Patent application number | Description | Published |
20090176866 | Complexes having adjuvant activity - A complex that comprises a narrow molecular weight distribution polymer that includes units derived from an acrylic acid or a salt thereof, and (i) a substance that has pharmacological activity against a pathogenic organism, or (ii) a substance that has pharmacological activity against a cancer, or (iii) one or more agents selected from antigens and immunogens is useful in treating and/or inducing immunity to the pathogenic organism or the cancer, and for inducing immunity to the antigen or immunogen. | 07-09-2009 |
20100239517 | NOVEL CONJUGATED PROTEINS AND PEPTIDES - The invention provides a novel process for conjugating a polymer, especially PEG, to a protein or peptide, which comprises reacting a polymeric conjugation reagent with a protein or peptide containing a polyhistidine tag under conditions such that conjugation occurs via said polyhistidine tag. The resulting conjugates are novel. The invention further relates to novel conjugates of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; Z represents a protein or a peptide linked to A and B via respective histidine residues; A is a C | 09-23-2010 |
20110136723 | NOVEL REAGENTS AND METHOD FOR CONJUGATING BIOLOGICAL MOLECULES - A compound of the general formula X-[Q-W—(CH═CH) | 06-09-2011 |
20110262994 | NOVEL REAGENTS AND METHOD FOR CONJUGATING BIOLOGICAL MOLECULES - A compound of the general formula X-[Q-W—(CH═CH) | 10-27-2011 |
20120115772 | CONJUGATION METHOD - A process for the conjugation of a polymer to a protein, which comprises reacting a polymeric conjugating agent with said protein, in an aqueous medium, in the presence of an amphipathic sugar polymer. The process is particularly useful when conjugating PEG to proteins, particularly to proteins which have previously proved difficult to PEGylate in acceptable yields, for example INF-β. | 05-10-2012 |
20130338231 | NOVEL CONJUGATION REAGENTS - The invention provides compound of the general formula: | 12-19-2013 |
20140081047 | NOVEL REAGENTS AND METHOD FOR CONJUGATING BIOLOGICAL MOLECULES - A compound of the general formula X-[Q-W—(CH═CH) | 03-20-2014 |
20150125473 | NOVEL PROCESS FOR PREPARATION OF ANTIBODY CONJUGATES AND NOVEL ANTIBODY CONJUGATES - The present invention concerns a process for the preparation of an antibody conjugate comprising the step of reacting an engineered antibody having a single inter-heavy chain disulfide bond with a conjugating reagent that forms a bridge between the two cysteine residues derived from the disulfide bond. | 05-07-2015 |
20150148544 | NOVEL REAGENTS AND METHOD FOR CONJUGATING BIOLOGICAL MOLECULES - A compound of the general formula X—[NR—CO—Ar—CO—(CH═CH) | 05-28-2015 |
Patent application number | Description | Published |
20100119484 | DERIVATISATION OF BIOLOGICAL MOLECULES - The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula | 05-13-2010 |
20120014905 | CONUGATED PROTEINS AND PEPTIDES - Novel compounds of the general formula (I): in which X represents a polymer; Q represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; each of R | 01-19-2012 |
20140030210 | DERIVATISATION OF BIOLOGICAL MOLECULES - The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula | 01-30-2014 |
20140369960 | CONJUGATED BIOLOGICAL MOLECULES AND THEIR PREPARATION - Novel biologically active compounds of the general formula (I) in which one of X and X′ represents a polymer, and the other represents a hydrogen atom; each Q independently represents a linking group; W represents an electron-withdrawing moiety or a moiety preparable by reduction of an electron-withdrawing moiety; or, if X′ represents a polymer, X-Q-W— together may represent an electron withdrawing group; and in addition, if X represents a polymer, X′ and electron withdrawing group W together with the interjacent atoms may form a ring; each of Z | 12-18-2014 |
20150216994 | CONJUGATED PROTEINS AND PEPTIDES - Novel compounds of the general formula: | 08-06-2015 |
20160089445 | DERIVATISATION OF BIOLOGICAL MOLECULES - The present disclosure relates to a new polymerisation process in which ethylenically unsaturated monomers are polymerised by a living radical polymerisation process in the presence of an initiator and a catalyst. Polymers produced by this new process are also thought to be novel and may be used to derivatise biological molecules to improve their efficacy as therapeutic treatments. A preferred polymer is of formula | 03-31-2016 |
Patent application number | Description | Published |
20090256282 | Multi-Material Injection Molding Apparatus and Method - A multi-material injection molding machine includes stationary and moving platens holding cores and first and second injection units for delivering first and second molding materials. The moving platen is slidable towards and away from the stationary platen. Further provided is a rotational distribution unit movable between the stationary platen and the moving platen and defining first cavities on one side and second cavities on an opposite side. The first cavities are for mating with cores to define first mold cavities and the second cavities are for mating with cores to define second mold cavities. Also provided are a rotational actuator for rotating the rotational distribution unit and a molding material delivery apparatus for delivering one or more of the first molding material to the first cavities and the second molding material to the second cavities. | 10-15-2009 |
20100183763 | Injection Molding Apparatus - An injection molding apparatus includes an inlet component, a plurality of nozzles, and a plurality of hoses, each of which is not heated. The hoses are connected between outlets of the inlet component and respective molding material inlets of the nozzles for conveying molding material from the inlet component to the nozzles. Hoses may also be connected between a rail plate and the nozzles for delivering cooling fluid or actuation fluid for an actuator to and from the nozzles. The nozzles may be fastened to a mold plate of the injection molding apparatus, such as by a threaded bushing. A heated insert may at least partially define the mold cavity to heat molding material in the mold cavity. | 07-22-2010 |
20100209547 | Valve Pin Bushing Assembly For An Injection Molding Apparatus - A valve pin bushing assembly for an injection molding apparatus. The assembly includes a bushing body for connection to a manifold, a flexible barrier having a first end that is continuously connected to the bushing body, and a valve pin continuously connected to a second end of the flexible barrier. The valve pin extends through a nozzle in a downstream direction towards a mold gate, wherein the valve pin is movable in an upstream direction and in the downstream direction for opening and closing the mold gate. The flexible barrier seals a channel of molding material from an outside space. | 08-19-2010 |
20100272849 | Melt Channel Geometries for an Injection Molding System - An injection molding system is disclosed that utilizes a melt channel wherein at least a portion of the melt channel has a noncircular cross-section for balancing shear in a melt stream of moldable material that flows therethrough. The noncircular cross-section of the melt channel portion may be, for e.g., capsule-shaped, extended egg-shaped, oval, teardrop-shaped, or peanut-shaped. A flow splitter is also disclosed that is positioned offset from a central axis of an upstream melt channel to protrude between inlets of respective downstream melt channels, where the upstream melt channel splits into the downstream melt channels, to thereby create a narrower inlet into one of the downstream melt channels and a wider inlet into the other of the downstream melt channels. | 10-28-2010 |
20130084355 | Melt Channel Geometries for an Injection Molding System - An injection molding system is disclosed that utilizes a melt channel wherein at least a portion of the melt channel has a noncircular cross-section for balancing shear in a melt stream of moldable material that flows therethrough. The noncircular cross-section of the melt channel portion may be, for e.g., capsule-shaped, extended egg-shaped, oval, teardrop-shaped, or peanut-shaped. A flow splitter is also disclosed that is positioned offset from a central axis of an upstream melt channel to protrude between inlets of respective downstream melt channels, where the upstream melt channel splits into the downstream melt channels, to thereby create a narrower inlet into one of the downstream melt channels and a wider inlet into the other of the downstream melt channels. | 04-04-2013 |
20140099397 | Melt Channel Geometries for an Injection Molding System - An injection molding system is disclosed that utilizes a melt channel wherein at least a portion of the melt channel has a noncircular cross-section for balancing shear in a melt stream of moldable material that flows therethrough. The noncircular cross-section of the melt channel portion may be, for e.g., capsule-shaped, extended egg-shaped, oval, teardrop-shaped, or peanut-shaped. A flow splitter is also disclosed that is positioned offset from a central axis of an upstream melt channel to protrude between inlets of respective downstream melt channels, where the upstream melt channel splits into the downstream melt channels, to thereby create a narrower inlet into one of the downstream melt channels and a wider inlet into the other of the downstream melt channels. | 04-10-2014 |
20150231809 | Melt Channel Geometries for an Injection Molding System - An injection molding system is disclosed that utilizes a melt channel wherein at least a portion of the melt channel has a noncircular cross-section for balancing shear in a melt stream of moldable material that flows therethrough. The noncircular cross-section of the melt channel portion may be, for e.g., capsule-shaped, extended egg-shaped, oval, teardrop-shaped, or peanut-shaped. A flow splitter is also disclosed that is positioned offset from a central axis of an upstream melt channel to protrude between inlets of respective downstream melt channels, where the upstream melt channel splits into the downstream melt channels, to thereby create a narrower inlet into one of the downstream melt channels and a wider inlet into the other of the downstream melt channels. | 08-20-2015 |
Patent application number | Description | Published |
20110041499 | LOW DIFFERENTIAL TEMPERATURE ROTARY ENGINES - An engine for extracting energy from a heat source, comprising a support, a shaft rotatably coupled to the support and being rotatable in a first direction, a plurality of vessels coupled to and spaced about the shaft, a working fluid provided in the plurality of vessels, and a plurality of conduits connecting the vessels together in a circuitous fluid circuit. Each conduit has an outlet end connected to one of the plurality of vessels, an inlet end connected to another one of the plurality of vessels, and a one-way check valve configured to allow the working fluid to flow out of the one vessel via the outlet end, through the conduit and into the another vessel via the inlet end. The plurality of vessels and conduits are shaped and arranged about the shaft and the working fluid is selected so that when the one vessel is heated by the heat source the working fluid in the one vessel experiences an increase in vapour pressure causing at least part of the working fluid to flow from the one vessel into the another vessel located above the one vessel so as to produce a gravitational moment that encourages rotation of the shaft in the first direction. | 02-24-2011 |
20130000303 | LOW DIFFERENTIAL TEMPERATURE ROTARY ENGINES - An engine is configured to extract energy from a heat source as follows. A shaft is adapted to be rotatably coupled to a support and rotatable in a first direction. A plurality of vessels is coupled to and arranged about the shaft. At least a first vessel of the plurality of vessels includes a thermally insulative portion and a thermally conductive portion. A plurality of conduits connects the plurality of vessels together. Each of the plurality of vessels is in communication with at least one other of the plurality of vessels via at least one of the conduits. The plurality of vessels is arranged to allow the thermally conductive portion of the first vessel to encounter the heat source. The thermally conductive portion is capable of transferring heat to at least partially vaporize volatile fluid within the first vessel to cause a mass to at least partially move towards a connected vessel located above the first vessel. This produces a gravitational moment that encourages rotation of the shaft and the plurality of vessels in the first direction. | 01-03-2013 |
20140150419 | LOW DIFFERENTIAL TEMPERATURE ROTARY ENGINES - An engine is configured to generate power by extracting energy from a low temperature or pressure differential. A plurality of movable masses (e.g., fluid contained in and movable between vessels) is coupled to and arranged about a shaft. When subject to a pressure differential, mass moves to a higher vessel thereby increasing its potential energy and producing a gravitational moment that encourages rotation of the plurality of masses in the first direction. The pressure differential can be created by an increase in pressure that can be generated by exposing a substance (e.g., a volatile material) to heat. | 06-05-2014 |
20150152747 | EXTERNAL HEAT ENGINES - An engine includes a plurality of vessels coupled to a rotatable frame and arranged about a center of rotation of the rotatable frame. Conduits connect pairs of vessels to allow mass to move between the pairs of vessels to generate a gravitational moment about the center of rotation. Each pair of vessels can have a pathway for conveying fluid heated by a heat source. The pathway extends from the heat source to a lower vessel of the pair, and can further extend from the lower vessel to an upper vessel of the pair. The pathway can be configured to expand volatile material in the lower vessel to tend to push the mass from the lower vessel into the upper vessel, and to contract volatile material in the upper vessel to tend to suck the mass into the upper vessel from the lower vessel. Vessels can be controllably connected to pressures to move mass via controllable pressure and temperature distribution systems. | 06-04-2015 |
Patent application number | Description | Published |
20080214397 | Fungicidal Compositions - A composition for control of diseases on useful plants or on propagation material thereof caused by phytopathogens, that, in addition to customary inert formulation adjuvants, comprises as active ingredient a mixture of component (A) and a synergistically effective amount of component (B), wherein component (A) is Cyprodinil; and component (B) a compound selected from compounds known for their fungicidal activity, is particularly effective in controlling or preventing fungal diseases of useful plants. | 09-04-2008 |
20110142802 | FUNGICIDAL COMPOSITIONS - A fungicidal composition suitable for control of disease caused by phytopathogens comprising (A) a compound of formula (I), wherein R | 06-16-2011 |
20130274307 | COMPOSITIONS COMPRISING ABSCISIC ACID AND A FUNGICIDALLY ACTIVE COMPOUND - The present invention relates to methods comprising applying to a useful plant, the locus thereof or propagation material thereof a combination of abscisic acid and a fungicidally active compound, which fungicidally active compound is a succinate dehydrogenase inhibitor, in particular for increasing the potency of a fungicidally active compound. The invention also relates to compositions comprising abscisic acid and the fungicidally active compounds as well as seeds comprising the combinations. | 10-17-2013 |