Patent application number | Description | Published |
20090005343 | B-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST ANTHRAX LETHAL TOXIN - The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of β-cyclodextrin. Per-substituted alkylamino derivatives displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides methods for protection against anthrax toxicity. | 01-01-2009 |
20090023210 | B-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST ANTHRAX LETHAL TOXIN - The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of β-cyclodextrin. Per-substituted alkylamino derivatives displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides methods for protection against anthrax toxicity. | 01-22-2009 |
20110071108 | Beta-Cyclodextrin Derivatives as Antibacterial Agents - The invention provides a new class of antibiotics to which pathogenic bacteria have not been exposed, and thus should not have developed resistance. This new class of antibiotics are derivatives of β-cyclodextrin (β-CD), which is a cyclic molecule comprising seven D-glucose units. | 03-24-2011 |
Patent application number | Description | Published |
20110247240 | Article Of Footwear With A Ball Contacting Surface - An article of footwear with a ball contacting surface is disclosed. The ball contacting surface includes a raised peak member at the top and gripping members along a medial side. The ball contacting surface enhances the ability of a wearer to kick a ball with a low trajectory and to control the ball. | 10-13-2011 |
20110247243 | Article of Footwear With Multiple Cleat System - An article of footwear including a sole structure with multiple cleat systems is disclosed. A first cleat system has a first cleat design and one or more cleat member sets that are tuned to provide different levels of traction and flexibility to different regions of the sole structure. A second cleat system has a second cleat design and is disposed on the sole structure in a location to provide maximum traction for various playing surfaces. The sizes, material properties and arrangement of each cleat system are varied. | 10-13-2011 |
20110258883 | Article Of Footwear With Ball Control Portion - A ball control portion for an article of footwear is disclosed. The ball control portion extends from a side to an underside of an article of footwear. The ball control portion includes a lattice with a plurality of protrusions arranged in a grid. The plurality of protrusions include multiple groups of protrusions arranged with one or more of different orientations, different types of protrusions, and different heights. | 10-27-2011 |
20110277355 | ARTICLE OF FOOTWEAR WITH MULTI-PART SOLE ASSEMBLY - An article of footwear includes an upper, a midsole beneath the upper, and an outsole beneath the midsole. The midsole includes a substantially U-shaped outer member defining a pair of forwardly extending arms spaced from one another and formed of a first material. An inner member is positioned between the arms of the outer member and is formed of a second material that is more resilient than the first material. | 11-17-2011 |
20130145655 | Article of Footwear with Ball Control Portion - A ball control portion for an article of footwear is disclosed. The ball control portion extends from a side to an underside of an article of footwear. The ball control portion includes a lattice with a plurality of protrusions arranged in a grid. The plurality of protrusions include multiple groups of protrusions arranged with one or more of different orientations, different types of protrusions, and different heights. | 06-13-2013 |
20130192092 | Article of Footwear With Multiple Cleat Systems - An article of footwear including a sole structure with multiple cleat systems is disclosed. A first cleat system has a first cleat design and one or more cleat member sets that are tuned to provide different levels of traction and flexibility to different regions of the sole structure. A second cleat system has a second cleat design and is disposed on the sole structure in a location to provide maximum traction for various playing surfaces. The sizes, material properties and arrangement of each cleat system are varied. | 08-01-2013 |
20140130376 | Article Of Footwear Incorporating A Knitted Component With Interior Layer Features - An article of footwear has an upper and a sole structure secured to the upper. The upper includes a knitted component and, in some configurations, a skin layer secured to the exterior surface of the knitted component. The knitted component may an asymmetric interior layer secured to the interior surface of the knitted component. The asymmetric interior layer has varying medial and lateral portions that provide for different amounts of feel and cushioning along the varying sides of the upper. The asymmetric interior layer includes a lining layer and a connecting layer that join to form the asymmetric interior layer. Other interior layer features are provided, including collar portions and a heel pad that extends along the heel region of the knitted component from a sockliner to an opening on an ankle cuff of the knitted component. | 05-15-2014 |
20140245637 | Article Of Footwear Incorporating A Knitted Component With Interior Layer Features - An article of footwear has an upper and a sole structure secured to the upper. The upper includes a knitted component and, in some configurations, a skin layer secured to the exterior surface of the knitted component. The knitted component may an asymmetric interior layer secured to the interior surface of the knitted component. The asymmetric interior layer has varying medial and lateral portions that provide for different amounts of feel and cushioning along the varying sides of the upper. The asymmetric interior layer includes a lining layer and a connecting layer that join to form the asymmetric interior layer. Other interior layer features are provided, including collar portions and a heel pad that extends along the heel region of the knitted component from a sockliner to an opening on an ankle cuff of the knitted component. | 09-04-2014 |
20150033587 | Article Of Footwear With A Ball Contacting Surface - An article of footwear with a ball contacting surface is disclosed. The ball contacting surface includes a raised peak member at the top and gripping members along a medial side. The ball contacting surface enhances the ability of a wearer to kick a ball with a low trajectory and to control the ball. | 02-05-2015 |
20150059209 | Article Of Footwear Incorporating A Knitted Component With An Integral Knit Ankle Cuff - An article of footwear with a knitted component including an upper and an integral knit ankle cuff is provided. The upper and the ankle cuff are formed as a one-piece knit element. The knit element forms a portion of an exterior surface of the upper and an opposite interior surface of the upper, with the interior surface forming a void for receiving a foot. The ankle cuff is formed of unitary knit construction with the upper as a one-piece knit element and extends above a throat area of the upper. The ankle cuff includes malleolus zones on medial and lateral sides to correspond with the ankle bones of a wearer. The knit component further incorporates features to assist with providing entry for a foot of a wear, providing comfort to a wearer, and to assist with orientation of the upper of the article of footwear when being worn. | 03-05-2015 |
20150101212 | Article Of Footwear Incorporating A Knitted Component With An Integral Knit Ankle Cuff - An article of footwear with a knitted component including an upper and an integral knit ankle cuff is provided. The upper and the ankle cuff are formed as a one-piece knit element. The knit element forms a portion of an exterior surface of the upper and an opposite interior surface of the upper, with the interior surface forming a void for receiving a foot. The ankle cuff is formed of unitary knit construction with the upper as a one-piece knit element and extends above a throat area of the upper. The ankle cuff includes malleolus zones on medial and lateral sides to correspond with the ankle bones of a wearer. The knit component further incorporates features to assist with providing entry for a foot of a wear, providing comfort to a wearer, and to assist with orientation of the upper of the article of footwear when being worn. | 04-16-2015 |