Golebiowski
Adam Golebiowski, Madison, CT US
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20090181995 | 2-ANILINO-4-AMINOALKYLENEAMINOPYRIMIDINES - The present invention relates to 2-arylamino-4-(aminoalkylene)aminopyrimidines inhibitors which are inhibitors and therefore inhibit Protein Kinase C-alpha (PKC-α). The PKC-α inhibitors of the present invention are important for improving myocardial intracellular calcium cycling, resulting in improved myocardial contraction and relaxation performance and thereby slowing the progression of heart failure. The present invention further relates to compositions comprising said 2-arylamino-4-(aminoalkylene)amino-pyrimidines and to methods for controlling, abating, or otherwise slowing the progression of heart failure. | 07-16-2009 |
Adam Golebiowski, Loveland, OH US
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20090069355 | Bicyclic pyrazolone cytokine inhibitors - The present invention relates to 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states. | 03-12-2009 |
Adam Golebiowski, Branford, CT US
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20120083469 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS - Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: | 04-05-2012 |
Adam Golebiowski, Mclean, VA US
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20140343019 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS - The inventive compounds are small molecule therapeutics that are potent inhibitors of Arginase I and II activity. The invention also provides pharmaceutical compositions of the inventive compounds and methods for using the inventive compounds for treating or preventing a disease or a condition associated with arginase activity. | 11-20-2014 |
20140371175 | INHIBITORS OF ARGINASE AND THEIR THERAPEUTIC APPLICATIONS - Compounds according to Formula I and Formula II are potent inhibitors of Arginase I and II activity: | 12-18-2014 |
Adam Golebiowski, Warszawa PL
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20160090639 | Method for selection of hDIS3 PIN domain inhibitors and use of hDIS3 PIN domain inhibitors for cancer treatment - The present invention relates to a method for selection or screening of hDIS3 PIN domain inhibitors, yeast strain and cell line used in such methods It also relates to new therapeutic agents selected hDIS3 PIN domain inhibitors and uses thereof in the treatment of cancers having mutations inhDIS3 RNB domain, especially multiple myeloma. The invention also relates to composition comprising new therapeutic agent hDIS3 PIN domain inhibitor and method for inducing synthetic lethality in a cancer cell. | 03-31-2016 |
Marek Golebiowski, Lombard, IL US
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20150316040 | Stress Reduction in Hydrostatic Cradle Bearing - In a piston pump assembly, cradle bearings support a swash plate on an inner surface of a housing assembly. The cradle bearing and/or the corresponding portion of the housing inner surface may have undercut portions allowing deflection of an inward portion of the cradle bearing when the swash plate is subjected to pressure forces from hydraulic fluid compressed within pump cylinders by the pump pistons. Deflection of the cradle bearings allows increased contact pressure to be further distributed across the engaging surfaces of the swash plates and the cradle bearings. | 11-05-2015 |