Hoffmeyer
Angelika Hoffmeyer, Konstanz DE
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20150080400 | Novel EP2 Receptor Agonists - The compounds of formula (1) | 03-19-2015 |
Daniel Hoffmeyer, San Jose, CA US
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20140353157 | DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEM - A digital microfluidics system for manipulating samples in liquid droplets within a gap between a first hydrophobic surface of a bottom layer and a second hydrophobic surface of at least one disposable cartridge. Disposable cartridges comprise a body and/or a rigid cover plate. The bottom layer of each disposable cartridge is a flexible film that is sealingly attached to the body or plate. The cartridge has no spacer between the first and second hydrophobic surfaces. When using these cartridges, the bottom layers configured as a working film for manipulating samples in liquid droplets thereon, is placed on an electrode array of a digital microfluidics system. The array has individual electrodes. The digital microfluidics system also comprises a central control unit for controlling the selection of the individual electrodes of the electrode array and for providing these electrodes with individual voltage pulses for manipulating liquid droplets by electrowetting. | 12-04-2014 |
20150144489 | DISPOSABLE CARTRIDGE FOR MICROFLUIDICS SYSTEMS - A disposable cartridge used in a digital microfluidics system has a bottom layer with first hydrophobic surface, a rigid cover plate with second hydrophobic surface, and a gap there-between. The bottom layer is a flexible film on an uppermost surface of a cartridge accommodation site of a system, attracted to and spread over the uppermost surface by an underpressure. A lower surface of the plate and the flexible bottom layer are sealed to each other. The assembled cartridge is removed from the cartridge accommodation site in one piece and potentially includes samples and processing fluids. The system has a base unit and a cartridge accommodation site with an electrode array of individual electrodes and a central control unit for controlling selection of individual electrodes and for providing these electrodes with individual voltage pulses for manipulating liquid droplets within the gap by electrowetting. | 05-28-2015 |
Eric Hoffmeyer, Burke, VA US
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20130277956 | ADAPTIVE SKI SYSTEM FOR CONNECTING TWO SKIS TOGETHER - An adaptive ski system can interconnect two skis together while still providing a range of motion of the skis relative to one another. The ski system includes one or two interconnection devices mounted between a pair of skis. The interconnection devices can mount in various locations on the front and/or rear of the skis in any set of mounting holes selected from a plurality of sets of mounting holes. The interconnection devices include a mounting bracket on each ski. A cross bar connects the mounting brackets, thereby interconnecting the skis, such that relative range of motion between the skis both up and down and side-to-side is possible. The interconnection devices quickly connect and disconnect from the skis. The resulting ski system enables a high degree of personal adaption for the needs individual skier. | 10-24-2013 |
Henrik Hoffmeyer, Hannover DE
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20140366854 | METHOD FOR OPERATING A DRIVE ASSEMBLY AND DRIVE ASSEMBLY - The present invention relates to a method for operating a drive assembly having a gasoline engine ( | 12-18-2014 |
20150134230 | METHOD FOR OPERATING AN INTERNAL COMBUSTION ENGINE, AND INTERNAL COMBUSTION ENGINE - A method for operating an internal combustion engine is provided. The internal combustion engine has a compressor for adjusting a charge density in an intake pipe of the internal combustion engine and has an adjusting device, such as a variable valve gear, for adjusting a volumetric efficiency of the internal combustion engine. A dynamic setpoint quantity for the internal combustion engine is determined as a function of a difference between a load demand upon the internal combustion engine and a current load output of the internal combustion engine. The volumetric efficiency and the charge density are adjusted as a function of the dynamic setpoint quantity. An internal combustion engine and a vehicle are also provided. | 05-14-2015 |
Mark A. Hoffmeyer, Torrance, CA US
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20150318914 | HITLESS REARRANGEMENT OF A SATELLITE-HOSTED SWITCH VIA PROPAGATED SYNCHRONIZATION - An apparatus includes an analog front end to receive an analog input including user data, and an analog-to-digital converter to convert the analog input to digital signals including the user data. A digital channelizer may process the digital signals to generate frequency slices of user data, and a digital combiner may assemble the frequency slices to form output sub-bands of user data. A digital switch may route the frequency slices from the digital channelizer to the digital combiner according to a selected map of a plurality of available maps. The apparatus also includes a map selector to communicate map select data that indicates the selected map. The digital channelizer may receive and insert the map select data into the frequency slices in-band with the user data thereof. And the digital switch may interpret the map select data inserted into and route the frequency slices according to the selected map. | 11-05-2015 |
Mark Andrew Hoffmeyer, Torrance, CA US
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20140119385 | Satellite Communications Data Processing - An apparatus comprising a backplane and a number of transponder slices connected to the backplane to form a transponder. The number of transponder slices comprise an analog front end configured to receive an analog input comprising a first plurality of bandwidths and a first plurality of interface frequencies, analog to digital converters configured to convert the analog input to digital signals, a digital channelizer configured to process the digital signals to generate a plurality of frequency slices, a digital combiner configured to assemble the plurality of frequency slices to form output sub-bands, a digital switch configured to route the plurality of frequency slices from the digital channelizer to the digital combiner, digital to analog converters configured to convert the output sub-bands to an analog output, and an analog back end configured to transmit the analog output comprising a second plurality of bandwidths and a second plurality of interface frequencies. | 05-01-2014 |
Michaela Hoffmeyer, Cedar Park, TX US
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20120021944 | Co-Coupling To Control Reactivity Of Reagents In Immunoassays - Methods and compositions for controlling immunoassay reactivity are provided. In one embodiment, a method for preparing a substrate for an immunoassay is provided in which a composition containing a reagent and a neutral material is applied to a substrate under conditions suitable to couple the reagent and the neutral material to the substrate. | 01-26-2012 |
20140024556 | CO-COUPLING TO CONTROL REACTIVITY OF REAGENTS IN IMMUNOASSAYS - Methods and compositions for controlling immunoassay reactivity are provided. In one embodiment, a method for preparing a substrate for an immunoassay is provided in which a composition containing a reagent and a neutral material is applied to a substrate under conditions suitable to couple the reagent and the neutral material to the substrate. | 01-23-2014 |
Michaela R. Hoffmeyer, Cedar Park, TX US
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20100317544 | Methods, Particles, and Kits for Determining Activity of a Kinase - Methods, particles and kits for determining kinase activity within a sample are provided. An embodiment of a method includes exposing a fluorescent particle to an assay, wherein the fluorescent particle includes a support substrate having one or more fluorescent materials and a peptide substrate coupled to the support substrate via a functional group of the support substrate. The method further includes phosphorylating the peptide substrate during exposure of the fluorescent particle to the assay and processing the fluorescent particle such that the peptide substrate is dephosphorylated and a polarized double bond is generated at a dephosphorylated site. In addition, the method includes coupling a fluorescent reporter having a nucleophilic terminal group to the fluorescent particle via the polarized double bond. | 12-16-2010 |
Ron Hoffmeyer, Dana Point, CA US
Ronald E. Hoffmeyer, Dana Point, CA US
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20130124334 | ORDER FULFILLMENT SYSTEM AND METHOD FOR PRINTING PRODUCTS INCLUDING INDIVIDUALIZED INFORMATION - Interactive custom printed order placement and fulfillment systems and methods for placing, selling, accepting, proofing, transmitting, producing, servicing, and delivering orders for printed products including individualized or personalized information in time-efficient ways. Video conferencing technicians can provide direct access to professional, expert, and knowledgeable help. The interactive custom printed order fulfillment systems and methods further provide opportunities for targeted up-sells, cross-promotion, advertising, marketing, and information management to benefit those placing orders, those facilitating or brokering orders, and those producing and delivering orders, thereby increasing information efficiency. | 05-16-2013 |
Sven Hoffmeyer, Eberfing DE
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20090144841 | Polymorphisms in the human gene for the multidrug resistance-associated protein 1 (MRP-1) and their use in diagnostic and therapeutic applications - The present invention relates to a polymorphic MRP-1 polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit. | 06-04-2009 |
20120190017 | POLYMORPHISMS IN THE HUMAN GENE FOR THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (MRP-1) AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a polymorphic MRP-1 polynucleotide, genes or vectors comprising the polynucleotides and a host cell genetically engineered with the polynucleotide or gene. Also provided are methods for producing molecular variant polypeptides, cells capable of expressing a molecular variant polypeptide and to a polypeptide encoded by the polynucleotide or the gene or obtainable by the method or cells produced herein. Also provided is an antibody to the polypeptide, a transgenic animal, and to a solid support comprising one or a plurality of the provided polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also provided. In addition, the invention relates to methods for producing of a pharmaceutical composition, diagnosing a disease and, detection of the polynucleotide. Furthermore, provided herein are uses of the polynucleotides, genes, vectors, polypeptides or antibodies herein. | 07-26-2012 |
20130309665 | POLYMORPHISMS IN THE HUMAN GENE FOR THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (MRP-1) AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a polymorphic MRP-1 polynucleotide, genes or vectors comprising the polynucleotides and a host cell genetically engineered with the polynucleotide or gene. Also provided are methods for producing molecular variant polypeptides, cells capable of expressing a molecular variant polypeptide and a polypeptide encoded by the polynucleotide or the gene or obtainable by the method or cells produced herein. Also provided is an antibody to the polypeptide, a transgenic animal, and a solid support comprising one or a plurality of the provided polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also provided. In addition, the invention relates to methods for producing a pharmaceutical composition, diagnosing a disease and detection of the polynucleotide. Furthermore, provided herein are uses of the polynucleotides, genes, vectors, polypeptides or antibodies herein. | 11-21-2013 |
20150018229 | POLYMORPHISMS IN THE HUMAN GENE FOR THE MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1 (MRP-1) AND THEIR USE IN DIAGNOSTIC AND THERAPEUTIC APPLICATIONS - The present invention relates to a polymorphic MRP-1 polynucleotide, genes or vectors comprising the polynucleotides and a host cell genetically engineered with the polynucleotide or gene. Also provided are methods for producing molecular variant polypeptides, cells capable of expressing a molecular variant polypeptide and a polypeptide encoded by the polynucleotide or the gene or obtainable by the method or cells produced herein. Also provided is an antibody to the polypeptide, a transgenic animal, and a solid support comprising one or a plurality of the provided polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a pro-drug or drug or an inhibitor are also provided. In addition, the invention relates to methods for producing a pharmaceutical composition, diagnosing a disease and detection of the polynucleotide. Furthermore, provided herein are uses of the polynucleotides, genes, vectors, polypeptides or antibodies herein. | 01-15-2015 |