Federica
Federica Accornero, Viarigi (at) IT
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20120010386 | RECOMBINANT MELUSIN FUSION PROTEIN AS PHARMACOLOGICAL AGENT IN THE TREATMENT OF HEART PATHOLOGIES AND COMPOSITIONS THEREOF - A recombinant melusin fusion protein having an improved stability and a capability to reach intracellular compartments as compared to recombinant melusin in vivo, wherein said protein comprises i) a human melusin protein having the amino acid sequence as defined in SEQ ID No.:1, or a homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity to SEQ ID No.:1 and having the function of native melusin protein or a human melusin portion derived from SEQ ID No.:1 or homologue thereof having at least 60%, preferably at least 80%, more preferably at least 90% sequence identity of the melusin portion derived from SEQ ID No.:1 and having the function of native melusin protein and ii) a cell penetrating polypeptide. | 01-12-2012 |
Federica Albiero, La Pineda ES
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20090071197 | STRETCHABLE FABRIC SUITABLE FOR SWIMWEAR APPLICATIONS - The present invention relates to new fabric designed for improved utility in swimwear applications, as well as the method for producing such fabric as well as garments made from such fabrics. The fabric can be characterized in terms elongation, instantaneous fabric growth at 15% strain and dimensional stability. The fabric comprises an elastic crosslinked polyolefin elastic yarn and a second yarn selected from the group consisting of polyester, nylon, and polypropylene. | 03-19-2009 |
Federica Baffigi, Livorno IT
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20140191059 | NOZZLE CAPABLE OF DEVIATING A SYNTHETIC JET IN A DYNAMIC AND CONTROLLABLE MANNER WITH NO MOVING MECHANICAL PARTS AND A CONTROL SYSTEM THEREOF - A nozzle is capable of producing a mixing of two primitive fluid jets and a selective and controllable angular deviation of the synthetic jet obtained by mixing the primitive jets without any moving mechanical part. The nozzle is also capable of generating a controllable deviation of the synthetic jet and of changing the direction of this jet in a continuous and dynamic manner so as to allow the jet to sweep a preset and arbitrary angle. The nozzle is constituted, in a first part thereof, by a conduit divided into two channels by a central baffle and, in a second part thereof, by a convergence zone and an outflow mouth whose walls have a curvilinear profile and are connected seamlessly to the walls of the conduit. | 07-10-2014 |
Federica Berardo, Koln DE
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20090004234 | DOSING DEVICE - A dosing device for dosing active substances in washing or cleaning processes, encompassing a container and a) a first active substance composition, present in said container, that contains at least one carrier material and at least one active substance; and b) a second active substance composition, present in said container, that likewise contains at least one carrier material and at least one active substance, but differs in terms of at least one of its ingredients from the first active substance composition, wherein the carrier material in at least one active substance composition is water-insoluble, is suitable for the release of different active substances and is notable for an improved release profile as compared with conventional dosing devices. | 01-01-2009 |
Federica Borgonovo, Milano (mi) IT
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20090312660 | Recognition and localisation of pathologic animal and human sounds - A system and method are described for combining the respiratory status (e.g. amount and type of cough) with the localization of organisms having the respiratory status in real time. The organisms are able to suffer from a respiratory complaint, i.e. they have lungs such as mammals especially farm animals and humans. In particular the present invention is advantageous for animals and humans who are exposed to closed confinements such as pens, cages, aircraft, public places where humans are in close proximity to each other. | 12-17-2009 |
Federica Buonsanti, Torino IT
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20130072719 | Process For The Iodination Of Phenolic Derivatives - The present invention relates to a process for the preparation of iodinated phenols; in particular; it relates to a process including the direct iodination, with suitably activated iodine, of 3,5-disubstituted phenol compounds to the corresponding 3,5-disubstituted-2,4,6-triiodophenols, which are useful intermediates for the synthesis of x-ray contrast media, and to the preparation of the contrast media themselves. | 03-21-2013 |
Federica Caldara, Torino IT
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20110158180 | METHOD OF PROCESSING RECEIVED SIGNALS, CORRESPONDING RECEIVER AND COMPUTER PROGRAM PRODUCT THEREFOR - Signals received from channels exposed to multi-path propagation via a plurality of diversity antennas and including at least one pilot signal are processed by detecting a set of multi-path components for each received signal and computing a set of channel coefficients from multi-path components of the at least one pilot signal in the set of multi-path components. The set of channel coefficients is organized as a channel coefficient vector. From the channel coefficient vector, a set of combining weights is estimated to be applied to the received signals by: computing a spatial correlation matrix of the channel coefficient vector by neglecting the correlations between multi-path components of the channel coefficient vector having different delays, whereby the correlation matrix is a block diagonal matrix including null coefficients other than for non-null sub-matrixes arranged along the diagonal of the correlation matrix, wherein the sub-matrixes have a size equal to the number of diversity antennas; deriving from the spatial correlation matrix a resulting matrix by calculating the inverse of the sub-matrixes or a scaled version thereof; and multiplying the resulting matrix and the channel coefficient vector in order to obtain the desired set of combining weights. | 06-30-2011 |
Federica Censi, Roma IT
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20130102864 | PORTABLE PULSEOXIMETER FOR A DIRECT AND IMMEDIATE AUTOMATED EVALUATION OF THE CARDIAC RHYTHM (REGULARITY) AND RELATED METHOD - A method and system of patient monitoring, the system performs short term acquisition of the plethysmographic waveform of a patient from a portable blood oxygenation level monitoring device and establishes whether the patient has an episode of Atrial Fibrillation (AF) or has a Normal Sinus Rhythm (NSR) or any other not-specific rhythm irregularity. Such classification is implemented directly in the device, suitable for at home use, and the result of the classification is displayed automatically using a three-state, traffic-light indicator. | 04-25-2013 |
Federica Ciamponi, Piombino IT
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20110175245 | ENCAPSULATION - A method of encapsulation comprises the steps of: (a) treating microbial microcapsules with a material to be encapsulated in a substantially anhydrous liquid medium containing a polar aprotic solvent having a dielectric constant greater than 35 under conditions to permit encapsulation of the material, and (b) subjecting the product of step (a) to a substantially aqueous liquid. The preferred solvent is dimethyl sulfoxide (DMSO). The method of the invention is useful for encapsulating hydrophobic and/or high molecular weight materials in yeast. | 07-21-2011 |
Federica Cossu, Milano IT
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20150119342 | New Homo- and Heterodimeric SMAC Mimetic Compounds as Apoptosis Inducers - The present invention relates to conformationally constrained homo- and heterodimeric mimetics of Smac with function as inhibitors of Inhibitor of Apoptosis Proteins (IAPs), the invention also relates to the use of these compounds in therapy, wherein the induction of apoptotic cell death is beneficial, especially in the treatment of cancer, alone or in combination with other active ingredients. | 04-30-2015 |
Federica Cruciani, Bologna IT
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20130028971 | Pharmaceutical Compositions Comprising Rifaximin, Processes For Their Preparation And Their Use In The Treatment Of Vaginal Infections - The invention relates generally to pharmaceutical compositions comprising rifaximin effective at treating vaginal infections, and in particular bacterial vaginosis. The pharmaceutical compositions comprising rifaximin granules are characterized in that they release rifaximin in the vagina in a controlled way. The present invention also relates to processes for preparation of the rifaximin pharmaceutical compositions and their use in the treatment of vaginal infections. Effective dosages and courses of treatment useful and effective at recovering from the disease and preventing any possible relapse are also provided. | 01-31-2013 |
20160047819 | METHOD FOR DIAGNOSING VAGINAL INFECTIONS - Diagnostic methods for evaluating vaginal infections comprising the use of specific proteins are described. Also described here is the use of specific proteins in a diagnostic method for evaluating recovery from the infections following antibiotic treatment of vaginal infections and predicting the recovery and remission of the infection. Diagnostic methods involving the use of specific proteins for evaluating recovery from the vaginal infections following rifaximin treatment and predicting the recovery and remission of the infection are also described. | 02-18-2016 |
Federica Defendi, La Tronche FR
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20140315232 | METHOD FOR DOSING THE CONTROL CAPACITY OF C1INH - The present invention relates to a method for dosing the control capacity of plasma serpin (SERine Protease INhibitor) C1 inhibitor (C1Inh) on the basis of a patient blood sample. The invention also relates to a kit specially designed for said dosing. | 10-23-2014 |
Federica Di Marcello, Siena IT
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20090285845 | Domains And Epitopes Of Meningococcal Protein NMB1870 - ‘NMB1870’ is a known surface protein in | 11-19-2009 |
Federica Filotto, Marano Vincentino IT
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20150118437 | MOTOR VEHICLE PARTS - The invention relates to a motor vehicle part material structure for sound insulation for the motor vehicle interior and motor vehicle trunk, namely floor mats floor coverings, and trunk linings, that makes it possible to industrially implement complete reprocessing of the entire composite, in particular the fiber material. The motor vehicle part has a PIT fiber layer, an optional substrate layer made of PET and/or COPET, an optional PET adhesive layer, a PET adhesive layer, a layer made of PET fiber nonwoven & brie or woven fabric, and an insulating layer made of PET/COPET. | 04-30-2015 |
Federica Gari, Rome IT
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20140149987 | Batch Jobs Using Positional Scheduling Policies of Mobile Devices - Mechanisms are provided for executing a batch job associated with a mobile device. A batch job data structure is retrieved that defines a batch job having a plurality of operations to be executed and a scheduling rule having one or more criteria is retrieved. The one or more criteria comprises at least one of a geographical position criteria or a geographical movement criteria for defining a position or path of motion of the mobile device required for initiating execution of the batch job. A determination is made as to whether one of current or predicted future position or path of motion of the mobile device satisfies the criteria of the scheduling rule. In response to the current or predicted future position or path of motion of the mobile device satisfying the criteria of the scheduling rule, execution of the batch job is initiated. | 05-29-2014 |
Federica Guerinoni, Agrate Brianza IT
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20130004954 | ANALYZER FOR BIOCHEMICAL ANALYSES AND METHOD OF DETERMINING CONCENTRATIONS OF FLUORESCENT SUBSTANCES IN A SOLUTION - An analyzer for biochemical analyses includes a seat for receiving a recipient. A first light source and a second light source illuminate the recipient with a luminous radiation, respectively, in a first excitation band and in a second excitation band, including a first excitation wavelength and a second excitation wavelength of fluorophores of a first type and of a second type. A first image sensor and a second image sensor are oriented so as to receive light emitted by fluorophores contained in the recipient and are, respectively, provided with a first detection filter and a second detection filter, having, respectively, a first detection passband and a second detection passband, including, respectively, a first emission wavelength and a second emission wavelength of the fluorophores of the first type and of the second type. | 01-03-2013 |
Federica Limana, Roma IT
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20090069227 | Use of HMGB1 to promote stem cell migration and/or proliferation - It is described a method to promote stem cell migration and/or proliferation in cell culture or in vivo comprising the step of exposing such cells to an effective amount of the HMGB1 protein or its active fragment. | 03-12-2009 |
Federica Minni, Falconara IT
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20110062952 | METHOD FOR ESTIMATING THE WEIGHT OF THE CONTENTS OF A HOUSEHOLD APPLIANCE - A method for estimating the value of the weight of the contents of the oscillating assembly of an electronically controlled household appliance is provided. The oscillating assembly is connected to a frame by a suspension system having a damper. The damper includes at least two mechanical elements adapted to move reciprocally, a magnetic element which detects reciprocal motion, depending upon the distance between the two elements, the magnetic sensor generates an electrical signal. A reading of an initial value of an electric parameter, is taken when the oscillating assembly is empty. A mathematical function is identified on the basis of the initial value and of a plurality of predetermined parameters, which relate the electrical parameter to the weight of the contents. A second reading is taken when contents have been loaded in, and the value of the weight of the contents is estimated by using the mathematical function and electric parameters. | 03-17-2011 |
Federica Minni, Falconara Marittima IT
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20100218564 | Household Appliance for Treating Soft Goods with Displacement Sensor - The present description relates to a household appliance for treating soft goods, in particular a laundry washing or washing/drying machine of the electronically controlled type fitted with an electronic control system ( | 09-02-2010 |
Federica Mori, Rome IT
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20120177679 | MATRIX METALLOPROTEINASE 11 VACCINE - Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid encoding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions comprise a nucleic acid encoding a fusion polypeptide that includes the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element wherein the codons encoding the MMP-11 and the immunoenhancing element have been optimized for enhanced expression of the fusion polypeptide in human cells. In other embodiments, the compositions comprise the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element. The compositions can be used alone or in synergy with vaccines against other tumor associated antigens as well as with conventional therapies such as radiation therapy and chemotherapy. | 07-12-2012 |
Federica Mori, Pomezia IT
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20090155298 | Matrix Metalloproteinase 11 Vaccine - Compositions comprising matrix metalloproteinase 11 (MMP-11) or stromelysin-3 (ST-3) or the nucleic acid en->coding the MMP-11 for use in vaccines for treating tumors and cancers, which overexpress MMP-11, are described. In particular embodiments, the compositions comprise a nucleic acid encoding a fusion polypeptide that includes the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element wherein the codons encoding the MMP-11 and the immunoenhancing element have been optimized for enhanced expression of the fusion polypeptide in human cells. In other embodiments, the compositions comprise the catalytically inactivated MMP-11 linked at the C-terminus to an immunoenhancing element. The compositions can be used alone or in synergy with vaccines against other tumor associated antigens as well as with conventional therapies such as radiation therapy and chemotherapy. | 06-18-2009 |
Federica Muratori, Bologna IT
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20120228067 | Magnetic Braking Device - A magnetic braking device ( | 09-13-2012 |
Federica Orvieto, Rome IT
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20080275004 | N-Substituted hydroxypyrimidinone carboxamide inhibitors of HIV integrase - N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula: | 11-06-2008 |
20110034449 | N-SUBSTITUTED HYDROXYPYRIMIDINONE CARBOXAMIDE INHIBITORS OF HIV INTEGRASE - N-substituted 5-hydroxypyrimidin-6-one-4-carboxamides of formula: | 02-10-2011 |
20110201657 | AMIDE SUBSTITUTED INDAZOLE AND BENZOTRIAZOLE DERIVATIVES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS - The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment. | 08-18-2011 |
Federica Orvieto, Pomezia IT
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20090275619 | Amide Substituted Indazole and Benzotriazole Derivatives as Poly(ADP-Ribose)Polymerase (PARP) Inhibitors - The present invention relates to compounds of formula (I) and pharmaceutically acceptable salts or tautomers thereof which are inhibitors of poly (ADP-ribose) polymerase (PARP) and thus useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure, cardiovascular diseases, vascular diseases other than cardiovascular diseases, diabetes, neurodegenerative diseases, retroviral infection, retinal damage or skin senescence and UV-induced skin damage, and as chemo- or radiosensitizers for cancer treatment. | 11-05-2009 |
Federica Ottogalli, Gorgonzola IT
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20130234102 | Bipolar Junction Transistors, Memory Arrays, and Methods of Forming Bipolar Junction Transistors and Memory Arrays - Some embodiments include methods of forming BJTs. A first type doped region is formed within semiconductor material. First and second trenches are formed within the semiconductor material to pattern an array of pedestals, and the trenches are filled with electrically insulative material. An upper portion of the first type doped region is counter-doped to form a first stack having a second type doped region over a first type doped region, and an upper portion of the first stack is then counter-doped to form a second stack having a second type doped region between a pair of first type doped regions. Some embodiments include a BJT array. A base implant region is between a pair of emitter/collector implant regions. Electrically insulative material is adjacent the base implant region, and contains at least about 7×10 | 09-12-2013 |
20140273390 | Bipolar Junction Transistors, Memory Arrays, and Methods of Forming Bipolar Junction Transistors and Memory Arrays - Some embodiments include methods of forming BJTs. A first type doped region is formed within semiconductor material. First and second trenches are formed within the semiconductor material to pattern an array of pedestals, and the trenches are filled with electrically insulative material. An upper portion of the first type doped region is counter-doped to form a first stack having a second type doped region over a first type doped region, and an upper portion of the first stack is then counter-doped to form a second stack having a second type doped region between a pair of first type doped regions. Some embodiments include a BJT array. A base implant region is between a pair of emitter/collector implant regions. Electrically insulative material is adjacent the base implant region, and contains at least about 7×10 | 09-18-2014 |
Federica Pericle, El Paso, TX US
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20150087621 | COMPOSITIONS AND METHODS RELATED TO INHIBITORS OF JAK KINASE - Embodiments are directed to JAK kinase inhibiting prodrug compounds of Formula Ib, containing a promoiety that results in alcohol derivative of the parent compound upon removal and methods of using an effective amount of said prodrug compounds in the treatment of a JAK-mediated disease or disorder in a subject. Preferred promoieties include phosphate, phosphonate, phosphate salt, sulfate, or sulfate salt. | 03-26-2015 |
Federica Pericle, Houston, TX US
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20090318334 | LACTOFERRIN AS AN AGENT IN THE PREVENTION OF ORGAN TRANSPLANT REJECTION AND GRAFT-VERSUS-HOST-DISEASE - The present invention relates to methods of using lactoferrin (LF) to treat, prevent or reduce the incidence of organ transplant rejection and graft-versus-host-disease. More particularly, the present invention relates to methods of reducing an immune response against miss-matched transplanted organs such as kidney, heart, lung, liver, pancreas and stem cells by administering a composition of lactoferrin to the recipient patients. In addition, this invention relates to the treatment of bone marrow transplant (BMT) donors with lactoferrin to attenuate the development of graft-versus-host-disease in the recipients. Moreover, this invention relates to the treatment of xenograft organ donors with lactoferrin to attenuate the development of graft rejection in the recipients. | 12-24-2009 |
20110076295 | LACTOFERRIN IN THE TREATMENT OF MALIGNANT NEOPLASMS AND OTHER HYPERPROLIFERATIVE DISEASES - The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies. | 03-31-2011 |
20110110983 | LACTOFERRIN AS AN ADJUVANT IN CANCER VACCINES - The present invention relates to methods of treating cancer by administering a composition of lactoferrin (LF) in combination with cancer vaccines. | 05-12-2011 |
20120276126 | LACTOFERRIN IN THE TREATMENT OF MALIGNANT NEOPLASMS AND OTHER HYPERPROLIFERATIVE DISEASES - The present invention relates to methods of treating a hyperproliferative disease by administering a composition of lactoferrin alone or in combination with standard anti-cancer therapies. | 11-01-2012 |
Federica Pisaneschi, London GB
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20160095946 | LABELLED CARBOXYLIC ACIDS AND THEIR USES IN MOLECULAR IMAGING - The present invention pertains generally to the field of imaging compounds, and more specifically to certain 2,2-dialkyl radionuclide-labelled carboxylic acids suitable for PEWT, SPECT and/or DNP imaging. Also described are uses of such compounds in the imaging of, inter alia, cancer tumors, metastasis, Alzheimer's disease and multiple sclerosis. | 04-07-2016 |
Federica Pisaneschi, South Kensington GB
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20130116206 | QUINOLINE DERIVATIVES USED AS PET IMAGING AGENTS - There is provided compounds of formula (I), wherein R | 05-09-2013 |
Federica Protti, Torino IT
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20130054652 | METHOD FOR EXPLORING A CATALOG OF DIGITAL INFORMATION CONTENTS - A method for exploring a catalog of digital information contents through a user apparatus is provided with a display screen, in which the catalog of digital information contents is structured according to at least two hierarchical tree structures, each including a respective hierarchy of nodes, each node corresponding to a respective category of digital information contents. The method includes: selecting a first sub-hierarchy of nodes of a first one of the at least two hierarchical tree structures, the first sub-hierarchy of nodes being built beginning from a selected category of the first hierarchical structure by selecting at least one among a first number of categories at immediately higher hierarchical levels in comparison to the selected category and a second number of categories at immediately lower hierarchical levels in comparison to the selected category; selecting a second sub-hierarchy of nodes of a second one of said at least two hierarchical tree structures, the second sub-hierarchy of nodes being built beginning from a destination category of the second hierarchical structure, the destination category being in relationship with the selected category, by selecting at least one among a first number of categories at immediately higher hierarchical levels in comparison to the destination category and a second number of categories at immediately lower hierarchical levels in comparison to the destination category; displaying on the screen icons representative of the categories of the first and of the second sub-hierarchy and respective relationships between the categories; and exploring the categories of the first and of the second sub-hierarchy reacting to commands imparted by the user through said user apparatus. | 02-28-2013 |
Federica Rodeghiero, Bologna IT
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20120009603 | METHOD FOR INCREASING AND REGULATING LIGHT EMISSION FROM A CHEMILUMINESCENT REACTION - Method for increasing and regulating the emission of light from a chemiluminescent reaction including luminol, a peroxidase enzyme, an oxidant and an electron mediator (primary enhancer) through the use of an acylation catalyst (secondary enhancer) belonging to the class of N-azoles., i.e., a class of five-membered nitrogen heteroaromatic ring compounds containing at least one other atom of nitrogen. N-azoles, which are especially useful as secondary enhancers are imidazole, 1-methylimidazole, 1,2,3-triazole and 1,2,4-triazole. The invention also describes the use in diagnostic assays of chemiluminescent substrates containing said N-azoles, as secondary enhancers. | 01-12-2012 |
Federica Rodeghiero, Granarolo Dell'Emilia IT
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20150328342 | NOVEL TRICARBOCYANINE-CYCLODEXTRIN(S) CONJUGATES AND USE THEREOF - The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production. | 11-19-2015 |
Federica Rogora, Churchtown IE
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20130124985 | Conditional Localization of Singular and Plural Words - Conditional localization may be provided. A message comprising a numeric component may be prepared for display on a user interface. In response to determining that the numeric component is associated with a descriptor word, a localized variant of the descriptor word may be retrieved according to the numeric component. | 05-16-2013 |
Federica Ruzzier, Trieste IT
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20080219963 | Composition Containing Micronutrients With Improved Anti-Oxidant Activity And The Use Thereof - Compositions in fine powder form that can be obtained by means of a dry co-grinding process of an at least ternary mixture consisting of an active substance, a carrier and at least one auxiliary co-grinding substance, wherein the active substance is constituted by one or more micronutrient substances with particular antioxidant activity. Such compositions have shown a significant increase in active substance antioxidant power in comparison to solutions of equal active substance content. Said effect is particularly useful for uses for active substances included in antioxidant compositions in the pharmaceutical, cosmetic and dietary-nutritional fields. | 09-11-2008 |
Federica Savazzini, Parma IT
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20110020286 | TRICHODERMA ATROVIRIDE SC1 FOR BIOCONTROL OF FUNGAL DISEASES IN PLANTS - An embodiment of the present invention is a | 01-27-2011 |
Federica Scacchia, Teramo IT
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20130103078 | SUTURE THREAD - A suture thread ( | 04-25-2013 |
20140236229 | SUTURE THREAD - A suture thread having: a thread-shaped main body with spikes and a stopper cylinder having a diameter enlarged with respect to the main body is described. | 08-21-2014 |
Federica Scotgia, Manchester GB
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20140378477 | MCT PROTEIN INHIBITOR-RELATED PROGNOSTIC AND THERAPEUTIC METHODS - This invention provides a method of identifying one or more subgroups of cancer patients that are likely to benefit from treatment with a monocarboxylate transporter (MCT) protein inhibitor comprising: (a) obtaining a sample of a cancer/tumor tissue from each of said cancer patients; (b) determining the expression level of stromal MCT4 protein in each of said samples of cancer/tumor tissue to obtain a first dataset; and (c) using the expression level of the stromal MCT4 protein from said first dataset to classify each of said sets of one or more cancer patients as stromal MCT4-positive or stromal MCT4-negative, wherein the cancer patients classified as stromal MCT4-positive are patients that are more likely to benefit from treatment with said MCT protein inhibitor. This invention also provides related methods for treating a cancer/tumor whose stromal component expresses the MCT4 protein in a patient. | 12-25-2014 |
Federica Sotgia, Philadelphia, PA US
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20120039805 | Therapeutics And Methods For Treating Neoplastic Diseases Comprising Determining The Level Of Caveolin-1 And/Or Caveolin-2 In A Stromal Cell Sample - The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial; lymphomas, sarcomas, melanomas, and the like, comprising determining the level of caveolin-1 and/or caveolin-2 in stromal cells adjacent to a neoplasm. | 02-16-2012 |
20120190565 | Method Of Diagnosis Or Prognosis Of A Neoplasm Comprising Determining The Level Of Expression Of A Protein In Stromal Cells Adjacent To The Neoplasm - The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, EF-I-delta, or M2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm. | 07-26-2012 |
20130172430 | PROGNOSIS AND TREATMENT OF BREAST CANCER - Methods of prognosis and monitoring of breast cancer include determining the level of one or more of the markers comprising asymmetric dimethyl arginine (ADMA), beta-hydroxybutyrate (BHB) and microRNA-31 (miR-31) in patient samples. An increased level is correlated with poor prognosis. Breast cancer is treated by administration of one or more inhibitors of ADMA and/or BHB. | 07-04-2013 |
Federica Sotgia, Withington GB
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20140221496 | Method of Diagnosis or Prognosis of a Neoplasm Comprising Determining the Level of Expression of a Protein in Stromal Cells Adjacent to the Neoplasm - The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression o caveolin-1, caveolin-2, vimentin, calponin2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, EF-I-delta, or M2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm. | 08-07-2014 |
20140322705 | Cancer diagnostic and cancer therapeutic - This invention relates to methods and kits for making a prognosis of disease course in a neoplastic disease patient by determining the level, expression and/or activity of a biomarker. | 10-30-2014 |
Federica Zanderigo US
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20120252202 | SEMICONDUCTOR MEMORY DEVICES AND METHOD OF MANUFACTURING THE SAME - The semiconductor memory devices include an interfacial improvement resistance layer is formed between a polysilicon layer and a conductive layer in order to improve interfacial resistance between the polysilicon layer and the conductive layer. The method of manufacturing semiconductor memory devices includes forming a polysilicon layer over a semiconductor substrate, amorphizing the polysilicon layer, and stacking an interfacial improvement resistance layer and conductive layers over the amorphized polysilicon layer. | 10-04-2012 |
Federica Zanderigo, Milano IT
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20120280195 | RESISTANCE VARIABLE MEMORY CELLS AND METHODS - Resistance variable memory cells and methods are described herein. One or more methods of forming a resistance variable memory cell include forming a silicide material on a terminal of a select device associated with the resistance variable memory cell, forming a modified region of the silicide material by modifying a resistivity of a region of the silicide material, forming a conductive element on at least a portion of the modified region, and forming a resistance variable material on the conductive element. | 11-08-2012 |