Haslett
Chris Haslett, Edinburgh GB
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20140134110 | OPTICAL IMAGING PROBES - The present invention relates to methods of visualising cells especially although not exclusively in vivo using a dye, such as a dendrimer-dye molecule or polybranched-dye molecule which is internalised by the cells and thus permits subsequent visualisation by confocal fluorescence endomicroscopy or other optical detectors. There is also provided internally quenched probes for use in visualising cells especially although not exclusively in vivo by confocal fluorescence endomicroscopy and the use of internally quenched probes in combination with confocal fluorescence endomicroscopy, for visualising cells by virtue of internalisation and dequenching of a probe by the cells. In a particular embodiment the cells are activated neutrophils, such as within the lung of a subject. | 05-15-2014 |
Christopher Haslett, Edinburgh GB
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20090325931 | USE OF CDK INHIBITORS FOR THE TREATMENT OF GRANULOCYTE MEDIATED DISORDERS - Described herein is the use of CDK inhibitors such as roscovitine for inducing apoptosis of granulocytes, for example neutrophils. Their use for treating inflammatory diseases is also provided. | 12-31-2009 |
David Haslett, Mackay AU
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20160002893 | AN EXCAVATOR WEAR ASSEMBLY - An excavator wear assembly comprising a mounting nose having a rear bearing face, a forward bearing face, an upper bearing face disposed at an angle between the rear bearing face and the forward bearing face, a front face substantially perpendicular to the forward bearing face and a rib extending over at least part of the upper bearing face, forward bearing face and front face; and a wear member having a rearwardly opening socket adapted to receive the mounting nose, the socket being at least partially defined by a top wall and a front wall, the wear member having a recess formed in the top wall and front wall adapted to receive at least part of the rib. | 01-07-2016 |
James W. Haslett, Calgary CA
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20080267280 | TIME-TO-DIGITAL CONVERTER - A Time-to-Digital Converter (TDC) is constructed using simple digital delay circuits. The design uses a clock compensation scheme to modify and adjust the TDC's operation under integrated circuit fabrication process variations. The TDC design is based on a novel digital processing algorithm that produces one conversion every clock cycle. Therefore, this TDC is the “first” single cycle latency TDC targeted at high speed circuit applications such as (but not limited to) time-based Analog to Digital Converters (ADCs) for direct analog to digital conversion of radio frequency signals in wireless communication systems and high speed signal measurement applications. Due to its hierarchical design approach, the TDC design uses an optimized number of delay circuits and therefore requires very little power consumption and silicon area. | 10-30-2008 |
Patrick Haslett, Somerville, MA US
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20130121984 | BIOMARKERS FOR SANFILIPPO SYNDROME AND USES THEREOF - The present invention provides biomarkers for efficient and accurate characterization of Sanfilippo syndrome. In particular, the present invention provides biomarkers differentially expressed in Sanfilippo syndrome. Those biomarkers, used alone or in combination, may permit more accurate robust characterization of Sanfilippo syndrome, resulting in more precise determination of the types and/or severity of the syndrome. In addition, inventive biomarkers according to the present invention can be used to effective monitor treatment response in Sanfilippo syndrome patients and/or to optimize treatment for Sanfilippo syndrome. | 05-16-2013 |
20150313971 | METHODS AND COMPOSITIONS FOR INTRATHECALLY ADMINISTERED TREATMENT OF MUCUPOLYSACCHARIDOSIS TYPE IIIA - The present invention provides, among other things, effective treatment for Sanfilippo Syndrome Type A (MPS IIIA) based on intrathecal delivery of recombinant heparin N-Sulfatase (HNS) enzyme. In some embodiments, the present invention includes methods of treating Sanfilippo Syndrome Type A (MPS IIIA) Syndrome by intrathecal administration of a recombinant HNS enzyme at a therapeutically effective dose and an administration interval for a period sufficient to decrease glycosaminoglycan (GAG) heparan sulfate level in the cerebrospinal fluid (CSF) and/or urine relative to a control. | 11-05-2015 |
Patrick Anthony John Haslett, Somerville, MA US
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20150158942 | ANTI-CCL2 ANTIBODIES FOR TREATMENT OF SCLERODERMA - The present invention provides, among other things, improved anti-CCL2 antibodies characterized with high affinity, potency, tissue selectivity and/or epitope specificity, and uses thereof, in particular, for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions. In some embodiments, the present invention provides methods and compositions for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions based on an anti-CCL2 antibody having an affinity of 10 | 06-11-2015 |
Susan Haslett, Dallas, TX US
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20090070202 | Competitive rewards benchmarking system and method - The invention concerns a system and method for implementing and/or administering a competitive rewards database. Member data is received from at least one member computer via a data feed. The (raw) member data is automatically mapped and incorporated into the competitive rewards database. A data capture tool, preferably coupled to a data network, is operable to adjust the mapping of member data. A rewards workbench, preferably coupled to a data network, is generally operable to query the competitive rewards database. | 03-12-2009 |
Thomas L. Haslett, Toronto CA
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20120188541 | NOVEL SPECTROMETER DESIGN FOR ABERRATION CORRECTION, SIMPLIFIED MANUFACTURE, AND COMPACT FOOTPRINT - This disclosure describes a spectrometer design that corrects aberration by using crossed optical paths, simplifies manufacture by applying the light entrance slit and aperture on opposite sides of a transparent input block, and creates a more compact footprint by placing a 45 degree mirror or right angle prism directly in front of the detector. | 07-26-2012 |
20120188542 | SHAPED INPUT APERTURES TO IMPROVE RESOLUTION IN GRATING SPECTROMETERS - This disclosure describes an aperture shaped to provide a narrow beam in the horizontal plane but a wider beam in the vertical plane that will provide improved image quality in spectrometers. | 07-26-2012 |
Tom Haslett, Toronto CA
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20120081699 | Downhole Gas Breakout Sensor - A downhole fluid analysis tool has a housing and a flow passage for downhole fluid. A device disposed in the tool housing relative to the flow passage has a one or more sources, one or more sensing optics, one or more detectors, and control circuitry. The source generates an input signal. The sensing optic has a refractive index (RI) higher than crude oil and other expected constituents. A sensing surface of the optic optically coupled to the source interfaces with a downhole fluid. When the variable RI of the downhole fluid reaches a defined relationship to the optic's RI, the input signal interacting with the sensing surface experiences total internal reflection, and the reflected signal from the sensing surface remains in the sensing optic and reflects to a detector. The control circuitry monitors the detector's response and indicates gas break out if the response is above a threshold. | 04-05-2012 |
20120298850 | Quaternary Photodetector for Downhole Optical Sensing - Detector assembly for downhole spectroscopy includes a near-infra-red quaternary photodiode that can operate at high temperatures without cooling it to the standard operation temperature range of the photodiode. High temperature operation of the photodiode right shifts the detector assembly's responsivity curve to include wavelengths of up to 2400-nm. The photodiode has manageable dark current at temperatures even at 200° C., and it can be packaged using high temperature construction. The photodiode is operated in photovoltaic mode at high temperatures but can be operated at photoconductive mode at lower temperatures. At least partial cooling can be provided above a predetermined temperature. | 11-29-2012 |
20130175438 | Quaternary Photodetector for Downhole Optical Sensing - Detector assembly for downhole spectroscopy includes a near-infra-red quaternary photodiode that can operate at high temperatures without cooling it to the standard operation temperature range of the photodiode. High temperature operation of the photodiode right shifts the detector assembly's responsivity curve to include wavelengths of up to 2400-nm. The photodiode has manageable dark current at temperatures even at 200° C., and it can be packaged using high temperature construction. The photodiode is operated in photovoltaic mode at high temperatures but can be operated at photoconductive mode at lower temperatures. At least partial cooling can be provided above a predetermined temperature. | 07-11-2013 |