Patent application number | Description | Published |
20080267983 | Peptide Inhibitors for Mediating Stress Responses - The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing peptides recognized by monoclonal anti-DNA antibodies, the peptides having anti-apoptotic and anti-inflammatory activity. The invention further provides antibody molecules and uses thereof for the isolation of such peptides. | 10-30-2008 |
20080279878 | Compositions of Hsp60 Peptides and Viral Antigens for Vaccination and Diagnosis - The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses. | 11-13-2008 |
20110256165 | COMPOSITIONS OF HSP60 PEPTIDES AND VIRAL ANTIGENS FOR VACCINATION AND DIAGNOSIS - The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses. | 10-20-2011 |
20120171233 | PEPTIDE INHIBITORS FOR MEDIATING STRESS RESPONSES - The present invention relates to peptides capable of inhibiting cellular and immune stress responses in a eukaryotic cell. The invention provides compositions and methods for the treatment of human degenerative diseases and inflammation, utilizing these peptides. | 07-05-2012 |
20140088017 | USE OF AKT PHOSPHORYLATION AS A BIOMARKER FOR PROGNOSING NEURODEGENERATIVE DISEASES AND TREATING SAME - The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 1, SEQ ID NO: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention. In addition, the present invention relates to prognosis of ALS progression, using Akt and phosphorylated Akt as biomarkers. | 03-27-2014 |
20140120126 | COMPOSITIONS OF HSP60 PEPTIDES AND VIRAL ANTIGENS FOR VACCINATION AND DIAGNOSIS - The present invention provides improved vaccines comprising an isolated viral antigenic peptide and a synthetic peptide derived from a T cell epitope of HSP60. The invention includes mixtures where the peptide serves as an adjuvant as well as conjugates where the peptide is covalently linked to the viral antigen. The known synthetic peptide carrier, p458, provides significantly improved immunogenicity for synthetic viral epitopes and analogs. Ec27 is a novel peptide derived from HSP60 which increases the immunogenicity substantially of the viral antigen both as a mixture or a covalent conjugate. Some of the isolated viral epitopes are novel and are claimed for diagnostic as well as therapeutic or prophylactic uses. | 05-01-2014 |
20140294982 | NANOPARTICLE COMPOSITIONS FOR GENERATION OF REGULATORY T CELLS AND TREATMENT OF AUTOIMMUNE DISEASES AND OTHER CHRONIC INFLAMMATORY CONDITIONS - The present invention relates to nanoparticles for the targeted delivery of antigen to liver cells, in particular, liver sinusoidal endothelial cells (LSEC) and/or Kupffer cells, and for the in vivo generation of regulatory T cells, notably CD4+CD25+FOXP3+ regulatory T cells (Treg). The invention provides pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, allergies or other chronic inflammatory conditions, and for generation of regulatory T cells. The nanoparticles used in the invention comprise a) a micelle comprising an amphiphilic polymer rendering the nanoparticle water-soluble, and b) a peptide comprising at least one T cell epitope associated with the outside of the micelle. The micelle may or may not comprise a solid hydrophobic core. | 10-02-2014 |
Patent application number | Description | Published |
20100155184 | ELEVATOR HAVING A SHALLOW PIT AND/OR A LOW OVERHEAD - The elevator has a car movable vertically within a shaft between lower and upper end positions and a drive system coupled to a traction system for controlling movement of the car. A limit switch which is open when the car is in a selected distance range from one of the end positions. The limit switch forms part of a power line supplying power to the drive system for controlling movement of the car in a direction towards that end position in an inspection operation. Thus movement of the car is prevented only in that direction when the car is in the selected distance range in an inspection operation. | 06-24-2010 |
20120043180 | Automatic Adjustment of Parameters for Safety Device - A device and method for automatically adjusting safety control parameters of a conveyor are disclosed. The safety device may include various sensors and a safety control module. The safety control module may be preprogrammed with a learn-run method configured to learn operational and mechanical characteristics of a conveyor, validate the operational characteristics of the conveyor based on predefined nominal specifications, and determine a safety function with calibrated safety control parameters by which to monitor conveyor operation. | 02-23-2012 |
20120080273 | ELEVATOR RESCUE SYSTEM - An elevator rescue system for moving an elevator car to a disembarkation position in a rescue operation comprises a rescue device ( | 04-05-2012 |
20120103756 | Signal Correlation For Missing Step Detection In Conveyors - A device and method for detecting a misaligned or missing step of a conveyor are disclosed. The missing step detector includes various sensors for detecting the drive speed of the conveyor and for detecting the presence of pallets or steps. The sensor output signals are correlated to determine fixed values characteristic of the specific conveyor in question. Using the fixed values as reference, the missing step detector is able to effectively monitor the conveyor for misaligned or missing steps independent of conveyor speed and time. | 05-03-2012 |
20120175193 | ELEVATOR HAVING A SHALLOW PIT AND/OR A LOW OVERHEAD - The elevator has a car movable vertically within a shaft between lower and upper end positions and a drive system coupled to a traction system for controlling movement of the car. A limit switch which is open when the car is in a selected distance range from one of the end positions. The limit switch forms part of a power line supplying power to the drive system for controlling movement of the car in a direction towards that end position in an inspection operation. Thus movement of the car is prevented only in that direction when the car is in the selected distance range in an inspection operation. | 07-12-2012 |
20120325588 | Healthcheck of Door Obstruction Device - Automatic door systems and methods capable of determining proper functionality thereof are provided. The door systems are provided with a healthcheck module which automatically determines functionality of the door system by initially monitoring a first output signal provided by a first sensor and a second output signal provided by a second sensor. More specifically, the healthcheck module correlates the first output signal with the second output signal and operates one or more doors of a door system according to the correlation. The healthcheck module then monitors the second output signal provided by the second sensor to determine the ability of the one or more doors to close, and determines functionality of the door system accordingly. | 12-27-2012 |
20130025976 | SAFETY CIRCUIT - An exemplary safety circuit includes a plurality of contacts that are configured to establish a conductive path across the contacts when the contacts are in electrically conductive contact with each other. The contacts selectively interrupt the conductive path across them when the contacts are separated. A controller selectively introduces a voltage pulse across the contacts at a voltage level that is effective to overcome an electrical resistance of any contamination on at least one of the contacts. The controller introduces the voltage pulse at least when the contacts are expected to be in contact to establish the conductive path. | 01-31-2013 |
20130192932 | ELEVATOR SAFETY SYSTEM AND METHOD - An elevator safety system including a controller, and a hoistway safety node arranged at a pit portion of an elevator hoistway. The hoistway node is operatively connected to one of a pit safety device and a lower hoistway device arranged at the elevator pit. A first bus links the hoistway node and the controller. The first bus passes communication signals directly from the hoistway node to the controller. A car node is arranged in an elevator car. The car node is operatively connected to a car safety device arranged at the elevator car. A second bus links the car node and the controller. The second bus passes communication signals directly from the car node to the controller. | 08-01-2013 |
20130270045 | Elevator Control Systems - An elevator control system includes a control power supply, a computing core in communication with the control power supply, a communication power supply in communication with the computing core, and a sleep monitor in communication with the control power supply, the computing core, and the communication power supply. The sleep monitor is disposed to selectively turn on/off the control power supply and the computing core, and the sleep monitor is disposed to selectively change an operating state of the communication power supply to a low voltage state. | 10-17-2013 |
20130327598 | ELEVATOR CAR MOVEMENT CONTROL IN A LANDING ZONE - An exemplary method is useful for controlling movement of an elevator car in an elevator system that includes a machine that selectively moves the elevator car and a machine brake that selectively resists movement of the elevator car. The method includes determining whether the elevator car is near a landing and determining whether a door of the elevator car is open. A desired operation includes desired movement of the elevator car while the elevator car is near the landing and the door is open. A determination is made whether the elevator car moves other than according to the desired movement. The machine brake is applied for stopping movement of the elevator car responsive to elevator car movement other than the desired movement while the elevator car is near the landing and the door is open. | 12-12-2013 |