Patent application number | Description | Published |
20090088723 | APPARATUS AND METHODS FOR TREATING PSEUDOANEURYSMS - Apparatus and methods are provided for treating pseudoaneurysms using freeze-dried hydrogel particles that expand and/or absorb fluid within a pseudoaneurysm. An apparatus includes an elongate tubular member including a proximal end, a distal end sized for introduction through tissue into a pseudoaneurysm or other body cavity, and a lumen communicating with an outlet on the distal end. The particles are provided within the lumen and dischargeable through the outlet, e.g., using a plunger or other actuator. The apparatus may include one or more of a bled-back channel, flow sensor, pressure sensor, and markers for monitoring the distal end during introduction into the pseudoaneurysm. | 04-02-2009 |
20100274280 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus and methods for sealing a puncture through tissue or otherwise treating a body lumen of a patient. The carrier includes at least one, but not all, of the adherent layer components required to form a tacky or sticky adherent layer on the carrier. The remaining adherent layer precursor(s) are delivered to the carrier in situ to form a sticky and/or tacky adherent layer on the carrier that enhances the attachment and retention of the carrier to tissue surrounding a target treatment location in which the carrier is delivered. The carrier may include hydrogel and/or other porous material, e.g., for releasing one or more agents carried by the carrier at the treatment location. | 10-28-2010 |
20110066183 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture. | 03-17-2011 |
20110092613 | MATERIALS FORMABLE IN SITU WITHIN A MEDICAL DEVICE - Certain embodiments of the invention include forming a material in situ by introducing into a space within a patient a water soluble polymer precursor of at least about 10,000 molecular weight solubilized in a flowable aqueous solution. Functional groups on the polymer precursor undergo covalent bonding in situ to form a solid and nonbiodegradable material having a swellability less than about 20% v/v and a Young's modulus of at least about 100 kPa within about 30 seconds to about 30 minutes of initiating a chemical reaction of the functional groups to form the solid material. | 04-21-2011 |
20120310276 | METHODS FOR SEALING A VASCULAR PUNCTURE - A method for sealing a puncture through a vessel wall using a sealing device including an elongate tubular body, a balloon carried by the body, an outer tubular member carried over the elongate tubular body, and a sealant carried by the elongate tubular body adjacent the balloon. Retracting the outer tubular member exposes the sealant. | 12-06-2012 |
20120310277 | APPARATUS FOR SEALING A VASCULAR PUNCTURE - An apparatus for sealing a puncture through a vessel wall including an elongate tubular body, a balloon carried by the body, an outer tubular member carried over the tubular body, and a sealant carried by the tubular body adjacent the balloon. Retracting the outer tubular member exposes the sealant. | 12-06-2012 |
20120330352 | TRANSAPICAL CLOSURE DEVICES AND METHODS FOR USE - Apparatus and methods are provided for sealing a puncture through the wall of a patient's heart into a heart chamber, e.g., at the apex of the heart into the left ventricle. A positioning member is advanced into the puncture until a positioning element thereon is disposed within the chamber, the positioning element is expanded within the chamber, and the positioning member is withdrawn until the expanded positioning element contacts the endocardial wall of the chamber. A cartridge carrying a solid sealant is advanced over the positioning member, and the sealant is deployed within the puncture, e.g., offset proximally from the endocardial wall, the sealant expanding upon exposure to fluid within the puncture to seal the puncture. | 12-27-2012 |
20130060316 | BALLOON CATHETERS AND METHODS FOR USE - Apparatus and methods are provided for flaring a stent deployed within a branch vessel including an ostium communicating with a main vessel, a first end of the stent extending at least partially from the branch. A catheter is provided that includes a first balloon carried on its distal end, and a second balloon that includes a distal section overlying at least a portion of the first balloon and a proximal section. The catheter distal end is introduced into the main vessel and positioned through the ostium and stent into the branch until the first balloon is disposed within the stent. The first balloon is expanded to anchor the stent, and the second balloon is expanded to flare the first end of the stent. Optionally, the first balloon is expanded further, e.g., to expand the stent within the branch body lumen and/or dilate the lesion. | 03-07-2013 |
20130066361 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus for sealing a puncture through tissue to a blood vessel includes a cartridge including a proximal end, a distal end sized for insertion into a puncture, and a lumen extending therebetween. A bioabsorbable plug is disposed within the lumen adjacent the distal end, and an anchoring element is disposed within the lumen proximal to the plug. A pusher member is disposed within the lumen for deploying the plug and anchoring element out the distal end of the cartridge. The plug may be formed from lyophilized hydrogel and the anchoring element may be formed from air-dried hydrogel, the anchoring element hydrating slower than the plug when exposed to an aqueous environment. During use, the plug and anchoring element are delivered into the puncture, the plug is cinched against the vessel wall. Protrusions on the anchoring element engage tissue surrounding the puncture to prevent proximal movement of the plug. | 03-14-2013 |
20130138147 | Apparatus and Methods for Facilitating Hemostasis within a Vascular Puncture - Apparatus for sealing a puncture communicating with a blood vessel includes a bioabsorbable sealing member secured to one end of a filament or other retaining member. The sealing member is delivered through the puncture into the vessel, and refracted against the wall of the vessel to provide temporary hemostasis. The sealing member is rapidly absorbed after exposure within the vessel, e.g., to an aqueous or heated physiological environment (e.g., exposure to blood or body temperature), immediately or shortly after completing a medical procedure via the puncture, e.g., within the time period that the patient is ambulatory. Optionally, extravascular sealing material is delivered into the puncture proximal to the sealing member. The retaining member and/or extravascular material may be bioabsorbable, being absorbed at a slower rate than the sealing member. Alternatively, the filament is removed from the puncture after hemostasis is established. | 05-30-2013 |
20130267996 | METHODS FOR SEALING A VASCULAR PUNCTURE - Methods for sealing a puncture communicating with a blood vessel are provided that include introducing a porous carrier formed from lyophilized hydrogel or other material into the puncture. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture. | 10-10-2013 |
20140100605 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture. | 04-10-2014 |
20140180333 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - Apparatus for sealing a puncture communicating with a blood vessel includes a porous carrier formed from lyophilized hydrogel or other material. The plug may include at least first and second hydrogel precursors and a pH adjusting agent carried by the porous carrier in an unreactive state prior to exposure to an aqueous physiological environment. Once exposed to bodily fluids, the carrier expands as the lyophilized material hydrates to enhance and facilitate rapid hemostasis of the puncture. When the plug is placed into the puncture, the natural wetting of the plug by bodily fluids (e.g., blood) causes the first and second precursors to react and cross-link into an adhesive or “sticky” hydrogel that aids in retaining the plug in place within the puncture. | 06-26-2014 |
20140214075 | APPARATUS AND METHODS FOR SEALING A VASCULAR PUNCTURE - An apparatus for sealing a puncture through tissue to a vessel includes an elongate occlusion member including an expandable member, a cartridge carried on the occlusion member, and a sealant carried within the cartridge. The cartridge includes an outer member and a pusher member within the outer member. The sealant is disposed within the outer member adjacent the expandable member distal to the pusher member. During use, the occlusion member is introduced into a puncture until the expandable member and the sealant extend from the puncture into the vessel. The expandable member is expanded, and withdrawn until the expanded expandable member contacts the vessel wall, thereby withdrawing the sealant back into the puncture. The outer member is withdrawn to expose the sealant within the puncture, while the pusher member prevents removal of the sealant, and then the cartridge, occlusion member, and pusher member are successively removed. | 07-31-2014 |
20140296907 | Apparatus and Methods for Facilitating Hemostasis within a Vascular Puncture - Apparatus for sealing a puncture communicating with a blood vessel includes a bioabsorbable sealing member secured to one end of a filament or other retaining member. The sealing member is delivered through the puncture into the vessel, and refracted against the wall of the vessel to provide temporary hemostasis. The sealing member is rapidly absorbed after exposure within the vessel, e.g., to an aqueous or heated physiological environment (e.g., exposure to blood or body temperature), immediately or shortly after completing a medical procedure via the puncture, e.g., within the time period that the patient is ambulatory. Optionally, extravascular sealing material is delivered into the puncture proximal to the sealing member. The retaining member and/or extravascular material may be bioabsorbable, being absorbed at a slower rate than the sealing member. Alternatively, the filament is removed from the puncture after hemostasis is established. | 10-02-2014 |