Patent application number | Description | Published |
20090186395 | Virus Removal by Nanofiltration - A method for purifying a protein solution from infective particles comprising (a) adding a macromolecule to the solution; and (b) passing the solution through a nanofilter. The macromolecule may be selected from a polymer of at least 3 monomers of sugars, amino acids, glycols, alcohols, lipids or phospholipids. | 07-23-2009 |
20100076464 | Implantable Device Comprising a Substrate Pre-Coated with Stabilized Fibrin - The invention relates to a prosthetic for repairing an opening or a defect in a soft tissue, to its preparation and use. The prosthetic of the invention comprises a substrate viscerally-coated with stabilized and non-completely dry fibrin. The prosthetic displays reduced postoperative complications following its implantation. | 03-25-2010 |
20100203033 | Kits, formulations and solutions having enzymatically- permissive amounts of visualization agents and uses thereof - The invention relates to a proteolytic enzyme which is capable of forming fibrin when it reacts with fibrinogen, a fibrin-glue kit and a fibrin-glue formulation comprising an enzymatically-permissive concentration of a visualization agent and to their use in methods for prevention and/or reduction of adhesions and/or methods for promotion of blood coagulation sealing or filling body surfaces. | 08-12-2010 |
20100217231 | Device for administering an at least two-component substance - The device for administering an at least two-component substance comprises a concentric lumen arrangement including (i) an inner cannula having a lumen with an inlet opening at a first end and a tip with an outlet opening at a second end opposite its first end, and (ii) an outer sheath having opposite first and second ends facing the respective first and second ends of the inner cannula, and surrounding the inner cannula along an axial length between the first and second ends of the inner cannula, wherein the outer sheath at its second end is sealingly and fixedly connected to the inner cannula and defining an outer lumen around the inner cannula, and wherein the inner cannula is provided with at least one opening for providing fluid communication between the outer lumen around the inner cannula and the lumen of the inner cannula. | 08-26-2010 |
20100310524 | Compositions Suitable for Treatment of Spinal Disease, Disorder or Condition - The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronectin/fibrinogen ratio for treating a spine disease, disorder or condition such as intervertebral disc degeneration. | 12-09-2010 |
20110182991 | METHOD FOR IMPROVED FIBRIN SEALING - The present invention relates to a fibrin matrix, its preparation and use for effectively sealing a defect in a mucosa or other moist tissue. | 07-28-2011 |
20110238009 | DEVICES FOR INJECTING A SUBSTANCE AND METHODS THEREFOR - A device for administering injections includes a housing having an upper end, a lower end including a bottom surface with an injection needle opening, and an axis extending between the upper and lower ends. The device includes an injection needle disposed within the housing for moving between a retracted position and an extended position. | 09-29-2011 |
20120039855 | FIBRIN BASED SCAFFOLD, PREPARATION AND USE THEREOF - The invention relates to a fibrin-based scaffold suitable for supporting a population of cells comprising mesenchymal stem cells (MSC) and/or umbilical tissue derived cells (UTC) at the site of administration for a prolonged period of time. The scaffold is capable of supporting at least 1×10 | 02-16-2012 |
20120043347 | DEVICE, SYSTEM AND METHOD FOR DISPENSING A FIXED DOSE OF FLUID - The invention relates to a device for dispensing a fixed dose of fluid, the device comprising at least one barrel; at least one plunger at least partially enclosed within the barrel; a motion conversion mechanism for transferring actuated pressure force applied outside the barrel into movement of the at least one plunger in a dispensing direction, wherein the motion conversion mechanism comprises at least one rotating gear; and a releasing mechanism for disconnecting the plunger from the motion conversion mechanism, wherein at a released position the at least one plunger can move in a direction opposite to the dispensing direction, independent of a rotational movement of the at least one gear, and wherein the movement of the plunger in the opposite direction to the dispensing enables loading the fluid into the barrel. | 02-23-2012 |
20120149030 | IMMUNOASSAY FOR THROMBIN DETECTION - The invention relates to an in vitro immunoassay for quantifying thrombin in a sample comprising anti-thrombin III (AT-III) and thrombin. The method comprises the following steps: contacting the sample with a small molecule that recognizes the substrate binding site of thrombin; contacting the thrombin with a thrombin specific antibody raised against a thrombin blocked in the active site; and measuring the level of bound antibody. | 06-14-2012 |
20120156306 | VIRAL INACTIVATED PLATELET EXTRACT, USE AND PREPARATION THEREOF - The invention relates to a viral-safe platelet extract, to its preparation and use. The extract comprises a mixture of biologically active platelet derived factors. | 06-21-2012 |
20120160721 | STAPLE CARTRIDGE LOADING ASSEMBLY - A fastener cartridge can comprise a support portion, a tissue thickness compensator positioned relative to the support portion, and a plurality of fasteners positioned within the support portion and/or the tissue thickness compensator which can be utilized to fasten tissue. In use, the fastener cartridge can be positioned in a first jaw of a surgical fastening device, wherein a second jaw, or anvil, can be positioned opposite the first jaw. To deploy the fasteners, a staple-deploying member is advanced through the fastener cartridge to move the fasteners toward the anvil. As the fasteners are deployed, the fasteners can capture at least a portion of the tissue thickness compensator therein along with at least a portion of the tissue being fastened. | 06-28-2012 |
20120213743 | TREATMENT OF PERIPHERAL VASCULAR DISEASE USING UMBILICAL CORD TISSUE-DERIVED CELLS - Compositions and methods of using cells derived from umbilical cord tissue, to stimulate and support angiogenesis, to improve blood flow, to regenerate, repair, and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients are disclosed. In particular, methods of treating a patient having a peripheral vascular disease with umbilical derived cells and fibrin glue are disclosed. | 08-23-2012 |
20120294847 | IMMUNOGLOBULIN REDUCED IN THROMBOGENIC AGENTS AND PREPARATION THEREOF - The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2. | 11-22-2012 |
20130005947 | METHOD FOR REMOVING A LYTIC ENZYME FROM A HETEROGENEOUS MIXTURE - The invention relates to purification of an intact, non-degraded macromolecule from a biological mixture comprising the macromolecule in the presence of its lytic enzyme. The method comprises providing the biological mixture as a heterogeneous mixture comprising the lytic enzyme, at least partially, in soluble form and the macromolecule, at least partially, in non-soluble form; batch-wise contacting the heterogeneous mixture with an immobilized inhibitor of the lytic enzyme; increasing the solubility of the macromolecule in the mixture; and removing the immobilized inhibitor from the mixture. | 01-03-2013 |
20130068816 | SURGICAL INSTRUMENT AND BUTTRESS MATERIAL - An apparatus including a surgical instrument may be used to sever and staple a portion of tissue. In some versions, the apparatus comprises a retainer cap. The retainer cap is in communication with the surgical instrument. The apparatus also comprises buttress material operable to couple with a portion of the surgical instrument. In some versions, the buttress material may comprise a plurality of tabs or other similar structures for coupling the buttress material to the surgical instrument. In some versions, a cutter may be operable to decouple the buttress material from the surgical instrument. | 03-21-2013 |
20130068820 | FIBRIN PAD MATRIX WITH SUSPENDED HEAT ACTIVATED BEADS OF ADHESIVE - A surgical instrument includes a handle portion, a shaft housing a firing bar, an end effector comprising an anvil, a lower jaw, and a stapling and severing assembly responsive to a longitudinal closing motion produced by the handle portion and the shaft. The lower jaw is configured to receive a cartridge when in an open position. The cartridge includes a housing, a plurality of staples disposed in the housing, and a deck disposed over the plurality of staples. The deck defines apertures, with each aperture being substantially disposed over each staple. The cartridge further receives a matrix including glue beads suspended in the matrix. The staples are driven through the matrix to secure the matrix to tissue. The glue beads are activated when the matrix is secured to the tissue, such that the activated adhesive further secures the staple line in the tissue. | 03-21-2013 |
20130082086 | ATTACHMENT OF SURGICAL STAPLE BUTTRESS TO CARTRIDGE - A surgical instrument includes an end effector and a staple cartridge that is insertable into the end effector. The staple cartridge includes a buttress material that is selectively coupled to the staple cartridge. In some versions the buttress material may be stapled to the staple cartridge by one or more attachment staples. Such attachment staples may be inserted into staple apertures formed through an upper deck of the staple cartridge. The attachment staples may include resiliently biased legs to frictionally resist removal. In some versions the attachment staples may be sized to form an interference fit in the staple apertures. Alternatively, the attachment staples may include barbs. A staple driver may be used to decouple the attachment staples. The staple driver may include staple forming pockets to bend the legs of the attachment staple when decoupling the attachment staple. | 04-04-2013 |
20130312868 | Method and Device for Fast Dissolution of Solid Protein Composition - Provided are methods and devices for dissolving solid protein compositions, such as solid compositions comprising fibrinogen, in an aqueous solvent. The methods comprise use of a closed container containing a volume of solid fibrinogen composition and a head space wherein the pressure within the headspace is sub-atmospheric. Aqueous solvent is introduced into the container while maintain the sub-atmospheric pressure, and subsequent to addition of the solvent, the size of the headspace is decreased to bring the pressure to atmospheric pressure. The devices are suitable for use in the disclosed method. | 11-28-2013 |
20140120151 | Gelatin Sponge Comprising an Active Ingredient, Its Preparation and Use - The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof. | 05-01-2014 |
20140154773 | THROMBIN SOLUTION AND METHODS OF USE THEREOF - Provided are methods for lyophilization of an aqueous thrombin solution, thrombin solutions for use in such lyophilization methods, and solid thrombin compositions produced by such methods. | 06-05-2014 |
20140179602 | Viral Inactivated Biological Mixture - The invention relates to a viral inactivated biological liquid or dry mixture and to its preparation. Principally, the invention relates, but is not limited, to a mixture derived from a platelet source. | 06-26-2014 |
20150125440 | METHOD FOR IMPROVED FIBRIN SEALING - The present invention relates to a fibrin matrix, its preparation and use for effectively sealing a defect in a mucosa or other moist tissue. | 05-07-2015 |
20150174215 | ONE COMPONENT FIBRIN GLUE COMPRISING ZYMOGENS - Provided herein is a single component sealant formulation (e.g. in a liquid form), methods for its preparation, and use. The formulation includes fibrinogen; vitamin K-dependent clotting zymogens comprising at least Factor II (FII) and Factor X (FX). | 06-25-2015 |
20150174289 | ONE COMPONENT FIBRIN GLUE COMPRISING A POLYMERIZATION INHIBITOR - Provided herein are stable liquid sealant formulations comprising fibrin monomers and a reversible fibrin polymerization blocking agent, methods of preparing and using the formulations. | 06-25-2015 |
20150196596 | COMPOSITIONS SUITABLE FOR TREATMENT OF SPINAL DISEASE, DISORDER OR CONDITION - The invention relates to the use of viral inactivated-plasma cryoprecipitate concentrate (VIPCC) comprising a suitable fibronactin/fibrinogen ratio for treating a spine disease, disorder or condition such as intervertebral disc degeneration. | 07-16-2015 |
20150196680 | GELATIN SPONGE COMPRISING AN ACTIVE INGREDIENT, ITS PREPARATION AND USE - The present invention is directed to a method for manufacturing a cross-linked gelatin sponge having a surface by providing a cross-linked gelatin sponge, wetting the surface of the sponge by applying a sufficient amount of liquid comprising a protein or peptide active ingredient, wherein a sufficient amount of liquid is one that retains the flexibility of the sponge even after drying. The sponge is then dried the sponge to obtain a flexible, dry and ready to use cross linked gelatin sponge having a layer of protein or peptide active ingredient on the surface thereof | 07-16-2015 |
20150210754 | IMMUNOGLOBULIN REDUCED IN THROMBOGENIC AGENTS AND PREPARATION THEREOF - The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a pH in the range of higher than 3.8 to equal to or lower than 5.3. The solution can also be subjected to a negative anion exchanger chromatography at a pH in the range of 7 to 8.2. | 07-30-2015 |
20150238529 | PLASMA-SUPPLEMENTED FORMULATION - Provided herein is a plasma-supplemented fibrinogen and/or fibrin formulation, method for the preparation and use thereof. | 08-27-2015 |
20150241430 | IMMUNOASSAY FOR THROMBIN DETECTION - The invention relates to an in vitro immunoassay for quantifying thrombin in a sample comprising anti-thrombin III (AT-III) and thrombin. The method comprises the following steps: contacting the sample with a small molecule that recognizes the substrate binding site of thrombin; contacting the thrombin with a thrombin specific antibody raised against a thrombin blocked in the active site; and measuring the level of bound antibody. | 08-27-2015 |