Horswill
Alexander R. Horswill, Coralville, IA US
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20100143972 | Method of Making Cyclic Polypeptides with Inteins - Methods for producing cyclic polypeptides comprising a lactone or thiolactone ring. In certain cases, intein fusion proteins may be used in a method for biologically producing internally cyclized polypeptides. The new methods enable the construction of cyclic polypeptide libraries that may be screened for the biological activity of cyclic polypeptides. Methods provided may be used, for instance, to produce and optimize novel cyclic peptides for use in treating Staphylococcal infections. | 06-10-2010 |
20110152176 | AGR-MEDIATED INHIBITION AND DISPERSAL OF BIOFILMS - The present invention involves the use of activators of bacterial agr quoroum-sensing systems to block, inhibit or reverse biofilm formation. The biofilm may be located on an industrial or medical surface, or may be located in a subject, such as in a wound or infected organ, or on an in-dwelling medical device. | 06-23-2011 |
20120064125 | AGR-MEDIATED INHIBITION OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS - The present invention involves the use of activators of bacterial Agrquoroum-sensing systems to prevent or reverse biofilm formation in methicillin resistant | 03-15-2012 |
Alexander R. Horswill, Iowa City, IA US
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20140199245 | OLIGONUCLEOTIDE-BASED PROBES FOR DETECTION OF BACTERIAL NUCLEASES - The present invention relates to a rapid detection of microbial-associated nuclease activity with chemically modified nuclease (e.g., ribonuclease) substrates, and probes and compositions useful in detection assays. Accordingly, in certain embodiments, the present invention provides a probe for detecting a microbial endonuclease comprising a substrate oligonucleotide of 2-30 nucleotides in length, a fluorescence-reporter group operably linked to the oligonucleotide, and a fluorescence-quencher group operably linked to the oligonucleotide. The fluorescence-reporter group and the fluorescence-quencher group are separated by at least one RNAse-cleavable residue, e.g., RNA base. | 07-17-2014 |
Craig A. Horswill, Barrington, IL US
Patent application number | Description | Published |
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20080286874 | REDUCING OR AVOIDING MUSCLE CRAMPS - Muscle cramps can be reduced or avoided by monitoring the concentration of salt in perspiration to indicate the degree of salt depletion. Based on the degree of salt depletion, a sufficient amount of rehydration beverage is consumed to normalize the salt level. | 11-20-2008 |
20080292499 | REDUCING OR AVOIDING MUSCLE CRAMPS - Muscle cramps can be reduced or avoided by monitoring the concentration of salt in perspiration to indicate the degree of salt depletion. Based on the degree of salt depletion, a sufficient amount of rehydration beverage is consumed to normalize the salt level. | 11-27-2008 |
20090148566 | Carbohydrate And Electrolyte Replacement Composition - The present invention discloses novel compositions and methods. These compositions and methods may be used to attenuate or reverse the effects of dehydration or other adverse effects of exercise, heat or other activity which causes bodily fluid loss. The novel compositions comprise carbohydrates, electrolytes and water along with flavoring agents. | 06-11-2009 |
20110262596 | Carbohydrate And Electrolyte Replacement Composition - The present invention discloses novel compositions and methods. These compositions and methods may be used to attenuate or reverse the effects of dehydration or other adverse effects of exercise, heat or other activity which causes bodily fluid loss. The novel compositions comprise carbohydrates, electrolytes and water along with flavoring agents. | 10-27-2011 |
James Horswill, Oxford GB
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20080261952 | Aryl Urea Derivatives for Treating Obesity - A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment. | 10-23-2008 |
20120214808 | Aryl Urea Derivatives for Treating Obesity - A method of treating a condition associated with the CB-1 receptor, in particular obesity, by administering an effective amount of an aryl urea CB-1 receptor modulating compound to a subject in need of such treatment. | 08-23-2012 |