Hoos
Axel Hoos, Philadelphia, PA US
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20160106835 | COMBINATION THERAPIES FOR CANCER - A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl; -2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and a PD-1 antagonist; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf and/or immune modulation through PD-1 is beneficial, e.g., cancer. | 04-21-2016 |
Axel Hoos, Collegeville, PA US
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20150273057 | Combination - A novel combination comprising a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and/or the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and an EGFR inhibitor suitably cetuximab (Erbitux) or erlotinib; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf and/or EGFR is beneficial, eg. cancer. | 10-01-2015 |
20160089434 | COMBINATIONS OF AN ANTI-PD-L1 ANTIBODY AND A MEK INHIBITOR AND/OR A BRAF INHIBITOR - A novel combination comprising the MEK inhibitor N-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl;-2,4,7-trioxo-3,4,6,7-tetrahydro-2H-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, and/or a B-Raf inhibitor, particularly N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, and an anti-PD-L1 antibody; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of MEK and/or B-Raf and/or neutralizing or inhibiting the interaction between PD-L1 and its receptor, e.g. PD-1, is beneficial, eg. cancer. | 03-31-2016 |
Frank Hoos, Mijnsheerenland NL
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20100089550 | Process And Apparatus For Transferring Heat From A First Medium To A Second Medium - A process of transferring heat from a first relatively cold medium to a second relatively hot medium features rotating a contained amount of a compressible fluid about an axis of rotation, thus generating a radial temperature gradient in the fluid, and heating the second medium by the fluid in a section of the fluid relatively far from the axis of rotation. An apparatus for carrying out the process includes a gastight drum rotatably mounted in a frame, and a first heat exchanger mounted inside the drum relatively far from the axis of rotation of the drum. | 04-15-2010 |
20100108295 | Process And Apparatus For Transferring Heat From A First Medium to a Second Medium - A process of transferring heat from a first relatively cold medium to a second relatively hot medium features rotating a contained amount of a compressible fluid about an axis of rotation, thus generating a radial temperature gradient in the fluid, and heating the second medium by means of the fluid in a section of the fluid relatively far from the axis of rotation. An apparatus for carrying out the process includes a gastight drum having a lumen for holding a compressible fluid and rotatably mounted in a frame, and a first heat exchanger mounted inside the drum relatively far from the axis of rotation of the drum. | 05-06-2010 |
20110146951 | PROCESS AND APPARATUS FOR TRANSFERRING HEAT FROM A FIRST MEDIUM TO A SECOND MEDIUM - The invention relates to a process and apparatus ( | 06-23-2011 |
20140060048 | PROCESS AND APPARATUS FOR GENERATING WORK - The invention relates to a process and apparatus ( | 03-06-2014 |
20160025196 | A TRANSMISSION MECHANISM - A transmission mechanism comprises a rotating shaft having an axis of rotation, a reciprocating member, a ring which is rotatably mounted to the rotating shaft and rotatable about a ring axis, a first rod pivotally coupled to the reciprocating member at a first reciprocating member pivot axis and to the ring at a first ring pivot axis, and a second rod pivotally coupled to the reciprocating member at a second reciprocating member pivot axis and to the ring at a second ring pivot axis. A circular member is attached to the rotating shaft and located eccentrically with respect to the axis of rotation. The ring is rotatably mounted about the circular member, and wherein an outer circumference of the circular member extends beyond an outer circumference of the rotating shaft in at least one direction of the axis of rotation. | 01-28-2016 |
Frank Hoos, Ah Mijnsheerenland NL
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20090139222 | System for storing, delivering and recovering energy - A system is described for storing, delivering and recovering energy, provided with a cylinder-piston assembly for absorbing a mass-induced load, which assembly is in fluid connection with a pressure source. The effective surface area of the piston of the cylinder-piston assembly is variable. The cylinder-piston assembly consists of, for instance, a number of cylinders connected in parallel, which can be selectively powered by the pressure source. | 06-04-2009 |
Holger H. Hoos, Vancouver CA
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20090094153 | Bidding Language For Combinatorial Auctions And Method Of Use Thereof - In a computer-implemented method for finding a high quality allocation of one or more bids in a combinatorial auction, a number of bids is electronically received. Each bid includes a number of sub bids and a Boolean operator logically connecting each pair of sub bids. Each sub bid is either (1) a good and an associated price or (2) one of the Boolean operators associated with a price and at least two other sub bids. From a number of allocations of goods to sub bids, wherein each allocation of the goods is to a different set of sub bids, an allocation is output that has the greatest value. The value of each allocation includes of a sum of prices of bids that have at least one satisfied sub bid. The price of each bid includes a sum of the prices associated with each satisfied sub bid of the bid. | 04-09-2009 |
Jason Hoos, Schaumburg, IL US
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20160072927 | ODATA ENABLED MOBILE SOFTWARE APPLICATIONS - A system and a method for accessing data objects provided through an OData service involve receiving, at an application server, a data access request from a client computing device. The data access request specifies in a platform-independent manner an access operation to be performed on a first data object. The application server translates the data access request into an OData compliant request. The OData compliant request is then transmitted to the OData service to perform the access operation. | 03-10-2016 |
Johannes Hoos, Berlin DE
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20110229976 | Sequencing of nucleic acid molecules by mass spectrometry - The present invention is related to a method for determining the nucleotide sequence of a nucleic acid molecule comprising the following steps: | 09-22-2011 |
John Hoos, West Hills, CA US
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20110037003 | MULTI-AXIS ARTICULATED SOLAR LIGHT SHADE FOR SPACE-BASED SENSORS - In one or more embodiments, a multi-axis articulated solar light shade that protects elements of a space-based sensor from direct solar illumination includes a base; a partial conical baffle tube having a first end portion, a second end portion, an elongated curved portion defining a shade between the first and second end portions, and an opening defined in an interior of the elongated curved portion, the first end portion rotatably attached to the base; and a visor pivotably attached to the second end portion. The partial conical baffle tube may be selectively rotated about a sensor line-of-sight in response to the sun's position relative to the sensor line-of-sight; and the visor may be selectively pivoted relative to the partial conical baffle tube in response to the sun's position relative to the sensor line-of-sight so as to protect the sensor from the direct solar illumination at any given time or any given orbital position. | 02-17-2011 |
Josef Hoos, Markt Einersheim DE
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20130266707 | Dough Cutting And Dough Shaping Device - A dough cutting device for producing a dough piece for baking toast or the like. The dough roll is moved on a lower conveyor belt having a roll centerline oriented transverse to a conveying direction. At least one cutting knife rotating about a front rotational axis is arranged at a distance corresponding to a variably adjustable front separating gap above the lower conveyor belt, and sectionally cuts the dough roll, wherein a front connecting web of the dough roll remains. | 10-10-2013 |
William Hoos, Aspinwall, PA US
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20120238800 | METHOD AND SYSTEM FOR PROVIDING BEHAVIOURAL THERAPY FOR INSOMNIA - The disclosed system and method provide for the automatic assessment of the presence/severity of the sleep problem and its exact nature. The assessment is based on qualitative information about sleep patterns, insomnia-related factors and daytime consequences, as well as quantitative information about sleep patterns measured by a sensor. By combining the different sources of information (subjective as well as objective data), the diagnosis gives more insight into the nature of the sleep problem and is therefore more accurate. Furthermore, the disclosed system may be used to select specific components of the system that are medically relevant to the individual and therefore create a personalized program. The system teaches a selection of self-management skills that could help the individual to better cope with sleep disturbances and target those factors that maintain the problem or make it worse by a particular individual. | 09-20-2012 |