Hastings, CA
Gregg Hastings, Westlake Village, CA US
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20090208974 | Human Neuronal Attachment Factor-1 - A human F-spondin-like protein and DNA (RNA) encoding such protein and a procedure for producing such protein by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating spinal cord injuries and damage to peripheral nerves by promoting neural-cell adhesion and neurite extension, inhibiting tumor metastases and tumor angiogenesis, and stimulating wound repair. Antagonists are also disclosed which may be utilized to prevent malaria. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed. | 08-20-2009 |
Gregg A. Hastings, Westlake Village, CA US
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20080312146 | METH1 and METH2 Polynucleotides and Polypeptides - The present invention relates to novel anti-angiogenic proteins, related to thrombospondin. More specifically, isolated nucleic acid molecules are provided encoding human METH1 and METH2. METH1 and METH2 polypeptides are also provided, as are vectors, host cells and recombinant methods for producing the same. Also provided are diagnostic methods for the prognosis of cancer and therapeutic methods for treating individuals in need of an increased amount of METH1 or METH2. Also provided are methods for inhibiting angiogenesis using METH1 or METH2. | 12-18-2008 |
20080317754 | Human Osteoclast Derived Cathepsin - Disclosed is a human osteoclast-derived cathepsin (Cathepsin O) polypeptide and DNA(RNA) encoding such cathepsin O polypeptides. Also provided is a procedure for producing such polypeptide by recombinant techniques. The present invention also discloses antibodies, antagonists and inhibitors of such polypeptide which may be used to prevent the action of such polypeptide and therefore may be used therapeutically to treat bone diseases such as osteoporosis and cancers, such as tumor metastases. | 12-25-2008 |
20080318835 | Novel Integrin Ligand ITGL-TSP - ITGL-TSP polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing ITGL-TSP polypeptides and polynucleotides in the design of protocols for the treatment of, angiogenic diseases (cancer, cancer metastasis, chronic inflammatory disorders, rheumatoid arthritis, atherosclerosis, macular degeneration, diabetic retmopathy), restenosis, Alzheimer's, disease and tissue remodeling, among others, and diagnostic assays for such conditions. | 12-25-2008 |
20090142329 | Interleukin-1 Beta Converting Enzyme Like Apoptosis Protease-3 and 4 - Disclosed are human interleukin-1 β converting enzyme like apoptosis proteases-3 and 4 and DNA (RNA) encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and antibodies and antagonists against such polypeptides. Also provided are methods of using the polypeptides, for example, as an antitumor agent, and antiviral agent, and antibodies and antagonists against such polypeptides for example, for treating Alzheimer's disease, Parkinson's disease, rheumatoid arthritis and head injury. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases are also disclosed. | 06-04-2009 |
20090311263 | HUMAN VASCULAR IBP-LIKE GROWTH FACTOR - A human Vascular IBP-Like Growth Factor polypeptide (VIGF) and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for wound healing or tissue regeneration, stimulating implant fixation and angiogenesis. Antagonist against such polypeptides and their use as a therapeutic to treat atherosclerosis, tumors and scarring are also disclosed. Diagnostic assays for identifying mutations in VIGF nucleic acid sequences and altered levels of the VIGF polypeptide are also disclosed. | 12-17-2009 |
Jeff Hastings, Los Altos, CA US
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20120039580 | Method and System for Remote Television Replay Control - A method, system, computer medium, and other embodiments for integrating unrelated web hosted services with stand-alone media-based devices are provided. Users can access and control the media-based device conveniently with a web-browser through various portals on the Internet. In one embodiment, users access the media-based device through one or more unrelated web portals, so as to control and to program the media-based device in a single web session, and to see information both stored on the media-based device and originating from third-party online sources of information and services in a single integrated presentation. | 02-16-2012 |
Jerome Hastings, Standford, CA US
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20080247512 | Sagittal Focusing Laue Monochromator - An x-ray focusing device generally includes a slide pivotable about a pivot point defined at a forward end thereof, a rail unit fixed with respect to the pivotable slide, a forward crystal for focusing x-rays disposed at the forward end of the pivotable slide and a rearward crystal for focusing x-rays movably coupled to the pivotable slide and the fixed rail unit at a distance rearward from the forward crystal. The forward and rearward crystals define reciprocal angles of incidence with respect to the pivot point, wherein pivoting of the slide about the pivot point changes the incidence angles of the forward and rearward crystals while simultaneously changing the distance between the forward and rearward crystals. | 10-09-2008 |
Jordan Hastings, Santa Barbara, CA US
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20090077100 | UNIFIED GEOGRAHIC DATABASE AND METHODS OF CREATING, MAINTAINING AND USING THE SAME - A Universal Geographic Database (“UGD”) is provided that includes a real-time, automated registry/clearinghouse for the publication and retrieval of real-world locations and location-related information for businesses and other entities. By this registry, entities may publish their location and location-related information in a single place, and information services and their users can refer to this single place, via telecommunications devices, to obtain static, real-time location and location-based information about the registered locations. Each UGD record is keyed by a proprietary location address (PLA) based on the World Geographic Referencing System (WGRS). PLAs may be used as key reference and addressing terms, e.g., imbedded in digital documents, websites, GPS devices, or other information services to provide links to maps, directions, and information in the registry related to such locations. PLAs may also provide a concise, user-friendly notation for location naming and designating real-world locations and on all types of location-sensitive electronic devices. | 03-19-2009 |
20140324844 | UNIFIED GEOGRAHIC DATABASE AND METHODS OF CREATING, MAINTAINING AND USING THE SAME - A Universal Geographic Database (“UGD”) is provided that includes a real-time, automated registry/clearinghouse for the publication and retrieval of real-world locations and location-related information for businesses and other entities. By this registry, entities may publish their location and location-related information in a single place, and information services and their users can refer to this single place, via telecommunications devices, to obtain static, real-time location and location-based information about the registered locations. Each UGD record is keyed by a proprietary location address (PLA) based on the World Geographic Referencing System (WGRS). PLAs may be used as key reference and addressing terms, e.g., imbedded in digital documents, websites, GPS devices, or other information services to provide links to maps, directions, and information in the registry related to such locations. PLAs may also provide a concise, user-friendly notation for location naming and designating real-world locations and on all types of location-sensitive electronic devices. | 10-30-2014 |
Matthew B. Hastings, Santa Barbara, CA US
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20140297708 | Fast Quantum and Classical Phase Estimation - A quantum phase estimator may include at least one phase gate, at least one controlled unitary gate, and at least one measurement device. The quantum phase estimator receives at least one ancillary qubit and a calculational state comprised of multiple qubits. The phase gate may apply random phases to the ancillary qubit, which is used as a control to the controlled unitary gate. The controlled unitary gate applies a second random phase to the calculational state. The measurement device may measure a state of the ancillary qubit from which a phase of the calculational state may be determined. | 10-02-2014 |
Michael Thomas Hastings, San Francisco, CA US
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20120198088 | INSERTION POINTS FOR STREAMING VIDEO AUTOPLAY - Techniques are described for presenting streaming media content to users in an engaging manner. A streaming media player may provide an interface that allows users to browse though a collection of available titles sorted into different categories (e.g., science fiction titles, television shows, westerns, etc.). The interface may be configured to automatically begin playback of one of the media titles at a designated insertion point, providing a user with a preview of the title. The insertion point itself may be selected as an interesting point in a given title, and therefore, likely to engage a user in that title. | 08-02-2012 |
Michal Hastings, Moorpark, CA US
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20150159690 | Turbocharger Dual Ball Bearing System - A bearing system for a turbocharger includes a bearing housing having a first end and a second end, with the bearing housing defining a central passageway. A first ball bearing and a second ball bearing are received by the bearing housing. The second ball bearing is spaced from the first ball bearing. The first and second ball bearings are each preloaded. | 06-11-2015 |
Paul James Hastings, San Francisco, CA US
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20150368329 | Methods of Treating Ocular Diseases - The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating ocular diseases. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit ocular neovascularization. | 12-24-2015 |
Stephan Hastings, Hemet, CA US
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20110036536 | FULL CONTACT FLEXIBLE SEAL ASSEMBLY FOR HEAT EXCHANGER - A seal assembly for a regenerative heat exchanger can include a primary sealing member with a mounting base and a flexible contact portion that defines a first distance between a proximal edge of the mounting base and a contact edge of the flexible contact portion, the first distance being generally constant along the length of the primary sealing member. The seal assembly can also include a second member with a mounting portion and a cantilevered portion that defines a second distance between a proximal edge of the mounting portion and a distal edge of the cantilevered portion, the second distance being generally constant along the length of the second member. The first distance is greater than the second distance by a predetermined amount so as to limit the preload flexure of the flexible contact portion against a sector plate of the heat exchanger when the seal assembly is installed in the regenerative heat exchanger. | 02-17-2011 |
20110037236 | FULL CONTACT FLEXIBLE SEAL ASSEMBLY FOR HEAT EXCHANGER - A seal assembly for a regenerative heat exchanger can include a sealing member with a mounting base and a flexible contact portion having a contact edge that resiliently contacts a sector plate of the heat exchanger housing when the seal assembly is mounted to the heat exchanger. The seal assembly can also include a curvilinear support with a mounting section and a curved extended portion attached to the mounting section and having a predetermined curvature that gradually contacts the flexible contact portion as flexion of the flexible contact portion is increased, thereby gradually moving a flex point of the flexible contact portion toward the contact edge of the curvilinear support and gradually increasing a spring constant of the unsupported end of the flexible contact portion to resist further flexion of the flexible contact portion. | 02-17-2011 |
Thomas N. Hastings, Manhattan Beach, CA US
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20100321733 | Protocol allowing a document management system to communicate inter-attribute constraints to its clients - A system facilitates communication between a control component and a plurality of processing components. One or more processing components performs one or more tasks, each processing component has at least one attribute associated therewith. One or more attribute banks are associated with each of the one or more processing components, wherein each attribute bank stores the at least one attribute. A control component initiates the one or more tasks for each processing component. A universal driver facilitates communication between the one or more processing components and the control component. The driver includes an interrogation component that queries the one or more processing components to receive the at least one attribute associated with each processing component. A constraint evaluator determines combinations of attributes that are supported and unsupported for each of the one or more processing components. An attribute filter categorizes each attribute combination based at least in part on whether it is supported or unsupported. | 12-23-2010 |
W. Reed Hastings, Santa Cruz, CA US
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20100010877 | APPROACH FOR ESTIMATING USER RATINGS OF ITEMS - According to an embodiment of the invention, an approach is provided for estimating how a particular user would rate a particular item from a plurality of items. The approach is applicable to any type of items, including rental items such as movies, music and games, and the invention is not limited to any particular type of item. One or more items from the plurality of items that have ratings similar to the particular item are identified. One or more other users are identified that have given ratings to the one or more items that are substantially similar to ratings given by the particular user to the one or more items. An estimation is made of how the particular user would rate the particular item based upon ratings for the particular item given by the one or more other users. | 01-14-2010 |