Haraldsson, SE
Börje Haraldsson, Landvetter SE
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20100152243 | Treatment of renal cell carcinoma - Methods are provided of treating renal cancer by administration of certain 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide compounds, especially 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide (Orellanine), using particular administration protocols and dosing regimens, as well as pharmaceutical compositions suitable for use in the treatment methods that are provided. | 06-17-2010 |
20130101507 | Treatment of Renal Cell Carcinoma - Methods for treating renal cancer by administration of certain 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide compounds, especially 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide (Orellanine), conjugated to an alpha-emitting radionuclide (e.g. Astatine-211) to increase the efficacy of the formulation and/or a large molecule (e.g. a oligomer/polymer such as a PEG or a polysaccharide such as a dextran or a Ficoll®) to reduce the filtration and consequently the renal exposure. Particular administration protocols and dosing regimens, as well as pharmaceutical compositions suitable for use in the treatment methods can be used. | 04-25-2013 |
Börje Haraldsson, Landvetter SE
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20100152243 | Treatment of renal cell carcinoma - Methods are provided of treating renal cancer by administration of certain 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide compounds, especially 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide (Orellanine), using particular administration protocols and dosing regimens, as well as pharmaceutical compositions suitable for use in the treatment methods that are provided. | 06-17-2010 |
20120077846 | Treatment of renal cell carcinoma - Methods are provided of treating renal cancer by administration of certain 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide compounds, especially 3,3′,4,4′-tetrahydroxy-2,2′-bipyridine-N,N′-dioxide (Orellanine), using particular administration protocols and dosing regimens, as well as pharmaceutical compositions suitable for use in the treatment methods that are provided. | 03-29-2012 |
Göran Haraldsson, Horby SE
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20130205773 | TURBO COMPOUND TRANSMISSION AND A METHOD FOR CONTROLLING A TURBO COMPOUND TRANSMISSION - A turbo compound transmission, such as in a heavy duty or medium duty diesel engine, includes a turbo compound turbine to be driven by exhaust gases from an internal combustion engine, and a coupling including a first rotor including a mechanical input drive adapted to be driven by the turbine, and a second rotor including a mechanical output drive. A brake is arranged to brake and limit the rotation of the turbine. The coupling is arranged to decouple when braking with the brake, subjecting the coupling to a torque above a predetermined torque limit. A method for controlling a turbo compound transmission is also disclosed. | 08-15-2013 |
Göran Haraldsson, Horby SE
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20130205773 | TURBO COMPOUND TRANSMISSION AND A METHOD FOR CONTROLLING A TURBO COMPOUND TRANSMISSION - A turbo compound transmission, such as in a heavy duty or medium duty diesel engine, includes a turbo compound turbine to be driven by exhaust gases from an internal combustion engine, and a coupling including a first rotor including a mechanical input drive adapted to be driven by the turbine, and a second rotor including a mechanical output drive. A brake is arranged to brake and limit the rotation of the turbine. The coupling is arranged to decouple when braking with the brake, subjecting the coupling to a torque above a predetermined torque limit. A method for controlling a turbo compound transmission is also disclosed. | 08-15-2013 |
Kajsa Haraldsson, Malmo SE
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20120255115 | SHOWER STRETCHER - A shower stretcher assembly includes a frame which supports a platform having panels that define a back rest section, a seat section, and a foot section. The seat section is of flexible material which conforms to the shape of a person lying thereon. This flexible material provides increase in the effective length of the mattress support that conforms to person's body between navel and knees. | 10-11-2012 |
Karin Haraldsson, Lund SE
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20090203572 | Method for in Vitro Molecular Evolution of Protein Function - The invention provides a method for generating a polynucleotide sequence or population of sequences from parent polynucleotide sequences, the method comprising the steps of (a) providing a first population of polynucleotide molecules and a second population of polynucleotide molecules, the first and second populations together constituting plus and minus strands of parent polynucleotide sequences, (b) digesting the first and second populations of polynucleotide molecules with a nuclease to generate polynucleotide fragments, (c) contacting said polynucleotide fragments generated from the plus strands with fragments generated from the minus strands and (d) amplifying the fragments that anneal to each other to generate at least one polynucleotide sequence encoding one or more protein motifs having an altered amino acid sequence as compared to those encoded by the parent polynucleotides, wherein the degree of sequence variability in a selected region of the at least one polynucleotide molecule produced in step (d) is controlled by the addition of one or more oligonucleotides of predetermined variability, which oligonucleotides anneal to a sequence that lies between, but excludes, the 3′ or 5′ terminal nucleotide of the parent polynucleotide molecule. The invention also provides polynucleotides obtained by the method of the invention and polypeptides encoded by the same. | 08-13-2009 |
20100298539 | NOVEL POLYPEPTIDES AND USE THEREOF - The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of | 11-25-2010 |
20120071394 | NOVEL POLYPEPTIDES AND USE THEREOF - The present invention provides a polypeptide having a biological activity of the Chemotaxis Inhibitory Protein of | 03-22-2012 |
20120077730 | Method for in Vitro Molecular Evolution of Protein Function - The invention provides a method for generating a polynucleotide sequence or population of sequences from parent polynucleotide sequences, the method comprising the steps of (a) providing a population of parent polynucleotide molecules, which population comprises plus and minus strands, (b) treating the population of parent polynucleotide molecules to generate a population of polynucleotide fragments thereof, (c) incubating the population of polynucleotide fragments under conditions which permit the formation of overlapping fragment pairs and (d) amplifying the overlapping fragment pairs using a polymerase to generate one or more product polynucleotide molecules which differ in sequence from the parent polynucleotide molecules, wherein step (d) is performed, at least in part, under conditions which favor the introduction of mutations into the one or more product polynucleotide molecules. | 03-29-2012 |
Klas Tommy Haraldsson, Jarfalla SE
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20090186306 | Polymeric microfluidic devices from liquid thermoset precursors - A method and apparatus for the fabrication of polymeric microfluidic devices through sequential photolithographic polymerization of micropatterned polymeric layers. | 07-23-2009 |
Martin Haraldsson, Stockholm SE
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20130102587 | New Enzyme Inhibitor Compounds - Disclosed are compounds which inhibit SSAO enzyme activity. Also disclosed are pharmaceutical compositions comprising these compounds and the use of these compounds in the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases, immune disorders and the inhibition of tumour growth. | 04-25-2013 |
20140357623 | NEW ENZYME INHIBITOR COMPOUNDS - 2-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}ethan-1-amine; 3-aminopropyl 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxylate; 1-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}-4-(dimethylamino)butan-1-one; 5-amino-1-{4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}pentan-1-one; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxamide; N-(3-aminopropyl)-4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidine-1-carboxamide; 4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-N-[3-(dimethylamino)propyl]piperidine-1-carboxamide; 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)piperazine; 4-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)morpholine; 1-({4-[1-(4-chlorophenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]piperidin-1-yl}carbonyl)-1,4-diazepane; ethyl 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; ethyl 1-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylate; 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxylic acid; N-(2-aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-4-carboxamide; 4-({1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-4 yl}carbonyl)morpholine; 1-({1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-4-yl}carbonyl)piperazine; {4-[1-(4-methylphenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl}methanol; {4-[1-(4-methyl-phenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-2-yl}methanol; [(3R)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl]methanol; methyl 4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholine-3-carboxylate; N-(2-aminoethyl)-4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholine-3-carboxamide; 2-{4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]morpholin-3-yl}ethan-1-ol; methyl 1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-2-carboxylate; N-(2-aminoethyl)-1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidine-2-carboxamide; 1-({1-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-2-yl}carbonyl)piperazine; 4-[1-(4-methylphenyl)-1H-pyrrolo[2,3-c]pyridin-3-yl]morpholine; 1-(4-chlorophenyl)-3-(piperidin-4-yl)-1H-pyrrolo[2,3-c]pyridin-4-ol; N-butyl-1-(4-chlorophenyl)-N-methyl-1H-pyrazolo[3,4-c]pyridin-3-amine; 1-[4-(fluoromethyl)phenyl]-3-(oxan-4-yl)-1H-pyrazolo[3,4-c]pyridine; and 3-({4-[1-(4-chlorophenyl)-1H-pyrazolo[3,4-c]pyridin-3-yl]piperidin-1-yl}methyl)pyridine are useful for the inhibition of SSAO activity. | 12-04-2014 |
Martin Haraldsson, Taby SE
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20100022590 | Novel compounds - The present invention relates to novel isoxazole compounds of formula (I), | 01-28-2010 |
20120010188 | Imidazopyridine Compounds - The invention relates to compounds of formula (I): and their pharmaceutically acceptable salts and solvates, which are inhibitors of SSAO activity. The invention further relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the treatment or prevention of medical conditions wherein inhibition of SSAO activity is beneficial, such as inflammatory diseases and immune disorders. | 01-12-2012 |
20140206662 | Imidazopyridine Compounds - A method of treating inflammation, an inflammatory disease, an immune or an autoimmune disorder comprising administering to a patient in need thereof compounds of formula (I): | 07-24-2014 |
Oscar Haraldsson, Lund SE
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20150207408 | SWITCH PROTECTION I AUXILIARY RESONANT CIRCUIT - A resonant power converter comprising electrical safety components comprising a combination of a diodes and a zener diodes coupled between DC conductors and an auxiliary switching circuit, the diodes being adapted to hinder the current from flowing from the auxiliary switching circuit to the negative DC conductor, and the zener diodes being adapted to allow current to flow from the negative DC conductor to the auxiliary switching circuit when the potential difference between the negative DC conductor and the phase conductor is above a threshold voltage. The Zener diodes being selected such that the threshold voltage of the Zener diodes is below the maximum blocking voltage of the transistors. | 07-23-2015 |
Peder Haraldsson, Orebro SE
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20110220419 | ACCUMULATOR MEMBRANE UNIT, METHOD FOR PRODUCTION THEREOF AND ROCK DRILLING MACHINE INCLUDING SUCH AN ACCUMULATOR MEMBRANE UNIT - An accumulator membrane unit ( | 09-15-2011 |
Tage Haraldsson, Smalandsstenar SE
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20090152862 | Fastening Device for a Binder - A device for fastening labels to binders which exhibit slots arranged in pairs at a mutual distance from each other for receiving end sections of label holders, and for firmly locking the end sections in the slots. The label holder is pocket-shaped, is flexible, and exhibits rows of recesses along lateral edge sections opposing each other. Hook-shaped locking elements distributed in rows are received inside the slots. The row of recesses and locking forms formed are adapted to each other in terms of shape for lockable receiving, interacting in pairs, of the respective locking elements in a suitable recess after insertion of the respective label end sections in a suitable slot. | 06-18-2009 |
20090175674 | Device at a Binder - A device for fastening prongs in binders, where the prongs are secured to a prong plate arranged to be fastened to the inner sections of a binder spine. Fastening mechanisms are arranged in rows along the binder spine sections. The fastening mechanisms are releasably connectable to supplementary fastening devices located on the respective prong plates. A device for fastening binder sides is also disclosed. | 07-09-2009 |
Tommy Haraldsson, Jarfalla SE
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20130331528 | METHOD FOR THE MANUFACTURE OF ARTICLES OF THIOL-ENE POLYMERS - A method for the manufacture of articles of thiol-ene polymers comprises the steps: a) reacting a compound comprising at least two thiol groups and a compound comprising at least two carbon-carbon double bonds, in off stochiometry ratios to obtain a first intermediate article, wherein said first intermediate article comprises at least one unreacted group selected from an unreacted thiol group and an unreacted carbon-carbon double bond, and b) contacting said first intermediate article with a second article, wherein the surface of said second article at least partially comprises reactive groups and reacting at least a part of said unreacted groups on said first intermediate article with chemical groups on said second article to obtain covalent bonds and forming a final article. | 12-12-2013 |
20150118456 | METHOD AND FORMULATIONS FOR THE MANUFACTURE OF COATED ARTICLES AND COMPOSITES - An object with a coating comprising: a) covalent bonds formed by reaction of a thiol group and a carbon-carbon double bond, b) covalent bonds formed by reaction of a thiol group and epoxide group, c) covalent bonds formed by a reaction of a carbon-carbon double bond and an epoxide group, said coating comprising a first primer coating and a second coating, said coating comprising covalent bonds between said first and second coatings, said first primer coating comprising covalent cross links between compounds, in the first coating the fraction (r3=ta/tc) of unreacted thiol groups (ta) to thiol groups which have reacted to form a covalent bond (tc) does not exceed 0.11, wherein the half height peak width of tan delta does not exceed 30° C. Advantages of the dual cure composition is that excellent strength is obtained and that the second curing is slow compared to the first initial curing. | 04-30-2015 |
20150203687 | MODIFICATION OF POLYMER SURFACE PROPERTIES - Modification of polymer surface properties is disclosed by using a method comprising providing a liquid curable monomer formulation comprising a surface-active compound so that the surface active component is attracted to or repelled from at least a specific part of a master surface and is fixed in the polymer article upon curing. The method is carried out in one step and is thus simple and inexpensive to carry out. | 07-23-2015 |
Tore Haraldsson, Smalandsstenar SE
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20090052978 | Binder Lock Mechanism including a Manually Adjustable Locking Bar - The invention relates to a binder lock mechanism ( | 02-26-2009 |
20090152862 | Fastening Device for a Binder - A device for fastening labels to binders which exhibit slots arranged in pairs at a mutual distance from each other for receiving end sections of label holders, and for firmly locking the end sections in the slots. The label holder is pocket-shaped, is flexible, and exhibits rows of recesses along lateral edge sections opposing each other. Hook-shaped locking elements distributed in rows are received inside the slots. The row of recesses and locking forms formed are adapted to each other in terms of shape for lockable receiving, interacting in pairs, of the respective locking elements in a suitable recess after insertion of the respective label end sections in a suitable slot. | 06-18-2009 |
20090175674 | Device at a Binder - A device for fastening prongs in binders, where the prongs are secured to a prong plate arranged to be fastened to the inner sections of a binder spine. Fastening mechanisms are arranged in rows along the binder spine sections. The fastening mechanisms are releasably connectable to supplementary fastening devices located on the respective prong plates. A device for fastening binder sides is also disclosed. | 07-09-2009 |