Patent application number | Description | Published |
20090026361 | Microengineered electrode assembly - Microengineered stacked ring electrode assemblies capable of acting as either RF or DC ion guides in an ion optical system, and method of fabricating same are described. The electrodes are fabricated using planar processing as sets of grooved, proud features formed in a layer of material lying on an insulating substrate. Two such structures are then stacked together to form a set of diaphragm electrodes with closed pupils. Arrangements for fabrication by patterning, etching and bonding are described, together with methods for tapering the electrode pupils or otherwise varying the ion path. | 01-29-2009 |
20090090197 | Pre-concentrator and sample interface - This invention describes a multi-stage pre-concentrator device for use with a detector system. One pre-concentrator stage is detachable and may be used to collect sample remotely from the detection system. The detachable pre-concentrator stage mates with the detector system and can transfer its desorbed sample to another pre-concentrator stage which also incorporates the functions of a sample loop serving as an injection volume to the separation column of an analytical instrument. In one embodiment the fixed pre-concentrator stage serves as a sample loop that preferably integrates suitable valves with sorbent materials onto the same structure to minimise dead volume, maximise sensitivity, improving column loading efficiency, reducing duty cycles and minimising detection system response time. | 04-09-2009 |
20090140135 | Electrode structures - This invention describes an electrode structure formed from a plurality of individual electrodes, the plurality of electrodes being arranged relative to one another to define a three dimensional geometric structure with individual ones of the plurality of electrodes located at each of the vertices of the geometric structure and wherein each electrode of the cell presents a curved surface to each other electrode of the cell. Such a structure may be configured as a RF ion guide, mass filter or ion trap. | 06-04-2009 |
20100276591 | Electrode Structures - This invention describes an electrode structure formed from a plurality of individual electrodes, the individual electrodes being provided on separate submounts, the submounts being coupled to one another using kinematic ball mounts. Such a structure may be configured as a RF ion guide, mass filter or ion trap. | 11-04-2010 |
Patent application number | Description | Published |
20090212210 | Mass spectrometer system - This invention describes a vacuum interface for a mass spectrometer system formed from a diverging nozzle. The vacuum interface may be used to transfer a beam of ions from an atmospheric pressure ionisation source into a vacuum chamber for analysis by a mass analyser. | 08-27-2009 |
20110084202 | Portable Analytical System for On-Site Analysis of Fluids - A portable analytical system for the rapid on-site analysis of fluids, and a method for using this system at the well-site for the analysis of samples extracted from drilling fluids is described. The portable analytical solution may be deployed at the well-site and used to perform detailed real-time analysis of formation fluids and extracts of rock cuttings. The method described could be used during hydrocarbon exploration and production to determine whether the drill stem has passed through a hydrocarbon-bearing region, or rocks that are capable of functioning as an oil reservoir or that may have been a source rock, or that may have come into contact with oil, or that may contain oil at present. | 04-14-2011 |
20110113866 | Microengineered Supercritical Fluid Chromatography System - This invention describes a microengineered SFC system for rapidly and efficiently separating the constituents of a complex mixture. The SFC system includes a microchannel that is microfabricated from a suitable substrate so that it forms a chromatographic column for separation of chemicals. The surface area of the microchannel of the column is sufficiently small as to permit use of miniature and relatively inexpensive pumps, and the thermal mass of the microengineered column is sufficiently low as to permit rapid temperature cycling using a miniature, low power and inexpensive heating element. At least a portion of this microchannel is packed with suitable sorbent materials or includes surfaces which are suitably coated with sorbent, or both, so as to retain and elute analyte under certain conditions. As a result analyte passing within this microchannel undergoes chromatographic separation. | 05-19-2011 |
20110127421 | Sample Collection and Detection System - A sample collection and detection system is described. The detection system provides a sample chamber fluidly coupled to a secondary ionisation source to allow the introduction of vapour generated from the sample into an ion path generated from the secondary ionisation source. The secondary ionisation source is a secondary electrospray ionisation (SESI) source, and is usefully employed in dust analysis. | 06-02-2011 |
20110127423 | Mass Spectrometer System - This invention describes an analytical system where a kinetic impact ionisation source is combined with an RF—only ion guide to form a mass spectrometer system for analysis of the elemental and chemical composition of exoatmospheric particles. The kinetic impact ionisation source may be used to transform a flux of particle debris into a beam of ions for analysis by a mass analyzer. | 06-02-2011 |
20110192215 | Analytical System for In-Line Analysis of Post-Combustion Capture Solvents - A device and method is described for direct analysis of solvents used to chemically bind with CO | 08-11-2011 |
Patent application number | Description | Published |
20100227858 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES - A compound of formula (I) or a pharamaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use intherapy, for example in the treatment of proliferative disease such as cancer and particularly in disease mediated by an mTOR kinase and/or one or more PI3K enzyme. | 09-09-2010 |
20100261723 | TRISUBSTITUTED PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PROLIFERATIVE DISEASES - A compound of formula (I) or a pharmaceutically acceptable salt thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of proliferative disease such as cancer and particularly in disease mediated by an mTOR kinase and/or one or more PI3K enzyme. | 10-14-2010 |
20110034454 | MORPHOLINO PYRIMIDINE DERIVATIVES AND THEIR USE IN THERAPY - A compound of formula (I) or a salt, ester or prodrug thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example in the treatment of proliferative disease such as cancer and particularly in disease mediated by an mTOR kinase and/or one or more PI3K enzyme. | 02-10-2011 |
20130053409 | 2-(2,4,5-SUBSTITUTED-ANILINO) PYRIMIDINE COMPOUNDS - The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof. | 02-28-2013 |
20150119379 | 2-(2,4,5-SUBSTITUTED-ANILINO)PYRIMIDINE COMPOUNDS - The present invention relates to certain 2-(2,4,5-substituted-anilino)pyrimidine compounds and pharmaceutically acceptable salts thereof which may be useful in the treatment or prevention of a disease or medical condition mediated through certain mutated forms of epidermal growth factor receptor (for example the L858R activating mutant, the Exon19 deletion activating mutant and the T790M resistance mutant). Such compounds and salts thereof may be useful in the treatment or prevention of a number of different cancers. The invention also relates to pharmaceutical compositions comprising said compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, intermediates useful in the manufacture of said compounds and to methods of treatment of diseases mediated by various different forms of EGFR using said compounds and salts thereof. | 04-30-2015 |
Patent application number | Description | Published |
20090112056 | CONTROL ASSEMBLY - A control assembly for manipulating the movement of an endoscopic instrument includes an endoscopic instrument mounting arrangement adapted to receive an endoscopic instrument, three driving arrangements, and three independent control elements. The mounting arrangement offers only three independent degrees of freedom of movement of an endoscopic instrument received by the arrangement, each degree of freedom of movement being about or along a respective axis. Each of the three driving arrangements are configured to drive the endoscopic instrument in only one of the degrees of freedom of movement. The three independent control elements are configured to receive user input, such that the actuation of each of the three independent control elements regulates one of three corresponding control signals, each control being a respective one of the driving arrangements independent of the other two driving arrangements in accordance with the user input. | 04-30-2009 |
20090192502 | ABLATION DEVICE - A surgical tool for use as an ablation device in a surgical operation including: an ablation module output configured to ablate a volume of material at a surgical site to form an ablated volume; a control module arranged to receive information indicative of the position of the surgical site; and a fluid output adapted to deliver fluid to the surgical site during a surgical operation such that at least part of the ablated volume is filled with fluid and the fluid is in direct contact with at least part of the surgical site. The control module is operable to control the flow rate of fluid delivered by the fluid output in response to the received information in order to control the position of the surgical site. | 07-30-2009 |
20090192520 | TOOL HOLDER - A surgical tool support device includes an arm. The arm includes a flexible tubular main body; and a plurality of beads contained within the tubular main body. In a first configuration, a fluid at least partially surrounds the plurality of beads. In a second configuration, at least some of the fluid is evacuated such that the rigidity of the arm is increased. | 07-30-2009 |