Patent application number | Description | Published |
20080245314 | FLUID DELIVERY ASSEMBLY - Assemblies in accordance with the invention can lead to an exceptionally easy to use, safe, and convenient system and method of applying a fixed dosage of chemicals to which a user might wish to avoid contact, such as parasiticides. In the present invention, a fluid, such as a pesticide or parasiticide, glue, solvent, lubricant, medicament and the like is loaded into a fluid reservoir and the reservoir sealed. The reservoir can be attached to a cap-applicator structure which is in an inactive configuration. In the inactive configuration, a piercing tip remains poised over the reservoir in an inactive configuration without forming an opening in the reservoir. The cap-applicator can have a sharp intsernal piercing tip capable of piercing the reservoir when the assembly is converted into an active configuration. This will allow the user to dispense the liquid out of the reservoir through the applicator. | 10-09-2008 |
20080245380 | FLUID APPLICATOR - An applicator tip is provided for operating in conjunction with a pierceable fluid reservoir. Assemblies in accordance with the invention can lead to an exceptionally easy to use, safe, and convenient system and method of applying a fixed dosage of chemicals to which a user might wish to avoid contact, such as parasiticides. The cap-applicator can have an internal piercing tip capable of piercing the reservoir when the assembly is converted into an active configuration. Projections can be provided, in the form of fins on a tube or a multi-prong structure with straight or curved projections. The tips of one or more projections can include dispensing ports or the ports can be recessed from the distal tip, such as in a notch, so as not to be obstructed if the distal tip of the cap is pressed against an animal to dispense the fluid. | 10-09-2008 |
Patent application number | Description | Published |
20080206757 | METHODS AND COMPOSITIONS FOR DETECTING RARE CELLS FROM A BIOLOGICAL SAMPLE - The present invention provides methods and compositions for isolating and detecting rare cells from a biological sample containing other types of cells. In particular, the present invention includes a debulking step that uses a microfabricated filters for filtering fluid samples and the enriched rare cells can be used in a downstream process such as identifies, characterizes or even grown in culture or used in other ways. The invention also include a method of determining the aggressiveness of the tumor or of the number or proportion of cancer cells in the enriched sample by detecting the presence or amount of telomerase activity or telomerase nucleic acid or telomerase expression after enrichment of rare cells. This invention further provides an efficient and rapid method to specifically remove red blood cells as well as white blood cells from a biological sample containing at least one of each of red blood cells and white blood cells, resulting in the enrichment of rare target cells including circulating tumor cells (CTC), stromal cells, mesenchymal cells, endothelial cells, fetal cells, stem cells, non-hematopoietic cells etc from a blood sample. The method is based upon combination of immuno-microparticles (antibody coated microparticles) and density-based separation. The final enriched target cells can be subjected to a variety of analysis and manipulations, such as flowcytometry, PCR, immunofluorescence, immunocytochemistry, image analysis, enzymatic assays, gene expression profiling analysis, efficacy tests of therapeutics, culturing of enriched rare cells, and therapeutic use of enriched rare cells. In addition, depleted plasma protein and white blood cells can be optionally recovered, and subjected to other analysis such as inflammation studies, gene expression profiling, etc. | 08-28-2008 |
Patent application number | Description | Published |
20080202516 | Portable pulmonary body core cooling and heating system - This invention relates to a fully adjustable Portable Pulmonary Body Core Cooling and Heating System specifically designed to provide several hours of high efficiency cooling or heating when worn and operated by a user. This combination Portable Pulmonary Body Core Cooling and Heating System invention is capable of delivering several hours of high efficiency personal cooling or heating without the use of caustic or toxic chemicals with virtually no risk of injury associated with its use. This Portable Pulmonary Body Core Cooling and Heating System invention utilizes the user's own pulmonary system to regulate core body temperature by introducing controlled temperature air into the user's lungs by their own breathing process. | 08-28-2008 |
20080238093 | Cooling, heating, bladder relief, gas, hydration and nutrition chem-bio suit connectivity system - This invention is a Cooling, Heating, Bladder Relief, Gas, Hydration and Nutrition Chem-Bio Suit Connectivity System used connecting various life function support systems in Chemical-Biological Protective Suits. The connectivity system provides means to quick connect and disconnect various user desired support systems including cooling and heating, bladder relief, gas, hydration and nutrition and external to a user that is inside a Chem-Bio Suit. The connectivity system is capable of allowing a user to use any of the support systems either in any combination thereof or individually. The connectivity system self perforates and self seals upon installation in the Chem-Bio Suit and seals upon connection and disconnection of life support systems to prevent contamination from entering inside the Chem-Bio Suit and threatening the health or safety of the user. The connectivity system is easily field installed with no tools required and contains internal electrical, electronic and fiber optic communications capability. | 10-02-2008 |
20110038713 | Dry running flexible impeller pump and method of manufacture - This invention relates to a Dry Running Flexible Impeller Pump and Method of Manufacture designed to provide a flexible impeller pump capable of being run dry for extended periods of time without damage. The pump's components are comprised of low friction materials limiting the heat of friction created by the impeller in use. The impeller is cast of pre-molding silicone substrate containing a quantity of mold release that will not prevent the deposition of a low friction compound coating on the surface of the impeller in a mold that is treated with a low friction industrial coating. Once the impeller is removed from the mold it is solvent cleaned, vacuum baked at a temperature high enough to drive off residual traces of mold release or compounds used to maintain the silicone substrate in suspension, and then coated with a polymer of Poly Para Xylylene by vacuum deposition. | 02-17-2011 |
20130042877 | OXYGEN HEALING SYSTEM AND METHOD OF USE - This invention relates to a pressure related ulcer and perineal dermatitis prevention and treatment device and method of use. The device may be used in conjunction with a urine collection and disposal system that would be beneficial for incontinent users. In use the device forms an automatic pressure controlled topical hyperbaric oxygen chamber and further incorporates a flexible inflated tube system that is controlled by a microprocessor to relief pressure on affected areas of a user's body and provide circulation stimulating therapeutic massage. When used by incontinent persons the device automatically removes expressed urine to minimize additional risk factors known to cause or exacerbate pressure related ulcers and perineal dermatitis. | 02-21-2013 |
Patent application number | Description | Published |
20080317839 | AMINO ACID LIPIDS AND USES THEREOF - This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects. | 12-25-2008 |
20100112042 | Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics - Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an impinging stream. A protocol including flow rates, pH, and an incubation period are used to control formation of liposomal components for therapeutic applications. The impinging stream may be collected and incubated to prepare a liposomal formulation which encapsulates the active agent. The composition can be quenched with buffer and filtered by tangential flow and diafiltration and other means for finishing as a pharmaceutical composition. An efficiency for delivering a drug cargo is provided. Compositions can include a liposome containing one or more carrier particles, each carrier particle having an active agent and a peptide, wherein the ratio of the mass of the peptide plus the mass of the liposome to the mass of the active agent is less than about 15. | 05-06-2010 |
20110177160 | Amino acid lipids and uses thereof - This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects. | 07-21-2011 |
20120277289 | ACTIVITY GENERATING DELIVERY MOLECULES - Activity-generating delivery molecules comprising the structure R | 11-01-2012 |
20130039970 | Processes and Compositions for Liposomal and Efficient Delivery of Gene Silencing Therapeutics - Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an impinging stream. A protocol including flow rates, pH, and an incubation period are used to control formation of liposomal components for therapeutic applications. The impinging stream may be collected and incubated to prepare a liposomal formulation which encapsulates the active agent. The composition can be quenched with buffer and filtered by tangential flow and diafiltration and other means for finishing as a pharmaceutical composition. | 02-14-2013 |
20140037714 | AMINO ACID LIPIDS AND USES THEREOF - This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects. | 02-06-2014 |
20150017233 | ARGININE-BASED LIPIDS FOR DELIVERY OF THERAPEUTICS - This disclosure provides a range of amino acid lipid compounds and compositions useful for drug delivery, therapeutics, and the diagnosis and treatment of diseases and conditions. The amino acid lipid compounds and compositions can be used for delivery of various agents such as nucleic acid therapeutics to cells, tissues, organs, and subjects. | 01-15-2015 |
20150073038 | DELIVERY MOLECULES FOR THERAPEUTICS - Activity-generating delivery molecules comprising the structure R | 03-12-2015 |
20150209283 | PROCESSES AND COMPOSITIONS FOR LIPOSOMAL AND EFFICIENT DELIVERY OF GENE SILENCING THERAPEUTICS - Processes and compositions for liposomal delivery of therapeuticals prepared by contacting an aqueous solution of an active agent with a solution of liposome-forming components containing one or more DILA2 amino acid compounds or lipids in organic solvent to form an impinging stream. A protocol including flow rates, pH, and an incubation period are used to control formation of liposomal components for therapeutic applications. The impinging stream may be collected and incubated to prepare a liposomal formulation which encapsulates the active agent. The composition can be quenched with buffer and filtered by tangential flow and diafiltration and other means for finishing as a pharmaceutical composition. | 07-30-2015 |