Patent application number | Description | Published |
20100063441 | DEFLECTABLE CATHETER WITH BONDED CENTER STRUT AND METHOD OF MANUFACTURE FOR SAME - A catheter for diagnosing or treating the vessels found within a body or body space includes a center strut that is bonded, preferably thermally, along its longitudinal axis with the thermoplastic tubular member within which it is housed. The tubular member preferably has three layers: an inner layer, a braided layer and an outer layer. The composite catheter is made using a process in which two half-cylinder shaped mandrels are placed on each side of the center strut while the strut is heated in order to cause the thermal bonding. The bonded center strut provides in-plane deflection and improved transfer of torque to the tip of the catheter. | 03-11-2010 |
20120111482 | DEFLECTABLE CATHETER WITH BONDED CENTER STRUT AND METHOD OF MANUFACTURE FOR SAME - A catheter for diagnosing or treating the vessels found within a body or body space includes a center strut that is bonded, preferably thermally, along its longitudinal axis with the thermoplastic tubular member within which it is housed. The tubular member preferably has three layers: an inner layer, a braided layer and an outer layer. The composite catheter is made using a process in which two half-cylinder shaped mandrels are placed on each side of the center strut while the strut is heated in order to cause the thermal bonding. The bonded center strut provides in-plane deflection and improved transfer of torque to the tip of the catheter. | 05-10-2012 |
20130053841 | ABLATION CATHETER FOR VEIN ANATOMIES - A catheter adapted for simultaneous tissue contact with two opposing ring electrodes carried on a generally linear portion of an electrode assembly is adapted to straddle an ostium for ablating two lesions along a chord of the ostium, wherein the generally linear portion is stabilized on the ostium to ensure proper tissue contact when a force is applied down the length of the catheter body. | 02-28-2013 |
20130060245 | CATHETER ADAPTED FOR DIRECT TISSUE CONTACT - An irrigated ablation catheter adapted for direct tissue contact has micro-elements that provide more accurate sensing of tissue, including thermal and electrical properties for temperature and impedance measurements. The micro-elements extend through a hollow chamber of an irrigated ablation electrode, and distal ends thereof can protrude outside of electrode or be flush with the electrode. The micro-elements have a protective guide tube in which components enabling temperature sensing or electrical sensing are encased. | 03-07-2013 |
20130085360 | MAPPING CATHETER WITH SPIRAL ELECTRODE ASSEMBLY - A mapping catheter adapted for use in a heart chamber, has a distal mapping assembly with a spiral ribbon that is radially expandable and contractable by means of an expander so that electrodes on the ribbon can contact heart wall at a plurality of locations simultaneously. The expander extends the length of the catheter between a control handle and a distal end of the spiral ribbon. The expander can be controlled directly at its proximal end by a user or the expander can be responsive to a puller wire controlled by a user interface on the control handle. | 04-04-2013 |
20130123775 | CATHETER ADAPTED FOR DIRECT TISSUE CONTACT AND PRESSURE SENSING - An irrigated ablation catheter adapted for direct tissue contact has micro-elements that provide more accurate sensing of tissue, including thermal and electrical properties for temperature and impedance and intracardiac ECG measurements. A pressure sensing assembly adds the ability to measure the force at the tip of the catheter as well as to have the micro-elements for accurately sensing tissue parameters. A system uses signals from the micro-elements (impedance, temperature, and ECG signals) as well as the measure of force or pressure at the tip electrode order to provide the operator with a means to control lesion depth, size, transmurality and to ablate tissue until successful treatment of an arrhythmia is achieved. | 05-16-2013 |
20130304047 | ABLATION TARGETING NERVES IN OR NEAR THE INFERIOR VENA CAVA AND/OR ABDOMINAL AORTA FOR TREATMENT OF HYPERTENSION - A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta. Catheters designed for use in the method where these targeted locations are also disclosed and claimed. | 11-14-2013 |
20130304062 | CATHETER WITH HELICAL END SECTION FOR VESSEL ABLATION - A catheter includes an elongated body, a distal assembly with a shape-memory member defining a generally helical form, and a control handle. The control handle may be adapted to actuate a deflection puller wire for deflecting a portion of the elongated body and a contraction wire for contracting the generally helical form. The generally helical form carries irrigated ablation ring electrodes. A nitinol support member with shape memory extends through the distal assembly and into the elongated body to provide the helical form. The support member may have a varying stiffness along its length, for example, a decreasing stiffness toward a distal end of the support member. The support member can also be hollow so that it can receive a mandrel whose stiffness is greater than that of the support member. | 11-14-2013 |
20140194716 | CATHETER WITH MULTIPLE SPINES OF DIFFERENT LENGTHS ARRANGED IN ONE OR MORE DISTAL ASSEMBLIES - A catheter having a distal assembly with multiple spines with proximal ends affixed to the catheter and free distal ends. The spines have different lengths so distal ends of the spines trace different circumferences along an inner tissue surface of a tubular region to minimize risk of vein stenosis. The spine lengths can be configured so that the distal ends trace a helical pattern. The distal assembly may have a plunger which deflects the spines when moved longitudinally relative to the distal assembly. The catheter may include a second distal assembly distal of a first distal assembly wherein the first and second distal assemblies are separated by a fixed distanced or an adjustable distance. | 07-10-2014 |
20140194813 | UNIDIRECTIONAL CATHETER CONTROL HANDLE WITH TENSIONING CONTROL - A catheter includes a tip electrode with a shell and a support member to provide a plenum chamber. The plug is formed with a U-shaped passage for a safety line to wrap around and secure the support member (with the shell affixed thereto) to the catheter. Additional passages are formed in the plug to accommodate components such as irrigation tubing, lead wire and thermocouple wire pair. A method of manufacture provides distal installation and/or anchoring of the safety line, lead wire and thermocouple wire pair in the support member prior to sealing the support member and mounting the shell. | 07-10-2014 |
20140276779 | CATHETER WITH NEEDLES FOR ABLATING TISSUE LAYERS IN VESSEL - A catheter has a catheter body and a distal tip section with needles that are positioned radially to extend outside of the distal tip section to pierce and penetrate tissue layers of a vessel or tubular region. The needles are supported in a retracted position inside the distal tip section on an elongated support member. For deployment, the needles are lifted and a portion thereof pushed through openings in the distal tip section by an actuator that is longitudinally slidable on the elongated support member. The actuator has a tapered end to help lift the needle onto the actuator. In another embodiment, an inflatable balloon member with needles is movable between retracted and deployed positions. | 09-18-2014 |
20140276780 | CATHETER ADAPTED FOR USE WITH GUIDE WIRE FOR ACCESSING VESSELS - An ablation catheter adapted for use with a guide wire has a 3-D shaped portion that carries ring electrodes for ablating a vessel or tubular region, including the renal artery. The 3-D shaped portion, for example, a helical portion, enables the ring electrodes to contact an inner surface of the vessel at a plurality of locations at different depths along the vessel to form a conduction block without forming a closed conduction loop which would otherwise increase the risk of stenosis of the vessel. In one embodiment, the catheter has a lumen with entry and exit ports to allow the guide wire to pass through the lumen but bypass the 3-D shaped portion. In another embodiment, the catheter has outer bands providing side tunnels through which the guide wire can pass through. | 09-18-2014 |
Patent application number | Description | Published |
20120286779 | SNMR PULSE SEQUENCE PHASE CYCLING - Technologies applicable to SNMR pulse sequence phase cycling are disclosed, including SNMR acquisition apparatus and methods, SNMR processing apparatus and methods, and combinations thereof. SNMR acquisition may include transmitting two or more SNMR pulse sequences and applying a phase shift to a pulse in at least one of the pulse sequences, according to any of a variety of phase cycling techniques. SNMR processing may include combining SNMR from a plurality of pulse sequences comprising pulses of different phases, so that desired signals are preserved and undesired signals are canceled. | 11-15-2012 |
20130193969 | RELAXATION TIME ESTIMATION IN SURFACE NMR - Technologies including NMR relaxation time estimation methods and corresponding apparatus are disclosed. Example techniques may generate two or more alternating current transmit pulses with arbitrary amplitudes, time delays, and relative phases; apply a surface NMR acquisition scheme in which initial preparatory pulses, the properties of which may be fixed across a set of multiple acquisition sequence, are transmitted at the start of each acquisition sequence and are followed by one or more depth sensitive pulses, the pulse moments of which are varied across the set of multiple acquisition sequences; and apply processing techniques in which recorded NMR response data are used to estimate NMR properties and the relaxation times T | 08-01-2013 |
20130293228 | NMR DETECTION OF WATER AND HYDROCARBONS DURING INDUCED ALTERATION PROCESSES - Technologies applicable to NMR detection of water and hydrocarbons during induced alteration: processes are disclosed. NMR measurements may be used to monitor properties of subsurface fluids within a subsurface formation. NMR measurement devices may be deployed proximal to or within a subsurface formation that contains hydrocarbons. Multiple NMR measurements may be performed during an induced alteration process applied, to the subsurface formation to determine properties of the subsurface formation or fluid as the induced alteration process progresses. Changes in properties of the subsurface formation or fluid may be determined and may be used to determine efficacy of optimize, or otherwise modify the induced alteration process. | 11-07-2013 |
20140084927 | SURFACE-BASED NMR MEASUREMENT - Technologies applicable to surface-based NMR measurement are disclosed. A surface probe is positionable at or above a surface of the Earth and adapted to make NMR measurements of shallow or very shallow subsurface volumes. NMR spectrometer components connected to the surface probe are configured to control electromagnetic pulses produced by the surface probe and to record resulting detected NMR signals from the subsurface volume. | 03-27-2014 |
20140203806 | COMBINATION NMR AND DIELECTRIC MEASUREMENT - Technologies applicable to detection and characterization of subsurface contaminants by NMR and dielectric measurements are disclosed. The disclosed technologies include methods for obtaining and combining data from NMR and dielectric measurements to detect, quantify, and characterize non-native non-aqueous phase liquid (NAPL) contaminants located in geologic materials. | 07-24-2014 |
Patent application number | Description | Published |
20090263376 | Breaking immunological toterance with a genetically encoded unnatural amino acid - The present invention comprises methods and compositions for producing and/or enhancing an immunological response in a subject against a target moiety such as a disease-related moiety by administration of an antigenic version of the target moiety having one or more unnatural amino acid and/or by administration of an antibody against a version of a target moiety having one or more unnatural amino acid which antibody is cross reactive with the natural target moiety. | 10-22-2009 |
20110052525 | Breaking Immunological Tolerance with a Genetically Encoded Unnatural Amino Acid - The present invention comprises methods and compositions for producing and/or enhancing an immunological response in a subject against a target moiety such as a disease-related moiety by administration of an antigenic version of the target moiety having one or more unnatural amino acid and/or by administration of an antibody against a version of a target moiety having one or more unnatural amino acid which antibody is cross reactive with the natural target moiety. | 03-03-2011 |
20110076718 | IN VIVO INCORPORATION OF AN UNNATURAL AMINO ACID COMPRISING A 1,2-AMINOTHIOL GROUP - The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate unnatural amino acids that comprise a 1,2 aminothiol group into polypeptides. The invention provides translation systems in which polypeptides comprising unnatural amino acids that comprise a 1,2 aminothiol group can be produced. The invention also provides methods for producing polypeptides containing unnatural amino acids that comprise a 1,2 aminothiol group. Also provided by the invention are compositions comprising orthogonal aminoacyl-tRNA synthetases that preferentially aminoacylate a cognate orthogonal tRNA with unnatural amino acids that comprise a 1,2 aminothiol group. The invention provides methods for the synthesis of the unnatural amino acid 2-amino-3-(4-(2-amino-3-mercaptopropan-amido)phenyl)-propanoic acid. | 03-31-2011 |
20110262963 | BIOSYNTHETICALLY GENERATED PYRROLINE-CARBOXY-LYSINE AND SITE SPECIFIC PROTEIN MODIFICATIONS VIA CHEMICAL DERIVATIZATION OF PYRROLINE-CARBOXY-LYSINE AND PYRROLYSINE RESIDUES - Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. | 10-27-2011 |
20140065171 | Site-Specific Labeling Methods and Molecules Produced Thereby - The present invention provides methods of site-specific labeling of antibodies, using proteins having 4′-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences (“peptide tags”) incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates. | 03-06-2014 |
20140302553 | BIOSYNTHETICALLY GENERATED PYRROLINE-CARBOXY-LYSINE AND SITE SPECIFIC PROTEIN MODIFICATIONS VIA CHEMICAL DERIVATIZATION OF PYRROLINE-CARBOXY-LYSINE AND PYRROLYSINE RESIDUES - Disclosed herein is pyrroline-carboxy-lysine (PCL), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating PCL. Also disclosed herein are proteins, polypeptides and peptides that have PCL incorporated therein and methods for incorporating PCL into such proteins, polypeptides and peptides. Also disclosed herein is the site-specific derivatization of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. Also disclosed herein is the crosslinking of proteins, polypeptides and peptides having PCL or pyrrolysine incorporated therein. | 10-09-2014 |
20150104468 | SITE-SPECIFIC LABELING METHODS AND MOLECULES PRODUCED THEREBY - The present disclosure provides methods of site-specific labeling of antibodies, using proteins having 4′-phosphopantetheinyl transferase activity that catalyze post-translational modification of peptide sequences (“peptide tags”) incorporated into one or more specific sites of an antibody of interest. Enzymatic labeling enables quantitative and irreversible covalent modification of a specific serine residue within the peptide tags incorporated into the antibody, and thus creates desirable antibody conjugates. | 04-16-2015 |