Hill, Oxford
Adrian Hill, Oxford GB
Patent application number | Description | Published |
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20080226678 | Compositions for Immunizing Against Mycobacterium - A method for generating a T cell immune response in a host involving administering a vectored vaccine comprising a non-replicating or replication impaired viral vector expressing the translation product of a mycobacterial antigen 85A gene. Vectored vaccines and uses thereof are also provided. Also provided is a method of inducing a CD8 and a CD4 memory T cell response against an antigen using an adenovirus vector expressing an antigen or an immunogenic fragment thereof. | 09-18-2008 |
20110044912 | Diagnostic And Therapeutic Epitope, And Transgenic Plant - A peptide analogue which is not more than 50 amino acids in length, and which is capable of being recognized by a T cell receptor that recognizes an epitope comprising sequence | 02-24-2011 |
20130183332 | Treatment and Prevention of Malaria - There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising a Reticulocyte-binding protein Homologue 5 (PfRH5) antigen having at least 90% identity with SEQ ID NO: 1, or a fragment thereof; or which comprise a viral vector that expresses PfRH5 antigen having at least 90% identity with SEQ ID NO: 2, or a fragment thereof. | 07-18-2013 |
20140127258 | Viral Vector Immunogenic Compositions - There is provided a composition comprising: (a) a modified vaccinia virus ankara (MVA) vector, wherein said MVA vector comprises a nucleic acid sequence encoding an antigen; and (b) an adjuvant comprising a saponin, or an emulsion. There is also provided a composition comprising: (a) an adenovirus vector, wherein said adenovirus vector comprises a nucleic acid sequence encoding an antigen, and wherein the adenovirus is selected from: a group B adenovirus, a group C adenovirus, and a group E adenovirus; and (b) an adjuvant comprising a saponin, or an emulsion; wherein the group B adenovirus is not an adenovirus 35, the group C adenovirus is not Ad5 having an intact E3 gene region, and the group E adenovirus is not an adenovirus C7. Also provided are corresponding uses of the compositions in medicine. | 05-08-2014 |
Adrian Vivian Hill, Oxford GB
Patent application number | Description | Published |
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20090269285 | Diagnostic And Therapeutic Epitope, And Transgenic Plant - A peptide analogue which is not more than 50 amino acids in length, and which is capable of being recognized by a T cell receptor that recognizes an epitope comprising sequence | 10-29-2009 |
20130318648 | DIAGNOSIS AND THERAPEUTIC EPITOPE, AND TRANSGENIC PLANT - A method of diagnosing coeliac disease, or susceptibility to coeliac disease, in an individual comprising: (a) contacting a sample from the host with an agent selected from (i) the epitope comprising sequence which is: SEQ ID NO: 1 or 2, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO: 3, (ii) an epitope comprising sequence comprising: SEQ ID NO: 1, or an equivalent sequence from a naturally occurring homologue of the gliadin represented by SEQ ID NO: 3, which epitope is an isolated oligopeptide derived from a gliadin protein, (iii) an analogue of (i) or (ii) which is capable of being recognised by a T cell receptor that recognises (i) or (ii), which in the case of a peptide analogue is not more than 50 amino acids in length, or (iv) a product comprising two or more agents as defined in (i), (ii) or (iii), and (b) determining in vitro whether T cells in the sample recognise the agent; recognition by the T cells indicating that the individual has, or is susceptible to, coeliac disease. Therapeutic compositions which comprise the epitope and gliadin proteins which do not cause coeliac disease are also provided. | 11-28-2013 |
Adrian Vivian Sinton Hill, Oxford GB
Patent application number | Description | Published |
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20100322896 | MOLECULAR ADJUVANT - This invention relates to the use of a molecular adjuvant to generate an immune response in a host. In particular, the molecular adjuvant may be a TLR signalling pathway component, a co-stimulatory molecule, an NKG2D ligand, IL- or IL-15. | 12-23-2010 |
20120282290 | Mycobacterial Vaccines - There is provided a fusion protein or a polynucleotide sequence encoding said fusion protein that comprises first and second domains, wherein the first domain of the fusion protein comprises an amino acid sequence having at least 70% sequence identity to the amino acid sequence of SEQ ID NO: 1, or a fragment thereof comprising at least 20 consecutive amino acids thereof; and wherein the second domain of the fusion protein comprises a mycobacterial antigen or an antigenic fragment thereof. Also provided are corresponding therapeutic uses thereof for the protection of primates against mycobacterial infections. | 11-08-2012 |
20150044766 | SIMIAN ADENOVIRUS AND HYBRID ADENOVIRAL VECTORS - The present invention provides recombinant adenoviral vectors, immunogenic compositions thereof and their use in medicine, and methods for generating recombinant adenoviral vectors. In particular, the present invention provides an adenovirus vector comprising a capsid derived from chimpanzee adenovirus AdY25, wherein said capsid encapsidates a nucleic acid molecule comprising an exogeneous nucleotide sequence of interest. | 02-12-2015 |
Adrian V.s. Hill, Oxford GB
Patent application number | Description | Published |
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20080220000 | Methods for Generating Improved Immune Reponse - This application relates to a method for generating an improved immune response in a host. The method involves the step of administering a vectored vaccine in the presence of an agent that impairs Treg cell function. | 09-11-2008 |
20100285050 | Compositions and Methods - The invention relates to a composition suitable for inducing a T cell mediated immune response against an influenza virus in a vertebrate, said composition comprising nucleic acid encoding one or more epitopes of one or more internal proteins of influenza virus, wherein said composition comprises nucleic acid encoding at least two said epitopes, at least one epitope being from each of two or more internal proteins of influenza virus. The invention also relates to uses of same and to methods involving same. | 11-11-2010 |
20110159034 | METHODS AND REAGENTS FOR VACCINATION WHICH GENERATE A CD8 T CELL IMMUNE RESPONSE - New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired pox virus vector carrying at least one CD8 T cell epitope which is also present in the priming composition. | 06-30-2011 |
20130110078 | Vaccination Method Using Microneedle Arrays | 05-02-2013 |
Hugh Allen Oliver Hill, Oxford GB
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20110262950 | REDOX MEDIATORS - The present invention relates to ruthenium and osmium complexes of Formula [M(A) | 10-27-2011 |
Jonathan M. D. Hill, Oxford GB
Patent application number | Description | Published |
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20100107172 | System providing methodology for policy-based resource allocation - A system providing methodology for policy-based resource allocation is described. In one embodiment, for example, a system for allocating computer resources amongst a plurality of applications based on a policy is described that comprises: a plurality of computers connected to one another through a network; a policy engine for. specifying a policy for allocation of resources of the plurality of computers amongst a plurality of applications having access to the resources; a monitoring module at each computer for detecting demands for the resources and exchanging information regarding demands for the resources at the plurality of computers; and an enforcement module at each computer for allocating the resources amongst the plurality of applications based on the policy and information regarding demands for the resources. | 04-29-2010 |
Lyndon Hill, Oxford GB
Patent application number | Description | Published |
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20100177239 | METHOD OF AND APPARATUS FOR FRAME RATE CONVERSION - A method is provided for performing robust frame rate conversion of video data to a higher frame rate. A metric is formed ( | 07-15-2010 |