Gonçalves Dos Reis
Ruiç Luis Gonçalves Dos Reis, Porto PT
Patent application number | Description | Published |
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20130017177 | PHOTO-CROSSLINKED GELLAN GUM-BASED HYDROGELS: PREPARATION METHODS AND USES THEREOFAANM Da Silva Correia; Joana CatarinaAACI BragaAACO PTAAGP Da Silva Correia; Joana Catarina Braga PTAANM Antunes De Oliveira; Joaquin MiguelAACI Ponte GMRAACO PTAAGP Antunes De Oliveira; Joaquin Miguel Ponte GMR PTAANM Teixeira De Oliveira; Joao ManuelAACI MatosinhosAACO PTAAGP Teixeira De Oliveira; Joao Manuel Matosinhos PTAANM Amandi Romero De Sousa; Rui PedroAACI MatosinhosAACO PTAAGP Amandi Romero De Sousa; Rui Pedro Matosinhos PTAANM Goncalves Dos Reis; Ruic LuisAACI PortoAACO PTAAGP Goncalves Dos Reis; Ruic Luis Porto PT - This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. Formulations of gellan gum with different degrees of acylation serve as precursor material for insertion of a polymerizable moiety. The materials are capable of free radical polymerization with a photo-initiator at mild temperatures and exposure to ultraviolet light, enabling control of reticulation and withstanding the encapsulation of human and animal cells and/or drugs, and any combination thereof. The physicochemical and biological properties can be adjusted by combining different formulations of gellan gum and reaction conditions. The matrix can be used either as an acellular or cellular system, dispensed manually or automatically by injection and crosslinked directly at the site of application, and can be processed using manual or automated systems in different types of scaffolds, such as hydrogels, fibres, | 01-17-2013 |
Rui Luis Gonçalves Dos Reis, Porto PT
Patent application number | Description | Published |
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20140350237 | PHOTO-CROSSLINKED GELLAN GUM-BASED HYDROGELS: METHODS AND USES THEREOF - This invention refers to photo-crosslinked hydrogel materials based in gellan gum suitable for tissue engineering and regenerative medicine applications or as drug delivery systems. | 11-27-2014 |
20160024453 | ROTATIONAL DUAL CHAMBER BIOREACTOR: METHODS AND USES THEREOF - A rotational dual chamber bioreactor for cell culture in bi- and multilayered scaffolds, in the context of tissue engineering (TE) and regenerative medicine strategies is disclosed which comprises at least two dual culture chambers, a multiposition magnetic stirrer plate, and at least two flow pumps which can be coupled to a monitor device to register biochemical parameters such as pH, pO2, glucose and urea sensors and physical parameters like pressure. The dual culture chambers have a central barrier with a hole to insert the bilayer scaffold, such chamber is used to culture cells with different conditions in each compartment of the chamber, avoiding medium exchange. Each chamber can rotate 180° (horizontal), being the rotations per minute controlled independently. The rotation is promoted by magnetic stirrers, having magnets performing the attraction between the bottom part of the dual chamber and the stirring position of the plate. The multiposition stirrer plate is adapted dimensionally to the requirements of the culture plate dimensions used, and also allows 180° vertical rotation. Each dual chamber has detachable caps for the top and the bottom chambers. The top cap has the possibly to compress the scaffold and thus providing a compressive stimulus with torsion simultaneously. This compression is applied by attaching a top plate adapted to fit the top caps of each dual chamber. | 01-28-2016 |
Ruis Luís Gonçalves Dos Reis, Porto PT
Patent application number | Description | Published |
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20160038645 | POLYMERIC MESH WITH SELECTIVE PERMEABILITY, FOR THE REPAIR AND REGENERATION OF TISSUES - The present application describes a polymeric mesh for the repair and regeneration of tissues from an organism that comprises pores wherein at least 70% of the pores of the said mesh have a size smaller than the one required to confine the cells of the said tissues, and wherein at least 70% of the pores of the said mesh has a size superior than the one needed for the passage of interstitial fluids of the said tissues; the degradation time of the said polymeric mesh within the organism is at least 8 weeks; the said polymeric mesh has an apparent tensile strength superior than 1 MPa; the said polymeric mesh has an apparent elastic modulus superior than 0.1 MPa. The mesh described in this application allows that the “new tissue” formed presents very similar properties to the ones of the damaged tissue. | 02-11-2016 |