Patent application number | Description | Published |
20100277607 | IMAGE SENSOR WITH HIGH DYNAMIC RANGE IMAGING AND INTEGRATED MOTION DETECTION - This disclosure describes: (1) two different schemes to enhance dynamic range, (2) a new motion detection scheme using in-pixel digital storage, and (3) the motion detection in high illumination for CMOS image sensors. The schemes may be implemented in a small pixel size and easily incorporated in simple column-level circuits for existing CMOS image sensor systems. | 11-04-2010 |
20110193633 | BIOAMPLIFIER FOR NEURAL INTERFACES - A bioamplifier that includes a high pass filter, open-loop amplifier, and low pass filter in an area efficient design that can be used in implantable neural interfaces. The high pass filter can be implemented by using a switch-capacitance resistor coupled with parasitic capacitance of the electrode. The amplifier can be chopper stabilized and can include a high gain, current-ratio first stage followed by one or more dimension-ratio stages. The low pass filter utilizes the output impedance of the open-loop amplifier to form an embedded g | 08-11-2011 |
20120302856 | DISTRIBUTED, MINIMALLY-INVASIVE NEURAL INTERFACE FOR WIRELESS EPIDURAL RECORDING - A neural interface for measuring or stimulating brain neural activity, either as a standalone unit or as a part of a larger system of similar neural interfaces. The neural interface includes a bolt-shaped housing having a tool-engaging head and threaded shank with internal circuitry and at least one electrode. In use, the housing is threaded into a cranial bore such that the electrode contacts the outer surface of the meninges. The neural interface circuitry includes an SAR ADC that provides at least rail-to-rail operation to convert received signals from the electrode(s) into digital data that can be modulated and wirelessly transmitted by intra-skin or other suitable communication. | 11-29-2012 |
20130079615 | NEURAL PROBE WITH OPTICAL STIMULATION CAPABILITY - A neural probe is disclosed for optically stimulating or silencing neurons and recording electrical responses to the stimulus. Using patterning techniques, an integral optical waveguide may be fabricated on the probe for transmitting neuron-affecting light from a light source to a probe tip. The probe tip may include one or more electrodes to receive electrical responses from stimulated neurons for recording or further processing. According to various embodiments, the disclosed neural probes may utilize multiple light sources simultaneously, switch between multiple light sources, or utilize a single light source to stimulate or silence multiple neuron locations simultaneously via multiple probe tips or via multiple light-emitting sites located along the length of the probe. Neural probes are thereby provided that have sufficient spatial resolution to accurately target, stimulate, and record the reaction of neurons, or as few as a single neuron, utilizing a slim, compact structure. | 03-28-2013 |
20130130301 | MICROFLUIDIC PLATFORM FOR DISCRETE CELL ASSAY - A microfluidic chamber for use in individual cell assays. The microfluidic chamber includes a cell microchamber having an interior region and front and rear valves, each of which are separately controllable so that they can be selectively opened and closed to thereby permit the transference of an individual cell into and out of the interior region. Cell secretion and contact interaction studies can be carried out using the microchambers, with the valves permitting either complete isolation or perfusion media flow through the microchambers. An internal perfusion wall can be included to partition the microchamber for non-contact perfusion studies of secretion interactions between cells. | 05-23-2013 |
20140093953 | NON-ADHERENT CELL SUPPORT AND MANUFACTURING METHOD - A non-adherent cell support for use as a substrate in fluidic chambers used for cell culturing and assays. The non-adherent cell support allows for the formation of sphere cultures from single cells, which can better mimic primary tumor-like behavior in the study of cancer stem cells. The non-adherent cell support can allow for adhesive culturing and may include a hydrophobic substrate having a lower body and a raised support structure extending upwardly from an upper surface of the body. The support structure comprises one or more vertically extending support members that extend from a proximal portion at the upper surface of the body to a distal end spaced from the upper surface of the body. The support structure may be formed from a biocompatible material such as poly-2-hydroxyethyl methacrylate, polydimethylsiloxane, polymethyl methacrylate, polystyrene, or a polyethylene glycol diacrylate-based hydrogel. | 04-03-2014 |
20140093962 | NON-ADHERENT CELL SUPPORT AND MANUFACTURING METHOD - A non-adherent cell support for use as a substrate in fluidic chambers used for cell culturing and assays. The non-adherent cell support allows for the formation of sphere cultures from single cells, which can better mimic primary tumor-like behavior in the study of cancer stem cells. The non-adherent cell support can allow for adhesive culturing and may include a hydrophobic substrate having a lower body and a raised support structure extending upwardly from an upper surface of the body. The support structure comprises one or more vertically extending support members that extend from a proximal portion at the upper surface of the body to a distal end spaced from the upper surface of the body. The support structure may be formed from a biocompatible material such as poly-2-hydroxyethyl methacrylate, polydimethylsiloxane, polymethyl methacrylate, polystyrene, or a polyethylene glycol diacrylate-based hydrogel. | 04-03-2014 |
20140118592 | CMOS IMAGE SENSORS WITH FEATURE EXTRACTION - A CMOS imaging sensor with ernbedded feature extraction capability operatable in different modes by a method that includes the steps of: (a) operating the CMOS imaging sensor in a motion-detecting mode at a first power level using circuitry on the imaging sensor that generates motion data based on received images detected by pixels in the pixel array; (b) switching the imaging sensor from the motion-detecting mode to a feature extraction mode in response to detecting motion; and (c) operating the imaging sensor in the feature extraction mode at a second power level that is higher than the first power level. | 05-01-2014 |