Patent application number | Description | Published |
20100196941 | Multi-Analyte Analysis of Saliva Biomarkers as Predictors of Periodontal and Pre-Implant Disease - The present invention relates to methods of measuring biomarkers to determine the probability of a periodontal and/or peri-implant disease. More specifically, the invention provides a panel of biomarkers that, when used in combination, can allow determinniation of the probability of a periodontal and/or peri-implant disease state with extremely high accuracy. | 08-05-2010 |
20110177618 | Multi-Directional Microfluidic Devices and Methods - Multi-directional microfluidic devices and methods for using the same are provided. Aspects of the invention include microfluidic devices that are configured to subject a sample to two or more directionally distinct flow fields, and include a separation medium and a binding medium, where the binding medium is in fluid communication with the separation medium. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays. | 07-21-2011 |
20120135541 | MULTI-DIRECTIONAL MICROFLUIDIC DEVICES COMPRISING A PAN-CAPTURE BINDING REGION AND METHODS OF USING THE SAME - Microfluidic devices and methods for using the same are provided. Aspects of the invention include microfluidic devices that include a separation medium and a pan-capture binding medium. The microfluidic devices are configured to subject a sample to two or more directionally distinct electric fields. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays. | 05-31-2012 |
20120142904 | PROTEIN RENATURATION MICROFLUIDIC DEVICES AND METHODS OF MAKING AND USING THE SAME - Microfluidic devices having a protein renaturation component and methods for using the same are provided. Aspects of the present disclosure include microfluidic devices that include a separation medium with a first flow path and a protein renaturation component in fluid communication with the separation medium and having a second flow path. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays. | 06-07-2012 |
20120329040 | MICROFLUIDIC DEVICES AND METHODS FOR SEPARATING AND DETECTING CONSTITUENTS IN A FLUID SAMPLE - Microfluidic devices and methods for using the same are provided. Aspects of the present disclosure include microfluidic devices that include a separation medium having functional groups which covalently bond to one or more analytes of interest, e.g., proteins, in a sample upon application of an applied stimulus, e.g., light. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays. | 12-27-2012 |
20130078663 | Pore-Limit Electrophoresis (PLE) Microchannel Assays - Pore-limit electrophoresis (PLE) microchannel assay methods are provided. Aspects of the methods include sequentially introducing samples at least suspected of containing first and second assay members into a PLE microchannel and then evaluating the microchannel for interaction between the first and second assay members. Aspects of the invention further include devices, systems and kits configured for practicing methods of invention. The methods, devices, systems and kits of the invention find use in a variety of different applications, including enzyme activity assays and immunoassays. | 03-28-2013 |
20130266956 | MICROFLUIDIC DEVICES AND METHODS FOR ASSAYING A FLUID SAMPLE USING THE SAME - Multi-directional microfluidic devices and methods for using the same are provided. Aspects of the present disclosure include microfluidic devices that include a chamber having a separation medium, a first binding medium, and a second binding medium. In addition, the devices include a flow field element configured to subject the chamber to two or more directionally distinct flow fields. Methods of using the devices, as well as systems and kits that include the devices are also provided. The devices, systems and methods find use in a variety of different applications, including diagnostic, research and validation assays. | 10-10-2013 |
20130327633 | Microchannel Gel Electrophoretic Separation Systems and Methods for Preparing and Using - A micro-analytical platform for performing electrophoresis-based immunoassays was developed by integrating photopolymerized cross-linked polyacrylamide gels within a microfluidic device. The microfluidic immunoassays are performed by gel electrophoretic separation and quantifying analyte concentration based upon conventional polyacrylamide gel electrophoresis (PAGE). To retain biological activity of proteins and maintain intact immune complexes, native PAGE conditions were employed. Both direct (non-competitive) and competitive immunoassay formats are demonstrated in microchips for detecting toxins and biomarkers (cytokines, c-reactive protein) in bodily fluids (serum, saliva, oral fluids). Further, a description of gradient gels fabrication is included, in an effort to describe methods we have developed for further optimization of on-chip PAGE immunoassays. The described chip-based PAGE immunoassay method enables immunoassays that are fast (minutes) and require very small amounts of sample (less than a few microliters). Use of microfabricated chips as a platform enables integration, parallel assays, automation and development of portable devices. | 12-12-2013 |
20140158537 | MICROFLUIDIC METHODS OF ASSAYING MOLECULE SWITCHING AND DEVICES FOR PRACTICING THE SAME - Microfluidic methods of assaying molecule switching are provided. Aspects of the methods include microfluidically separating a sample containing the molecule of interest and then employing the resultant separation pattern to determine a switching characteristic of the molecule. Also provided are microfluidic devices, as well as systems and kits that include the devices, which find use in practicing embodiments of the methods. The methods, devices, systems and kits find use in a variety of different applications, such as analytical and diagnostic assays. | 06-12-2014 |
20140332382 | Two-Dimensional Microfluidic Devices and Methods of Using the Same - Microfluidic devices and methods for using the same are provided. Embodiments include microfluidic devices that have a first separation region configured to separate a sample along a first directional axis based on a first property, and a second separation region in fluid communication with the first separation region and configured to separate the sample along a second directional axis based on a second property. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays. | 11-13-2014 |
20140332383 | FREE-STANDING MICROFLUIDIC GEL ELECTROPHORESIS DEVICES AND METHODS - Provided are devices that include a support, a free-standing polymeric separation medium associated with the support and configured to separate a sample along a directional axis, and a sample-loading element associated with the polymeric separation medium. Systems that include the devices, as well as methods of using the devices, are also provided. Embodiments of the present disclosure find use in a variety of different applications, including detecting whether an analyte is present in a fluid sample. | 11-13-2014 |
20150099660 | MULTI-DIRECTIONAL MICROFLUIDIC DEVICES COMPRISING A PAN-CAPTURE BINDING REGION AND METHODS OF USING THE SAME - Microfluidic devices and methods for using the same are provided. Aspects of the invention include microfluidic devices that include a separation medium and a pan-capture binding medium. The microfluidic devices are configured to subject a sample to two or more directionally distinct electric fields. Also provided are methods of using the devices as well as systems and kits that include the devices. The devices, systems and methods find use in a variety of different applications, including diagnostic and validation assays. | 04-09-2015 |
20150293089 | Electrophoretic Bar Code Assay Devices and Methods for Making and Using the Same - A microfluidic device for determining whether an analyte is present in a sample is provided. The microfluidic device includes an elongated flow path having a polymeric medium, where the polymeric medium includes a first analyte detection domain having a first immobilized capture member that specifically binds to a first analyte and a second analyte detection domain having a second immobilized capture member that specifically binds to a second analyte. Also provided are methods, systems and kits in which the subject microfluidic devices find use, as well as methods of producing the same. | 10-15-2015 |
20150316547 | Electrophoretic Separation Devices and Methods for Using the Same - Electrophoretic separation devices and methods for using the same are provided. Aspects of the devices include a polymeric separation medium that includes a plurality of microwells. Also provided are methods, systems and kits in which the subject devices find use. The devices and methods find use in a variety of different electrophoretic separation applications. | 11-05-2015 |
Patent application number | Description | Published |
20100317536 | CRYSTAL STRUCTURE OF HUMAN GPVI AND APPLICATIONS THEREOF - A crystal comprising the collagen binding domain of human GPVI is provided and defined by structural atomic coordinates. Employing computer modeling based on the crystal structure, including methods for identifying inhibitors of GPVI collagen binding activity, methods for screening libraries of compounds for potential to bind to the GPVI collagen binding domain, and methods of identifying a compound useful for the treatment of a GPVI-mediated disorder, are also provided. | 12-16-2010 |
20110189260 | USE OF ZINC CHELATORS TO INHIBIT BIOFILM FORMATION - A method is provided for inhibiting formation of a biofilm of bacteria, the method including contacting the bacteria with an effective amount of at least one zinc chelator, wherein the bacteria contain at least one zinc adhesion module, whereby formation of the biofilm is inhibited. A method for inhibiting biofilm formation on a device and a topical pharmaceutical composition for the inhibition of biofilm formation are also provided. | 08-04-2011 |
20120135880 | Crystal of Human Glycoprotein VI Collagen Binding Domain - A crystal comprising the collagen binding domain of human GPVI is provided and defined by structural atomic coordinates. Employing computer modeling based on the crystal structure, including methods for identifying inhibitors of GPVI collagen binding activity, methods for screening libraries of compounds for potential to bind to the GPVI collagen binding domain, and methods of identifying a compound useful for the treatment of a GPVI-mediated disorder, are also provided. | 05-31-2012 |
20140308326 | ANTIMICROBIAL COMPOSITIONS OF AMINOGLYCOSIDIC ANTIBIOTICS AND ZINC ION CHELATORS SPECIFICALLY FORMULATED FOR ENHANCED INHIBITION OF BACTERIAL COLONIZATION AND ANTIBACTERIAL EFFICACY - Pharmaceutical compositions comprising an aminoglycosidic antibiotic and at least one zinc-chelating agent in a specified concentration, and methods of inhibiting bacterial colonization, biofilm formation and if treating bacterial infections utilizing the compositions are provided. Topical formulations suitable for wound care, and surface-applicable formulations suitable for medical, industrial and household disinfecting needs are also described. | 10-16-2014 |
Patent application number | Description | Published |
20100033206 | METHOD AND APPARATUS FOR BALLISTIC SINGLE FLUX QUANTUM LOGIC - In one embodiment, the disclosure relates to a single flux quantum (SFQ) signal transmission line powered by an AC power source. The AC power source supplies power to a transformer having a primary winding and a secondary winding. The primary winding receives the AC signal and the secondary winding communicates the signal to the SFQ transmission line. The transmission line can optionally include an input filter circuit for receiving the incoming SFQ pulse. The filter circuit can have a resistor and an inductor connected in parallel. In an alternative arrangement, the filter circuit can comprise of an inductor. A first Josephson junction can be connected to the filter circuit and to the secondary winding. The Josephson junction triggers in response to the incoming SFQ pulse and regenerates a pulse signal in response to a power discharge from the secondary winding. | 02-11-2010 |
20100207657 | Method and Apparatus for Ballistic Single Flux Quantum Logic - In one embodiment, the disclosure relates to a single flux quantum (SFQ) signal transmission line powered by an AC power source. The AC power source supplies power to a transformer having a primary winding and a secondary winding. The primary winding receives the AC signal and the secondary winding communicates the signal to the SFQ transmission line. The transmission line can optionally include an input filter circuit for receiving the incoming SFQ pulse. The filter circuit can have a resistor and an inductor connected in parallel. In an alternative arrangement, the filter circuit can comprise of an inductor. A first Josephson junction can be connected to the filter circuit and to the secondary winding. The Josephson junction triggers in response to the incoming SFQ pulse and regenerates a pulse signal in response to a power discharge from the secondary winding. | 08-19-2010 |
20100237899 | Method and Apparatus for Ballistic Single Flux Quantum Logic - In one embodiment, the disclosure relates to a single flux quantum (SFQ) signal transmission line powered by an AC power source. The AC power source supplies power to a transformer having a primary winding and a secondary winding. The primary winding receives the AC signal and the secondary winding communicates the signal to the SFQ transmission line. The transmission line can optionally include an input filter circuit for receiving the incoming SFQ pulse. The filter circuit can have a resistor and an inductor connected in parallel. In an alternative arrangement, the filter circuit can comprise of an inductor. A first Josephson junction can be connected to the filter circuit and to the secondary winding. The Josephson junction triggers in response to the incoming SFQ pulse and regenerates a pulse signal in response to a power discharge from the secondary winding. | 09-23-2010 |
20110267878 | Josephson Magnetic Random Access Memory System and Method - One aspect of the present invention includes a Josephson magnetic random access memory (JMRAM) system. The system includes an array of memory cells arranged in rows and columns. Each of the memory cells includes an HMJJD that is configured to store a digital state corresponding to one of a binary logic-1 state and a binary logic-0 state in response to a word-write current that is provided on a word-write line and a bit-write current that is provided on a bit-write line. The HMJJD is also configured to output the respective digital state in response to a word-read current that is provided on a word-read line and a bit-read current that is provided on a bit-read line. | 11-03-2011 |
20130009677 | CONTROLLING A STATE OF A QUBIT ASSEMBLY - Methods and apparatuses are provided for controlling the state of a qubit. A qubit apparatus includes a qubit and a load coupled to the qubit through a filter. The filter has at least a first pass band and a first stop band. A qubit control is configured to tune the qubit to alter an associated transition frequency of the qubit from a first frequency in the first stop band of the filter to a second frequency in the first pass band of the filter. | 01-10-2013 |
20130040818 | SUPERCONDUCTING LATCH SYSTEM - A reciprocal quantum logic (RQL) latch system is provided. The latch system comprises an output portion that retains a state of the latch system, and a bi-stable loop that comprises a set input, a reset input and an output coupled to the output portion. A positive single flux quantum (SFQ) pulse on the set input when the latch system is in a reset state results in providing a SFQ current in the output portion representative of the latch system being in a set state. | 02-14-2013 |
20150043273 | JOSEPHSON MAGNETIC MEMORY CELL SYSTEM - One aspect of the present invention includes a Josephson magnetic memory system. The system includes a superconducting electrode that conducts a read current. The system also includes a hysteretic magnetic Josephson junction (HMJJ). The HMJJ can store a binary value and convert superconducting pairs associated with the read current flowing through the HMJJ from a singlet-state to a triplet-state. The system further includes a write circuit magnetically coupled to the HMJJ and configured to write the binary value into the at HMJJ in response to at least one write current and a read circuit configured to determine the binary value stored in the HMJJ in response to application of the read current to the HMJJ. | 02-12-2015 |
20150092465 | JOSEPHSON AC/DC CONVERTER SYSTEMS AND METHOD - One embodiment describes an AC/DC converter system. The system includes a flux-shuttle loop that is inductively coupled with an AC input signal. The system also includes a plurality of Josephson junctions spaced about the flux shuttle loop that are configured to sequentially trigger in response to the AC input signal and to provide a single-flux quantum (SFQ) pulse that moves sequentially around the flux-shuttle loop that results in a DC output signal being provided through an output inductor. | 04-02-2015 |
20150094207 | PHASE HYSTERETIC MAGNETIC JOSEPHSON JUNCTION MEMORY CELL - One embodiment describes a memory cell. The memory cell includes a phase hysteretic magnetic Josephson junction (PHMJJ) that is configured to store one of a first binary logic state corresponding to a binary logic-1 state and a second binary logic state corresponding to a binary logic-0 state in response to a write current and to generate a superconducting phase based on the stored digital state. The memory cell also includes at least one Josephson junction having a critical current that is based on the superconducting phase of the PHMJJ and being configured to provide an output corresponding to the stored digital state in response to a read current. | 04-02-2015 |
20150263736 | SYSTEMS AND METHODS FOR APPLYING FLUX TO A QUANTUM-COHERENT SUPERCONDUCTING CIRCUIT - Systems and methods are provided for applying flux to a quantum-coherent superconducting circuit. In one example, a system includes a long-Josephson junction (LJJ), an inductive loop coupled to the LJJ and inductively coupled to the quantum-coherent superconducting circuit, and a single flux quantum (SFQ) controller configured to apply a SFQ pulse to a first end of the LJJ that propagates the SFQ pulse to a second end of the LJJ, while also applying a flux quantum to the inductive loop resulting in a first value of control flux being applied to the quantum-coherent superconducting circuit. | 09-17-2015 |
Patent application number | Description | Published |
20120014788 | DIFFUSER USING DETACHABLE VANES - A system, in certain embodiments, includes a plurality of detachable, three-dimensional diffuser vanes attached to a diffuser plate of a centrifugal compressor. In certain embodiments, the detachable, three-dimensional diffuser vanes may be attached to the diffuser plate using threaded fasteners. In addition, dowel pins may be used to align the detachable, three-dimensional diffuser vanes with respect to the diffuser plate. However, in other embodiments, the detachable, three-dimensional diffuser vanes may include a tab configured to fit securely within a groove in the diffuser plate. In addition, the tabs of the detachable, three-dimensional diffuser vanes may include indentions that mate with extensions extending from the diffuser plate, wherein the tabs may slide into slots between the extensions and the grooves of the diffuser plate. | 01-19-2012 |
20120014801 | DIFFUSER HAVING DETACHABLE VANES WITH POSITIVE LOCK - A system, in certain embodiments, includes a centrifugal compressor diffuser that includes an elliptical plate including multiple vane receptacles disposed about an axis of the plate and multiple detachable vanes attached to the plate. Each vane receptacle includes a first two dimensional (2D) projection along a plane of the elliptical plate and each detachable vane includes a second two dimensional (2D) projection along a base portion of the vane, where each detachable vane is disposed in a respective vane receptacle with the first and second 2D projections blocking movement of the detachable vane in at least a first axial direction relative to the elliptical plate. In certain embodiments, the first and second 2D projections may include a first tab to fit in a recess between a pair of second tabs, respectively, or vice versa. However, in other embodiments, the first and second 2D projections may include alternative mating surfaces. | 01-19-2012 |
20130315741 | DIFFUSER HAVING DETACHABLE VANES WITH POSITIVE LOCK - A system, in certain embodiments, includes a centrifugal compressor diffuser that includes an elliptical plate including multiple vane receptacles disposed about an axis of the plate and multiple detachable vanes attached to the plate. Each vane receptacle includes a first two dimensional (2D) projection along a plane of the elliptical plate and each detachable vane includes a second two dimensional (2D) projection along a base portion of the vane, where each detachable vane is disposed in a respective vane receptacle with the first and second 2D projections blocking movement of the detachable vane in at least a first axial direction relative to the elliptical plate. In certain embodiments, the first and second 2D projections may include a first tab to fit in a recess between a pair of second tabs, respectively, or vice versa. However, in other embodiments, the first and second 2D projections may include alternative mating surfaces. | 11-28-2013 |
20140186173 | DIFFUSER USING DETACHABLE VANES - A system, in certain embodiments, includes a plurality of detachable, three-dimensional diffuser vanes attached to a diffuser plate of a centrifugal compressor. In certain embodiments, the detachable, three-dimensional diffuser vanes may be attached to the diffuser plate using threaded fasteners. In addition, dowel pins may be used to align the detachable, three-dimensional diffuser vanes with respect to the diffuser plate. However, in other embodiments, the detachable, three-dimensional diffuser vanes may include a tab configured to fit securely within a groove in the diffuser plate. In addition, the tabs of the detachable, three-dimensional diffuser vanes may include indentions that mate with extensions extending from the diffuser plate, wherein the tabs may slide into slots between the extensions and the grooves of the diffuser plate. | 07-03-2014 |
Patent application number | Description | Published |
20150247340 | RAIL SYSTEM AND METHOD FOR ASSEMBLY - A rail system that may be comprised of various components such as an upper rail, support rail, bottom rail, squash blocks, balusters, post covers, and ancillary components, such as post skirts and caps. In one exemplary embodiment, the rail system may be uniquely designed to accommodate perpendicular and angled installations (e.g., both in the horizontal and vertical planes). Furthermore, in another exemplary embodiment, the rail system may be easily assembled such that the support hardware is substantially hidden from view after installation, thereby enhancing the appearance of the railing. | 09-03-2015 |
20150247341 | RAIL SYSTEM AND METHOD FOR ASSEMBLY - A rail system that may be comprised of various components such as an upper rail, support rail, bottom rail, squash blocks, balusters, post covers, and ancillary components, such as post skirts and caps. In one exemplary embodiment, the rail system may be uniquely designed to accommodate perpendicular and angled installations (e.g., both in the horizontal and vertical planes). Furthermore, in another exemplary embodiment, the rail system may be easily assembled such that the support hardware is substantially hidden from view after installation, thereby enhancing the appearance of the railing. | 09-03-2015 |
Patent application number | Description | Published |
20120082840 | THERMALLY REVERSIBLE HOT MELT ADHESIVE COMPOSITION CONTAINING MULTIFUNCTIONAL DIENE AND DIENOPHILE COMPOUNDS - The invention relates to a thermally reversible hot melt adhesive that is isocyanate-free, moisture independent, crosslinkable and thermally reversible. The thermally reversible hot melt adhesive may be repeatedly heated and cooled without negatively affecting the performance of the adhesive. The thermally reversible composition may also be used as a primer layer. The thermally reversible hot melt adhesive and primer are particularly well suited for end use applications such as packaging, graphic arts, construction, footwear, textiles, general assembly, automotive and consumer goods. | 04-05-2012 |
20130233485 | REACTIVE CONDUCTIVE PRESSURE-SENSITIVE ADHESIVE TAPE - A reactive pressure sensitive adhesive composition is disclosed. A tape formed using the reactive pressure sensitive adhesive is also disclosed. In its cured state, the pressure sensitive adhesive shows superior mechanical and electrical properties compared to conventional, non-curable charge collection tapes. The tape has a cure profile pre-selected to correspond to that of a photovoltaic cell fabrication process, such that curing can take place during cell fabrication and may occur simultaneously with one or more other curing steps employed in cell fabrication. | 09-12-2013 |
20140158296 | REACTIVE FILM ADHESIVE - An actinic radiation activated, thermally curable solid film adhesive is disclosed that includes a film forming polymeric binder, a cationically curable resin, and a cationic photoinitiator. The solid film adhesive is capable of being processed at temperatures up to 120° C. prior to exposure to actinic radiation without curing, has a latency period at room temperature following activation of the initiator, and is curable at temperatures above 50° C. following activation of the initiator. | 06-12-2014 |
Patent application number | Description | Published |
20100114329 | HYBRID TERRAIN-ADAPTIVE LOWER-EXTREMITY SYSTEMS - Hybrid terrain-adaptive lower-extremity apparatus and methods that perform in a variety of different situations by detecting the terrain that is being traversed, and adapting to the detected terrain. In some embodiments, the ability to control the apparatus for each of these situations builds upon five basic capabilities: (1) determining the activity being performed; (2) dynamically controlling the characteristics of the apparatus based on the activity that is being performed; (3) dynamically driving the apparatus based on the activity that is being performed; (4) determining terrain texture irregularities (e.g., how sticky is the terrain, how slippery is the terrain, is the terrain coarse or smooth, does the terrain have any obstructions, such as rocks) and (5) a mechanical design of the apparatus that can respond to the dynamic control and dynamic drive. | 05-06-2010 |
20130312483 | HYBRID TERRAIN-ADAPTIVE LOWER-EXTREMITY SYSTEMS - Hybrid terrain-adaptive lower-extremity apparatus and methods that perform in a variety of different situations by detecting the terrain that is being traversed, and adapting to the detected terrain. In some embodiments, the ability to control the apparatus for each of these situations builds upon five basic capabilities: (1) determining the activity being performed; (2) dynamically controlling the characteristics of the apparatus based on the activity that is being performed; (3) dynamically driving the apparatus based on the activity that is being performed; (4) determining terrain texture irregularities (e.g., how sticky is the terrain, how slippery is the terrain, is the terrain coarse or smooth, does the terrain have any obstructions, such as rocks) and (5) a mechanical design of the apparatus that can respond to the dynamic control and dynamic drive. | 11-28-2013 |
20140081420 | IMPLEMENTING A STAND-UP SEQUENCE USING A LOWER-EXTREMITY PROSTHESIS OR ORTHOSIS - Knee orthoses or prostheses can be used to automatically when it is appropriate to initiate a stand-up sequence based on the position of the person's knee with respect to the person's ankle while the person is in a seated position. When the knee is moved to position that is forward of the ankle, at least one actuator of the orthosis or prosthesis is actuated to help raise the person from the seated position to a standing position. | 03-20-2014 |
20140081421 | HYBRID TERRAIN-ADAPTIVE LOWER-EXTREMITY SYSTEMS - Hybrid terrain-adaptive lower-extremity apparatus and methods that perform in a variety of different situations by detecting the terrain that is being traversed, and adapting to the detected terrain. In some embodiments, the ability to control the apparatus for each of these situations builds upon five basic capabilities: (1) determining the activity being performed; (2) dynamically controlling the characteristics of the apparatus based on the activity that is being performed; (3) dynamically driving the apparatus based on the activity that is being performed; (4) determining terrain texture irregularities (e.g., how sticky is the terrain, how slippery is the terrain, is the terrain coarse or smooth, does the terrain have any obstructions, such as rocks) and (5) a mechanical design of the apparatus that can respond to the dynamic control and dynamic drive. | 03-20-2014 |
20140081424 | HYBRID TERRAIN-ADAPTIVE LOWER-EXTREMITY SYSTEMS - Hybrid terrain-adaptive lower-extremity apparatus and methods that perform in a variety of different situations by detecting the terrain that is being traversed, and adapting to the detected terrain. In some embodiments, the ability to control the apparatus for each of these situations builds upon five basic capabilities: (1) determining the activity being performed; (2) dynamically controlling the characteristics of the apparatus based on the activity that is being performed; (3) dynamically driving the apparatus based on the activity that is being performed; (4) determining terrain texture irregularities (e.g., how sticky is the terrain, how slippery is the terrain, is the terrain coarse or smooth, does the terrain have any obstructions, such as rocks) and (5) a mechanical design of the apparatus that can respond to the dynamic control and dynamic drive. | 03-20-2014 |
20140088727 | CONTROLLING POWERED HUMAN AUGMENTATION DEVICES - In a communication system for controlling a powered human augmentation device, a parameter of the powered device is adjusted within a gait cycle by wirelessly transmitting a control signal thereto, whereby the adjusted parameter falls within a target range corresponding to that parameter. The target range is selected and the device parameters are controlled such that the powered device can normalize or augment human biomechanical function, responsive to a wearer's activity, regardless of speed and terrain and, in effect, provides at least a biomimetic response to the wearer of the powered device. | 03-27-2014 |
20140088728 | VARIABLE-MECHANICAL-IMPEDANCE ARTIFICIAL LEGS - In one aspect, the invention provides methods and apparatus facilitating an adjustable-stiffness prosthesis or orthosis (including approximations to arbitrarily definable non-linear spring functions). Spring rates may be varied under no-load conditions during a walking gate cycle to minimize power consumption. In another aspect, the invention provides methods and apparatus for outputting positive power from a prosthesis or orthosis, facilitating high-performance artificial limbs. In one embodiment of the invention, the positive power is transferred from a functioning muscle to the prosthesis or orthosis, which mimics or assists a non-functioning or impaired muscle. In another embodiment of the invention, the positive power comes from an on-board power source in the prosthesis or orthosis. | 03-27-2014 |
20140114437 | CONTROLLING POWER IN A PROSTHESIS OR ORTHOSIS BASED ON PREDICTED WALKING SPEED OR SURROGATE FOR SAME - In some embodiments of a prosthetic or orthotic ankle/foot, a prediction is made of what the walking speed will be during an upcoming step. When the predicted walking speed is slow, the characteristics of the apparatus are then modified so that less net-work that is performed during that step (as compared to when the predicted walking speed is fast). This may be implemented using one sensor from which the walking speed can be predicted, and a second sensor from which ankle torque can be determined. A controller receives inputs from those sensors, and controls a motor's torque so that the torque for slow walking speeds is lower than the torque for fast walking speeds. This reduces the work performed by the actuator over a gait cycle and the peak actuator power delivered during the gait cycle. In some embodiments, a series elastic element is connected in series with a motor that can drive the ankle, and at least one sensor is provided with an output from which a deflection of the series elastic element can be determined. A controller determines a desired torque based on the output, and controls the motor's torque based on the determined desired torque. | 04-24-2014 |
20140121782 | CONTROLLING TORQUE IN A PROSTHESIS OR ORTHOSIS BASED ON A DEFLECTION OF SERIES ELASTIC ELEMENT - In some embodiments of a prosthetic or orthotic ankle/foot, a prediction is made of what the walking speed will be during an upcoming step. When the predicted walking speed is slow, the characteristics of the apparatus are then modified so that less net-work that is performed during that step (as compared to when the predicted walking speed is fast). This may be implemented using one sensor from which the walking speed can be predicted, and a second sensor from which ankle torque can be determined. A controller receives inputs from those sensors, and controls a motor's torque so that the torque for slow walking speeds is lower than the torque for fast walking speeds. This reduces the work performed by the actuator over a gait cycle and the peak actuator power delivered during the gait cycle. In some embodiments, a series elastic element is connected in series with a motor that can drive the ankle, and at least one sensor is provided with an output from which a deflection of the series elastic element can be determined. A controller determines a desired torque based on the output, and controls the motor's torque based on the determined desired torque. | 05-01-2014 |
20140296997 | BIOMIMETIC TRANSFEMORAL PROSTHESIS - In an artificial limb system having an actuator coupled to a joint for applying a torque characteristic thereto, a control bandwidth of a motor controller for a motor included in the actuator can be increased by augmenting a current feedback loop in the motor controller with a feed forward of estimated back electromotive force (emf) voltage associated with, the motor. Alternatively, the current loop is eliminated and replaced with a voltage loop related to joint torque. The voltage loop may also be augmented with the feed forward of estimated back emf, to improve the robustness of the motor controller. | 10-02-2014 |
20150127118 | PROSTHETIC, ORTHOTIC OR EXOSKELETON DEVICE - A time-dependent decay behavior is incorporated into one or more joint actuator control parameters during operation of a lower-extremity, prosthetic, orthotic or exoskeleton device. These parameters may include joint equilibrium joint impedance (e.g., stiffness, damping) and/or joint torque components (e.g., gain, exponent). The decay behavior may be exponential, linear, piecewise, or may conform to any other suitable function. Embodiments presented herein are used in a control system that emulates biological muscle-tendon reflex response providing for a natural walking experience. Further, joint impedance may depend on an angular rate of the joint. Such a relationship between angular rate and joint impedance may assist a wearer in carrying out certain activities, such as standing up and ascending a ladder. | 05-07-2015 |
20150265427 | BIOMIMETIC JOINT ACTUATORS - In a powered actuator for supplying torque, joint equilibrium, and/or impedance to a joint, a motor is directly coupled to a low-reduction ratio transmission, e.g., a transmission having a gear ratio less than about 80 to 1. The motor has a low dissipation constant, e.g., less than about 50 W/(Nm) | 09-24-2015 |
Patent application number | Description | Published |
20080274117 | Validation of Tssk Family Members and Tsks as Male Contraceptive Targets - The present invention relates to a family of testis specific kinases (the TSSK family) and a substrate (TSKS) of TSSK, nucleic acid sequences encoding those kinases and substrate, and antibodies and antagonists against the kinases and substrate, methods of regulating these proteins, and their use as contraceptive targets. | 11-06-2008 |
20090136962 | DIAGNOSTIC MARKERS FOR CANCER - The present invention provides compositions and methods useful for diagnosing cancer and for monitoring the progression and treatment of cancer, as well as targets for treating cancer. The invention provides sperm and testis associated antigens, such as the protein CABYR, as biomarkers and as targets for chemotherapy. | 05-28-2009 |
20100183617 | COMPOSITIONS AND METHODS FOR REGULATING SAS1R - The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor. Six SAS1R variants, including the full length SAS1R, were identified. mSLLP1 and SAS1R co-localized to oocytes and to acrosomes of acrosome-reacted sperm. Interactions between mSLLP1 and SAS1R were demonstrated by far-western analysis, in a yeast two-hybrid system under stringent selection conditions, and by immunoprecipitation of SAS1R by anti-mSLLP1 as well as the converse. Purified recombinant SAS1R was found to have protease activity, to inhibit fertilization in-vitro, and to induce an immune response in females. Together, the results suggest SAS1R is a proteolytically active, oocyte and early embryo specific oolemmal metalloprotease receptor for the sperm intra-acrosomal ligand SLLP1 and is a target for regulating fertilization and as a contraceptive. | 07-22-2010 |
20120252031 | COMPOSITIONS AND METHODS FOR REGULATING SAS1R - The present invention provides compositions and methods useful for regulating fertilization and for use as a contraceptive based on the discovery herein of an oocyte specific protein, SAS1R (Sperm Acrosomal SLLP1 Receptor), which is a sperm protein receptor. Six SAS1R variants, including the full length SAS1R, were identified. mSLLP1 and SAS1R co-localized to oocytes and to acrosomes of acrosome-reacted sperm. Interactions between mSLLP1 and SAS1R were demonstrated by far-western analysis, in a yeast two-hybrid system under stringent selection conditions, and by immunoprecipitation of SAS1R by anti-mSLLP1 as well as the converse. Purified recombinant SAS1R was found to have protease activity, to inhibit fertilization in-vitro, and to induce an immune response in females. Together, the results suggest SAS1R is a proteolytically active, oocyte and early embryo specific oolemmal metalloprotease receptor for the sperm intra-acrosomal ligand SLLP1 and is a target for regulating fertilization and as a contraceptive. | 10-04-2012 |
20130164215 | COMPOSITIONS AND METHODS FOR DETECTING, DIAGNOSING, AND TREATING CANCER - The present invention provides compositions and methods useful for diagnosing, treating, and preventing cancer, particularly ovarian cancer and uterine cancer, based on the discovery that the oocyte specific protein, SAS1R (Sperm Acrosomal SLL-P1 Receptor), which is a sperm protein receptor, is also expressed in various cancers, including ovarian cancer and uterine cancer. Six SAS1R variants have been previously identified, and they are encompassed by the invention. The present invention further provides antibodies useful for targeting SAS1R expressing cells and for killing such cells. | 06-27-2013 |
20150125445 | COMPOSITIONS AND METHODS FOR TREATING CANCER - The present invention provides compositions for targeting SAS1B positive cancer cells using immunotoxin technology and discloses that kidney and pancreatic cancer cells are SAS1B positive, but not normal kidney and pancreatic cells. The invention discloses that despite being expressed only in growing oocytes in females among normal tissues SAS1B is expressed in cancers of both men and women. | 05-07-2015 |
Patent application number | Description | Published |
20080266994 | LEVEL DETECT CIRCUIT - A detect circuit may be used to detect one or more characteristics corresponding to the fuse being programmed. When the one or more characteristics of the fuse being programmed reach the desired states or values, the programming of the fuse is discontinued. Thus, the programming duration for each fuse is customized for each fuse. As a result, for some embodiments, there may be fewer fuses that have been over-programmed. In addition, for some embodiments, the range of impedances of the programmed fuses have a narrower distribution of impedances due to the use of the detect circuit. | 10-30-2008 |
20090075428 | ELECTROMAGNETIC SHIELD FORMATION FOR INTEGRATED CIRCUIT DIE PACKAGE - Electromagnetic shielding for an integrated circuit packaged device. The method includes forming shielding structures by forming openings in an encapsulated structure. The openings are filled with conductive material that surrounds at least one die. The encapsulated structure may include a plurality of integrated circuit die. A layered redistribution structure is formed on one side of the encapsulated structure. | 03-19-2009 |
20100027360 | INTEGRATED CIRCUIT HAVING AN ARRAY SUPPLY VOLTAGE CONTROL CIRCUIT - An integrated circuit comprises a plurality of memory cells and an array supply voltage control circuit. The plurality of memory cells are organized in rows and columns. A row comprises a word line and all of the memory cells coupled to the word line. A column comprises a bit line pair and all of the memory cells coupled to the bit line pair. The array supply voltage control circuit is coupled to the plurality of memory cells. The array supply voltage control circuit is for receiving a power supply voltage and for providing a reduced power supply voltage to memory cells of a selected column during a write operation in response to a voltage differential on the bit line pair of the selected column. | 02-04-2010 |
20100181629 | METHOD OF FORMING AN INTEGRATED CIRCUIT - A method includes forming a source, a drain, and a disposable gate ( | 07-22-2010 |
20110003435 | ELECTROMAGNETIC SHIELD FORMATION FOR INTEGRATED CIRCUIT DIE PACKAGE - Electromagnetic shielding for an integrated circuit packaged device. The method includes forming shielding structures by forming openings in an encapsulated structure. The openings are filled with conductive material that surrounds at least one die. The encapsulated structure may include a plurality of integrated circuit die. A layered redistribution structure is formed on one side of the encapsulated structure. | 01-06-2011 |
20120299190 | METHODS AND APPARATUS TO IMPROVE RELIABILITY OF ISOLATED VIAS - A method for tiling selected vias in a semiconductor device is provided. The semiconductor device includes a plurality of vias. The method includes: generating a layout database for the semiconductor device; identifying isolated vias of the plurality of vias; selecting the isolated vias; defining a zone around each of the selected isolated vias; and adding tiling features on a metal layer above the selected isolated vias and within the zone. The method improves reliability of the semiconductor device by allowing moisture to vent from around the vias. | 11-29-2012 |
20130127064 | METHOD AND APPARATUS TO IMPROVE RELIABILITY OF VIAS - In a disclosed embodiment, a method for tiling selected vias in a semiconductor device having a plurality of vias comprises generating a layout database for the semiconductor device; creating zones around the plurality of vias; measuring density of covering metal in each zone; selecting a low density zone as being a zone that has a metal density less than a threshold metal density; and adding at least one tiling feature on a metal layer above the plurality of vias in the low density zone so that metal density of the low density zone increases to at least the same as the threshold metal density. | 05-23-2013 |
Patent application number | Description | Published |
20080214448 | Compounds, Methods and Formulations for the Oral Delivery of a Glucagon-Like Peptide (Glp)-1 Compound or a Melanocortin-4 Receptor (Mc4) Agonist Peptide - The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide. | 09-04-2008 |
20090170861 | Pyridazinone Derivatives Useful as Glucan Synthase Inhibitors - In its many embodiments, the present invention provides -substituted pyridazinone compounds as glucan synthase inhibitors, methods of preparing such compounds, pharmaceutical including one or more of such compounds, methods of preparing pharmaceutical formulations including one or more such compounds or one or more such compounds along with other antifungal agents, and methods of treatment, prevention, inhibition, or amelioration of one or more fungal infections associated with glucan synthase using such compounds or pharmaceutical compositions. | 07-02-2009 |
20090239798 | Compounds, Methods and Formulations for the Oral Delivery of a Glucagon-Like Peptide (Glp)-1 Compound or a Melanocortin-4 Receptor (Mc4) Agonist Peptide - The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide. | 09-24-2009 |
20100120876 | COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL DELIVERY OF A GLUCAGON-LIKE PEPTIDE (GLP-1) COMPOUND OR A MELANOCORTIN-4 RECEPTOR (MC4) AGONIST PEPTIDE - The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide. | 05-13-2010 |
20100204207 | Compounds and Methods for Treating Dyslipidemia - Compounds of Formula (I): wherein n, m, p, q, Y, R1, R2, R3a, R3b, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed. | 08-12-2010 |
20110190205 | Compounds, Methods and Formulations for the Oral Delivery of a Glucagon-Like Peptide (Glp)-1 Compound or a Melanocortin-4 Receptor (Mc4) Agonist Peptide - The present application relates to novel compounds, methods and formulations useful for the oral delivery of a glucagon like peptide-1 compound or a melanocortin 4 receptor agonist peptide. | 08-04-2011 |
20140031287 | COMPOUNDS, METHODS AND FORMULATIONS FOR THE ORAL DELIVERY OF A GLUCAGON-LIKE PEPTIDE (GLP-1) COMPOUND OR A MELANOCORTIN-4 RECEPTOR (MIC4) AGONIST PEPTIDE - The present invention relates to novel compounds, methods, and formulations useful for the oral delivery of a GLP-1 compound or an MC4 agonist peptide. | 01-30-2014 |
Patent application number | Description | Published |
20110108064 | METHODS AND SYSTEMS FOR MOVEMENT OF AN AUTOMAIC CLEANING DEVICE USING VIDEO SIGNAL - A method of cleaning an area using an automatic cleaning device may include receiving, from a video camera, information associated with an edge located on a surface, determining, by an automatic cleaning device, a position of the automatic cleaning device on the surface relative to the edge and using the received information to move the automatic cleaning device from the determined position along a path so that the automatic cleaning device cleans the surface along the path. The path may be substantially parallel to the edge, and the edge may be located a distance from a reference point on the automatic cleaning device during movement of the automatic cleaning device. | 05-12-2011 |
20110112714 | METHODS AND SYSTEMS FOR MOVEMENT OF ROBOTIC DEVICE USING VIDEO SIGNAL - A method of navigating an area using a mobile robotic device may include receiving, from a video camera, information associated with an edge located on a surface, determining, by a mobile robotic device, a position of the mobile robotic device on the surface relative to the edge and using the received information to move the mobile robotic device from the determined position along a path. The path may be substantially parallel to the edge, and may be located a distance from a reference point on the mobile robotic device during movement of the mobile robotic device. | 05-12-2011 |
20120260948 | CLEANING DEVICE WITH SINGLE TANK RECYCLING SYSTEM - A cleaning device may include a solution tank configured to store cleaning solution. The solution tank may include an inlet and an outlet. The cleaning device may include at least one discharge line filter in fluid communication with the solution tank and a pump having a pump intake and a pump discharge. The pump may be configured to direct cleaning solution from the solution tank outlet through the at least one discharge line filter. The cleaning device may include a cleaning head in fluid communication with the pump discharge and a bypass line in fluid communication with the pump discharge and the inlet. The bypass line may be configured to divert cleaning solution received from the pump discharge away from the cleaning head and toward the solution tank. | 10-18-2012 |
20140190518 | METHODS AND SYSTEMS FOR MOVEMENT OF AN AUTOMATIC CLEANING DEVICE USING VIDEO SIGNAL - A method of cleaning an area using an automatic cleaning device may include receiving, from a video camera, information associated with an edge located on a surface, determining, by an automatic cleaning device, a position of the automatic cleaning device on the surface relative to the edge and using the received information to move the automatic cleaning device from the determined position along a path so that the automatic cleaning device cleans the surface along the path. The path may be substantially parallel to the edge, and the edge may be located a distance from a reference point on the automatic cleaning device during movement of the automatic cleaning device. | 07-10-2014 |
20150238060 | CLEANING DEVICE WITH SINGLE TANK RECYCLING SYSTEM - A cleaning device may include a solution tank configured to store cleaning solution. The device delivers the cleaning solution from a pump discharge of the cleaning device to a flow meter. The device initiates a priming mode by opening a first valve associated with a bypass line of the device, closing a second valve associated with a cleaning head of the cleaning device, and delivering the cleaning solution from a discharge of the flow meter to the inlet of the solution tank through the bypass line. When the device is primed, it initiates cleaning by closing the first valve associated with the bypass line, opening the second valve associated with the cleaning head, and delivering the cleaning solution to the cleaning head. | 08-27-2015 |