Patent application number | Description | Published |
20080267985 | Variants of Group 1 Allergens from Poaceae Having Reduced Allergenicity and Maintained T-Cell Reactivity - The present invention relates to the preparation and use of variants of the group 1 allergens of the Poaceae (sweet grasses) which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially maintained reactivity with T-lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventive immunotherapy of grass pollen allergies. | 10-30-2008 |
20090069236 | PROCESS FOR THE PREPARATION OF HYPOALLERGENIC MAJOR BIRCH POLLEN ALLERGEN rBet v 1 - The invention relates to a process for the preparation of hypoallergenic major birch pollen allergens by means of one or more chromatographic purification steps using essentially unbuffered aqueous bases as eluent and subsequent neutralisation. The hypoallergenic major birch pollen allergens are distinguished by a lack of, but at least by reduced immunoglobulin E binding with simultaneous retention of therapeutically relevant T-cell stimulation. They can therefore be employed as low-side-effect therapeutic agents for specific immunotherapy. | 03-12-2009 |
20100158955 | Phl p 5a derivatives having reduced allergeneity and retained t-cell reactivity - The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies. | 06-24-2010 |
20100310472 | DNA SEQUENCE, AND RECOMBINANT PREPARATION OF THE GRASS POLLEN ALLERGEN LOL P 4 - The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies. | 12-09-2010 |
20110104209 | DNA SEQUENCE, AND RECOMBINANT PREPARATION OF THE GRASS POLLEN ALLERGEN LOL P4 - The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies. | 05-05-2011 |
20120263741 | VARIANTS OF THE MAJOR ALLERGEN PHL P 1 FROM TIMOTHY GRASS - The invention relates to pharmaceutically important variants of the major allergen Phl p 1 from timothy grass, characterised in that a preparation, hitherto not possible, of monomeric molecules which are soluble and stable in physiological media can be carried out with the aid of prokaryotic expression systems and subsequent purification thereof. | 10-18-2012 |
20120288526 | DNA SEQUENCE AND PREPARATION OF GRASS POLLEN ALLERGEN PHL P4 BY RECOMBINANT METHODS - The present invention relates to the provision of the genetic sequence of the major grass pollen allergen Phl p 4. The invention covers fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for the in vitro and in vivo diagnosis of pollen allergies. | 11-15-2012 |
20130164313 | DNA SEQUENCE, AND RECOMBINANT PREPARATION OF GROUP 4 MAJOR ALLERGENS FROM CEREALS - The present invention relates to the provision of DNA sequences of group 4 major allergens from cereals. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies. | 06-27-2013 |
20130224251 | VARIANTS OF GROUP 6 ALLERGENS OF THE TRUE GRASSES HAVING REDUCED ALLERGENEITY DUE TO MUTAGENESIS OF PROLINE RESIDUES - The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes. | 08-29-2013 |
20140255434 | PHL P 5A DERIVATIVES HAVING REDUCED ALLERGENEITY AND RETAINED T-CELL REACTIVITY - The present invention relates to the preparation and use of variants of the group 5 allergen of the Pooideae which are characterised by reduced IgE reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with T lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies. | 09-11-2014 |
20150056229 | DNA SEQUENCE, AND RECOMBINANT PREPARATION OF THE GRASS POLLEN ALLERGEN LOL P 4 - The present invention relates to the provision of a DNA sequence of the major grass pollen allergen Lol p 4. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant DNA molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins prepared by recombinant methods can be employed for in vitro and in vivo diagnosis of pollen allergies. | 02-26-2015 |
20150071953 | VARIANTS OF GROUP 6 ALLERGENS OF THE TRUE GRASSES HAVING REDUCED ALLERGENEITY DUE TO MUTAGENESIS OF PROLINE RESIDUES - The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the Poaceae (true grasses), which are characterised by reduced IgE reactivity compared with known wild-type allergens and at the same time substantially retained reactivity with T-lymphocytes. | 03-12-2015 |
20150079120 | DNA SEQUENCE AND PREPARATION OF GRASS POLLEN ALLERGEN PHL P4 BY RECOMBINANT METHODS - The present invention relates to the preparation and use of recombinant variants of group 6 allergens of the | 03-19-2015 |
Patent application number | Description | Published |
20080270371 | Method and Database System for Executing a XML Database Query - Executing a XML database query. The method may include compiling the XML database query to provide at least two alternative execution plans, wherein the at least two alternative execution plans provide the same response to the XML database query. The method may further include deciding during runtime, which of the at least two alternative execution plans is executed. The method may include executing the selected execution plan. | 10-30-2008 |
20090063401 | Method and Database System for Pre-Processing an XQuery - A method of pre-processing an XQuery on a XML data base and may comprise parsing the XQuery to obtain an abstract syntax tree and typing the abstract syntax tree to provide at least one pointer into a schema for XML documents of the XML data base. The typing step may involve the use of schema and accumulated instance data of the XML data base. Use of the accumulated instance data in addition to schema data allows for reduction of the set of pointers to a smaller set, which in turn reduces the number of documents to be examined when the query is executed. | 03-05-2009 |
20100005108 | Method and system for generating indexes in an XML database management system - The invention concerns a method for generating at least one index ( | 01-07-2010 |
20100250519 | XML database management system for an XML database comprising access protected XML data - The present invention concerns an XML data base management system (XDBMS, | 09-30-2010 |
20130219361 | SYSTEM AND METHOD FOR CONTROLLING THE DEVELOPMENT OF A SOFTWARE APPLICATION - Certain example embodiments relate to techniques for controlling the development of a software application. The system includes an event channel for receiving at least one event that indicates an action performed by one of a plurality of existing development tools used in the development of the software application, a policy-based event engine for evaluating the at least one event and for initiating at least one action of one of the plurality of existing development tools in accordance with at least one policy, and a repository, for storing at least one artifact to define an architecture of the software application. The at least one artifact corresponds to a component of the software application and/or to a dependency between a first component and a second component of the software application. | 08-22-2013 |
20130262646 | METHOD AND REGISTRY FOR ENABLING THE ENFORCEMENT OF DESIGN-TIME POLICIES DURING RUNTIME IN A SERVICE-ORIENTED ARCHITECTURE - Certain example embodiments relate to computer-implemented methods enabling the enforcement of design-time policies during runtime in a service-oriented architecture (SOA). The SOA includes SOA assets (e.g., web services), and at least one runtime container configured to enforce runtime policies on SOA assets executed therein. Example methods may include:
| 10-03-2013 |
20140173633 | METHOD AND SYSTEM FOR PROPAGATING MODIFICATION OPERATIONS IN SERVICE-ORIENTED ARCHITECTURE - Certain example embodiments relate to techniques for propagating modification operations for Service-oriented Architecture (SOA) objects in a SOA. The SOA includes at least two SOA objects that are connected by at least one relationship that defines one SOA object as referencing SOA object and another SOA object as referenced SOA object. Steps of an appropriate may include: receiving a request for propagating a modification operation from the referencing SOA object to the referenced SOA object; evaluating at least one propagation rule to determine whether the requested modification can be performed on the referenced SOA object; and if it is determined that the requested modification cannot be performed in accordance with the at least one propagation rule, evaluating at least one approval rule to determine whether the requested modification can be performed on the referenced SOA object. | 06-19-2014 |
20140380267 | LIFECYCLE MANAGEMENT SYSTEM WITH CONDITIONAL APPROVALS AND CORRESPONDING METHOD - Certain example embodiments concern a lifecycle management system for at least one computing component. A lifecycle model, including lifecycle states assignable to the at least one computing component, is defined. The lifecycle states include a production state. The lifecycle management system ensures the at least one computing component can be productively used only if it is assigned the production state. A lifecycle transition request assigning a requested target lifecycle state of the lifecycle model to the at least one computing component is received. A conditional lifecycle state, different from the requested target lifecycle state, is assigned to the at least one computing component. At least one condition to be fulfilled for the at least one computing component to be assigned the requested target lifecycle state is assigned. The requested target lifecycle state is automatically assigned to the at least one computing component when the at least one condition is fulfilled. | 12-25-2014 |