Jacob Jan
Jacob Jan Briedé, Bunde NL
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20120077704 | METHOD FOR SCREENING COMPOUNDS FOR THE TREATMENT OR PREVENTION OF COLON CANCER - The invention is in the field of molecular medicine, more in particular in the field of identifying new compounds for the treatment or prevention of colorectal cancer. The invention provides a method for the screening and/or identification of compounds that are capable of preventing or ameliorating the adverse effects of reactive oxygen species on eukaryotic cells. More in particular, the invention provides a method for the identification of an active therapeutic compound for preventing or ameliorating the adverse effects of reactive oxygen species on eukaryotic cells comprising the steps of: providing an assay wherein the expression of the WNT pathway in Caco cells can be determined under the influence of a reactive oxygen species, providing a candidate therapeutic compound, determining the ability of said therapeutic compound to normalize the expression of said WNT pathway in the presence or absence of said oxidant. | 03-29-2012 |
Jacob Jan Kriekaard, Soest NL
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20090167569 | METHOD AND APPARATUS FOR INDICATING DIRECTION USING A SCREEN, AND VEHICLE EQUIPPED THEREWITH - The invention relates to a method for indicating direction using a screen, wherein a pattern of relatively dark and relatively bright sections is moved over a screen, in a direction in which an observer is to be directed. The invention further relates to an apparatus for indicating information on a screen, comprising at least one screen and image information-generating means, wherein the image information-generating means comprise at least one algorithm for displaying, on said screen, at least one first image in the form of a moving pattern of first and second sections, wherein the first sections are relatively bright compared to the second sections, wherein the screen has longitudinal edges and said image information-generating means are preferably arranged for at least temporarily moving said pattern in the direction of at least one of the longitudinal edges. | 07-02-2009 |
Jacob Jan Van Craaikamp, Oostzaan NL
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20120196519 | METHOD AND PROCESSING LINE FOR PROCESSING POULTRY - Method and processing line for stunning and/or killing of poultry, comprising a plurality of treatment stations to execute the stunning and/or killing of poultry contained in containers or crates, a feed-line for supplying the poultry in containers or crates to the plurality of treatment stations, and an exit line to transport the stunned and/or killed poultry contained in the containers or crates away from the treatment stations, wherein a shuttle unit is provided that is movable on the one part to and from the plurality of treatment stations and on the other part to and from the feedline and the exit line. | 08-02-2012 |
Jacob Jan Van Nielen, Heemstede NL
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20120216736 | Disconnectable mooring system and method for disconnecting or reconnecting it - A disconnectable mooring system for a vessel is presented, comprising a moonpool in the vessel, a turret structure mounted for a rotation in said moonpool and a buoy member having a plurality of passages each adapted to receive a riser. The turret structure has a lower end comprising a buoy receptacle for detachably receiving the buoy member, wherein the mooring system further comprises a plurality of mooring lines for transmitting mooring forces and each have a lower end and an upper end connected to the seabed and the buoy member, respectively. The mooring lines each comprise a first section which in a disconnectable manner is connected to the turret structure and a second section connected to the first section at a coupling point and connected to the buoy member. Also methods for disconnecting and reconnecting such a mooring system are presented. | 08-30-2012 |
Jacob Jan Zwaginga, Naarden NL
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20090297541 | MATURATION OF DENDRITIC CELLS - The invention relates to immunotherapy using dendritic cells (DCs). More specifically, it relates to methods for the maturation of DCs, a mature DC population and clinical uses thereof. Provided is a method for the ex vivo maturation of DCs, comprising providing immature DCs and contacting the immature DCs with an effective concentration of a non-toxic TLR4 agonist, such as Monophosphoryl lipid A (MPLA) or Diphosphoryl lipid A (DPLA), and an interferon gamma (IFNg) receptor agonist, under culture conditions suitable for maturation of the immature DCs to form a mature DC population. Also provided is an isolated population of mature DCs, preferably human mature DCs, and the use thereof in immunotherapy. | 12-03-2009 |