Patent application number | Description | Published |
20090009962 | COMPUTER SYSTEM WITH MOTOR COOLER - A computer system comprises a chassis, an electronic component disposed within the chassis, and a cooling fan that comprises a motor support fixed to a housing that is coupled to the chassis and a hub disposed within the housing. A plurality of blades extend radially from the hub. A motor is disposed within a motor enclosure formed by the motor support and the hub. The hub is rotatably coupled to the motor such that the plurality of blades generates a flow of air around the motor enclosure. The system comprises a motor cooler comprising a flow path through the motor enclosure, where the flow path has a first opening and a second opening, and where the second opening is disposed within an area of lowered downstream pressure so as to develop a differential pressure between the first and second openings and generate a flow of air through the motor enclosure. | 01-08-2009 |
20090010771 | MOTOR COOLER - A cooling fan comprises an outer housing. A motor support is fixed to the outer housing and a motor is mounted to the motor support. A hub is rotatably coupled to the motor and, with the motor support, forms a motor enclosure that substantially surrounds the motor. A plurality of blades extends radially from the hub and are arranged so as to generate a flow of air around the motor enclosure when the blades are rotated. The cooling fan also comprises a motor cooler comprising a flow path through the motor enclosure, wherein the flow path has a first opening and a second opening, wherein the second opening is disposed within an area of lowered downstream pressure so as to develop a differential pressure between the first and second openings and generate a flow of air through the motor enclosure as the motor operates. | 01-08-2009 |
20090083487 | Maintaining data stored in a memory module when transferring the memory module from a first controller to a second controller - To transfer a memory module between controllers, an external power source is connected to a memory module mounted to a first controller. The memory module is removed from the first controller with the external power source connected to the memory module to maintain data stored in volatile memory of the memory module. The memory module is mounted to a second controller. | 03-26-2009 |
20110007472 | CABLE MANAGEMENT MODULE - A cable management module having of a first module capable of connecting to a hard disk drive drawer; a second module releasably connected to the first module. A plurality of pairs of connecting arms connect the first module to the second module with each of the pairs of connecting arms being pivotally joined to each other at an intermediate point. A catch member is located on at least one side of the first module and a locking release mechanism is attached to the second module and to a locking member capable of engaging the catch member. A method for accessing a hard disk drive without disconnecting input/output cables and a method of replacing the input/output cables is also disclosed. | 01-13-2011 |
Patent application number | Description | Published |
20110257034 | METHODS FOR IDENTIFYING GENES WHICH PREDICT DISEASE OUTCOME FOR PATIENTS WITH COLON CANCER - Closures for containers and methods for using same are provided. In a general embodiment/the present disclosure provides a closure having a top portion ( | 10-20-2011 |
20140161729 | COFLUORONS AND METHODS OF MAKING AND USING THEM - The present invention is directed to method of using a collection of monomers capable of forming multimers as a fluorescence reporter in different applications such as ligand detection/screening, disease diagnosis, drug discovery or screening, fluorescent labeling and imaging, or other fluorescent methodologies. Each monomer in the collection includes one or more ligand elements useful for binding to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the ligand elements directly or indirectly through a connector. Association of linker elements of different combinations of monomers, with their ligand elements bound to the target molecule to form a multimer, will generate a unique fluorescent signature different from that produced by those monomers either alone or in association with each other in the absence of the target molecule, when subjected to electromagnetic excitement. | 06-12-2014 |
20140163229 | SILYL MONOMERS CAPABLE OF MULTIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME - Described herein are silyl monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. Such multimer forming associations of monomers may be promoted by the proximal binding of the monomers to their target biomolecule(s). In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins. | 06-12-2014 |
20140194383 | MONOMERS CAPABLE OF DIMERIZING IN AN AQUEOUS SOLUTION, AND METHODS OF USING SAME - Described herein are monomers capable of forming a biologically useful multimer when in contact with one, two, three or more other monomers in an aqueous media. In one aspect, such monomers may be capable of binding to another monomer in an aqueous media (e.g. in vivo) to form a multimer, (e.g. a dimer). Contemplated monomers may include a ligand moiety, a linker element, and a connector element that joins the ligand moiety and the linker element. In an aqueous media, such contemplated monomers may join together via each linker element and may thus be capable of modulating one or more biomolecules substantially simultaneously, e.g., modulate two or more binding domains on a protein or on different proteins. | 07-10-2014 |
Patent application number | Description | Published |
20110263688 | COFERONS AND METHODS OF MAKING AND USING THEM - A monomer useful in prepaπng therapeutic compounds includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 11 M and a linker element connected to the diversity element The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or noncovalent interaction with a binding partner of the linker element The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof | 10-27-2011 |
20120295874 | COFERONS AND METHODS OF MAKING AND USING THEM - The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes one or more pharmacophores which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the pharmacophore. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to the pharmacophore. | 11-22-2012 |
20150105553 | COFERONS AND METHODS OF MAKING AND USING THEM - The present invention is directed to a monomer useful in preparing therapeutic compounds. The monomer includes a diversity element which potentially binds to a target molecule with a dissociation constant of less than 300 μM and a linker element connected to the diversity element. The linker element has a molecular weight less than 500 daltons, is connected, directly or indirectly through a connector, to said diversity element, and is capable of forming a reversible covalent bond or non-covalent interaction with a binding partner of the linker element. The monomers can be covalently or non-covalently linked together to form a therapeutic multimer or a precursor thereof. Also disclosed is a method of screening for therapeutic multimer precursors which bind to a target molecule associated with a condition and a method of screening for linker elements capable of binding to one another. The present invention additionally relates to a therapeutic multimer, which includes a plurality of covalently or non-covalently linked monomers, therapeutic monomers, and uses of such dimers and monomers. | 04-16-2015 |