Patent application number | Description | Published |
20100041663 | Organic Compounds as Smo Inhibitors - The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway. | 02-18-2010 |
20100069368 | Organic Compounds and Their Uses - The present disclosure relates to compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders; specifically relating to compounds of formula I: | 03-18-2010 |
20110065708 | HETEROCYCLIC OXIME COMPOUNDS - The invention relates to compounds of formula (I) and salts thereof: | 03-17-2011 |
20120142681 | HETEROCYCLIC HYDRAZONE COMPOUNDS - The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I). | 06-07-2012 |
20120207769 | Inhibitors of IAP - Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I). | 08-16-2012 |
20120289507 | ORGANIC COMPOUNDS AS SMO INHIBITORS - The present invention relates generally to novel compounds relating to the diagnosis and treatment of pathologies relating to the Hedgehog pathway, including but not limited to tumor formation, cancer, neoplasia, and non-malignant hyperproliferative disorders. The present invention includes novel compounds, novel compositions, methods of their use and methods of their manufacture, where such compounds are generally pharmacologically useful as agents in therapies whose mechanism of action involve methods of inhibiting tumorigenesis, tumor growth and tumor survival using agents that inhibit the Hedgehog and Smo signaling pathway. | 11-15-2012 |
20120302570 | HETEROCYCLIC OXIME COMPOUNDS - The invention relates to compounds of formula (I) and salts thereof: | 11-29-2012 |
20130005663 | SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS - The present invention is directed to a compound of the formula: | 01-03-2013 |
20130245002 | Triazolopyridine Compounds - The invention relates to compounds of formula (I) and salts thereof: | 09-19-2013 |
20130261299 | PYRIDAZINYL DERIVATIVES AS SMO INHIBITORS - The present invention relates to compounds of formula I: | 10-03-2013 |
20130324526 | [1,2,4] TRIAZOLO [4,3-B] PYRIDAZINE COMPOUNDS AS INHIBITORS OF THE C-MET TYROSINE KINASE - The invention relates to compounds of formula (I) and salts thereof: wherein the substituents are as defined in the specification; a compound of formula (I) for use in the treatment of the human or animal body, in particular with regard to c-Met tyrosine kinase mediated diseases or conditions; the use of a compound of formula (I) for manufacturing a medicament for the treatment of such diseases; pharmaceutical compositions comprising a compound of the formula (I), optionally in the presence of a combination partner, and processes for the preparation of a compound of formula (I). | 12-05-2013 |
20140004101 | SMAC PEPTIDOMETICS USEFUL AS IAP INHIBITORS | 01-02-2014 |
20140089684 | METHOD AND APPARATUS FOR PROTECTING FILE - Embodiments of the present invention provide a method and a system for protecting a file, which belong to the field of information security. The method includes: replacing a secure file header of a file to be protected with its original file header to convert the file to be protected to a secure file; and preventing, by the secure file header of the secure file acquired by the conversion, another peripheral from performing an access operation on content of the secure file. By using this method, in a terminal device such as an Android mobile phone or a computer, without affecting normal use by a subscriber, the protection of files such as multimedia files can be realized and content of a protected secure file in a mobile phone is not allowed to be opened on another device to achieve a purpose of avoiding private information leakage and protecting personal privacy. | 03-27-2014 |
20140115516 | METHOD FOR CONTROLLING SYSTEM BAR OF USER EQUIPMENT, AND USER EQUIPMENT - Embodiments of the present invention provide a method for controlling a system bar of a user equipment, and a user equipment. The method includes: detecting a display status of the system bar; and when the system bar is presented on the screen of the user equipment, and the presented system bar includes a hidden button, receiving a first input used to select the hidden button and input by an input unit to hide the system bar; or when the system bar is not presented on the screen of the user equipment, receiving a second input which is input by the input unit to present the system bar. In the foregoing technical solutions, by flexibly invoking or hiding a system bar integrated with various information and/or convenient buttons, the screen can be used to display content to the greatest extent, so as to improve the utilization rate of the screen. | 04-24-2014 |
20150055343 | LUMINAIRE ELEMENT - The invention describes a luminaire element ( | 02-26-2015 |