Huang, MD
Alex Huang, Baltimore, MD US
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20090304596 | Methods for Predicting Psychotropic Drugs Which Elicit Weight Gain - The atypical antipsychotic drugs (AAPDs) have markedly enhanced the treatment of schizophrenias but their use has been hindered by the major weight gain elicited by some AAPDs. We found that orexigenic AAPDs potently and selectively activate hypothalamic AMP kinase (AMPK), an action abolished in mice with deletion of histamine H1 receptors. These findings afford a means of developing better therapeutic agents and provide insight into the hypothalamic regulation of food intake. | 12-10-2009 |
Austin B. Huang, N. Potomac, MD US
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20090304794 | CONTROLLED RELEASE FORMULATIONS OF PRAMIPEXOLE - A controlled release formulation of pramipexole for once-a-day administration to a mammalian subject, which formulation releases pramipexole along a pre-determined release profile, is provided. | 12-10-2009 |
20110244042 | STABILIZED FORMULATIONS OF CNS COMPOUNDS - Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone. | 10-06-2011 |
20130202661 | FORMULATIONS OF VILOXAZINE - Modified release formulations of viloxazine and methods of administering the same are disclosed. High-drug load formulations of viloxazine are further disclosed. | 08-08-2013 |
20150086629 | STABILIZED FORMULATIONS OF CNS COMPOUNDS - Formulations of molindone having superior stability and methods of administering same are provided. The formulations may be immediate, modified, or otherwise delayed release formulations of molindone. | 03-26-2015 |
Bert Huang, Silver Spring, MD US
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20130144818 | NETWORK INFORMATION METHODS DEVICES AND SYSTEMS - Methods and systems for predicting links in a network, such as a social network, are disclosed. The existing network structure can be used to optimize link prediction. The methods and systems can learn a distance metric and/or a degree preference function that are structure preserving to predict links for new/existing nodes based on node properties. | 06-06-2013 |
20140129320 | B-MATCHING USING SUFFICIENT SELECTION BELIEF PROPAGATION - A method, system, computer program product and computer readable media for b-matching using sufficient selection belief propagation is disclosed. The belief propagation method, is adapted to use a simplified compressed message update rule and is suitable for use with distributed processing systems. Embodiments for online advertisement/search term matching, product recommendation, dating service and social network matching, auction buyer/seller matching and resource allocation, among others, are disclosed. | 05-08-2014 |
Bert Huang, Berwyn Heights, MD US
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20150324699 | NETWORK INFORMATION METHODS DEVICES AND SYSTEMS - Methods and systems for predicting links in a network, such as a social network, are disclosed. The existing network structure can be used to optimize link prediction. The methods and systems can learn a distance metric and/or a degree preference function that are structure preserving to predict links for new/existing nodes based on node properties. | 11-12-2015 |
Hailiang Huang, Silver Spring, MD US
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20140032122 | GENE-WIDE SIGNIFICANCE (GWIS) TEST: NOVEL GENE-BASED METHODS FOR THE IDENTIFICATION OF GENETIC ASSOCIATIONS HAVING MULTIPLE INDEPENDENT EFFECTS - A novel set of methods for gene-based tests of association are provided. By gathering multiple independent effects into a single test, GWiS has greater power than conventional tests to identify genes with multiple causal variants. GWiS also retains power for low-frequency minor alleles that are increasingly important for personal genetics, a feature not shared by other multi-SNP tests. The methods of the present invention can be combined with conventional computing platforms to provide a new analytical tool for analyzing genes which are linked to multiple traits. | 01-30-2014 |
Haley Huang, Baltimore, MD US
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20130304096 | FASCIAL CLOSURE SUTURE DEVICE - An embodiment in accordance with the present invention provides a device and method for suturing the fascia or other tissue in a patient. The device includes a first arm and a second arm pivotally coupled to one another and housing a spring-based lever system that is configured to frictionally hold a portion of a needle within each of the first and second arms. A switch allows the spring-based lever system to be used to pass the needle between the first and second arms. When the switch is in a first position, the needle is frictionally held by the spring-based lever system within the first arm and released within the second arm. Likewise, when the switch is in a second position, the needle is frictionally held by the spring-based lever system within the second arm and released within the first arm. | 11-14-2013 |
Ho C. Huang, Potomac, MD US
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20120299658 | High efficiency, high frequency amplifiers - The invention is an improvement in microwave and millimeter wave amplifiers. Capacitors are connected in parallel with the source and drain terminals of all of the amplifying elements in a series of such elements except the first, compensating for current leakage due to gate capacitance. This results in improved synchronism of the amplifying elements, and improved overall efficiency and circuit performance. | 11-29-2012 |
Huapeng Huang, Ellicott City, MD US
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20110038457 | X-RAY DIFFRACTION APPARATUS AND TECHNIQUE FOR MEASURING GRAIN ORIENTATION USING X-RAY FOCUSING OPTIC - An x-ray diffraction apparatus for measuring crystal orientation of a multiple grain sample. An x-ray excitation path is provided having a focusing optic for collecting x-rays from an x-ray source and redirecting the collected x-rays into an x-ray beam converging on a single grain of the multiple grain sample. At least one point detector and the sample are rotated relative to each other; and a grain orientation is obtained based upon diffraction patterns collected from first and second grain crystal planes within the apparatus. | 02-17-2011 |
Jiahn-Dar Huang, Rockville, MD US
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20130143966 | METHODS OF TREATMENT USING STERCULIC ACID - The use of sterculic acid, and the pharmaceutically acceptable salt forms thereof, described for the treatment of inflammation, in particular, 7-ketocholesterol induced inflammation, 7-keto-cholesterol toxicity, and unregulated angiogenesis. | 06-06-2013 |
Jianping Huang, Rockville, MD US
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20140341931 | SOLUBLE CD27 (SCD27) AND THE USE THEREOF - Disclosed are methods of diagnosing a subject as having a solid tumor or a predisposition to developing a solid tumor. The methods include detecting or quantitating the amount of sCD27 in a serum sample obtained from a subject and comparing that amount of sCD27 with a control value indicative of the basal level of sCD27 present in the serum of a subject that does not have a solid tumor or a predisposition to developing a solid tumor, wherein a reduction of the amount of sCD27 relative to the control value indicates that the subject has the solid tumor or the predisposition to developing the solid tumor. The disclosed methods can be used to monitoring disease progression in a subject or determine a subject's suitability for immunotherapy. Also disclosed are methods of stimulating a subject's immune system by administering a therapeutically effective amount of sCD27 or a functional fragment. | 11-20-2014 |
Jiaqi Huang, Potomac, MD US
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20110256155 | METHODS TO MOLECULARLY CHARACTERIZE CIRCULATING TUMOR CELLS - The invention relates to a rapid, sensitive method to obtain a gene expression profile from a target cell population in a blood sample. The target cells can be circulating tumor cells. Disclosed are methods and kits for obtaining such profiles. | 10-20-2011 |
20120283121 | Quantification of IR-A and IR-B for Tumor Classification - Without limitation, this disclosure relates to compositions and methods for detecting and quantifying the expression of insulin receptor isoform A (IR-A) and/or insulin receptor isoform B (IR-B) in a tissue sample. The disclosure also relates to methods of diagnosis and classification based at least in part upon detecting and quantifying the expression of insulin receptor isoform A (IR-A) and/or insulin B (IR-B) in a tissue sample. Methods of treating a subject based upon such a classification are among additional aspects of the disclosure presented herein. | 11-08-2012 |
20130035249 | METHODS AND COMPOSITIONS FOR DETECTING AND TREATING CEA-EXPRESSING CANCERS - Provided are improved methods and compositions for detecting, monitoring and/or treating a CEA-expressing cancer. | 02-07-2013 |
Jinghe Huang, Bethesda, MD US
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20140342407 | NEUTRALIZING GP41 ANTIBODIES AND THEIR USE - Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection. | 11-20-2014 |
20140348785 | NEUTRALIZING GP41 ANTIBODIES AND THEIR USE - Monoclonal neutralizing antibodies are disclosed that specifically bind to the HIV-1 gp41 membrane-proximal external region (MPER). Also disclosed are compositions including the disclosed antibodies that specifically bind gp41, nucleic acids encoding these antibodies, expression vectors including the nucleic acids, and isolated host cells that express the nucleic acids. The antibodies and compositions disclosed herein can be used for detecting the presence of HIV-1 in a biological sample, or detecting an HIV-1 infection or diagnosing AIDS in a subject. In additional, the broad neutralization breadth of the disclosed antibodies makes them ideal for treating a subject with an HIV infection. Thus, disclosed are methods of treating and/or preventing HIV infection. | 11-27-2014 |
Kuan-Tsae Huang, Rockville, MD US
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20150029660 | CONFIGURABLE HEAT CONDUCTING PATH FOR PORTABLE ELECTRONIC DEVICE - A portable electronic device includes at least one energy module which further included thermoelectric materials which may convert heat to electric power. A plurality of heat removers selectively thermal contact to at least one wall of an enclosure of the portable electronic device depended on the configuration of the portable electronic device. | 01-29-2015 |
20150029661 | WEARABLE PORTABLE ELECTRONIC DEVICE WITH HEAT CONDUCTING PATH - A wearable portable electronic device includes at least one energy module which further included thermoelectric materials which may convert heat to electric power. A plurality of heat spreader thermally and electronically contact to at least one wall of an enclosure of the wearable portable electronic device by using graphene layer. | 01-29-2015 |
Lanqing Huang, Ellicott City, MD US
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20110293608 | ANNEXIN A2 AS IMMUNOLOGICAL TARGET - AnnexinA2 (ANXA2), a member of the Annexin family of calcium-dependent, phospholipid binding proteins, is one of a panel of identified antigens recognized by the post-vaccination sera of patients who demonstrated prolonged disease-free survival following multiple vaccinations. AnnexinA2 is abundantly expressed in pancreatic adenocarcinomas and cell surface/membrane AnnexinA2 increases with the progression from premalignant lesions to invasive pancreatic adenocarcinomas. The cytoplasmic to cell surface translocation of AnnexinA2 expression is critical for pancreatic cancer cell invasion. In addition, phosphorylation of AnnexinA2 at Tyrosine 23 is important for its localization to the cell surface and for the invasion of pancreatic cancer cells. Finally, loss of AnnexinA2 leads to the loss of the Epithelial-Mesenchymal Transition. | 12-01-2011 |
Lan-Qing Huang, Baltimore, MD US
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20090209034 | TUMOUR REJECTION ANTIGENS - Polypeptides comprising an unbroken sequence of amino acids from SEQ. ID. NO. 1 or 2, with an ability to complex with a major histocompatibility complex molecule type HLA-A2, and preferably HLA-A2.1. | 08-20-2009 |
Lucas K. Huang, Ellicott City, MD US
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20140222805 | APPARATUS, METHOD AND COMPUTER READABLE MEDIUM FOR TRACKING DATA AND EVENTS - A methods, an apparatus, a computer-readable medium, and a system for integrating data from a plurality of devices. The first data is received from a first device and the second data is received from a second device, which is a different type of device than the first device. Type of data is determined and additional data is generated based on the determined type of data received from these different devices. The additional data includes searchable metadata and/or one or more triggers based on a combination of the first and second received data. Accordingly, searchable metadata for recordings and metric values from various devices used in a session are generated. Additionally, annotations may be provided to emphasize the occurrence of triggering events. | 08-07-2014 |
20140255893 | METHOD AND SYSTEM FOR MANAGING SKILLS ASSESSMENT - The present invention is directed to a method and skills assessment tool for managing a testing session in a clinical skills testing center comprising a plurality of assessment stations. The method according to the preferred embodiment of the present invention includes configuring the plurality of assessment stations by associating each of the stations with a case type prior to the beginning of the testing session, receiving electronic identification of a student at one of a plurality of assessment stations prior to the student commencing an encounter at the one assessment station during the testing session, and, in response to receiving the student's identification, automatically assigning the student to the one assessment station for the encounter, where the encounter corresponds with the case type associated with the one assessment station. | 09-11-2014 |
Lucas K. Huang, Columbia, MD US
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20080261192 | SYNCHRONOUS MULTI-MEDIA RECORDING AND PLAYBACK WITH END USER CONTROL OF TIME, DATA, AND EVENT VISUALIZATION FOR PLAYBACK CONTROL OVER A NETWORK - A system and system are provided for providing synchronous multimedia recording and playback. Aspects the exemplary embodiment include in response to a training session is being conducted, synchronously recording in real-time simulator data from a simulator captured by a simulator capture tool, and video of the training session captured by a plurality of A/V sources; encoding each of the videos captured by the plurality of A/V sources as respective digital media files formatted as streaming media; and transmitting both the simulator data and the video media files from a server to a client over a network, such that when the client receives the simulator data and the stream, the respective videos are synchronously played back with the simulator data on the client | 10-23-2008 |
20120208162 | METHOD AND SYSTEM FOR MANAGING SKILLS ASSESSMENT - The present invention is directed to a method and skills assessment tool for managing a testing session in a clinical skills testing center comprising a plurality of assessment stations. The method according to the preferred embodiment of the present invention includes configuring the plurality of assessment stations by associating each of the stations with a case type prior to the beginning of the testing session, receiving electronic identification of a student at one of a plurality of assessment stations prior to the student commencing an encounter at the one assessment station during the testing session, and, in response to receiving the student's identification, automatically assigning the student to the one assessment station for the encounter, where the encounter corresponds with the case type associated with the one assessment station. | 08-16-2012 |
Mingjun Huang, Potomac, MD US
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20080207760 | Pharmaceutical Compositions For and Methods of Inhibiting Hcv - The present invention relates generally to replicase complex defect inducers and pharmaceutical compositions containing such inducers. Methods of developing mutants that are resistant to replicase complex defect inducers are also provided. Further included are mutants that can be used in screening for replicase complex defect inducers. Methods of screening test compounds for the ability to induce the formation of replicase complex defects are also described. Also included are methods of inhibition of HCV replication by replicase complex defect inducers. | 08-28-2008 |
20090081636 | Pharmaceutical compositions for and methods of inhibiting HCV replication - The present invention relates generally to replicase complex defect inducers and pharmaceutical compositions containing such inducers. Methods of developing mutants that are resistant to replicase complex defect inducers are also provided. Further included are mutants that can be used in screening for replicase complex defect inducers. Methods of screening test compounds for the ability to induce the formation of replicase complex defects are also described. Also included are methods of inhibition of HCV replication by replicase complex defect inducers. | 03-26-2009 |
20100029652 | Combination Therapy For Treating Hepatitis C Infections - The invention provides a method of treating hepatitis C, by providing compound of Formula I (shown below) in combination with a second active agent to a patient infected with the hepatitis C virus. Also provided herein are pharmaceutical combinations comprising a compound of Formula I and a second active agent. The pharmaceutical combination may be a unit dosage form or a packaged pharmaceutical composition. Packaged pharmaceutical combinations include a compound of Formula I and a second active agent in a package with instructions for using the formulation to treat a hepatitis C infection. | 02-04-2010 |
20100093018 | CELLS EXPRESSING CHIMERIC PROTEINS AND ASSAYS USING SUCH CELLS - Cells expressing chimeric hepatitis C virus NS4A protein are disclosed, as are vectors and methods for preparing such cells and methods of using the cells and the chimeric proteins therein in screening assays for detecting compounds that alter the associative characteristics of NS4A proteins. Disclosed screening assays are suitable for use in high throughput screening of compound libraries to identify compounds with a exhibiting specific anti-viral activity against hepatitis C virus. | 04-15-2010 |
Norden Eh Huang, Bethesda, MD US
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20130080378 | Method for Quantifying and Modeling Degree of Nonlinearity, Combined Nonlinearity, and Nonstationarity - A degree of nonlinearity based on intra-wave frequency modulation is proposed here with the value substantially between 0 and 1. The degree of nonlinearity is used for obtaining the state rather than a system. The data required for defining the degree of nonlinearity is the state of the motion or the observed data. For a complicate state with more than one IMF containing prominent energy density, the degree of nonlinearity has also considered the amplitude variations. The combination of the intra-wave frequency modulation and the amplitude variation gives the Combined Degree of nonlinearity. With the definitions of degree of nonlinearity, the nonlinearity characteristic can be quantified, and the discussion of nonlinear effects could be conducted more precisely. | 03-28-2013 |
Peng Huang, Owings Mills, MD US
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20140221242 | GENOME-WIDE METHYLATION ANALYSIS AND USE TO IDENTIFY GENES SPECIFIC TO BREAST CANCER HORMONE RECEPTOR STATUS AND RISK OF RECURRANCE - To better understand the biology of hormone receptor-positive and negative breast cancer and to identify methylated gene markers of disease progression, a genome-wide methylation array analysis was performed on 103 primary invasive breast cancers and 21 normal breast samples using the Illumina Infinium HumanMethylation27 array that queried 27,578 CpG loci. Forty CpG loci showed differential methylation specific to either ER-positive or ER-negative tumors. Each of the 40 ER-subtype-specific loci was validated in silico using an independent, publicly available methylome dataset from The Cancer Genome Atlas (TCGA). In addition, 100 methylated CpG loci were identified that were significantly associated with disease progression. Arrays containing the ER-subtype-specific loci and their use in methods of diagnosis and treatment of breast cancer are provided. | 08-07-2014 |
Renhua Huang, Rockville, MD US
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20150315566 | METHOD FOR GENERATING HIGH AFFINITY, BIVALENT BINDING AGENTS - A combined Kunkel mutagenesis and phage-display method for producing bivalent binding agents is provided. | 11-05-2015 |
Ru Chih Huang, Baltimore, MD US
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20080207532 | Use of Nordihydroguaiaretic Acid Derivatives in the Treatment of Drug Resistant Cancer, Viral and Microbial Infection - Compositions and methods for using nordihydroguaiaretic acid (NDGA) derivatives for preventing the expression of MDR-1 gene and the synthesis of PgP protein or reversing multiple drug resistance in cells, and for using NDGA derivatives in combination with additional chemotherapeutic agents to treat drug resistant cancer and infections. | 08-28-2008 |
20110014192 | SUPPRESSION OF CANCER GROWTH AND METASTASIS USING NORDIHYDROGUAIARETIC ACID DERIVATIVES WITH METABOLIC MODULATORS - Disclosed is a composition comprising a derivative of NDGA and at least one metabolic modulator. The composition can be in a unit dose form or kit. The composition can comprise at least two metabolic modulators. Also disclosed are methods for achieving cytotoxicity, particularly of rapidly dividing cells such as cancer, by administering a composition of the invention. In various embodiments of the invention subjects with cancer achieve prolonged survival and/or diminution in the size of their malignancies and cancer metastasis. | 01-20-2011 |
20150018302 | COMPOSITIONS COMPRISING NDGA DERIVATIVES AND SORAFENIB AND THEIR USE IN TREATMENT OF CANCER - The present invention provides pharmaceutical compositions comprising derivatives of NDGA, including M4N (tetra-O-methyl nordihydroguaiaretic acid) and sorafenib and their use in the inhibition and treatment of neoplastic diseases, such as liver cancer, colon cancer, breast cancer, brain cancers and ovarian cancers, for example, in a subject. Compositions comprising derivatives of NDGA, including M4N, sorafenib and additional therapeutic agents are also provided. | 01-15-2015 |
20150209304 | METHODS FOR INHIBITION OF BNIP3 AND PREVENTION AND TREATMENT OF ISCHEMIA REPERFUSION INJURY BY TETRA-O-METHYL NORDIHYDROGUAIARETIC ACID - Provided herein are methods for prevention and treatment of ischemia-reperfusion (IR) injury in the cardiac myocytes of a subject, by administration to the subject, a compound of formula I, or a salt, solvate, or stereoisomer thereof, in a sufficient amount either prior to, or during and/or after an ischemic event to mitigate or prevent IR injury to the cardiac tissue. Pharmaceutical compositions including the compound of formula I, or a salt, solvate, or stereoisomer thereof, and/or at least one additional therapeutic agent, are also provided. | 07-30-2015 |
Ru Chih C. Huang, Baltimore, MD US
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20100173861 | COMBINATIONAL PARADIGM COMBATING HIV, HIV/HSV, OR HIV/HPV INFECTIONS IN HUMANS USING SMALL MOLECULAR WEIGHT COMPOUNDS FROM PLANTS - Compounds, compositions and methods for the treatment of HIV/HSP/HPV, in particular, compositions and methods for a 3 part combination therapy for HIV/HSV/HPV, comprising a viral attachment inhibitor, a viral sequence integration inhibitor, and a proviral transcription inhibitor. The therapy is advantageous for the treatment of HIV infection, and is also effective for HSV and HPV infection. Also disclosed are novel viral attachment inhibitors and methods of use. | 07-08-2010 |
20110135711 | Methods and Compositions for Delivery of Catecholic Butanes for Treatment of Tumors - The present invention provides kits, methods and compositions for the treatment of diseases such as cancers. The compositions herein contain a substantially pure preparation of at least one catecholic butane, including, for example, NDGA compounds in a pharmaceutically acceptable carrier or excipient. The catecholic butane such as NDGA or its derivatives are administered to one or more subjects in need of treatment by a route other than direct injection into the affected tissues or topical application on affected tissues. | 06-09-2011 |
20130053335 | SUPPRESSION OF CANCER GROWTH AND METASTASIS USING NORDIHYDROGUAIARETIC ACID DERIVATIVES WITH 7-HYDROXYSTAUROSPORINE - Disclosed is a composition comprising a derivative of NDGA and 7-hydroxystaurosporine. The composition can be in a unit dose form or kit. Also disclosed are methods for achieving cytotoxicity, particularly of rapidly dividing cells such as cancer, by administering a composition of the invention. In various embodiments of the invention subjects with cancer achieve prolonged survival and/or diminution in the size of their malignancies and cancer metastasis. | 02-28-2013 |
20140065699 | NOVEL BACTERIAL EXPRESSION PLASMID - The present invention provides expression vectors useful for high-throughput screening of gene libraries. In a specific embodiment, an expression vector comprising (a) the Rop gene operatively linked to the trp promoter-operator; (b) a purification tag sequence and a protease cleavage site downstream of the Rop gene; and (d) a multiple cloning site downstream of the protease cleavage site, wherein the insertion of a heterologous gene of interest into the multiple cloning site and subsequent expression thereof in a host cell produces a high yield of a fusion protein comprising the Rop protein and the protein encoded by the heterologous gene of interest without the need of chemical inducers, temperature shifts, or growth medium alterations to initiate protein synthesis, and wherein the fusion protein controls plasmid replication at temperatures below about 30° C. but exhibits runaway plasmid replication when cultured at about 37° C. | 03-06-2014 |
20140186266 | CONJUGATES OF NITROIMIDAZOLES AND THEIR USE AS CHEMOTHERAPEUTIC AGENTS - Novel compounds which are derivatives of tetra-O-methyl nordihydroguaiaretic acid (NDGA), as well as pharmaceutically acceptable salts, solvates, and stereoisomers thereof are provided. These NDGA derivatives have a nitroimidazole moiety and these derivatives show preferential toxicity to hypoxic cells as hypoxic cytotoxins. Their cytotoxicity toward hypoxic cells is a result of abstraction of hydrogen from target molecules by free radicals formed in the reduction of the nitro group. This makes the disclosed compounds an effective anti cancer drug because hypoxic cells are generally considered to be more resistant to anti cancer drugs than normal cells. Pharmaceutical compositions comprising such compounds, as well as methods of use, and treatment for cancers, including hepatocellular carcinoma, breast cancer and prostate cancer, are also provided. | 07-03-2014 |
20150238511 | SYNERGISTIC ANTIVIRAL COMPOSITIONS COMPRISING A VIRAL ATTACHMENT INHIBITOR, AN INTEGRATION INHIBITOR, AND A PROVIRAL TRANSCRIPTION INHIBITOR, AND THEIR USE - Compounds, compositions and methods for the treatment of HIV/HSP/HPV, in particular, compositions and methods for a 3 part combination therapy for HIV/HSV/HPV, comprising a viral attachment inhibitor, a viral sequence integration inhibitor, and a proviral transcription inhibitor. The therapy is advantageous for the treatment of HIV infection, and is also effective for HSV and HPV infection. Also disclosed are novel viral attachment inhibitors and methods of use. | 08-27-2015 |
Ruili Huang, Rockville, MD US
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20110112079 | PHOSPHODIESTERASE INHIBITORS - The invention related to compounds for formula I useful for inhibiting phosphodiesterase-4. | 05-12-2011 |
20120196882 | COMPOUNDS THAT TREAT MALARIA AND PREVENT MALARIA TRANSMISSION - The invention provides methods and compounds for the treatment and prevention of malaria infection and transmission in a mammal by administering compounds of the invention to a mammal having or suspected of having a malaria infection. The invention also provides pharmaceutical compositions that can kill or arrest the growth of | 08-02-2012 |
20130029983 | AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY - The present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula I: | 01-31-2013 |
20130065842 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF - Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as RORγt modulators that have a formula represented by the following: | 03-14-2013 |
20130085162 | AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF - Amido compounds are disclosed that have a formula represented by the following: | 04-04-2013 |
20150057278 | AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF - Amido compounds are disclosed that have a formula represented by the following: | 02-26-2015 |
Ruilli Huang, Rockville, MD US
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20100041617 | Modulating mxa expression - The invention provides compositions and methods for inhibiting cell motility, metastatic cancer and viral infections in a mammal that involve increasing the activity or expression of MxA. | 02-18-2010 |
Steve Chien-Wen Huang, Germantown, MD US
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20080260707 | Isolated homozygous stem cells, differentiated cells derived therefrom and materials and methods for making and using same - The present invention discloses and describes pluripotent homozygous stem (HS) cells, and methods and materials for making same. The present invention also provides methods for differentiation of HS cells into progenitor (multipotent) cells or other desired cells, groups of cells or tissues. Further, the applications of the HS cells disclosed herein, include (but are not limited to) the diagnosis and treatment of various diseases (for example, genetic diseases, neurodegenerative diseases, endocrine-related disorders and cancer), traumatic injuries, cosmetic or therapeutic transplantation, gene therapy and cell replacement therapy. | 10-23-2008 |
Stuart Huang, Kensington, MD US
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20140367969 | SYSTEM AND METHOD FOR GENERATING ELECTRICITY USING GRID OF WIND AND WATER ENERGY CAPTURE DEVICES - A system for maintaining buoyant, energy-capture devices in general relative position in water in the presence of surface waves allows heeling of the energy capture devices while preventing collision. The system includes a grid of structural members that resists compression while permitting limited relative surface displacement between the first and second energy-capture devices. The structural members may be partially compressible and provide a restoring force, and they may allow heeling. Electricity from wave energy capture devices is combined in a way that smoothes variations inherent in wave action. Electricity from wind energy capture devices is combined with energy from wave energy capture devices for transmission to shore. | 12-18-2014 |
Szuyuan Huang, Rockville, MD US
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20150289279 | APPARATUS AND METHOD FOR AN ADAPTIVE PERIODIC BANDWIDTH ALLOCATION APPROACH IN A SHARED BANDWIDTH COMMUNICATIONS SYSTEM - An approach is provided for bandwidth allocation on a per terminal utilization and per inroute/inroute group basis, which optimizes bandwidth utilization. An aggregate average bandwidth usage of a plurality of remote terminals over a wireless communications channel is determined. A maximum rate for bandwidth allocations to each of the remote terminals for respective data transmissions over the channel is determined. A utilization metric reflecting a bandwidth utilization by one of the remote terminals for data transmissions over the channel is determined. An updated rate for bandwidth allocations to the one terminal is determined based on the utilization metric for the terminal, a target bandwidth utilization and tolerance range for the one terminal, and the maximum rate for the data allocations to each of the remote terminals. The updated rate for the bandwidth allocations to the one terminal is applied to subsequent bandwidth allocations for the one terminal. | 10-08-2015 |
Tony Huang, Germantown, MD US
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20130315346 | METHOD AND APPARATUS FOR PARALLEL DEMODULATION OF HIGH SYMBOL RATE DATA STREAMS IN A COMMUNICATIONS SYSTEM - A dynamic and flexible architecture and methods for demodulation of high data-rate streams with high symbol-rates, such as in satellite communications systems or computer network communications systems, is provided. A data stream of a data transmission is received, the data stream corresponding to a plurality of data symbols. A plurality of data samples corresponding to each of the data symbols is generated. Further, one or more representative data samples, corresponding each of the data symbols, are generated based at least in part on timing control signals and the generated data samples for the respective data symbol. The generated data samples corresponding to each of the data symbols other than the representative data samples are dropped. The timing control signals are then adjusted based at least in part on the generated representative data samples. | 11-28-2013 |
20130322511 | METHOD AND APPARATUS FOR SYNCHRONIZATION OF DATA AND ERROR SAMPLES IN A COMMUNICATIONS SYSTEM - A method and apparatus for processing input data signals transmitted in a continuous mode, or in a burst mode, of signal transmission, such as in a satellite or a computer network communications system. A receiver receives input data signals and a buffer stores the received input data. Processing circuitry generates frame timing synchronization control signals for writing the frames of the input data for storage, generates timing error control signals corresponding to a processing delay for the input data, for synchronizing reading out the stored data from the buffer based on a timing difference between the timing error control signals and the frame timing synchronization control signals to adjust for an arbitrary delay in processing the input data. The processing circuitry can include a tap gradient update circuit for generating a tap gradient corresponding to the read out data, based on equalizer error signals generated by the processing circuitry. | 12-05-2013 |
Weiguo Huang, Baltimore, MD US
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20140349005 | BIOSENSOR SYSTEMS AND RELATED METHODS FOR DETECTING ANALYTES IN AQUEOUS AND BIOLOGICAL ENVIRONMENTS - Disclosed herein are biosensor systems and related methods for detecting analytes in aqueous and biologic environments. A biosensor system for detecting binding of an analyte of interest may include a detector configured to detect a change in an electrical property on a surface thereof. The detector may be a FET. The system also may include a passive layer disposed on a top surface of the detector. Further, the system may include a hydrophobic layer disposed on the passive layer. The system also may include a receptor-attachment material configured for binding to an analyte. A receptor may bind to the analyte, and the receptor may be attached to the receptor-attachment material. The binding of the analyte to the receptor can cause the change of the electrical property at the surface. In response to the change for example, a current may change for indicating the binding of the analyte to the receptor. | 11-27-2014 |
Wei-Hao Huang, College Park, MD US
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20090072191 | Nor-Seco-Bis-Nor-Seco, Tris-Nor-Seco, and Higher Nor-Seco-Cucurbit[n]Uril Compounds - Nor-seco-type cucurbit[n]uril compounds and methylene bridged glycoluril oligomers are produced by reacting glycoluril and formaldehyde in strong organic or mineral acid at a temperature adequate to condense the reactants. These compounds are characterized by lacking —CH | 03-19-2009 |
Wenwei Huang, Rockville, MD US
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20110195018 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS - Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder. | 08-11-2011 |
20120315217 | INVERSE AGONISTS AND NEUTRAL ANTAGONISTS FOR THE TSH RECEPTOR - TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer. | 12-13-2012 |
20130029983 | AMINOTHIENOPYRIDAZINE INHIBITORS OF TAU ASSEMBLY - The present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula I: | 01-31-2013 |
20130065842 | COMPOUNDS AS RORyT MODULATORS AND USES THEREOF - Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as RORγt modulators that have a formula represented by the following: | 03-14-2013 |
20130085162 | AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF - Amido compounds are disclosed that have a formula represented by the following: | 04-04-2013 |
20130251631 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS - Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder. | 09-26-2013 |
20130251761 | ORGANIC COMPOUNDS - The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery. | 09-26-2013 |
20140301944 | LOW MOLECULAR WEIGHT THYROID STIMULATING HORMONE RECEPTOR (TSHR) AGONISTS - Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder. | 10-09-2014 |
20150031693 | PAK INHIBITORS FOR THE TREATMENT OF FRAGILE X SYNDROME - Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of Fragile X syndrome. | 01-29-2015 |
20150050325 | ORGANIC COMPOUNDS - The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to a drug-eluting stent comprising said compounds and methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery. | 02-19-2015 |
20150057278 | AMIDO COMPOUNDS AS RORyT MODULATORS AND USES THEREOF - Amido compounds are disclosed that have a formula represented by the following: | 02-26-2015 |
Xiaofen Huang, Gaithersburg, MD US
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20150079612 | Assays, Antibodies, Immunogens and Compositions Related to 5-FU - The present invention relates to conjugates of 5-fluorouracil, 5-fluorouracil immunogens, antibodies that bind 5-FU and/or 5-FU conjugated to another molecule, and assays for detecting, quantitating, and monitoring amounts of 5-fluorouracil in a sample such as in blood plasma. | 03-19-2015 |
Xiaoling Huang, Boyds, MD US
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20120218141 | METHOD FOR ITERATIVE ESTIMATION OF GLOBAL PARAMETERS - A method for iterative estimation of a set of unknown channel parameters in a beamforming network including determining a first order estimate of offsets at measurement nodes and an estimate of the confidence in the initial estimate of the measurement nodes' offsets, and iterating, until a desired estimation accuracy is obtained, determining an improved estimate of a parameter set, and the confidence in the estimates, using the prior estimate of the offsets at the measurement nodes and determining an improved estimate of the offsets at the measurement nodes and the associated confidence values using the prior estimate of the parameter set and the corresponding confidence values. | 08-30-2012 |
20130044024 | METHOD FOR ITERATIVE ESTIMATION OF GLOBAL PARAMETERS - A method for iterative estimation of a set of unknown channel parameters in a beamforming network including determining a first order estimate of offsets at measurement nodes and an estimate of the confidence in the initial estimate of the measurement nodes' offsets, and iterating, until a desired estimation accuracy is obtained, determining an improved estimate of a parameter set, and the confidence in the estimates, using the prior estimate of the offsets at the measurement nodes and determining an improved estimate of the offsets at the measurement nodes and the associated confidence values using the prior estimate of the parameter set and the corresponding confidence values. | 02-21-2013 |
Yi En Huang, North Potomac, MD US
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20140037419 | PROCESS FOR REACTOR CATALYST LOADING - Methods, devices and processes for effectively loading catalysts into reactor vessels. In particular methods, devices and processes for effectively loading catalysts into fixed bed reactors utilizing inducted vibrational energy to improve catalyst loading performance, thereby resulting in improved flow distribution through the catalyst beds at designed operating conditions. The methods herein are particularly effectively for improving the performance of new or existing catalyst bed configurations of vertically-oriented two-phase hydroprocessing fixed bed reactors. | 02-06-2014 |
20140251783 | FLUID BED COKING PROCESS WITH DECOUPLED COKING ZONE AND STRIPPING ZONE - A fluid coking unit for converting a heavy oil feed to lower boiling products by thermal has a centrally-apertured annular baffle at the top of the stripping zone below the coking zone to inhibit recirculation of solid particles from the stripping zone to the coking zone. By inhibiting recirculation of the particles from the stripping zone to the coking zone, the temperatures of the two zones are effectively decoupled, enabling the coking zone to be run at a lower temperature than the stripping zone to increase the yield of liquid products. | 09-11-2014 |
20150101406 | REAL-TIME LEVEL MONITORING FOR FIXED BED CATALYST LOADING USING MULTIPLE LEVEL SENSORS - In various aspects, methods and systems are provided for monitoring catalyst bed levels using multiple sensors that are temporarily installed in a reactor during catalyst loading. The multiple sensors are able to take distance measurements at substantially the same time and at predetermined time intervals so as to provide a catalyst time profile. The catalyst time profile allows an operator monitor catalyst levels during and after catalyst loading. Once catalyst loading is completed, the multiple sensors are removed from the reactor. | 04-16-2015 |
Yue Huang, Silver Spring, MD US
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20090214588 | Vaccines against aids comprising cmv/r-nucleic acid constructs - The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided. | 08-27-2009 |
20110200636 | METHOD FOR IMPROVING THE BREADTH OF THE IMMUNE RESPONSE TO DIVERSE STRAINS AND CLADES OF HIV - The present disclosure provides compositions for eliciting an immune response, including a prophylactic immune response, against human immunodeficiency virus. The composition includes nucleic acid constructs encoding HIV antigenic polypeptides of multiple clades or strains. Methods for eliciting an immune response by administering the composition to a subject are also provided. | 08-18-2011 |
Yue Huang, Bethesda, MD US
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20080286306 | HIV vaccines based on Env of multiple clades of HIV - In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens. | 11-20-2008 |
20090175910 | Modifications of HIV Env, Gag, and Pol enhance immunogenicity for genetic immunization - Modified HIV Env, Gag, Pol, or Nef DNA with improved ability to elicit antibody and CTL responses to HIV antigens have been identified as prototype immunogens for the treatment and prevention of HIV infections. | 07-09-2009 |
20100111998 | HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIV - In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a single Glade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens. | 05-06-2010 |
20110274721 | HIV VACCINES BASED ON ENV OF MULTIPLE CLADES OF HIV - In one embodiment, the invention provides a multiclade HIV plasmid DNA or viral vector vaccine including components from different clades of Env (optionally Env chimeras) and Gag-Pol-(optionally)Nef from a singlr clade. The vaccine of the invention may further include V1, V2, V3, or V4 deletions or combinations thereof. In another embodiment, the invention provides multiclade HIV envelope immunogens. | 11-10-2011 |
Yuefang Huang, Highland, MD US
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20140369989 | METHODS AND COMPOSITIONS FOR REDUCING THE ENVIRONMENTAL IMPACT OF ANIMAL WASTE - Methods for reducing the environmental impact of animal waste are described. In particular embodiments, the methods comprise administering to an animal an enzyme, such as alkaline phosphatase, that is effective to reduce the amount of a detrimental compound, such as ammonia or phosphorous, that is present in or released from animal waste. Also provided is a method for increasing phosphorus digestion in an animal. Compositions suitable for use in such methods are also described. | 12-18-2014 |
Yufeng Huang, Andover, MD US
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20140305193 | CRITICAL FLOW IN MOISTURE GENERATION SYSTEM FOR NATURAL GAS - A moisture provision and analyzer arrangement includes a conduit for obtaining a sample flow of natural gas, a moisture analyzer, and a bypass flow conduit. A main orifice is in fluid communication within the moisture provision and analyzer arrangement with flow proceeding to the moisture analyzer. A bypass orifice is located along the bypass flow conduit. The main orifice is sized and the flow provided to the moisture analyzer via the main orifice is at a pressure such that the flow provided to the moisture analyzer is at a critical flow condition and the bypass orifice is sized and the bypass flow is provided at a pressure such that the bypass flow is at a critical flow condition. Components in the moisture provision and analyzer arrangement are selected such that the critical flow rate through the main orifice and the critical flow rate through the bypass orifice are equal. | 10-16-2014 |
20150177131 | METHOD AND SYSTEM FOR DETECTING MOISTURE IN A PROCESS GAS INVOLVING CROSS INTERFERENCE - A system includes a moisture analyzer configured to detect moisture in a process gas. The moisture analyzer includes an absorption cell that encloses and conducts the process gas. The moisture analyzer also includes a pressure control device that may reduce a pressure of the process gas inside the absorption cell. The moisture analyzer includes a light emitting device that may transmit light through the process gas inside the absorption cell, as well as a photodetector that may detect an intensity of the light transmitted through the process gas and exiting the absorption cell. | 06-25-2015 |
Yunhan Huang, College Park, MD US
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20120017978 | Energy harvesting using RF MEMS - Described herein is an energy harvesting device and a method for its fabrication for the harvesting of solar energy. Solar energy is absorbed using a photosensitive material which is coated upon a flexible membrane, which is suspended over a metal signal line of an RF MEMS structure. By controlling the discharge sequence the stored electrical charge can be transferred as high voltage pulses to an external load or rechargeable batteries. The output voltage can be adjusted by controlling the on/off frequency of operation of the switch. | 01-26-2012 |
20120018514 | MEMS barcode device for monitoring medical systems at point of care - This invention relates to a novel wireless barcode MEMS canary which can be embedded in electronic systems that can be monitored at any time for their degradation over a period of time until they fail. By establishing the relationship between the healthy state of the barcode and its degradation to that of the electronic system and the components, the residual life of the system can be established and preventive measures can be taken before part failure. | 01-26-2012 |
20120019386 | Wireless biosensor network for point of care preparedness for critical patients - A biodegradable, bio-compatible material is described for use in wireless biosensors for point-of-care applications. The biosensor made from this biomaterial is capable of sensing environmental effects and as well as presence of bio-logical entities in the environment of concern simultaneously. Such a sensor can be used for evaluating point-of-care environmental preparedness for a specific patient through continuous monitoring of patient health performance due to environmental exposure. A two-tier network architecture is established for real-time monitoring (static case) that also provides warning of accumulated exposure. Wavelet analysis can be used to identify anomalies in the sensed data to initiate a warning. | 01-26-2012 |
Yu-Wen A. Huang, Baltimore, MD US
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20150148405 | Expression Construct for a Lin28-Resistant Let-7 Precursor MicroRNA - Precursor microRNA molecules that have been modified to prevent a protein involved in regulating developmental timing, oncogenesis, and/or neuronal growth from blocking processing of the precursor microRNA sequence to the mature microRNA are provided. Methods and kits for using the precursor microRNA molecules also are provided. | 05-28-2015 |
Zhuhui Huang, College Park, MD US
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20120064112 | RECOMBINANT NEWCASTLE DISEASE VIRUSES USEFUL AS VACCINES OR VACCINE VECTORS - The present invention concerns an antigenomic RNA of Newcastle Disease virus (NDV) carrying one or more foreign genes inserted before NP gene, between P and M genes, and/or between HN and L genes. The invention is also directed toward a cDNA encoding a recombinant antigenomic RNA having one or more foreign genes inserted according to the invention, a cell containing the cDNA, a plasmid comprising the cDNA, a cell containing the plasmid, a cell containing the recombinant antigenomic RNA, and a recombinant NDV containing the recombinant antigenomic RNA of the invention, such as a recombinant NDV carrying one or more foreign genes recovered from transcription of the cDNA or the plasmid in a competent cell. The recombinant NDV carrying the one or more foreign genes can be used as a vaccine or vaccine vector. | 03-15-2012 |