Patent application number | Description | Published |
20080286882 | Method and Apparatus for Measuring the Concentration of a Ligand Contained in a Sample That Is To Be Tested - In a method for measuring the concentration of a ligand contained in a sample that is to be tested, at a plurality of test sites that are located on the surface of at least one substrate, in each case at least one receptor that is suitable upon contact with the ligand for specifically binding to said ligand, is immobilized. The sample is brought into contact for a predetermined time with the test sites in such a way that in the sample differently sized diffusion volumes are adjacent to the receptors from which at least one ligand can diffuse to the respective receptor during the predetermined time. After the predetermined time has passed, for each test site a measured signal for the number or density of the binding events at the test site is acquired. | 11-20-2008 |
20080287322 | Method and Coating Apparatus for the Manufacture of a Microarray - In a method for the manufacture of a microarray, surface areas of a chip are brought into contact with different aqueous solutions that contain at least one coating substance. For each of the individual surface areas, an absorbent substrate is provided and is filled with the solution that is to be brought into contact with the surface area in question. Then, for the printing of the surface area with the at least one coating substance contained in the solution, each substrate is brought into contact with the surface area in question. | 11-20-2008 |
20090017505 | Process and device for mixing microdroplets - In a process for mixing microdroplets ( | 01-15-2009 |
20090093047 | Kit and Device for Generating Chemiluminescence Radiation - A device for generating a chemiluminescence radiation depending on the binding of at least one ligand that is contained in a sample that is to be tested to at least one receptor that is binding-specific for the ligand has a flow cell having an internal cavity. The internal cavity has a separating wall on which the at least one receptor is immobilized. The internal cavity has at least two compartments. In a first compartment solid is deposited that contains at least one peroxidase-enzyme-possessing marker for marking the ligand in lyophilized form. A second compartment contains salt-stabilized luminol and a solid substance that releases hydrogen peroxide upon contact with water. | 04-09-2009 |
20090175764 | Measurement Device with At Least One Sensor - A measurement device has at least one sensor for detecting a parameter, a data storage unit, and a power supply for said sensor and data storage unit. In addition to the first sensor, the measurement device has at least one second sensor connected to the power supply and to the data storage unit. The second sensor is provided for detecting a physical quantity acting on the first sensor and is capable of permanently altering the measurement characteristic of the first sensor. An evaluator functions coactively with the second sensor and the data storage unit so that the permanent alteration of the measurement characteristic of the first sensor is recordable as a function of the measurement signal of the second sensor. | 07-09-2009 |
20090317917 | Biosensor and Method for Detecting Analytes - The present invention concerns in general a biosensor in the form of a microchip for the optical detection of analytes and a method using this biosensor. In particular the invention concerns biosensors for detecting an analyte by time-resolved luminescence measurement and a corresponding method. | 12-24-2009 |
20100003702 | Procedure And Device For Determining The Concentrations Of At Least Two Ligands - In a procedure for determining the concentrations of ligands contained in a sample wherein a first ligand is bond-specific to a first receptor and a second ligand is bond-specific to a second receptor, the first receptor is immobilized on a first test site and the second receptor is immobilized on a second test site on a substrate. A competitor that is bond-specific to the second receptor is mixed with the sample so that it is present in a predetermined concentration in the mixture. The mixture is brought into contact with the substrate so that the first ligand and the second ligand and/or the competitor bind to the first receptor and the second receptor, respectively. Afterwards, the unbound components of the mixture are removed from the substrate. A first metering signal relative to the concentration of the first ligand bound to the first receptor and a second metering signal relative to the concentration of the competitor bound to the second receptor are then generated. The concentrations of the ligands in the sample are determined with reference to the metering signals and the known concentration of the competitor in the mixture. | 01-07-2010 |
20100129894 | Method For Regenerating A Biosensor - In a method for regenerating a biosensor, a biosensor is prepared having a substrate surface on which at least one receptor is immobilized. At least one ligand that is binding specific to the receptor is bound to the receptor, said ligand, together with the receptor, forming a ligand-receptor complex. To regenerate the biosensor, the ligand-receptor complex is brought into contact with an enzyme. The enzyme is selected so that it catalyzes the ligand into fragments. The enzyme is inert with respect to the receptor. | 05-27-2010 |