Goldberg, MA
Alexander Goldberg, Boston, MA US
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20150346201 | SYSTEM AND METHOD FOR PICOLITER VOLUME MICROFLUIDIC DIAGNOSTICS - The present invention provides a method for a picoliter volume microfluidic assay. The method includes the steps of providing a first solution comprising a sensor, preparing a sample comprising at least one analyte, and combining the sample with an indicator, thereby forming a second solution. The method further includes co-encapsulating the first solution and the second solution in a plurality of droplets with a microfluidic device, incubating the plurality of droplets, thereby forming at least one complex comprising the sensor, at least one analyte and indicator, and detecting the at least one complex. A primary signal associated with the at least one complex is distinguishable from a background signal associated with at least one of the sensor, at least one analyte and indicator individually. | 12-03-2015 |
Alfred Goldberg, Chestnut Hill, MA US
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20080293089 | Assays for Modulators of Parkin Activity Using Novel Substrates - The invention provides in vitro and cell-based assays for parkin activity, in which parkin-mediated ubiquitination of the S5a subunit of the 26S proteasome is measured, or ubiquitination of troponin 1. The assays may be used to screen for agents that modulate parkin protein ligase activity. | 11-27-2008 |
Alfred Lewis Goldberg, Brookline, MA US
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20140243255 | TREATMENTS FOR MYCOBACTERIUM TUBERCULOSIS - The technology described herein relates to treatments for tuberculosis which target the ClpP1P2 protease complex, including ClpC1. Further embodiments relate to assays and screens for modulators of the ClpP1P2 protease complex, including ClpC1. | 08-28-2014 |
Aryeh Goldberg, Newton, MA US
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20110072034 | PRIVACY-SENSITIVE COOPERATIVE LOCATION NAMING - A location database may be configured to store a set of subjective, arbitrary, and/or ephemeral names assigned to a location by various users. When a user of a device arrives at a particular location, the device may retrieve and present to the user the set of names assigned to the location. Moreover, the names may be associated with a privacy designation, which may permit an author of a location name to indicate whether the name of a location should be shared with the public or restricted to access by the user (or to a specified group of users, etc.) Other access criteria may also be specified, e.g., read-only access to a name for the public and read/write access to a particular group of users. Within the set of names of a location, particular names may be designated as authoritative, and may be presented to users with emphasis. | 03-24-2011 |
Bennett B. Goldberg, Newton, MA US
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20080220440 | Waveguide sensors optimized for discrimination against non-specific binding - A system for interferometrically detecting the present of bound material using a wave propagating waveguide and the influence on propagation time of bound material in the proximity of the waveguide. The waveguide layer thickness and the radiation wavelength λ are selected so that the effects on phase difference between the two radiations applied in the beam are minimal in the region directly adjacent the surface of the waveguide, so as to unmask the influence of the more distant bound materials. | 09-11-2008 |
20090011948 | Structured Substrates for Optical Surface Profiling - This disclosure provides methods and devices for the label-free detection of target molecules of interest. The principles of the disclosure are particularly applicable to the detection of biological molecules (e.g., DNA, RNA, and protein) using standard SiO | 01-08-2009 |
20150185474 | SOLID IMMERSION MICROSCOPY SYSTEM WITH DEFORMABLE MIRROR FOR CORRECTION OF ABERRATIONS - A system and method for correction of aberrations in a solid immersion microscopy system using a deformable mirror. A solid immersion lens is provided having a surface configured to make optical contact with a nearly planar surface of a substrate, an object to be imaged disposed on the opposite side of the substrate. A convex surface of the solid immersion lens faces an objective lens. A deformable mirror assembly, including a plurality of individually controllable actuators, receives light transmitted from the object. A control system controls in communication with the deformable mirror assembly provides individual actuation of each of the actuators of the deformable mirror to compensate or counteract the effects of aberrations. | 07-02-2015 |
20150276864 | DUAL-PHASE INTERFEROMETRY FOR CHARGE MODULATION MAPPING IN ICS - A dual-phase interferometric method and device for charge modulation mapping in integrated circuits provides significant improvement in signal to noise ratio over conventional detection configurations. The method and device can be used for failure analysis and testing of advanced technology IC chips for which high sensitivity in modulation mapping is required. | 10-01-2015 |
Brian Goldberg, Cambridge, MA US
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20110255561 | APPARATUS CONFIGURED TO PROVIDE A WAVELENGTH-SWEPT ELECTRO-MAGNETIC RADIATION - Exemplary embodiments of apparatus according to the present disclosure are provided. For example, an apparatus for providing electromagnetic radiation to a structure can be provided. In one exemplary embodiment, the apparatus can provide at least one electromagnetic radiation, and include at least one first arrangement which can be configured to generate the electromagnetic radiation(s) having at least one wavelength that varies over time. The exemplary apparatus can also include at least one second arrangement which can be configured to power the first arrangement(s) independently from an external power source. In another exemplary embodiment the apparatus can include at least one particular arrangement which is configured to generate the electromagnetic radiation(s) having at least one wavelength that varies over time. The particular arrangement(s) can include a resonant cavity that has a roundtrip optical transit time of approximately less than 0.7 nsec. | 10-20-2011 |
20120162659 | Integrated Dual Swept Source for OCT Medical Imaging - An optical coherence analysis system comprising: a first swept source that generates a first optical signal that is tuned over a first spectral scan band, a second swept source that generates a second optical signal that is tuned over a second spectral scan band, a combiner for combining the first optical signal and the second optical signal for form a combined optical signal, an interferometer for dividing the combined optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample, and a detector system for detecting an interference signal generated from the combined optical signal from the reference arm and from the sample arm. In embodiments, the swept sources are tunable lasers that have shared laser cavities. | 06-28-2012 |
20130271772 | Multi-speed OCT swept source with optimized k-clock - An optical coherence tomography system utilizes an optical swept source that frequency scans at least two different sweep rates. In this way, the system can perform large depth scans of the sample and then the same system can perform shorter depth high precision scans, in one specific example. In order to optimally use the analog to digital converter that samples the interference signal, the system further samples the interference signals at different optical frequency sampling intervals depending upon the selected sweep rates of the optical swept source. This allows the system to adapt to different sweep rates in an optimal fashion. | 10-17-2013 |
20140152997 | Integrated Dual Swept Source for OCT Medical Imaging - An optical coherence analysis system comprising: a first swept source that generates a first optical signal that is tuned over a first spectral scan band, a second swept source that generates a second optical signal that is tuned over a second spectral scan band, a combiner for combining the first optical signal and the second optical signal for form a combined optical signal, an interferometer for dividing the combined optical signal between a reference arm leading to a reference reflector and a sample arm leading to a sample, and a detector system for detecting an interference signal generated from the combined optical signal from the reference arm and from the sample arm. In embodiments, the swept sources are tunable lasers that have shared laser cavities. | 06-05-2014 |
20160025478 | Real Time FPGA Resampling for Swept Source Optical Coherence Tomography - Real-time swept source OCT data is most often sampled using a specially cut hardware k-clock. The present invention involves mathematically resampling signals within an FPGA-based data acquisition board based on data sampled from a wide free spectral range reference interferometer. The FPGA can then multiply up the reference clock rate to achieve greater imaging depth. The Nyquist fold-over depth can thus be programmed from a standard reference to an arbitrary depth, much as PLL frequency synthesizer can produce many frequencies from a standard stable reference. The system is also capable of real-time performance. | 01-28-2016 |
Brian Goldberg, Wellesley, MA US
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20150184995 | Spectral filtering of k-clock signal in OCT system and method - A system and method for spectral filtering of a k-clock signal in a swept-source Optical Coherence Tomography (“OCT”) system to remove artifacts in the k-clock signal. The system synchronizes sampling of the k-clock and interference signals generated from scanning a sample. Using a filtered k-clock signal, the system resamples an interference dataset of the interference signals. The system then performs Fourier transform based processing upon the resampled interference dataset to yield axial depth images of the sample. The system preferably performs the reconstruction, resampling, and associated Fourier-Domain signal processing in software via a Field Programmable Gate Array (“FPGA”) of a rendering system. | 07-02-2015 |
20150300806 | System and Method for Resampling Optical Coherence Tomography Signals in Segments - A system and method for resampling interference datasets of samples in segments, in a swept-source based Optical Coherence Tomography (OCT) system. The resampling is preferably performed within a Field Programmable Gate Array (FPGA) of the OCT system, the FPGA preferably having Fourier-transform based signal processing capabilities such as Fast Fourier Transform (FFT) cores. Resampling the interference datasets in segments provides a flexible approach to resampling that makes efficient use of system resources such as FFT cores. By resampling the interference datasets in segments, the system adjusts to an increased number of resampling points as the imaging depth upon the sample increases. The OCT system then combines the segments using overlapping values of the resampling points between adjacent resampling regions of the resampled segments, and performs Fourier Transform based post-processing on the combined segments to obtain axial profiles of the sample at desired imaging depths. | 10-22-2015 |
Dennis Goldberg, Sudbury, MA US
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20160002315 | APOLIPOPROTEIN MIMETICS AND USES THEREOF - The disclosure provides dosing regimens and methods for treating atherosclerosis with an effective amount of Apo E mimetic to provide sustained therapeutic effects even after withdrawal of the treatment. The dosing regimens and methods involve a treatment cycle followed by a rest phase wherein a subject is administered an effective amount of an Apo E mimetic during the treatment cycle and no Apo E mimetic during the rest phase. The treatment cycle and the rest phase can vary. | 01-07-2016 |
Dennis I. Goldberg, Sudbury, MA US
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20080312579 | METHOD AND SYSTEM FOR MITIGATING CURRENT CONCENTRATION IN ELECTROKINETIC DRUG DELIVERY - An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a segmented active electrode; a medicament matrix having one side abutting the segmented active electrode and another side adapted to contact a surface of skin over the treatment site, wherein the matrix includes at least one current direction barrier suppressing transverse current flow through the matrix. | 12-18-2008 |
20080312580 | CURRENT CONCENTRATION SYSTEM AND METHOD FOR ELECTROKINETIC DELIVERY OF MEDICAMENTS - An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a flux concentrator including an active electrode and a counter electrode adapted to be applied to the surface of a toenail or fingernail of the user, and a medicament matrix adjacent the active electrode and arranged to be sandwiched between the active electrode and nail. | 12-18-2008 |
20080319371 | METHOD AND SYSTEM FOR TREATING OF ONYCHOMYCOSIS WITH AN APPLICATOR HAVING A GEL MEDICAMENT LAYER - A method to electrokinetically deliver a medicament to a nail of a mammalian user including: forming a cast of the nail of the user wherein the cast is a reverse impression of the nail; applying a medicament matrix to the nail; sandwiching the medicament matrix between the cast and the nail; pressing the medicament matrix to the nail using the cast; applying electrical current to an electrical current path extending through the medicament matrix and the nail, and delivering medicament from the matrix into the nail by electrokinetic transporting the medicament along the current path. | 12-25-2008 |
20110071491 | Current Concentration System and Method for Electrokinetic Delivery of Medicaments - An electrokinetic apparatus to apply medicament to a treatment site of a mammalian user, the apparatus including: a flux concentrator including an active electrode and a counter electrode adapted to be applied to the surface of a toenail or fingernail of the user, and a medicament matrix adjacent the active electrode and arranged to be sandwiched between the active electrode and nail. | 03-24-2011 |
Dennis I. Goldberg, South Brookline, MA US
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20110208111 | Electrokinetic Delivery System for Self-Administration of Medicaments and Methods Therefor - The invention relates to systems and methods for treating a fungal infection of the nail of an individual. In various embodiments, the methods include applying a device to at least one nail of the individual that is infected by a fungus. In various embodiments, the devices include at least one active electrode and at least one counter electrode, with the at least one counter electrode in contact with the individual. | 08-25-2011 |
20110213295 | Methods and Systems for Electrokinetic Delivery of a Substance - A method for delivering a substance to an infected nail of an individual is described. The method includes the step of applying a device to at least one infected nail of an individual, where the device includes at least one active electrode and at least one counter electrode, where the at least one counter electrode is in contact with the individual, and where the device is connected to at least one power source. The method also includes the steps of disposing a medicament between the at least one active electrode and the at least one infected nail, applying a salt solution to the at least one infected nail, and providing an electrical current from the power source to the at least one active electrode to facilitate delivery of the medicament into the region of the at least one infected nail. | 09-01-2011 |
Jeff Goldberg, Sudbury, MA US
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20160086216 | Facilitating the Sale of Expiring Commodities - A computer-implemented method comprising receiving, on a server, an offer for sale from a computing device related to a retailer, the offer for sale including a description of an expiring commodity and a discounted price of the expiring commodity; identifying, by the server, one or more consumers as targeted consumers by comparing the offer for sale with purchase preferences previously provided by consumers; sending, from the server, a currently unsolicited notification to a computing device related to at least one of the targeted consumers, the currently unsolicited notification including information related to the offer for sale; and receiving, on the server, from the computing device related to the targeted consumer, a purchase indication related to the expiring commodity. | 03-24-2016 |
Jeffrey M. Goldberg, Framingham, MA US
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20120121704 | Aliphatic Amine Polymer Salts for Tableting - The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions. | 05-17-2012 |
20150104510 | Aliphatic Amine Polymer Salts for Tableting - The tablets, compositions and methods of the present invention, comprising a carbonate salt of an aliphatic amine polymer and s monovalent anion can prevent or ameliorate acidosis, in particular acidosis in patients with renal disease. The tablets and compositions of the present invention maintain a disintegration time of no greater than 30 minutes at 37° C. and at pH of at least 1 for a period of at least ten weeks at 60° C. Furthermore, the tablets are stable for extended periods of time without the need for specialized storage conditions. | 04-16-2015 |
Keith Goldberg, Waltham, MA US
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20140344216 | Garbage collection predictions - Described herein are systems and methods for garbage collection prediction. A temporal graph is received, the temporal graph including nodes, the nodes including hash references to objects. An accumulated difference count is updated when a node is added to the temporal graph, the accumulated difference count including a number of hash differences between a parent node and its children nodes in the temporal graph. A divested difference count is updated when a node is removed from the temporal graph, the divested difference count including a number of hash differences referenced by the removed node but not by either a parent node of the removed node or any child nodes of the removed node. The outcome of the garbage collection is predicted based on at least one of the accumulated difference count and the divested difference count. | 11-20-2014 |
20140351214 | Efficient data replication - Described herein are systems and methods for efficient data replication. A set of hashes for a source object to be replicated is sent from the source local deduplication store to the remote server. The remote server generates a set of object hashes representative of data in the source object that is already present on the remote server, and data indicative of source object hashes that are not present on the remote server. The remote server transmits the generated data to the source local deduplication store. The source local deduplication store identifies portions of the source object that are not already present on the remote server based on the received data. The source local deduplication store transmits the identified portions of the source object to the remote server to replicate the source object on the remote server. | 11-27-2014 |
Manijeh Nazari Goldberg, Newburyport, MA US
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20140234212 | Targeted Buccal Delivery of Agents - A delivery device for topical and systemic delivery of agents to targeted oral locations, such as mouth cancer cells, has been developed. The formulation includes a mucoadhesive polymeric matrix such as chitosan, which contains one or more therapeutic and/or diagnostic agents, taste masking agents, permeation enhancers, the therapeutic or diagnostic agent to be delivered, and a hydrophilic polymeric coating such as polyethyleneglycol (“PEG”). In the preferred embodiment, the matrix is formulated with one side having the PEG-mucoadhesive polymer exposed for topical placement onto epithelial or cancer cells in the mouth or other mucosal area and the side(s) facing the inside of the oral cavity being covered with a biocompatible, inert membrane that is impermeable to the therapeutic and/or diagnostic agent(s) to be delivered. | 08-21-2014 |
Michael Solomon Goldberg, Cambridge, MA US
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20130018086 | SIRNAS TARGETING EXON 10 OF PYRUVATE KINASE M2 - The invention relates to nucleic acid molecules and compositions for specific post-transcriptional inhibition of PKM2 expression. Methods for specific inhibition of PKM2 expression in a target cell, for example a cancer cell, are also provided. | 01-17-2013 |
Nahum Goldberg, Boston, MA US
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20090070090 | Three-Dimensional Finite-Element Code for Electerosurgery and Thermal Ablation Simulations - A method for performing a simulation of an electrosurgical procedure is provided. The method includes the step of generating a three-dimensional model of a medium comprising one or more material regions representing a physical object or a region of the tissue. The method also includes the step of calculating one of an electrical energy solution and a thermal transport solution based on one of a mathematical model and finite element method. The method further includes the step of updating one or more property values of the material region in response to temperature changes based on an empirically derived value, wherein one of the electrical energy solution and the thermal transport solution is updated as a function of the updated property value. | 03-12-2009 |
Neal J. Goldberg, Duxbury, MA US
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20080288335 | Home valuator - A system for estimating home and property values is based upon current market data including recent comparable properties sold. The comparable sales may be chosen based on their proximity to the subject and their similarity in building and land assessments by the town or city in which the property is located, among other factors. The sale prices of the comparable properties may be adjusted based on the differences in assessments and appreciation rates from the time of sale to the date of valuation. This may be called an automated valuation model (AVM). | 11-20-2008 |
Richard Goldberg, Boston, MA US
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20090014667 | EXTERNAL CATHODE ION SOURCE - An ion source is disclosed for use in fabrication of semiconductors. The ion source includes an electron emitter that includes a cathode mounted external to the ionization chamber for use in fabrication of semiconductors. In accordance with an important aspect of the invention, the electron emitter is employed without a corresponding anode or electron optics. As such, the distance between the cathode and the ionization chamber can be shortened to enable the ion source to be operated in an arc discharge mode or generate a plasma. Alternatively, the ion source can be operated in a dual mode with a single electron emitter by selectively varying the distance between the cathode and the ionization chamber. | 01-15-2009 |
20090081874 | METHOD FOR EXTENDING EQUIPMENT UPTIME IN ION IMPLANTATION - The invention features in-situ cleaning process for an ion source and associated extraction electrodes and similar components of the ion-beam producing system, which chemically removes carbon deposits, increasing service lifetime and performance, without the need to disassemble the system. In particular, an aspect of the invention is directed to an activating, catalytic, or reaction promoting species added to the reactive species to effectively convert the non-volatile molecular residue into a volatile species which can be removed by conventional means. | 03-26-2009 |
20090183679 | ION SOURCE GAS REACTOR - An ion source is disclosed which includes a gas reaction chamber. The invention also includes a method of converting a gaseous feed material into a tetramer, dimer, other molecule or atomic species by supplying the feed material to the gas reaction chamber wherein the feed material is converted to the appropriate gas species to be supplied to the ion source and ionized. More particularly, the gas reaction chamber is configured to receive hydride and other feed materials in gaseous form, such as, AsH | 07-23-2009 |
Richard David Goldberg, Cambridge, MA US
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20100288940 | FRONT PLATE FOR AN ION SOURCE - The present invention relates to a front plate for an ion source that is suitable for an ion implanter. The front plate according to the invention comprises obverse and reverse sides, an exit aperture for allowing egress of ions from the ion source that extends substantially straight through the front plate between the obverse and reverse sides, and a slot penetrating through the front plate from obverse side to reverse side at a slant for at least part of its depth, the slot extending from a side of the front plate to join the exit aperture. The slot is slanted to occlude line of sight into the ion source when viewed from in front, yet provides an expansion gap. | 11-18-2010 |
Richard David Goldberg, Boston, MA US
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20090211896 | Cathode and Counter-Cathode Arrangement in an Ion Source - The present invention relates to ion sources ( | 08-27-2009 |
Robert Goldberg, Lincoln, MA US
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20110245633 | DEVICES AND METHODS FOR TREATING PSYCHOLOGICAL DISORDERS - A wearable biosensor device gathers physiological data from the wearer and uses this information over time to diagnose, detect, monitor, and treat psychological disorders. The device triggers real-time psychological treatments based on personalized estimates of the wearer stored on the biosensor device. A therapeutic stimulus is selected from a library based on the data received from the wearable biosensor device and relating to psychological condition(s), and that stimulus is delivered to the wearer via an associated display. The aggregate data from use of the device is provided to clinicians and/or patients, in detail and in summary report forms, to indicate the symptoms of, detect and diagnose among disorders or subtypes, to analyze treatment effects, and to isolate the underlying causes of one or more psychological disorders or states. | 10-06-2011 |
Robert F. Goldberg, Boston, MA US
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20150313542 | WEARABLE ELECTRONICS - A wearable article includes a flexible band comprising one or more band segments; one or more biosensors located in the flexible band; one or more processing units located in the flexible band; and at least one connecting mechanism configured to connect at least one end of the flexible band to a housing of a watch face. A method of monitoring a physiological state of a wearer via a flexible band connected to a watch face housing worn at the wearer's wrist includes: receiving, at one or more processing units located in the flexible band, sensor data from one or more biosensors located in the flexible band; and analyzing the received sensor data, via the one or more processing units, to compute a score representative of a physiological state of the wearer. | 11-05-2015 |
20150342511 | OPERATING SYSTEM WITH COLOR-BASED HEALTH STATE THEMES - Techniques for implementing a platform configured to interact with a plurality of applications on a computing device to provide health information of an individual. The platform may be implemented by receiving information representative of a health state of an individual. The information may be provided by a sensor associated with the individual and provide data indicating the individual's physiological and/or emotional state. An indication of the individual's health state may be generated by selecting a value from a set of values representative of different health states. The indication may be provided through a programming interface to one or more applications. An application may provide context information associated with the individual at a time associated with the individual's health state, and the context information may be used to generate the indication. | 12-03-2015 |
Roger A. Goldberg, Boston, MA US
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20150238357 | MAGNETIC EYE SHIELDS AND METHODS OF TREATMENT AND DIAGNOSIS USING THE SAME - In certain aspects, the invention is directed to magnetic eye shields that comprise a magnet. When worn by a patient, the magnetic eye shields are configured to generate an intraocular magnetic field of sufficient magnitude and direction to move a magnetic therapeutic and/or diagnostic agent positioned inside the eye to target tissue within the eye. Other aspects of the invention pertain to kits which comprise such magnetic eye shields as well as one or more additional components, for example, one or more containers of a magnetic diagnostic and/or or therapeutic agent. Further aspects of the invention pertain to methods of treatment, which comprise intraocularly introducing a magnetic therapeutic and/or diagnostic agent into an eye of a patient and fitting a magnetic eye shield to the head of the patient, wherein the magnetic therapeutic and/or diagnostic agent may be introduced to the patient before or after fitting the magnetic eye shield to the head of the patient. | 08-27-2015 |
20150305929 | MAGNETIC CONTACT LENSES AND METHODS OF TREATMENT AND DIAGNOSIS USING THE SAME - In certain aspects, the invention is directed to magnetic contact lenses that comprise one or more magnets. When worn by a patient, the magnetic contact lenses are configured to generate an intraocular magnetic field of sufficient magnitude and direction to move a magnetic therapeutic and/or diagnostic agent positioned inside the eye to target tissue within the eye. Other aspects of the invention pertain to kits which comprise such magnetic contact lenses as well as one or more additional components, for example, one or more containers of a magnetic diagnostic and/or or therapeutic agent. Further aspects of the invention pertain to methods of treatment, which comprise intraocularly introducing a magnetic therapeutic and/or diagnostic agent into an eye of a patient and fitting a magnetic contact lens to the head of the patient, wherein the magnetic therapeutic and/or diagnostic agent may be introduced to the patient before or after fitting the magnetic contact lens to the head of the patient. | 10-29-2015 |
20160022485 | MAGNETIC OPERATING MICROSCOPES AND METHODS OF TREATMENT AND DIAGNOSIS USING THE SAME - In certain aspects, the present invention is directed to a device selected from (a) an operating microscope with an attached or attachable magnet and (b) a magnet that is configured for attachment to an operating microscope. In either case, the magnet is configured to allow a patient's tissue to be viewed through the operating microscope while at the same time permitting the creation of a magnetic field of sufficient magnitude and direction to move a magnetic therapeutic and/or diagnostic agent lying within the tissue to a preferred location in the tissue. | 01-28-2016 |
S. Nahum Goldberg, Brookline, MA US
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20120179154 | TISSUE ABLATION USING PULSE MODULATED RADIO FREQUENCY ENERGY - Tissue ablation systems and methods are provided. Ablation energy (e.g., radio frequency energy) is delivered to the tissue and a physiological parameter (e.g., impedance and/or temperature) indicative of a change in moisture concentration of the tissue is sensed. The ablation energy is alternately pulsed on and off to generate an energy pulse train, with the ablation energy being pulsed on if the sensed physiological parameter crosses a threshold value indicative of an increase in the moisture concentration, and being pulsed off if the sensed physiological parameter crosses a threshold value indicative of a decrease in the moisture concentration. | 07-12-2012 |