Harding, GB
Adrian L. Harding, Derby GB
Patent application number | Description | Published |
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20120219402 | VANE - A vane is provided for directing hot gases in a gas turbine engine. The vane includes a hollow aerofoil portion, which in use spans the working gas annulus of the engine. The vane further includes an impingement tube which forms a covering over the interior surface of the aerofoil portion and which has jet-forming apertures formed therein for the production of impingement cooling jets. The impingement tube includes two tube portions which are separately insertable into position into the aerofoil portion to form the covering. The o impingement tube further includes an expansion member which, when the tube portions are in position in the aerofoil portion, is locatable in the aerofoil portion to urge each tube portion outwardly and thereby holds the tube portions in position against the aerofoil portion. | 08-30-2012 |
20130089414 | STRIP SEALS - A strip seal for providing a seal between adjacent components, which include a first groove and a second groove angled with respect to and intersecting the first groove. The grooves of respective components are opposed to one another when the components are assembled. The strip seal includes a first strip section to span between and be received in the opposed first grooves, and a second strip section to span between and be received in the opposed second grooves. One end of the first strip section is arranged to butt against the second strip section at the intersection of the grooves. The other end of the first strip section has at least one deformable projection that can engage the end of the first groove. The projection deforms as it engages the end of the groove and urges the end of the first strip section against the second strip section. | 04-11-2013 |
Adrian Lewis Harding, Derby GB
Patent application number | Description | Published |
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20130136599 | AEROFOIL COOLING ARRANGEMENT - An aerofoil typically for a blade or vane for a gas turbine engine comprises a pressure wall and a suction wall, at least one of the pressure and suction walls comprise corrugations and a coolant hole on an inner surface, the corrugations define a downstream surface and the coolant hole having an inlet defined in the downstream surface. | 05-30-2013 |
20130255278 | EFFUSION COOLED SHROUD SEGMENT WITH AN ABRADABLE SYSTEM - A turbine casing assembly, comprising an annular seal segment assembly for surrounding the turbine adjacent to the turbine blades. An abradable coating is provided on the inboard surface of the seal segments of the assembly and one or more coolant ducts extend from the outboard surface of the seal segment assembly through respective seal segments and the abradable coating, for carrying a coolant towards the blade tips. One or more annular grooves are formed in the inboard surface of the abradable coating, the or each coolant duct opening into one of the one or more annular grooves. | 10-03-2013 |
20140064967 | AEROFOIL COOLING ARRANGEMENT - An aerofoil typically for a blade or vane for a gas turbine engine comprises a pressure wall, a suction wall and a web that extends therebetween. One of the walls comprises an inner leaf and an outer leaf which defines a cavity, the other wall defines a first outlet, the aerofoil defines at least one first passage extending from the cavity through the web and to the outlet. Coolant in the cavity on one side wall of the aerofoil is thereby routed across the web to be used to cool the other wall by convention and formation of a coolant film. | 03-06-2014 |
Alan Harding, Leicester GB
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20120272936 | ELECTRONIC FUEL CONTROL SYSTEM - The present invention is concerned with an electronic fuel control system including a carburettor having a throttle bore, a fuel chamber, and at least one fuel circuit extending between the fuel chamber and the throttle bore and controlled by an adjustment member such as a needle, the control system further including an actuator operable to automatically adjust the adjustment member in response to one or more engine operating parameters. | 11-01-2012 |
Amanda Harding, Abingdon, Oxfordshire GB
Patent application number | Description | Published |
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20150368623 | CYCLODEXTRIN GLUCANOTRANSFERASE - The present invention relates to a novel cyclodextrin glucanotransferase (CGTase) enzyme which is obtainable from | 12-24-2015 |
20150368678 | PRODUCTION OF BUTANOL - The present invention relates to methods of making solvents, such as butanol, acetone or ethanol. In particular, the invention relates to a process for producing a solvent, comprising the step of culturing a solventogenic | 12-24-2015 |
Cressida Harding, Cambridge GB
Patent application number | Description | Published |
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20130021447 | DUAL IMAGE CAPTURE PROCESSING - Embodiments of imaging devices of the present disclosure automatically utilize simultaneous image captures in an image processing pipeline. In one embodiment, control processing circuitry initiates simultaneous capture of the first image by the first image sensor and the second image by the second image sensor; and image processing circuitry generates an enhanced monoscopic image comprising at least portions of the first image and the second image. | 01-24-2013 |
Cressida Harding, Burwell GB
Patent application number | Description | Published |
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20110254995 | METHOD AND SYSTEM FOR MITIGATING SEESAWING EFFECT DURING AUTOFOCUS - A mobile multimedia device may be operable to crop a series of image samples received during an autofocus operation. Each of the cropped image samples may be scaled by the mobile multimedia device to fit a display unit in the mobile multimedia device. Each of the scaled image samples may then be displayed on the display unit for viewing during the autofocus operation. The received image samples may be cropped based on an operating mode in which the mobile multimedia device is currently operating. The autofocus operation may be initiated utilizing a shutter button in the mobile multimedia device. The autofocus operation may be terminated when a desired focus is achieved. After the autofocus operation is terminated, the mobile multimedia device may be operable to display one or more image samples received after the termination of the autofocus operation for continuous viewing, with or without further cropping and scaling. | 10-20-2011 |
Dave Harding, London GB
Patent application number | Description | Published |
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20140068591 | Monitoring Software - A networked computer system comprises a source of usage data relating to usage of software installed on respective computers of the system, and a source of attribute data relating to attributes associated with the computers. A usage engine evaluates usage of the installed software based on the usage data. A mapping engine selects a mapping rule associated with the installed software in dependence on the evaluated usage data and the attribute data and provides an action to take in relation to an item of software in accordance with the selected rule. The action comprises, for at least some installed software, replacement of the software by alternative software selected by the rule. | 03-06-2014 |
20140164583 | Providing Policy Data to a Computer - A network comprises a plurality of computers including a first computer and a target computer. It also has a source of a plurality of policies, and an arrangement which installs policies on the computers of the network. The first computer has program code for accessing the source and for selecting one of the policies. The source responds to the selection to provide the selected policy to the installing arrangement. The installing arrangement has program code for automatically installing the selected policy on the target computer. | 06-12-2014 |
Deborah Phyllis Harding, Cambridge GB
Patent application number | Description | Published |
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20150133483 | Dihydroetorphines and Their Preparation - The present invention provides a process for the preparation of a compound of formula (VI), or a salt or derivative thereof, | 05-14-2015 |
Deborah Phyllis Harding, Cambirdge GB
Patent application number | Description | Published |
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20160115174 | DIHYDROETORPHINES AND THEIR PREPARATION - The present invention provides a process for the preparation of a compound of formula (VI), or a salt or derivative thereof, | 04-28-2016 |
Deborah Phyllis Harding, Cambridgeshire GB
Patent application number | Description | Published |
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20120010231 | Dihydroetorphines and Their Preparation - The present invention provides a process for the preparation of a compound of formula (VI), or a salt or derivative thereof, wherein R | 01-12-2012 |
Denise Jamilla Harding, London GB
Patent application number | Description | Published |
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20100317646 | COMPOUNDS - A compound of formula I, or a pharmaceutically acceptable salt or ester thereof, | 12-16-2010 |
Edward James Harding, Snerrisham GB
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20110151069 | Infant or baby feeding systems - An infant feeding system comprising a sterile sealed laminated bag having a predetermined quantity of liquid infant food sealed therein, a compressed integral sterile teat sealed with the bag closure and or spout and a protective cap for the teat, the system being arranged such that the cap can be removed to enable the infant to feed from the sterile teat and food. | 06-23-2011 |
Edward James Harding, Norfolk GB
Patent application number | Description | Published |
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20090294454 | UTENSIL SHAPED CONTAINER - A spoon or utensil shaped food and or liquid chamber or container that may be designed to contain or store a foodstuff and or liquid or other contents, and may be attached to or part of or within one or more chambers or container. | 12-03-2009 |
Emma R. Harding, Stevenage GB
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20130310281 | NOVEL ANTIGEN BINDING PROTEINS - The present invention provides novel antigen-binding proteins derived from human germline V | 11-21-2013 |
Fraser Harding, Berkshire GB
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20140222366 | Apparatus And Methods For Monitoring And Analysing The Performance Of A Heating Or Cooling System - Apparatus for monitoring and analysing the performance of a heating and/or cooling system for a space within a building. The apparatus comprises a processing arrangement and an electronic memory, wherein the processing arrangement is configured to receive temperature signals representing temperature measurements from a temperature sensor within the space over a monitored period of time, to process the temperature signals so as to generate output data which attributes a proportion of the energy consumption of the heating and/or cooling system to a specified energy output, and to transmit the output data to the electronic memory for retrieval by a user. Corresponding monitoring and analysis methods are also described. | 08-07-2014 |
20150226445 | Apparatus And Method For Analysing The Operation Of A Temperature Management System By A User - Apparatus for analysing the operation by a user of a temperature management system for heating and/or cooling a space within a building. The apparatus comprises a data processing arrangement configured to analyse a user control input to determine whether it corresponds to predetermined category of user input. If so, it calculates a value relating to the effect of the user control input on the energy consumption of the system over a subsequent time period and generates an output signal to cause a message to be delivered to the user comprising the calculated value. | 08-13-2015 |
Ian S. Harding, Wells GB
Patent application number | Description | Published |
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20130306492 | Method and apparatus for assay of electrochemical properties - A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component. | 11-21-2013 |
20160038063 | Method and Apparatus for Assay of Electrochemical Properties - A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component. | 02-11-2016 |
Ian S. Harding, Wells, Somerset GB
Patent application number | Description | Published |
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20150219550 | Method and apparatus for assay of electrochemical properties - A method for monitoring a select analyte in a sample in an electrochemical system. The method includes applying to the electrochemical system a time-varying potential superimposed on a DC potential to generate a signal; and discerning from the signal a contribution from the select analyte by resolving an estimation equation based on a Faradaic signal component and a nonfaradaic signal component. | 08-06-2015 |
John Harding, Essex GB
Patent application number | Description | Published |
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20100045077 | MOTOR VEHICLE STOWABLE ROOF ASSEMBLY - An actuation mechanism for a stowable front roof panel includes a first support assembly to provide vertical movement of the roof panel and a second sliding support structure to provide horizontal movement of the front roof panel. The first support assembly includes first and second upwardly extending supports and a transverse tubular cross member that in combination form an inverted U-shaped roll over protection member. The roll over protection member is used to provide roll over protection to the occupants of the motor vehicle in the event of a vehicle roll over. | 02-25-2010 |
John K. Harding, Leigh-On-Sea GB
Patent application number | Description | Published |
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20080265610 | MOTOR VEHICLE HAVING A STOWABLE ROOF - A motor vehicle is disclosed having front and rear roof panels and which can be moved from in use to stowed positions to change the style of the motor vehicle from a two box style to a convertible or pick-up style. A stowage mechanism for the rear roof panel having two interlinked four bar linkages is disclosed which allows a small linear actuator to produce the range of displacement required to stow the rear roof panel. | 10-30-2008 |
20100230451 | ROOF BAR FOR A MOTOR VEHICLE - A roof bar ( | 09-16-2010 |
20100230452 | ROOF BAR FOR A MOTOR VEHICLE - A roof bar ( | 09-16-2010 |
20100230453 | ROOF BAR FOR A MOTOR VEHICLE - A roof bar ( | 09-16-2010 |
20100259074 | ARMREST ASSEMBLY FOR A SEAT - An armrest assembly for a vehicle seat | 10-14-2010 |
20110103926 | Vehicle Storage/Loading System for Sheets - A motor vehicle having an assembly for loading sheet material includes a cargo area having a loading opening and a bulkhead located at an opposite end of the cargo area from the loading opening. Also included is a passenger compartment located at a forward region of the vehicle. Further included is at least one fixed end stop located proximate a rear area of the cargo area. Yet further included is at least one load assist strip, where a first end of the strip is mounted to the bulkhead, wherein the strip extends rearward to a second end of the strip that is mounted to the end stop. | 05-05-2011 |
20110148134 | MOVABLE BULKHEAD SYSTEM TO INCREASE LOAD CAPACITY OF A VEHICLE - A moveable bulkhead | 06-23-2011 |
20110241544 | LIGHTING SYSTEM ARRANGED IN VEHICLE DOOR - A lighting system for a motor vehicle | 10-06-2011 |
20140153163 | COMBINED STORAGE AND DOCKING UNIT FOR A PORTABLE ELECTRONIC DEVICE - A combined storage and docking unit for attachment to the instrument panel of a motor vehicle is disclosed in which a portable electronic device such as an MP3 player or GPS navigation device can be held in a display position by clamping it between lid and storage box parts of the combined storage and docking unit. The storage box includes a trough shaped portion in which the portable electronic device can be stowed if it is not required to be used. The combined storage and docking unit is of a simple construction and allows portable electronic devices of differing size and shape to be accommodated. | 06-05-2014 |
20150258943 | COMBINED STORAGE AND DOCKING UNIT FOR A PORTABLE ELECTRONIC DEVICE - A combined storage and docking unit for attachment to the instrument panel of a motor vehicle is disclosed in which a portable electronic device such as an MP3 player or GPS navigation device can be held in a display position by clamping it between lid and storage box parts of the combined storage and docking unit. The storage box includes a trough shaped portion in which the portable electronic device can be stowed if it is not required to be used. The storage box also includes a lid hingedly connected thereto. A lid opening mechanism includes an arm fixed to a shaft. A drive cable is connected to the arm and to a spring on opposing ends. A pulley is configured to guide the drive cable from the arm to the spring, wherein the shaft is rotatably supported by a shaft bracket. | 09-17-2015 |
John K. Harding, Essex GB
Patent application number | Description | Published |
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20100259065 | MOTOR VEHICLE - A motor vehicle ( | 10-14-2010 |
20140028043 | MOVEABLE BULKHEAD SYSTEM TO INCREASE LOAD CAPACITY OF A VEHICLE - A movable bulkhead | 01-30-2014 |
John Robert Harding, Brighton GB
Patent application number | Description | Published |
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20100253863 | IMAGE DISPLAY APPARATUS - Image display apparatus ( | 10-07-2010 |
Julian Harding, Coventry GB
Patent application number | Description | Published |
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20120290733 | METHOD OF ESTABLISHING COMMUNICATION IN A COMMUNICATIONS NETWORK - The invention provides a method of establishing communication in a communications network in which a communication initiation request including service suppression information indicating that the whole or part of a communication service associated with the communication should be suppressed is generated and sent to initiate communication. When the communication initiation request is received ( | 11-15-2012 |
Keith Harding, Cardiff GB
Patent application number | Description | Published |
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20130116134 | METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF WOUNDS - The invention relates to a method and kit for identifying chronic or acute mammalian wound tissue or for determining the prognosis of mammalian wound tissue based upon the identification of at least one key set of molecular markers or genes whose expression pattern is indicative of a given wound type and so representative of a given prognosis. | 05-09-2013 |
20140213629 | MOLECULAR TARGETS FOR HEALING OR TREATING WOUNDS - The invention relates to at least one molecular target for healing or treating wounds and, in particular chronic, human wounds. The molecular target is PTPRK, or a protein 50% homologous therewith, and which retains the same activity as PTPRK protein. Further, the invention concerns a novel therapeutic for treating said wounds and a novel gene therapy approach, involving said molecular target, for treating said wounds. | 07-31-2014 |
Keith Harding, South Glamorgan GB
Patent application number | Description | Published |
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20120321613 | MOLECULAR TARGETS FOR HEALING OR TREATING WOUNDS - The invention relates to at least one molecular target for healing or treating wounds and, in particular chronic, human wounds. The molecular target is nWASP or a protein 50% homolgous therewith and which retains the same activity as nWASP protein, such as WASP. Further, the invention concerns a novel therapeutic for treating said wounds and a novel gene therapy approach, involving said molecular target, for treating said wounds. | 12-20-2012 |
20160038563 | MOLECULAR TARGETS FOR HEALING OR TREATING WOUNDS - The invention relates to at least one molecular target for healing or treating wounds and, in particular chronic, human wounds. The molecular target is nWASP or a protein at least 75% homologous therewith and which retains the same activity as nWASP protein, such as WASP. Further, the invention concerns a novel therapeutic for treating said wounds and a novel gene therapy approach, involving said molecular target, for treating said wounds. | 02-11-2016 |
Keith Gordon Harding, Cardiff GB
Patent application number | Description | Published |
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20120315637 | METHOD AND KIT FOR THE CLASSIFICATION AND PROGNOSIS OF CHRONIC WOUNDS - A method and kit are provided for identifying non-healing or healing chronic mammalian wound tissue or for determining the prognosis of chronic mammalian wound tissue based upon the identification of at least one key set of molecular markers or genes whose expression pattern is indicative of a given wound type and so representative of a given prognosis. | 12-13-2012 |
Lynda Joy Harding, Portsmouth GB
Patent application number | Description | Published |
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20090211022 | Device for Supporting, Rolling and/or Rocking a Mattress - A device for a cot or child's bed comprises a mattress support mounted on springs. Actuation means is provided to roll and/or rock the mattress support on the springs such that the side portions and/or the end portions of the mattress support repeatedly rise and fall. The actuation means could, for example, comprise a linear actuator, a swash plate mechanism or an air bag. | 08-27-2009 |
Nick Harding, London GB
Patent application number | Description | Published |
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20150335066 | SMOKING ARTICLE - A smoking article comprises a first part ( | 11-26-2015 |
20150335067 | SMOKING ARTICLE - A smoking article, comprises a first and a second engaging surface ( | 11-26-2015 |
20150335068 | SMOKING ARTICLE - A smoking article comprises a first part, a second part movable relative to the first part. At least one of the first or second parts comprises a section of sheet material wrapped around one or more rod articles, wherein the section of sheet material comprises a circumferentially leading edge and/or a trailing edge. The circumferentially leading edge and/or a trailing edge is angled to a longitudinal axis of the smoking article. The section of the first part or second part comprising the angled edge is configured to be rotatable relative to the other of the first or second part, the relative rotational position of the first and second parts configured to control a property of the smoking article. | 11-26-2015 |
20150342248 | SMOKING ARTICLE - A smoking article comprises a first part ( | 12-03-2015 |
Piers Sebastian Harding, London GB
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20100261179 | SAMPLE PREPARATION DEVICES AND ANALYZERS - The application provides sample preparation devices and analyses. The devices and analyzes allow for the rapid preparation and analysis of samples using a variety of techniques, including PCR, by even unskilled users. | 10-14-2010 |
Piers Sebastian Harding, Buckworth GB
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20100192706 | SAMPLE PREPARATION APPARATUS - Apparatus for preparing a biological sample for PCR analysis has an inlet ( | 08-05-2010 |
Piers Sebastian Harding, Cambridgeshire GB
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20150291317 | Apparatus - A cartridge for replenishing a vehicle fluid, a fluid reservoir system comprising same and a holder, a holder, a vehicle engine comprising the fluid reservoir system and a vehicle comprising said engine in which, the cartridge comprises: a housing comprising a first part and a second part; a fluid reservoir in the housing; a port arranged on the first part of the housing to couple the reservoir in fluidic communication with a fluid system of the vehicle; wherein the second part of the housing is configured to rotate with respect to the first part of the housing to secure the cartridge with respect to the fluid system to hold the reservoir in fluidic communication, via the port, with the fluid system of the vehicle, wherein the second part of the housing is configured such that rotating the second part of the housing does not rotate the port. | 10-15-2015 |
20150291318 | Replaceable Fluid Container - A replaceable fluid container for a vehicle, the container comprising: a housing comprising a fluid reservoir; an outlet port arranged on the housing to couple the reservoir in fluidic communication with a fluid system of the vehicle for supplying fluid from the reservoir to the vehicle; an inlet port arranged on the housing to couple the reservoir in fluidic communication with the fluid system of the vehicle for receiving fluid from the engine to the reservoir; and a vent port arranged on the housing to couple the reservoir in fluidic communication with the vehicle for allowing gas to be passed into and out from the reservoir, wherein the inlet, outlet and vent ports are arranged on a common end of the housing and are arranged such that the distance between the vent port and the nearest of the inlet port and outlet port is greater than the distance between the inlet port and the outlet port. | 10-15-2015 |
20150292674 | Replaceable Fluid Container - A replaceable fluid container for a vehicle, for example a vehicle engine, the container comprising: a housing comprising a fluid reservoir; at least one fluid port arranged on the housing to couple the reservoir in fluidic communication with a fluid system of the vehicle; a vent port arranged on the housing to couple the reservoir in fluidic communication with the vehicle for allowing gas to be passed into and out from the reservoir; a vent tube connected at a first end, to said vent port and arranged within the reservoir to pass through fluid contained in the reservoir when the container is connected with the fluid reservoir in fluidic communication with the fluid system of the vehicle, with a second end of the vent tube in a headspace above the fluid in the reservoir, to allow gas communication between the vent port and the headspace, in which the vent tube comprises a vent valve at the second end of the vent tube adapted to close to prevent ingress of fluid and gas from the reservoir into the vent tube when the vent port is not in fluidic communication with the vehicle and to open to allow gas communication between the head space and the engine through the vent tube and vent port when the vent port is in fluid communication with the vehicle. | 10-15-2015 |
Richard Harding, Hants GB
Patent application number | Description | Published |
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20080316418 | Lc Material with Homeotropic Alignment - The invention relates to a liquid crystal (LC) material that aligns homeotropically on substrates with high or low surface energy. | 12-25-2008 |
20090066890 | TRANSFLECTIVE LCD COMPRISING A PATTERNED RETARDATION FILM - The invention relates to a transflective liquid crystal display (LCD) with a polymerised LC film comprising at least one photoisomerisable compound and having a pattern of regions with different retardation and/or different orientation of the LC material. | 03-12-2009 |
20090073352 | TRANSFLECTIVE VERTICALLY ALIGNED LIQUID CRYSTAL DISPLAY WITH IN-CELL PATTERNED QUARTER-WAVE RETARDER - The invention relates to a transflective vertically aligned (VA) liquid crystal display (LCD) comprising a patterned quarter wave foil (QWF). The display ( | 03-19-2009 |
20130012654 | ALIGNMENT LAYER WITH REACTIVE MESOGENS FOR ALIGNING LIQUID CRYSTAL MOLECULES - The invention relates to an alignment layer with improved adhesion to liquid crystal (LC) films, to a precursor material used for the preparation of such a layer, to a laminate comprising such a layer and at least one LC polymer film, and to the use of the alignment layer and the laminate for optical, electrooptical, decorative or security uses and devices, wherein the alignment layer and the precursor material comprise at least one reactive mesogen in monomeric, oligomeric or polymeric form. | 01-10-2013 |
Russell Harding, London GB
Patent application number | Description | Published |
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20130300767 | METHOD AND SYSTEM FOR AUGMENTED REALITY - A method of augmented reality includes associating tint information with a predetermined graphical object, and receiving a video image of a real scene comprising a feature for detection. The method further includes detecting the feature in the video image of the real scene and selecting a graphical object responsive to the detected feature, and augmenting the video image with the selected graphical object. If the selected graphical object is the predetermined graphical object, the method further includes retrieving the tint information associated with the predetermined graphical object, and modifying the colour balance of the video image responsive to the tint information. | 11-14-2013 |
20130303285 | APPARATUS AND METHOD FOR AUGMENTED REALITY - A method of incorporating an augmented reality video image into a virtual environment comprises detecting a state of a real-world control object captured in a video image and augmenting the video image responsive to the state of the control object. The method further includes calculating trajectory parameters for an action with respect to a local co-ordinate system of the video image, responsive to the state of the control object, and embedding the augmented video image within a 3D virtual environment. The method also includes calculating the trajectory parameters for the action with respect to a local co-ordinate system of the 3D virtual environment, and rendering a graphical effect corresponding to the action within the 3D virtual environment. | 11-14-2013 |
Sarah Victoria Harding, Salisbury GB
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20120020993 | VACCINE - The present invention relates to a pharmaceutical formulation comprising lipopolysaccharide derived from | 01-26-2012 |
Sarah Victoria Harding, Wiltshire GB
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20100062022 | IMMUNOGENIC PROTEINS OF BURKHOLDERIA PSEUDOMALLEI AND USES THEREOF - A protein derived from an outer layer of | 03-11-2010 |
Stephen Harding, West Midlands GB
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20150024416 | CORRECTION METHOD FOR ESTIMATING FREE LIGHT CHAIN PRODUCTION - The invention provides a method of estimating free light chain production (FLC) in a subject comprising (i) determining an amount of FLC in a sample from the subject; and (ii) correcting the amount of FLC in the sample for FLC cleared from the source of the sample by glomerular filtration and by reticuloendothelial (RE) clearance. | 01-22-2015 |
20150051839 | METHOD FOR CHARACTERISING PLASMA CELL ASSOCIATED DISEASES - The invention provides a method for characterising a plasma cell associated disease in a patient comprising: (i) providing at least one sample from the patient; (ii) determining in the sample(s) two or more of; (a) the κ:λ free light chain (FLC) ratio; (b) the ratio of κ light chains bound to a class of heavy chain:λ light chain bound to the same class of heavy chain (HLCκ:HLC λ ratio); (c) the total amount of FLC in the samples and (d) the total amount of κ light chains bound to the heavy chain class plus λ light chains bound to the same heavy chain class (total HLC); (iii) comparing each ratio or amount from (a) (b), (c) and/or (d) to predetermined values and assigning a score to each amount or ratio; and (iv) using the scores to characterise the plasma cell associated disease. Apparatus configured to carry out the method of the invention are also provided. The invention also provides a kit comprising, in combination, (i) anti-κ FLC specific and anti-λ FLC specific antibodies or fragments thereof and (ii) anti-κ heavy chain class specific and anti-λ heavy chain class specific antibodies or fragments thereof, optionally mixed together. | 02-19-2015 |
Stephen Harding, Birmingham GB
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20150173685 | TRIAGE SCORING SYSTEM - The application discloses a method of determining the severity of symptoms in a patient comprising (i) producing a triage score, such as an early warning score (EWS) modified early warning score (MEWS), paediatric early warning score (PEWS), NHS early warning score (NEWS), simple clinical score (SCS), rapid emergency score (REMS) or mortality in emergency department sepsis score for the patient, (ii) measuring an amount of free light chains (FLC), preferably combined free light chains (cFLC), in a sample from the patient, and (iii) using the triage score and the amount of FLC measured to assess the severity of symptoms in the patient. This also allows patients to be triaged to provide better treatment of them. | 06-25-2015 |
Stephen Harding, Oldham GB
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20080285586 | Multiplexer - A multiplexer ( | 11-20-2008 |
Stephen C. Harding, Bristol GB
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20120260664 | FUEL INJECTOR ARRANGEMENT HAVING AN IGNITER - An arrangement for a combustion chamber the arrangement comprising a combustion chamber, an injector for injecting fuel into the combustion chamber and an igniter for supplying a spark for igniting fuel so injected, wherein the injector has a passage through which air is supplied to the combustion chamber in use, the igniter being positioned upstream of the combustion chamber such that a spark generated by the igniter is conveyed along the passage by the injector air. | 10-18-2012 |
20130020413 | FUEL INJECTOR - A fuel injector comprising: a prefilmer; a plurality of discrete fuel sources each arranged to supply fuel to a surface of the prefilmer; wherein the prefilmer comprises circumferential dispersion structure which, in use, spreads the fuel in a circumferential direction as it passes from an impingement point on the surface of the prefilmer to a downstream edge of the prefilmer. | 01-24-2013 |
20130032639 | FUEL INJECTOR - A fuel injector head for a gas turbine engine comprising: a pilot injector having a central axis, the pilot injector being arranged to direct fuel and air to a pilot combustion zone, a main injector located radially outwardly of the pilot injector and being arranged to direct fuel and air to a main combustion zone, a splitter separating the pilot injector from the main injector and comprising a body, the body defining an axis, an annular surface and a downstream edge wherein the annular surface has a circumferentially varied axial length so that interaction between the pilot combustion zone and the main combustion zone initiates from least two different axial positions. | 02-07-2013 |
20160097539 | COMBUSTION CHAMBER AND A METHOD OF MIXING FUEL AND AIR IN A COMBUSTION CHAMBER - A combustion chamber including a first fuel injector and a second fuel injector, the first and second fuel injectors being arranged to inject fuel into a mainstream flow of air with the second fuel injector arranged downstream of the first fuel injector. A method of mixing fuel and air in a combustion chamber, including injecting fuel into a mainstream flow of air with a first fuel injector; injecting fuel into the mainstream flow of air with a second fuel injector, which is arranged downstream of the first fuel injector; injecting fuel into the mainstream flow with the first fuel injector such that the resulting mixture between the first and second fuel injectors has an equivalence ratio less than the lean flame stability limit; and injecting fuel into the mainstream flow with the second fuel injector such that a combustion zone is provided downstream of the second fuel injector. | 04-07-2016 |
Stephen C. Harding, Derby GB
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20160097285 | COOLED COMPONENT - A cooled gas turbine engine component comprises a wall which has a plurality of effusion cooling apertures extending there-through from a first surface to a second surface. Each aperture has an inlet in the first surface and an outlet in the second surface. Each aperture has a metering portion and a diffusing portion arranged in flow series and each metering portion is elongate and the width is greater than the length of the metering portion. The metering portion of each aperture has a U-shaped bend. The diffusing portion of each aperture is arranged at an angle to the second surface. Each outlet has a rectangular shape in the second surface of the wall. Each inlet has an elongate shape in the first surface of the wall and the inlet in the wall is arranged substantially diagonally with respect to the outlet in the wall. | 04-07-2016 |
Stephen Charles Harding, Bristol GB
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20150241062 | COMBUSTION CHAMBER WALL AND A METHOD OF MANUFACTURING A COMBUSTION CHAMBER WALL - A combustion chamber wall is hollow, has a first surface and a second surface and includes a plurality of polyhedron shaped chambers defined by a matrix of integral interconnected walls. The walls of the chambers in a first layer define the first surface of the combustion chamber wall and the walls of the chambers in a third layer define the second surface of the combustion chamber wall. The chambers are fluidly interconnected by apertures extending through the integral interconnected walls of the chambers for the flow of coolant there-between. The walls of the chambers in the first layer have apertures extending there-through to supply coolant into the first layer and the walls of the chambers in the third layer have apertures extending there-through to supply coolant from the third layer into the combustion chamber. The combustion chamber wall is manufactured by additive layer manufacture. | 08-27-2015 |
20160097325 | COOLED COMPONENT - A cooled gas turbine engine component comprises a wall which has a plurality of effusion cooling apertures extending there-through from a first surface to a second surface. The apertures are arranged at an angle to the second surface and each aperture has an inlet in the first surface and an outlet in the second surface. Each aperture has a metering portion and a diffusing portion arranged in flow series and each metering portion is elongate and the width is greater than the length of the metering portion. Each diffusing portion increases in dimension in the length from the metering portion to the outlet. Each outlet has a rectangular shape in the second surface of the wall. Each inlet has an elongate shape in the first surface of the wall and the inlet in the wall is arranged substantially diagonally with respect to the outlet in the wall. | 04-07-2016 |