiable human mesenchymal cells, wherein the matrix forms a supporting scaffold for growing the isolated differentiable human mesenchymal cells, and wherein the differentiable human mesenchymal cells differentiate into a mature cell phenotype. The invention further provides methods of preparing the implantable nanofiber matrix scaffolding seeded with differentiable human mesenchymal cells for use in tissue engineering.09-16-2010
20100298520POLYOXAZOLIDONES DERIVED FROM BISANHYDROHEXITOLS - Disclosed is a method for preparing polyoxazolidones wherein an ether of a bisanhydrohexitol is reacted with a diisocyanate under conditions which form polyoxazolidones. Preferred bisanhydrohexitols include isoidide, isomannide and isosorbide. The polyoxazolidones are highly crosslinked, rigid, and have high solvent resistance.11-25-2010
20110237757Polyesters From Assymetrical Monomers Based Upon Bisanhydrohexitols - Asymmetrically substituted compounds of bisanhydrohexitols are described, including the bisanhydrohexitol isosorbide. The compounds are useful as AB monomers. The synthesis of polymers from the monomers is also described.09-29-2011
20110257346Polyester Ethers Derived From Asymmetrical Monomers Based Upon Bisanydrohexitols - Asymmetrically substituted compounds of bisanhydrohexitols are described, including the bisanhydrohexitol isosorbide. The compounds are useful as monomers. The synthesis of polymers from the monomers is also described.10-20-2011
20150307650ISOSORBIDE-DERIVED EPOXY RESINS AND METHODS OF MAKING SAME - Isosorbide-derived epoxies and methods of making same are disclosed. Isosorbide and its isomers are attached to glycidyl ether to make crosslinkable epoxy resin monomers. Adding the hydrophobic functional group into the backbone of isosorbide epoxy or adjusting the amount and type of crosslinker is operable to modify the mechanical properties and water uptake ratio (from <1 wt % to >50 wt %) of the isosorbide-derived epoxies for different uses. High water uptake epoxies with controllable biodegradation rate are suitable for drug delivery systems or extracellular matrices for biomedical applications, while low water uptake epoxies with strong mechanical properties may be used for can coatings, bone cements and other industrial additives and adhesives.10-29-2015

Patent applications by Michael Jaffe, Maplewood, NJ US

Michael B. Jaffe, Cheshire, CT US

Patent application numberDescriptionPublished
20080228096End-Tidal Gas Estimation System and Method - An apparatus and method of indicating the reliability of an end-tidal gas value that includes measuring a plurality of gas concentration values, measuring a plurality of ventilation values, determining an end-tidal gas value from the gas concentration values, determining the degree of ventilatory stability from the ventilation values, and providing an estimate of reliability of the end-tidal gas values using the degree of ventilatory stability.09-18-2008
20090118633End-Tidal Gas Estimation System and Method - An apparatus and method of using an end-tidal gas value taken from an non-intubated patient that includes measuring a plurality of gas concentration values, determining an end-tidal gas value from the gas concentration values, and reporting the end-tidal gas value for a breath as the greater of either: (a) a maximum gas concentration values observed during such a breath, or (b) the end-tidal gas value reported for a previous breath decreased by a maximum allowable breath-to-breath percent change.05-07-2009
20100036272METABOLIC MEASURE SYSTEM INCLUDING A MULTIPLE FUNCTION AIRWAY ADAPTER02-11-2010
20100097380RESPIRATORY PROFILE PARAMETER DETERMINATION METHOD AND APPARATUS - A method of sampling one or more respiratory profile characteristics and monitoring a variety of respiratory profile parameters. The sampled respiratory characteristics include respiratory flow rate, respiratory pressure, and partial pressure of at least one constituent of a patient's respiration. The method detects patient breaths, determines whether each breath is a spontaneous breath or a ventilator-induced breath and calculates various respiratory profile parameters based on the sampled measurements. The method displays the respiratory profile parameters in graphic and numeric forms. Preferably, the method allows a user to select the displayed respiratory profile parameters.04-22-2010
20100132710APPARATUS AND METHOD FOR NON-INVASIVELY MEASURING CARIDAC OUTPUT - Apparatus and methods for non-invasively determining cardiac output using partial re-breathing techniques are disclosed in which the apparatus is constructed with an instantaneously adjustable deadspace for accommodating differences in breathing capacities of various patients. The apparatus is constructed of inexpensive elements, including a single two-way valve which renders the apparatus very simple to use and inexpensive so that the unit may be readily disposable. The method of the invention provides a novel means of estimating cardiac output based on alveolar CO06-03-2010
20120209096NASAL AND ORAL PATIENT INTERFACES - A patient interface for communicating fluids to and/or from a patient's nasal cavity and/or oral cavity is disclosed. In addition, a patient interface for fluid and physiological function monitoring proximate to the patient's nasal cavity and/or oral cavity is disclosed. An apnea monitor and a method for monitoring apnea are also disclosed.08-16-2012
20140094669NASAL AND ORAL PATIENT INTERFACES - A patient interface for communicating fluids to and/or from a patient's nasal cavity and/or oral cavity is disclosed. In addition, a patient interface for fluid and physiological function monitoring proximate to the patient's nasal cavity and/or oral cavity is disclosed. An apnea monitor and a method for monitoring apnea are also disclosed.04-03-2014

Patent applications by Michael B. Jaffe, Cheshire, CT US

Michael Brian Jaffe, Cheshire, CT US

Patent application numberDescriptionPublished
20100168599RESPIRATORY COMPONENT MEASUREMENT SYSTEM WITH INDICATING ELEMENTS - A respiratory component measurement system that includes an airway adapter adapted to be placed in fluid communication with an airway of a patient and a sensor element in physical communication with the airway adapter. The sensor element is adapted to detect an orientation related characteristic of the airway adapter, a motion related characteristic of the airway adapter, or both. A respiratory component sensor is also adapted to be disposed on the airway adapter so as to measure a characteristic associated with a flow of gas through the airway adapter. An indicating element coupled to the respiratory component sensor is adapted to output a representation of the orientation related characteristic.07-01-2010
20130018288SYSTEM FOR MONITORING ONGOING CARDIOPULMONARY RESUSCITATION - Cardiopulmonary resuscitation being provided to a subject is monitored. An enhanced measurement of the effectiveness of the cardiopulmonary resuscitation received by the subject is determined by correlating chest compressions with changes in movement and/or composition of gas at or near the airway of the subject. For example, one or more therapy parameters may be measured with an enhanced accuracy and/or precision, and/or one or more therapy parameters not monitored in conventional cardiopulmonary resuscitation monitoring systems may be measured.01-17-2013
20130267862SYSTEM AND METHOD FOR DETERMINING ONE OR MORE BREATHING PARAMETERS OF A SUBJECT - A system is configured to determine one or more breathing parameters of a subject, such as one or both of end-tidal carbon dioxide concentration and/or breath rate. The system is configured to make a plurality of preliminary determinations of an individual breathing parameter according to a plurality of different algorithms. A final determination of the breathing parameter is obtained by selecting one of the preliminary determinations based on therapy parameters, gas parameters, and/or other parameters that impact the accuracy and/or precision of the different algorithms.10-10-2013
20140052014Mainstream Gas Analyzer Configurable To Removably Couple With A Sidestream Gas Sampling Component - Systems and methods for analyzing respiratory gas are configured to function in both divertive and non-divertive configurations. A mainstream gas analyzer housing economically and removably couples with a sidestream gas sampling component.02-20-2014
20140216451PRESSURE BASED GAS LEAK TESTING - Gas-pressure-based testing, in some embodiments, features a self-leak-testing module (08-07-2014
20140316241SYSTEM AND METHOD FOR MONITORING COMPOSITION IN A SIDESTREAM SYSTEM USING A PUMP AND DETECTOR WITH CONTROL ELECTRONICS THAT ARE TIGHTLY INTEGRATED - A system and method are configured to monitor composition of a flow of breathable gas being provided to a subject. The monitoring is accomplished in a sidestream configuration in which control of a pump and a detector are implemented in a tightly integrated controller.10-23-2014
20140326048SYSTEM AND METHOD FOR MONITORING COMPOSITION IN A SIDESTREAM SYSTEM USING A DISPOSABLE SAMPLING CHAMBER - A system and method are configured to monitor composition of a flow of breathable gas being provided to a subject. A measurement flow of breathable gas is diverted in order to monitor composition of the flow of breathable gas, and then the measurement flow of breathable gas is returned to the flow of breathable gas. This will tend to conserve the constituent gases within the flow of breathable gas, which may be significant in instances where the flow of breathable gas is being used to deliver medicaments or drugs (e.g., relatively expensive anesthetic, and/or other medicaments or drugs). Since the measurement flow of breathable gas will tend to have contaminants (e.g., mucus blood, medications, or other materials), routing the measurement flow of breathable gas back into the flow of breathable gas constitutes a placement solution for the contaminants. In system 10, the components that contact the measurement flow of breathable gas may be disposable, in order to facilitate reintroduction of the measurement flow of breathable gas back into the flow of breathable gas.11-06-2014
20150320949RESPIRATORY MEASUREMENT APPARATUS HAVING INTEGRATED FILTER - An apparatus comprises a flow sensor configured to sense airflow between a respiration machine and a patient, a first connector configured to communicate air between the flow sensor and the patient, a second connector configured to communicate air between the flow sensor and the respiration machine, multiple pressure sensing ports configured for connection to pressure sensing tubes and configured to communicate gas pressure between the flow sensor and a pressure flowmeter, and a filter integrated with the flow sensor between the first connector and the pressure sensing ports and configured to communicate gas pressure therethrough while preventing contaminants from passing from the flow sensor to the pressure sensing tubes.11-12-2015

Patent applications by Michael Brian Jaffe, Cheshire, CT US

Michael Brian Jaffe, Chesire, CT US

Patent application numberDescriptionPublished
20120215125SYSTEM AND METHOD OF MONITORING BREATHING - Sidestream sampling of gas to determine information related to the composition of gas at or near the airway of a subject is implemented. From such information one or more breathing parameters of subject 08-23-2012

Mike Jaffe, Cincinnati, OH US

Patent application numberDescriptionPublished
20130195784WATER DISPERSIBLE SOLID DISPERSION OF PIGMENT - A solid dispersion of pigment for an aqueous composition includes a pigment and an ethoxylated alcohol. The solid dispersion of pigment is adapted for being directly incorporated into the aqueous composition with reduced shear for coloration. A method of preparing a solid dispersion of pigment for an aqueous composition with reduced shear mixing includes heating the mixture of an ethoxylated alcohol and a pigment, and cooling the mixture to obtain the solid dispersion of pigment.08-01-2013

Mike Jaffe, East Hartford, CT US

Patent application numberDescriptionPublished
20090306579DELIVERY OF CORTICOSTEROIDS THROUGH IONTOPHORESIS - Disclosed herein are formulations of dexamethasone or a prodrug thereof suitable for delivery by ocular iontophoresis and methods of use thereof.12-10-2009
20120283231Delivery Of Corticosteroids Through Iontophoresis - Disclosed herein are formulations of dexamethasone or a prodrug thereof suitable for delivery by ocular iontophoresis and methods of use thereof.11-08-2012
20140046242DELIVERY OF CORTICOSTEROIDS THROUGH IONTOPHORESIS - Disclosed herein are formulations of dexamethasone or a prodrug thereof suitable for delivery by ocular iontophoresis and methods of use thereof.02-13-2014

Patent applications by Mike Jaffe, East Hartford, CT US

Miriam Jaffe, Columbia, MD US

Patent application numberDescriptionPublished
20090100499Database System and Method for Encryption and Protection of Confidential Information - A database system for encryption and protection of confidential data is provided. The database system includes a data source system receiving confidential data and first associated data. A secure data network interface system is connected to the data source system over an open network, the data network interface system receives the confidential data and the first associated data from the data source system and further comprises a secure data storage system coupled to the data network interface system and isolated from the open network, a data encryption system generating a unique encrypted identifier for the confidential data, and a data association system associating the confidential data with the unique encrypted identifier and storing the confidential data, the first associated data and the unique encrypted identifier in the secure data storage system.04-16-2009
20110314277ELECTRONIC AUTHORIZATION SYSTEM AND METHOD - An electronic authorization system comprising a data source system configured to transmit transaction data. A secure data system is coupled to the data source system over an open network, the secure data system is configured to receive the transaction data from the data source system, generate a unique encrypted identifier for the transaction data and to transmit the unique encrypted identifier to the data source system. The data source system is configured to receive the unique encrypted identifier and replace payment card data associated with the transaction data in a database with the unique encrypted identifier.12-22-2011
20130232077ELECTRONIC AUTHORIZATION SYSTEM AND METHOD - An electronic authorization system comprising a data source system configured to transmit transaction data. A secure data system is coupled to the data source system over an open network, the secure data system is configured to receive the transaction data from the data source system, generate a unique encrypted identifier for the transaction data and to transmit the unique encrypted identifier to the data source system. The data source system is configured to receive the unique encrypted identifier and replace payment card data associated with the transaction data in a database with the unique encrypted identifier.09-05-2013
20140249940ELECTRONIC AUTHORIZATION SYSTEM AND METHOD - An electronic authorization system comprising a data source system configured to transmit transaction data. A secure data system is coupled to the data source system over an open network, the secure data system is configured to receive the transaction data from the data source system, generate a unique encrypted identifier for the transaction data and to transmit the unique encrypted identifier to the data source system. The data source system is configured to receive the unique encrypted identifier and replace payment card data associated with the transaction data in a database with the unique encrypted identifier.09-04-2014

Patent applications by Miriam Jaffe, Columbia, MD US

Paul I. Jaffe, Springfield, VA US

Patent application numberDescriptionPublished
20130099599Thermally Efficient Power Conversion Modules for Space Solar Power - A space solar power system that has sun-tracking curved reflectors, such as off-axis parabolic reflectors, a secondary reflector, and a power conversion module for converting the sunlight into microwave energy and transmit the energy to remote locations. The power conversion module can have a modular stepped conical shape, with additional radiator area configured in vertical sidewalls, horizontal radiator panels, or both. Hinged, fold-out units can house the microwave conversion electronics and the antenna for transmitting the microwave radiation to the remote ground station.04-25-2013

Peter Jaffe, Princeton, NJ US

Patent application numberDescriptionPublished
20150306595Nanoparticulate Apatite Coated Calcite/Limestone Filter Materials for Removing Contaminants from Contaminated Water - The invention provides hydroxyapatite-coated carbonate mineral particulate filter materials, and a novel synthesis process. The filter materials are particularly effective in removing fluoride contaminants from contaminated water and may render the treated water ingestible. Also disclosed are articles containing the hydroxyapatite-coated carbonate mineral particulate filter materials.10-29-2015

Peter R. Jaffe, Princeton, NJ US

Patent application numberDescriptionPublished
20150321933METHODS AND COMPOSITIONS FOR NITROGEN REMOVAL USING FEAMMOX MICROORGANISMS - Processes and compositions for removal nitrogen, organic and inorganic contaminants from wastewater using Feammox bacterium are provided.11-12-2015

Peter S. Jaffe, Philadelphia, PA US

Patent application numberDescriptionPublished
20080264938CONTAINER HAVING SLIDING CORNER SUPPORT - A container having multiple wall panels forming container sides, the container having at least first and second wall panels that meet at a first corner. The container is assembleable from a flat or knockdown state to an opened or assembled state. A first inner panel is attached to a first wall panel, the first inner panel having an end spaced from the first corner. A slidable corner support is attached to the end of the first inner panel and extends towards the second wall panel. When the container is assembled from the knockdown state, the slidable corner support moves away from the first corner to form a support member that can help support a container stacked on top and prevent nesting.10-30-2008

Russell Jaffe, Vienna, VA US

Patent application numberDescriptionPublished
20110183034ENHANCEMENT OF MAGENESIUM UPTAKE IN MAMMALS - Disclosed are methods and complexes for increasing magnesium uptake in mammals. Increasing magnesium uptake in mammals is accomplished by concurrently administering one or more magnesium salts with one or more quaternary amines and/or phosphatides and one or more di- or tri-carboxylic acids.07-28-2011
20130022673ENHANCEMENT OF MAGNESIUM UPTAKE IN MAMMALS - Disclosed are methods and complexes for increasing magnesium uptake in mammals. Increasing magnesium uptake in mammals is accomplished by concurrently administering one or more magnesium salts with one or more quaternary amines and/or phosphatides and one or more di- or tri-carboxylic acids, in a one part dosage system or a multi-part dosage system. Increasing magnesium uptake in mammals may also be accomplished by concurrently administering one or more magnesium salts with an organic acid.01-24-2013
20160022594SOFT GEL ENCAPSULATION - A stable soft gel dosage form for micronized magnesium complexes is provided wherein soft gel capsules containing various magnesium complexes can be stored for prolonged periods under typical home storage conditions with better than 98% or 99% ASA integrity and with negligible physical or chemical deterioration of the soft gelatin capsule over an extended period of time. The stable soft gel capsule is sealed at a selected temperature forming a seam in which the gelatin promotes cross-linking across the heat seam. This method of sealing the soft gel provides for a better seal that cures the weeping problem that can result from the prior methods of heat sealing soft gel capsules.01-28-2016

Patent applications by Russell Jaffe, Vienna, VA US

Russell M. Jaffe, Sterling, VA US

Patent application numberDescriptionPublished
20100003351COMPOSITIONS COMPRISING RHODIOLA ROSEA AND METHODS OF USE THEREOF - The present invention relates to compositions and kits comprising an extract of 01-07-2010

Sam Jaffe, Pepper Pike, OH US

Patent application numberDescriptionPublished
20140059416SEGMENTING FORMS FOR MULTIPLE USER COMPLETION - The claimed subject matter provides a system and/or a method that facilitates completing multiple electronic document applications. An interface component can receive two or more electronic documents, wherein each electronic document includes at least two or more questions with respective fill-in fields to be completed by a user input. A master field component can create a master field list that includes a first subset of questions and a second subset of questions and the first subset of questions is targeted toward a first user to answer and the second subset of questions are targeted toward second user to answer. A user segregation manager component can ensure an independent and secure log in to the master field list for each user to provide information. A form aggregation component can leverage the master field list to populate or update the electronic document.02-27-2014

Sam Jaffe, Cookesville, TN US

Patent application numberDescriptionPublished
20100163483FOOD PROCESSING RESOURCE RECOVERY - A method of hydrolyzing peptide bonds in waste material from dissolved air flotation (DAF float) wastewater treatment systems is disclosed. The method according to the disclosure comprises controlling the pH of said DAF float; adding a lytic agent to said pH controlled DAF float; and incubating the lytic agent/DAF float mixture. The hydrolyzed peptide bonds allow for the cleaving of oil molecules from protein material thereby increasing oil extraction from wastewater streams.07-01-2010

Sam M. Jaffe, Cookeville, TN US

Patent application numberDescriptionPublished
20080226782PATHOGEN REDUCTION USING CHLORAMINES - A method and apparatus for implementing pathogen reduction within a poultry processing or food processing plant that uses water that has been treated with chloramines at an advantageous dosage before being introduced to the production process at processing steps. The water treated with chloramines may be from a fresh water source or reclaimed water from the processing plant. The reintroduction of the treated reclaimed water advantageously causes a dramatic reduction in the levels of microorganisms associated with poultry processing, while substantially conserving water use.09-18-2008
20090173697METHOD AND APPARATUS FOR THE PRODUCTION AND DELIVERY OF MONOCHLORAMINE INTO WATER STREAMS - Monochloramine is efficiently manufactured by introducing controlled quantities of an ammonia source and a chlorine source in a small side-stream of water in a small diameter pipe under turbulent flow conditions. The ammonia source and chlorine source can be injected in either order and are separated by a sufficient distance to ensure that the first chemical is adequately diffused throughout the water prior to the injection of the second chemical. A sufficient length of a mixing chamber insures that turbulent flow is maintained for a length of time sufficient to thoroughly mix the two chemicals to produce monochloramine. This mixing technique allows for the manufacture of high concentrations of monochloramine at atmospheric pressure without off gassing.07-09-2009

Patent applications by Sam M. Jaffe, Cookeville, TN US

Stephen B. Jaffe, Moorestown, NJ US

Patent application numberDescriptionPublished
20090105966Estimating detailed compositional information from limited analytical data - A method for determining the composition of a material including the steps of fitting multivariate analytical data of the material to a combination of multivariate analytical data in a database to determine coefficients of the combination so as to determine a reference model of composition based on the coefficients and the compositions in the database, wherein the database includes multivariate analytical data of database materials whose compositions are known, and reconciling the reference model of composition to match properties of the material.04-23-2009

Stephen E. Jaffe, Alpharetta, GA US

Patent application numberDescriptionPublished
20090063693SYSTEM AND METHOD FOR ACTIVE TRANSCODING OF CONTENT IN A DISTRIBUTED SYSTEM - A system and method for streaming media and, more particularly, to a system and method for active transcoding of content in a distributed system. The method includes receiving a file having predetermined parameters and sizing the file up to an optimal packet size according to a logarithmic scheme. The optimal packet size is a largest packet size. In further aspects, the method also includes providing a computer infrastructure operable to perform the steps herein. The system includes a media service, rules engine, log based job creator and a stream constructor. A computer infrastructure having computer readable medium to perform the processes described herein is also provided.03-05-2009

Stephen E. Jaffe, Canton, GA US

Patent application numberDescriptionPublished
20080222253SYSTEM AND METHOD OF CREATING AND RATING ITEMS FOR SOCIAL INTERACTIONS - A system and method for providing items to users and, more particularly, a system and method for rating items and placing such items into a queued list. The method includes providing an item from a web browser to a recipient on a preferred list and placing the item into a queued list with respect to other items based on a rating. The system includes a computer infrastructure being operable to provide a rated item from a web browser to a recipient on a preferred list and place the rated item in a queued list with respect to other items.09-11-2008
20090202115MINUTIAE MASK - A system and method of authenticating fingerprints. A method of authenticating a fingerprint includes comparing a geometric shape of a scanned fingerprint to a corresponding geometric shape of a stored fingerprint. The geometric shape and the corresponding geometric shape are defined by vertices. The vertices are defined by minutiae points, while the vertices are spaced apart from the minutiae points.08-13-2009
20090204617CONTENT ACQUISITION SYSTEM AND METHOD OF IMPLEMENTATION - A system is provided which solves content acquisition issues by providing an automated method to acquire content in mass and maintain an association between available meta-data and the actual content, e.g., video file. The system includes a first component configured to log network traffic. The system also includes a second component configured to correlate downloaded content of the logged network traffic with an XML stream of URLs and respective content descriptions.08-13-2009
20100112990SYSTEM AND METHODS FOR LOCATION BASED ROUTING AND ADVERTISING FOR STREAMED MEDIA AND MEDIA BLOCKING - A location based service configured to route local advertising for streamed media and media blocking based on a location of the recipient. The method include detecting a location of a mobile user and routing streaming media of a local affiliate to a mobile device of the mobile user based on the detected location of the mobile user.05-06-2010
20100211300SYSTEM AND METHODS FOR GEOBOUNDARY BASED TRAFFIC MONITORING USING QUICK TEAR DOWN BOUNDARIES - A location based service and method configured to provide a mechanism for delivering traffic information to a subscribing user. The method is implemented on a computing infrastructure and includes setting up geo-boundaries at one or more predefined intervals. The method further includes receiving a signal from an active mobile device as it passes at least two of the geo-boundaries at the one or more predefined intervals, and determining a traffic incident from the received signal.08-19-2010
20100306074SYSTEM AND METHOD TO SUPPORT CODEC DELIVERY MODELS FOR IMS NETWORKS - An architecture (system) and method is provided for transcoding codec information to be sent in a Session Initiation Protocol (SIP) signaling stream for rendering rich digital media content. The method is implemented on a computer infrastructure and includes: determining a codec associated with content to be sent to one or more requesting devices; determining that at least one of the one or more requesting devices do not have the codec associated with the content to be sent to the one or more requesting devices; providing codec information to the at least one of the one or more requesting devices; and sending the content to the one or more requesting devices.12-02-2010
20120226674SYSTEM AND METHOD TO SUPPORT CODEC DELIVERY MODELS FOR IMS NETWORKS - An architecture (system) and method is provided for transcoding codec information to be sent in a Session Initiation Protocol (SIP) signaling stream for rendering rich digital media content. The method is implemented on a computer infrastructure and includes: determining a codec associated with content to be sent to one or more requesting devices; determining that at least one of the one or more requesting devices do not have the codec associated with the content to be sent to the one or more requesting devices; providing codec information to the at least one of the one or more requesting devices; and sending the content to the one or more requesting devices.09-06-2012
20120239447APPARATUS AND METHOD FOR TRANSPORTATION AND UPSELLING OF PRODUCT - A system and method for using product profiling to maximize load capacity of a vehicle. The method includes defining product profiles and retrieving product information associated with the product profiles. The method further includes performing cubing operations for products associated with the product information. The system includes components to perform the method steps.09-20-2012
20120239448APPARATUS AND METHOD FOR TRANSPORTATION AND UPSELLING OF PRODUCT - A system and method for using product profiling to maximize load capacity of a vehicle. The method includes defining product profiles and retrieving product information associated with the product profiles. The method further includes performing cubing operations for products associated with the product information. The system includes components to perform the method steps.09-20-2012
20120239460APPARATUS AND METHOD FOR TRANSPORTATION AND UPSELLING OF PRODUCT - A system and method for using product profiling to maximize load capacity of a vehicle. The method includes defining product profiles and retrieving product information associated with the product profiles. The method further includes performing cubing operations for products associated with the product information. The system includes components to perform the method steps.09-20-2012
20120246571SYSTEM AND METHOD OF CREATING AND RATING ITEMS FOR SOCIAL INTERACTIONS - A system and method for providing items to users and, more particularly, a system and method for rating items and placing such items into a queued list. The method includes providing an item from a web browser to a recipient on a preferred list and placing the item into a queued list with respect to other items based on a rating. The system includes a computer infrastructure being operable to provide a rated item from a web browser to a recipient on a preferred list and place the rated item in a queued list with respect to other items.09-27-2012
20120297021SYSTEM AND METHOD TO SUPPORT CODEC DELIVERY MODELS FOR IMS NETWORKS - An architecture (system) and method is provided for transcoding codec information to be sent in a Session Initiation Protocol (SIP) signaling stream for rendering rich digital media content. The method is implemented on a computer infrastructure and includes: determining a codec associated with content to be sent to one or more requesting devices; determining that at least one of the one or more requesting devices do not have the codec associated with the content to be sent to the one or more requesting devices; providing codec information to the at least one of the one or more requesting devices; and sending the content to the one or more requesting devices.11-22-2012
20130297701SYSTEM AND METHOD OF CREATING AND RATING ITEMS FOR SOCIAL INTERACTIONS - A system and method for providing items to users and, more particularly, a system and method for rating items and placing such items into a queued list. The method includes providing an item from a web browser to a recipient on a preferred list and placing the item into a queued list with respect to other items based on a rating. The system includes a computer infrastructure being operable to provide a rated item from a web browser to a recipient on a preferred list and place the rated item in a queued list with respect to other items.11-07-2013
20140019376APPARATUS AND METHOD FOR TRANSPORTATION AND UPSELLING OF PRODUCT - A system and method for using product profiling to maximize load capacity of a vehicle. The method includes defining product profiles and retrieving product information associated with the product profiles. The method further includes performing cubing operations for products associated with the product information. The system includes components to perform the method steps.01-16-2014
20140222970SYSTEM AND METHOD FOR ACTIVE TRANSCODING OF CONTENT IN A DISTRIBUTED SYSTEM - A system and method for streaming media and, more particularly, to a system and method for active transcoding of content in a distributed system. The method includes receiving a file having predetermined parameters and sizing the file up to an optimal packet size according to a logarithmic scheme. The optimal packet size is a largest packet size. In further aspects, the method also includes providing a computer infrastructure operable to perform the steps herein. The system includes a media service, rules engine, log based job creator and a stream constructor. A computer infrastructure having computer readable medium to perform the processes described herein is also provided.08-07-2014

Patent applications by Stephen E. Jaffe, Canton, GA US

Steven M. Jaffe, Beaverton, OR US

Patent application numberDescriptionPublished
20130234047SYSTEM AND METHOD FOR CONTROLLED INTENSITY ILLUMINATION IN A BIOANALYSIS OR OTHER SYSTEM - A system and method for controlled illumination in a bioanalysis or other system where excitation of fluorescent molecules is desirable. In an embodiment, an illumination system is described which can provide excitation light at a controlled intensity to provide quantitative results. In an embodiment, a solid state light engine is described which includes a plurality of color channels each providing light output suitable for exciting a fluorescent molecule, a light to frequency converter which receives a portion of the light output, a counter which maintains a count of a signal from the light to frequency converter, and a light intensity circuit, responsive to the counter, which adjusts the color channels to control the intensity of the light output.09-12-2013

Steven M. Jaffe, Portland, OR US

Patent application numberDescriptionPublished
20100187440LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.07-29-2010
20110044858BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM - The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.02-24-2011
20120168643LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.07-05-2012
20120181936SYSTEM AND METHOD FOR METERED DOSAGE ILLUMINATION IN A BIOANALYSIS OR OTHER SYSTEM - A system and method for metered dosage illumination in a bioanalysis or other system. In accordance with an embodiment, an illumination system or subsystem is described that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can also be precisely controlled to generate only a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. Although the examples herein illustrate the providing of metered dosage illumination in the context of a bioanalysis system, the techniques can be similarly used to provide metered dosage illumination in the context of other types of system.07-19-2012
20120181937SYSTEM AND METHOD FOR METERED DOSAGE ILLUMINATION IN A BIOANALYSIS OR OTHER SYSTEM - A system and method for metered dosage illumination in a bioanalysis or other system includes an illumination system or subsystem that can provide optimized amounts of excitation light within the short exposure times necessary to measure fast biological activity. The amount of light can be precisely measured to provide quantitative results. The light flux can be precisely controlled to generate a prescribed minimum amount of light, in order to reduce adverse lighting effects on both fluors and samples. The system and method is particularly useful in any quality-control, analysis, or assessment-based environment. Typical research and development applications can include quality control, instrument calibration, and light output standardization; while clinical and diagnostics applications can include clinical monitoring, bioassay calibration and control for diagnostics, treatment and or therapeutic evaluation.07-19-2012
20120235061LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.09-20-2012
20120236585LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.09-20-2012
20120238472BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM - The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.09-20-2012
20120252704BIOANALYTICAL INSTRUMENTATION USING A LIGHT SOURCE SUBSYSTEM - The invention relates to a light source for irradiating molecules present in a detection volume with one or more selected wavelengths of light and directing the fluorescence, absorbance, transmittance, scattering onto one or more detectors. Molecular interactions with the light allow for the identification and quantitation of participating chemical moieties in reactions utilizing physical or chemical tags, most typically fluorescent and chromophore labels. The invention can also use the light source to separately and simultaneously irradiate a plurality of capillaries or other flow confining structures with one or more selected wavelengths of light and separately and simultaneously detect fluorescence produced within the capillaries or other flow confining structures. In various embodiments, the flow confining structures can allow separation or transportation of molecules and include capillary, micro bore and milli bore flow systems. The capillaries are used to separate molecules that are chemically tagged with appropriate fluorescent or chromophore groups.10-04-2012
20130099135LIGHTING DESIGN OF HIGH QUALITY BIOMEDICAL DEVICES - The invention relates to a plurality of light sources to power a variety of applications including microarray readers, microplate scanners, microfluidic analyzers, sensors, sequencers, Q-PCR and a host of other bioanalytical tools that drive today's commercial, academic and clinical biotech labs.04-25-2013
20130188331SOLID STATE CONTINUOUS WHITE LIGHT SOURCE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output.07-25-2013
20130188383SOLID STATE CONTINUOUS WHITE LIGHT SOURCE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.07-25-2013
20130188384SOLID STATE CONTINUOUS WHITE LIGHT SOURCE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.07-25-2013
20130188388SOLID STATE CONTINUOUS WHITE LIGHT SOURCE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. The white light output is continuous in the visible spectrum from 380 nm to 650 nm and is suitable for imaging all the most common fluorophores and fluorescent proteins. In embodiments, an LED light pipe engine is used to generate a portion of the spectral content of the white light output. In alternative embodiments the solid state illumination system produces light output of a selectable color.07-25-2013
20130242595SOLID STATE LIGHT SOURCE WITH HYBRID OPTICAL AND ELECTRICAL INTENSITY CONTROL - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon light sources for applications in microscopy, fluorescence microscopy, and endoscopy. The illumination system includes hybrid optical and electrical control of output intensity in which the light output of one or more of the light sources is attenuated optically such that it is not necessary to reduce the electrical drive power/current of the LEDs at a level where the spectral power distribution is variable. One or more fixed, selectable, or variable neutral density filters is interposed in the output beam of one or more sources to achieve optical attenuation of the light output. The hybrid optical and electrical control of output intensity allows greater dynamic range of intensity to be achieved than could be achieved with electrical control of the LEDs alone while maintaining the desired spectral power distribution.09-19-2013
20130335992SOLID STATE LIGHT SOURCE FOR PHOTOCURING - A compact passively-cooled solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for photocuring applications. The solid state illumination system utilizes LED modules to generate high intensity light output suitable for photocuring. The light output is continuous in the visible spectrum from 380 nm to 530 nm and is suitable for photocuring using a wide range of photoinitiators. A touchscreen interface allows programming of spectral output, intensity and duration. Output can be initiated using the touchscreen interface and/or a foot pedal.12-19-2013
20140192405ADJUSTABLE COLLIMATOR FOR COUPLING A LIGHT GUIDE TO A MICROSCOPE - A solid state illumination system is provided as a replacement for conventional arc light, metal halide and Xenon white-light sources for applications in life sciences including, microscopy, fluorescence microscopy, and endoscopy. The solid state illumination system generates high quality white light output from LED light sources. In an embodiment, the solid state illumination system is coupled to a microscope using a liquid light guide. The liquid light guide is coupled to a microscope using an adjustable collimator which optimizes the light output for input to the optical train of the microscope.07-10-2014
20160123886INTEGRATED FLUORESCENCE SCANNING SYSTEM - An integrated fluorescence scanning system is provided. The integrated fluorescence scanner combines an embedded computer, light engine, microscope, and motion stage into a compact rack-mountable network appliance that allows for automation of fluorescence microscopy. In an embodiment, the integrated fluorescence scanner includes a solid-state light engine which can provide intense, pure, and stable light across the spectrum required for imaging of all fluorophores of interest. The embedded computer allows for autonomous operation, and network appliance features including synchronous multi-scanner operation and monitoring, multisite operation via a single control terminal, and calibration for inter and intra instrument consistency.05-05-2016

Patent applications by Steven M. Jaffe, Portland, OR US

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